Objective:To find out factors related to the delay in diagnosis of panic disorder. Methods: One hundred patients with panic disorder were assessed and investigated with SCL-90 and a self-compiled questionnaire.Linear ...Objective:To find out factors related to the delay in diagnosis of panic disorder. Methods: One hundred patients with panic disorder were assessed and investigated with SCL-90 and a self-compiled questionnaire.Linear regression was applied in the multivariate statistical analysis,with the delayed time (from the age at onset to the age at being definitely diagnosed) as dependent variable and SCL-90 factorial scores, the existing symptoms and the demographic factors as independent variables. Results:Factors negatively correlated with the delayed time were depression ,nausea/abdominal discomfort and fear of dying while those positively correlated with it were phobia and depersonalization/derealization. Conclusion: Depression may contribute to early diagnosis of panic disorder.展开更多
目的综合评价惊恐障碍与外周血脑源性神经营养因子(BDNF)水平的相关性,探索该类患者外周血BDNF水平特点及相关因素。方法计算机检索ISI Web of science,Embase,Pubmed和中国期刊网(CNKI)、万方数据资源系统、中国科技期刊数据库(维普数...目的综合评价惊恐障碍与外周血脑源性神经营养因子(BDNF)水平的相关性,探索该类患者外周血BDNF水平特点及相关因素。方法计算机检索ISI Web of science,Embase,Pubmed和中国期刊网(CNKI)、万方数据资源系统、中国科技期刊数据库(维普数据库),并辅以文献追溯方法,收集1980年1月~2010年8月国内外公开发表的关于惊恐障碍患者外周血BDNF水平的研究文献,采用Revman5.0软件进行Meta分析。结果共纳入3篇文献,累计299名被试者。由于文献数量较少且存在明显的异质性(I2=96%),不进行Meta分析,故仅就文献内容进行了描述。结论目前关于惊恐障碍患者外周血BDNF水平的研究数量尚少。各研究之间结果差异甚大,且在已有研究中存在信息不明确、报告不标准和不全面等问题,需采用公认的测量方法和全面报告结果的准则,进行大样本、前瞻性对照研究。展开更多
目的观察惊恐伤肾对大鼠记忆力的影响及左归丸的脑保护作用。方法将40只雌性Waster大鼠按体重随机分为4组,分别为假手术组、脑缺血模型组、肾虚模型组与实验组,后3组进行大脑中动脉阻塞(MCAO)造模手术;肾虚模型组于MCAO手术前10天,用&qu...目的观察惊恐伤肾对大鼠记忆力的影响及左归丸的脑保护作用。方法将40只雌性Waster大鼠按体重随机分为4组,分别为假手术组、脑缺血模型组、肾虚模型组与实验组,后3组进行大脑中动脉阻塞(MCAO)造模手术;肾虚模型组于MCAO手术前10天,用"猫吓鼠"法进行恐吓,实验组于MCAO手术前3天,灌胃1.62 g·kg-1左归丸汤剂2 m L,每日1次,连续给药10 d,其他3组给予等体积生理盐水。新奇物认知法检测大鼠记忆力;免疫组化法及免疫印迹法检测脑源性神经营养因子(BDNF)的表达。结果与假手术组比较,脑缺血模型组大鼠记忆力下降;与脑缺血模型组比较,肾虚模型组大鼠记忆力下降且BDNF表达明显下调(P<0.05)。与肾虚模型组比较,实验组大鼠记忆力明显改善,同时BDNF表达量明显增加(P<0.05)。结论惊恐伤肾可加重大鼠缺血后记忆障碍,左归丸可以改善惊恐伤肾大鼠缺血后记忆力,这种作用有可能通过上调BDNF来实现。展开更多
文摘Objective:To find out factors related to the delay in diagnosis of panic disorder. Methods: One hundred patients with panic disorder were assessed and investigated with SCL-90 and a self-compiled questionnaire.Linear regression was applied in the multivariate statistical analysis,with the delayed time (from the age at onset to the age at being definitely diagnosed) as dependent variable and SCL-90 factorial scores, the existing symptoms and the demographic factors as independent variables. Results:Factors negatively correlated with the delayed time were depression ,nausea/abdominal discomfort and fear of dying while those positively correlated with it were phobia and depersonalization/derealization. Conclusion: Depression may contribute to early diagnosis of panic disorder.
文摘目的综合评价惊恐障碍与外周血脑源性神经营养因子(BDNF)水平的相关性,探索该类患者外周血BDNF水平特点及相关因素。方法计算机检索ISI Web of science,Embase,Pubmed和中国期刊网(CNKI)、万方数据资源系统、中国科技期刊数据库(维普数据库),并辅以文献追溯方法,收集1980年1月~2010年8月国内外公开发表的关于惊恐障碍患者外周血BDNF水平的研究文献,采用Revman5.0软件进行Meta分析。结果共纳入3篇文献,累计299名被试者。由于文献数量较少且存在明显的异质性(I2=96%),不进行Meta分析,故仅就文献内容进行了描述。结论目前关于惊恐障碍患者外周血BDNF水平的研究数量尚少。各研究之间结果差异甚大,且在已有研究中存在信息不明确、报告不标准和不全面等问题,需采用公认的测量方法和全面报告结果的准则,进行大样本、前瞻性对照研究。
文摘目的观察惊恐伤肾对大鼠记忆力的影响及左归丸的脑保护作用。方法将40只雌性Waster大鼠按体重随机分为4组,分别为假手术组、脑缺血模型组、肾虚模型组与实验组,后3组进行大脑中动脉阻塞(MCAO)造模手术;肾虚模型组于MCAO手术前10天,用"猫吓鼠"法进行恐吓,实验组于MCAO手术前3天,灌胃1.62 g·kg-1左归丸汤剂2 m L,每日1次,连续给药10 d,其他3组给予等体积生理盐水。新奇物认知法检测大鼠记忆力;免疫组化法及免疫印迹法检测脑源性神经营养因子(BDNF)的表达。结果与假手术组比较,脑缺血模型组大鼠记忆力下降;与脑缺血模型组比较,肾虚模型组大鼠记忆力下降且BDNF表达明显下调(P<0.05)。与肾虚模型组比较,实验组大鼠记忆力明显改善,同时BDNF表达量明显增加(P<0.05)。结论惊恐伤肾可加重大鼠缺血后记忆障碍,左归丸可以改善惊恐伤肾大鼠缺血后记忆力,这种作用有可能通过上调BDNF来实现。