Quantification of In Vivo Epidermal Keratinocyte Architecture Associated with the Signs of Skin Aging and the Skin Benefit Evaluation by Application of Galactomyces Ferment Filtrate (Pitera)-Containing Skin Care Product

Background: Aged skin exhibits visual alterations such as wrinkles, rough texture, pore dilation, and dull skin tone, as well as physiological aging, namely, decreased hydration and increased transepidermal water loss (TEWL). Recent advances in coherence tomography have also revealed that skin aging affects in vivo epidermal keratinocyte architecture. However, the interconnectivity between spatial architectural aging and visual/physiological aging parameters remains largely unknown. Purpose: To elucidate whether the tomographic keratinocyte architectural aging is correlated with visual and physiological skin aging parameters and to quantitatively evaluate the improvements of the architectural, visual, and physiological aging parameters by the daily treatment of the skin care formula containing Galactomyces Ferment Filtrate (GFF, 8X PiteraTM). Method: We measured the in vivo keratinocyte cellular architecture with two-photon stereoscopic tomography obtaining by-layer epidermal section images in 78 Asian females of various ages. Visual aging parameters were analyzed using a portable image capture system. Hydration and TEWL were also assessed. The anti-aging effects of GFF-containing skin moisturizer (SK-II LXP CreamTM) were also examined in two studies after twice-daily application for 2 (N = 35) and 4 (N = 32) weeks. Results: As for the keratinocyte cellular architecture, skin aging was significantly associated with decreased cell density and increased cell uniformity. These architectural aging parameters were significantly correlated with visual and physiological aging parameters, namely, rough texture, wrinkles, pore dilation, dull skin tone, dehydration, and increased TEWL. The strong interconnectivity allowed us to develop formulae to estimate the keratinocyte architecture from visual aging parameters. Moreover, twice-daily application of SK-II significantly improved the keratinocyte architecture associated with multiple skin aging visual and physiological parameters. Conclusion: Skin aging is a process involving mutual interconnections among epidermal keratinocyte cellular architecture, visual, and physiological parameters. The GFF-containing moisturizer SK-II effectively improves spatial architecture of keratinocytes in epidermis and these evaluated skin aging parameters in a new trajectory over the course of treatment. .

Study of the Effect of Operating Temperatures (1320 K, 1420 K and 1520 K) on the Vacant Sites of TiN Alloy in B2 Structure at 45%, 50% and 55% N by MEAM Method

In this work, we have studied the vacancy formation energy of TiN alloy of structure B2 of size 10 × 10 × 10 for nitrogen percentages of 45%, 50% and 55% under the influence of temperature at 1320 K, 1420 K and 1520 K using the Modified Embedded Atom Method MEAM under the calculation code LAMMPS version 2020. This study has enabled us to understand the behavior of the TiN alloy under different nitrogen percentages in terms of total energy, vacancy formation energy, crystalline parameter, occupancy rate and order parameter. For total energy, we have shown that as temperature increases, total energy decreases, making it easier to obtain TiN at higher temperatures;reaching the value of -7344.9169 eV for the 55% nitrogen structure for the temperature of 1420 K. For the energy of formation, we have shown that the compounds obtained at 1320 K and 1520 K have a more considerable energy of formation than that obtained at 1420 K. The study of fractions and the order parameter showed us that the structure of TiN with 55% nitrogen is less likely, as the composition obtained is at most 53.35%.

3-D velocity structure in the central-eastern part of Qilianshan

The 3-D velocity tomography image of the central-eastern part of Qilianshan is obtained by the joint inversion of 3-D velocity structure and focal parameters based on the S-P data of micro-earthquakes recorded by the digital seismic network set up for a Sino-French cooperation program since 1996. The inversed velocity structure does primarily reflect some important features of the deep structure in the region and provide the scientific background for the further study of active tectonic structure and the calculation of earthquake parameters.

A novel analytic potential function applied to neutral diatomic molecules and charged lons

In this paper, a new method on constructing analytical potential energy functions is pre-sented, and from this a analytical potential en-ergy function applied to both neutral diatomic molecules and charged diatomic molecular ions is obtained. This potential energy function in-cludes three dimensionless undetermined pa-rameters which can be determined uniquely by solving linear equations with the experimental spectroscopic parameters of molecules. The solutions of the dimensionless undetermined parameters are real numbers rather than com-plex numbers, this ensures that the analytical potential energy function has extensive uni-versality. Finally, the potential energy function is examined with four kinds of diatomic molecules or ions—homonuclear neutral diatomic mole-cule , and , homonuclear charged diatomic molecular ion , and , heter-nuclear neutral diatomic Molecule , and , heternuclear ch- arged diatomic Molecular ion , and ,as a conseque- nce, good results are obtained.

Influence of the Structure Parameters on the Characteristics of Dynamic Mixer with Striped Channels

The influence of the structure parameters on the characteristics of dynamic mixer with striped channels is studied. As results indicate that, given the proper structure parameters, the output of the extruder can be increased with low energy consumption and stable temperature. Furthermore, the mixing effect will be improved up to or even above that of spherical cavity mixer.

基于Simulink的数控机床多惯量伺服进给系统的建模与仿真（英文）

针对双惯量伺服进给系统对其中间环节分析不足、参数整定算法精度较低等问题,提出了一种多惯量伺服进给系统模块化建模的方法。将数控机床伺服进给系统转化为多惯量系统,分为电机、丝杠、工作台3个单元,单元间的连接件(联轴器和丝杠螺母)均等效为柔性连接件。基于PID的三闭环控制系统,运用Matlab对永磁同步电机矢量控制系统模型、机械传动系统模型进行仿真,整定优化各项参数。仿真结果表明:模块化建模方法能够对多惯量伺服系统存在的问题进行精准分析,对系统中间连接环节具有更为有效的分析效果;提高了仿真模型以及参数整定算法的精度,且仿真效果较好。

SVD-LSSVM and its application in chemical pattern classification

Pattern classification is an important field in machine learning; least squares support vector machine (LSSVM) is a powerful tool for pattern classification. A new version of LSSVM, SVD-LSSVM, to save time of selecting hyper parameters for LSSVM is proposed. SVD-LSSVM is trained through singular value decomposition (SVD) of kernel matrix. Cross validation time of selecting hyper parameters can be saved because a new hyper parameter, singular value contribution rate (SVCR), replaces the penalty factor of LSSVM. Several UCI benchmarking data and the Olive classification problem were used to test SVD-LSSVM. The result showed that SVD-LSSVM has good performance in classification and saves time for cross validation.