Pacinian corpuscle is a tactile receptor that responds to high-frequency(20-1000 Hz)vibration and has high-pass filtering and mechanical signal amplification functions.It is the main receptor of vibration tactility cl...Pacinian corpuscle is a tactile receptor that responds to high-frequency(20-1000 Hz)vibration and has high-pass filtering and mechanical signal amplification functions.It is the main receptor of vibration tactility closely related to fine touch sensation,which is the ability to perceive and localize objects’shape,texture,and size.Currently,it is still difficult to measure and calculate the friction generated by robots grasping objects.The resolution of touch and vibration sensors cannot satisfy the demand for understanding tribological behavior.The simulation of Pacinian corpuscles’structure and replication of its key functions will bring richer touch information to robots.In this review article,the structure and functions of Pacinian corpuscles are summarized from the internal structure of a single Pacinian corpuscle and the spatial distribution of multiple Pacinian corpuscles.Then,theoretical models and research on the bionics design of Pacinian corpuscles are introduced based on the three reception processes of Pacinian corpuscles:mechanical transmission,electromechanical transduction,and neural excitation.Finally,the bottlenecks of current research on the simulation of Pacinian corpuscles are summarized,followed by the proposal of research ideas on the simulation of Pacinian corpuscles.展开更多
t Touch sensation is critical for our social and environmental interactions. In mammals, most discriminative light touch sensation is mediated by the Aβ low-threshold mechanoreceptors. Cell bodies of Aβ low-threshol...t Touch sensation is critical for our social and environmental interactions. In mammals, most discriminative light touch sensation is mediated by the Aβ low-threshold mechanoreceptors. Cell bodies of Aβ low-threshold mechanoreceptors are located in the dorsal root ganglia and trigeminal ganglia, which extend a central projection innervating the spinal cord and brain stem and a peripheral projection innervating the specialized mechanosensory end organs. These specialized mechanosensory end organs include Meissner＇s corpuscles, Pacinian corpuscles, lanceolate endings, Merkel cells, and Ruffini corpuscles. The morphologies and physiological properties of these mechanosensory end organs and their innervating neurons have been investigated for over a century. In addition, recent advances in mouse genetics have enabled the identification of molecular mechanisms underlying the development of Aβ low- threshold mechanoreceptors, which highlight the crucial roles of neurotrophic factor signaling and transcription factor activity in this process. Here, we will review the anatomy, physiological properties, and development of mammalian low- threshold Aβ mechanoreceptors.展开更多
基金support from the National Natural Science Foundation of China (No.51805218)Natural Science Foundation of Jiangsu Province (No.BK20170552)China Postdoctoral Science Foundation Funded Project (No.2018M632239).
文摘Pacinian corpuscle is a tactile receptor that responds to high-frequency(20-1000 Hz)vibration and has high-pass filtering and mechanical signal amplification functions.It is the main receptor of vibration tactility closely related to fine touch sensation,which is the ability to perceive and localize objects’shape,texture,and size.Currently,it is still difficult to measure and calculate the friction generated by robots grasping objects.The resolution of touch and vibration sensors cannot satisfy the demand for understanding tribological behavior.The simulation of Pacinian corpuscles’structure and replication of its key functions will bring richer touch information to robots.In this review article,the structure and functions of Pacinian corpuscles are summarized from the internal structure of a single Pacinian corpuscle and the spatial distribution of multiple Pacinian corpuscles.Then,theoretical models and research on the bionics design of Pacinian corpuscles are introduced based on the three reception processes of Pacinian corpuscles:mechanical transmission,electromechanical transduction,and neural excitation.Finally,the bottlenecks of current research on the simulation of Pacinian corpuscles are summarized,followed by the proposal of research ideas on the simulation of Pacinian corpuscles.
文摘t Touch sensation is critical for our social and environmental interactions. In mammals, most discriminative light touch sensation is mediated by the Aβ low-threshold mechanoreceptors. Cell bodies of Aβ low-threshold mechanoreceptors are located in the dorsal root ganglia and trigeminal ganglia, which extend a central projection innervating the spinal cord and brain stem and a peripheral projection innervating the specialized mechanosensory end organs. These specialized mechanosensory end organs include Meissner＇s corpuscles, Pacinian corpuscles, lanceolate endings, Merkel cells, and Ruffini corpuscles. The morphologies and physiological properties of these mechanosensory end organs and their innervating neurons have been investigated for over a century. In addition, recent advances in mouse genetics have enabled the identification of molecular mechanisms underlying the development of Aβ low- threshold mechanoreceptors, which highlight the crucial roles of neurotrophic factor signaling and transcription factor activity in this process. Here, we will review the anatomy, physiological properties, and development of mammalian low- threshold Aβ mechanoreceptors.
