Background The relationship between symptom elimination and normalization of esophageal acid level of gastroesophageal reflux disease （GERD） on proton-pump inhibitor （PPI） therapy has been questioned. This study a...Background The relationship between symptom elimination and normalization of esophageal acid level of gastroesophageal reflux disease （GERD） on proton-pump inhibitor （PPI） therapy has been questioned. This study aimed to evaluate the relationship between symptom response and gastro-esophageal acidity control in Chinese patients with GERD on esomeprazole therapy, and to assess the role of 24-hour esophageal pH-metry after therapy in GERD patients.Methods GERD patients with typical reflux symptoms were enrolled and received esomeprazole 40 mg once daily for 4 weeks. Patients with positive baseline 24-hour esophageal pH-metry were divided into two groups depending on an additional dual-channel 24-hour pH-metry after treatment. The pH- group achieved normalization of esophageal pH level whereas the pH＋ group did not.Results Of the 80 patients studied, 76 had abnormal baseline esophageal pH levels. Of these, 90% （52/58） of symptom-free patients and 67% （12/18） of symptom-persistent patients achieved esophageal pH normalization after therapy （P=0.030）. The mean post-therapy gastric nocturnal percent time of pH 〈4.0 was significantly higher in pH＋group than that in pH- group （P 〈0.001） after therapy. The multivariate regression analysis identified hiatus hernia （P〈0.001） and persistent reflux symptom （P=0.004） were two independent factors predicting the low post-therapy esophageal pH level.Conclusions Symptom elimination is not always accompanied by esophageal pH normalization, and vice verse.Esophageal pH-metry is recommended for GERD patients with hiatus hernia or with persistent reflux symptoms after PPI therapy.展开更多
目的:探讨改良人工唾液对鼻咽癌放疗患者全唾液pH值和缓冲能力的影响。方法:选择8例因鼻咽癌放疗并伴有口干症的患者为受试者,收集唾液时间为上午9点至11点。用改良人工唾液含漱1 m in,收集基线时及含漱后2分钟静止性及刺激性全唾液,对...目的:探讨改良人工唾液对鼻咽癌放疗患者全唾液pH值和缓冲能力的影响。方法:选择8例因鼻咽癌放疗并伴有口干症的患者为受试者,收集唾液时间为上午9点至11点。用改良人工唾液含漱1 m in,收集基线时及含漱后2分钟静止性及刺激性全唾液,对含漱前后静止性唾液的pH值和含漱前后刺激性唾液的缓冲能力进行测定。结果:经改良人工唾液含漱后,患者静止性全唾液pH值较含漱前为高,经统计学检验其差异具有显著性(P<0.05);患者刺激性全唾液缓冲能力大于含漱前,经统计学检验其差异具有高度显著性意义(P<0.01)。结论:改良人工唾液具有改善鼻咽癌放疗患者全唾液pH值和缓冲能力的作用。展开更多
文摘Background The relationship between symptom elimination and normalization of esophageal acid level of gastroesophageal reflux disease （GERD） on proton-pump inhibitor （PPI） therapy has been questioned. This study aimed to evaluate the relationship between symptom response and gastro-esophageal acidity control in Chinese patients with GERD on esomeprazole therapy, and to assess the role of 24-hour esophageal pH-metry after therapy in GERD patients.Methods GERD patients with typical reflux symptoms were enrolled and received esomeprazole 40 mg once daily for 4 weeks. Patients with positive baseline 24-hour esophageal pH-metry were divided into two groups depending on an additional dual-channel 24-hour pH-metry after treatment. The pH- group achieved normalization of esophageal pH level whereas the pH＋ group did not.Results Of the 80 patients studied, 76 had abnormal baseline esophageal pH levels. Of these, 90% （52/58） of symptom-free patients and 67% （12/18） of symptom-persistent patients achieved esophageal pH normalization after therapy （P=0.030）. The mean post-therapy gastric nocturnal percent time of pH 〈4.0 was significantly higher in pH＋group than that in pH- group （P 〈0.001） after therapy. The multivariate regression analysis identified hiatus hernia （P〈0.001） and persistent reflux symptom （P=0.004） were two independent factors predicting the low post-therapy esophageal pH level.Conclusions Symptom elimination is not always accompanied by esophageal pH normalization, and vice verse.Esophageal pH-metry is recommended for GERD patients with hiatus hernia or with persistent reflux symptoms after PPI therapy.
文摘目的:探讨改良人工唾液对鼻咽癌放疗患者全唾液pH值和缓冲能力的影响。方法:选择8例因鼻咽癌放疗并伴有口干症的患者为受试者,收集唾液时间为上午9点至11点。用改良人工唾液含漱1 m in,收集基线时及含漱后2分钟静止性及刺激性全唾液,对含漱前后静止性唾液的pH值和含漱前后刺激性唾液的缓冲能力进行测定。结果:经改良人工唾液含漱后,患者静止性全唾液pH值较含漱前为高,经统计学检验其差异具有显著性(P<0.05);患者刺激性全唾液缓冲能力大于含漱前,经统计学检验其差异具有高度显著性意义(P<0.01)。结论:改良人工唾液具有改善鼻咽癌放疗患者全唾液pH值和缓冲能力的作用。
