N-(1-Phenyl-3-methyl-4-benzal-pyrazolone-5)-furoic hydrazide (PMBP-FUH, C22H18N4O3, CCDC No: 188946) has been synthesized and characterized by IR spectrum, 1H NMR and single-crystal X-ray diffraction. The crystal is o...N-(1-Phenyl-3-methyl-4-benzal-pyrazolone-5)-furoic hydrazide (PMBP-FUH, C22H18N4O3, CCDC No: 188946) has been synthesized and characterized by IR spectrum, 1H NMR and single-crystal X-ray diffraction. The crystal is of orthorhombic, space group Pbca with a = 11.870(2), b = 15.951(3), c = 19.674(3) ? V = 3725.0(11) ?, Mr = 386.40, Z = 8, Dc = 1.378 g/cm3, F(000) = 1616, R = 0.0455 and wR = 0.0809. The inter- or intramolecular hydrogen bonds result in the formation of three-dimensional network structure.展开更多
A novel compound PMPP-SAL （1-phenyl-3-methyl-4-（salicylidene hydrazide）- propenylidene-pyrazolone-5） has been synthesized and characterized by elemental analysis, IR,^1H NMR and single-crystal X-ray diffraction. T...A novel compound PMPP-SAL （1-phenyl-3-methyl-4-（salicylidene hydrazide）- propenylidene-pyrazolone-5） has been synthesized and characterized by elemental analysis, IR,^1H NMR and single-crystal X-ray diffraction. The X-ray diffraction reveals that the compound is of orthorhombic, space group Pbca with a=16.132（5）, b=10.113（3）, c=23.143（7） A, V=3776（2）A°^3, Z=8, C20H20N4O3, Mr=364.40, Dc =1.282 g/cm^3, F（000）=1536,μ（MoKa）=0.089 mm^-1, S=0.992, R=0.0578 and wR=0.1362 for 1871 observed reflections with I〉2σ（I）. In the crystal, the compound possesses two C=O bonds and exists in the NH-form＇ other than NH-form.展开更多
The presence of fluorine in biologically active compounds can impart a profound influence on their biological active. This influence has lead to the development of several potent agricultural and therapeutic agents[1]...The presence of fluorine in biologically active compounds can impart a profound influence on their biological active. This influence has lead to the development of several potent agricultural and therapeutic agents[1]. During the study on the reactions of 4 - ethoxyl - 1, 1, 1 -trifluoromathyl-3-butenone 1, we found which is a very useful building-block in synthesis of fluoro-containing heterocyclic compounds[2]. Compound 1 can react with perfluorophenyl hydrazine and afford 1- perfluorophenyl-5-trifluoromethyl- 5 -hydroxy-4, 5 -2H- pyrazole 2 in excellent yield. It’s structure is further supported by X-ray diffraction.展开更多
A series of 1 substituted phenoxyacetyl 4 aroyl thiosemicarbazides were synthe sized by reaction of aroylisothiocyanate with (substituted)phenoxyacetic acid hydrazides under solid liquid phase transfer catalysis condi...A series of 1 substituted phenoxyacetyl 4 aroyl thiosemicarbazides were synthe sized by reaction of aroylisothiocyanate with (substituted)phenoxyacetic acid hydrazides under solid liquid phase transfer catalysis condition. The preliminary bioassay results showed that some of the compounds have good antibiotic activity and plant growth regulation activity. The compounds were characterized by elemental analysis, IR and 1H NMR.展开更多
基金the National Natural Science Foundation of China (No. 20262005)
文摘N-(1-Phenyl-3-methyl-4-benzal-pyrazolone-5)-furoic hydrazide (PMBP-FUH, C22H18N4O3, CCDC No: 188946) has been synthesized and characterized by IR spectrum, 1H NMR and single-crystal X-ray diffraction. The crystal is of orthorhombic, space group Pbca with a = 11.870(2), b = 15.951(3), c = 19.674(3) ? V = 3725.0(11) ?, Mr = 386.40, Z = 8, Dc = 1.378 g/cm3, F(000) = 1616, R = 0.0455 and wR = 0.0809. The inter- or intramolecular hydrogen bonds result in the formation of three-dimensional network structure.
基金This work was supported by the National Natural Science Foundation of China (20262005 and 20366005)
文摘A novel compound PMPP-SAL （1-phenyl-3-methyl-4-（salicylidene hydrazide）- propenylidene-pyrazolone-5） has been synthesized and characterized by elemental analysis, IR,^1H NMR and single-crystal X-ray diffraction. The X-ray diffraction reveals that the compound is of orthorhombic, space group Pbca with a=16.132（5）, b=10.113（3）, c=23.143（7） A, V=3776（2）A°^3, Z=8, C20H20N4O3, Mr=364.40, Dc =1.282 g/cm^3, F（000）=1536,μ（MoKa）=0.089 mm^-1, S=0.992, R=0.0578 and wR=0.1362 for 1871 observed reflections with I〉2σ（I）. In the crystal, the compound possesses two C=O bonds and exists in the NH-form＇ other than NH-form.
基金The authors thank the National Natural Science Foundation ofChina (NNSFC) !(No. 29872051 and No 29672041 ) for financial support
文摘The presence of fluorine in biologically active compounds can impart a profound influence on their biological active. This influence has lead to the development of several potent agricultural and therapeutic agents[1]. During the study on the reactions of 4 - ethoxyl - 1, 1, 1 -trifluoromathyl-3-butenone 1, we found which is a very useful building-block in synthesis of fluoro-containing heterocyclic compounds[2]. Compound 1 can react with perfluorophenyl hydrazine and afford 1- perfluorophenyl-5-trifluoromethyl- 5 -hydroxy-4, 5 -2H- pyrazole 2 in excellent yield. It’s structure is further supported by X-ray diffraction.
文摘A series of 1 substituted phenoxyacetyl 4 aroyl thiosemicarbazides were synthe sized by reaction of aroylisothiocyanate with (substituted)phenoxyacetic acid hydrazides under solid liquid phase transfer catalysis condition. The preliminary bioassay results showed that some of the compounds have good antibiotic activity and plant growth regulation activity. The compounds were characterized by elemental analysis, IR and 1H NMR.
