目的探究D-二聚体、C肽水平结合经皮氧分压对糖尿病周围神经病变(DPN)的诊断价值。方法选取2022年1月至2023年1月于安徽省皖南医学院附属太和医院接受治疗的60例2型糖尿病合并DPN患者作为研究组,另纳入60例同期未合并DPN的2型糖尿病患...目的探究D-二聚体、C肽水平结合经皮氧分压对糖尿病周围神经病变(DPN)的诊断价值。方法选取2022年1月至2023年1月于安徽省皖南医学院附属太和医院接受治疗的60例2型糖尿病合并DPN患者作为研究组,另纳入60例同期未合并DPN的2型糖尿病患者作为对照组。收集两组患者临床资料、生化指标等进行比较,多因素Logistic回归分析糖尿病患者周围神经病变的危险因素,并通过受试者临床特征(ROC)曲线分析D-二聚体、C肽水平结合经皮氧分压(TcPO_(2))对糖尿病周围神经病变的诊断价值。结果研究组患者BMI、进食后2 h C肽及TcPO_(2)水平明显低于对照组,差异有统计学意义(t=2.435、6.215、5.849,P<0.05)。糖尿病病程、血清尿酸(SUA)、糖化血红蛋白(HbA1c)、D-二聚体数值高于对照组,差异有统计学意义(t=6.677、5.789、5.621、5.285,P<0.05);多因素Logistics回归分析结果显示糖尿病病程、HbA1c、D-二聚体、进食后2hC肽、TcPO_(2)均是糖尿病患者周围神经病变的独立影响因素(P<0.05);ROC曲线分析结果显示D-二聚体、C肽水平、经皮氧分压三者单独检测及联合检测的曲线下面积(AUC)分别为:0.752、0.784、0.769、0.861,三者联合检测的诊断价值优于单一指标(P<0.05)。结论糖尿病患者血清C肽、经皮氧分压及血清D-二聚体三者联合检测对其是否发生周围神经病变具有较高诊断价值。展开更多
Densities of glycine,L-alanine and L-serine in various aqueous D-xylose solutions were measured at 298.15 K by an Anton Paar Model 55 densimeter.Apparent molar volumes,limiting partial molar volumes and hydration numb...Densities of glycine,L-alanine and L-serine in various aqueous D-xylose solutions were measured at 298.15 K by an Anton Paar Model 55 densimeter.Apparent molar volumes,limiting partial molar volumes and hydration numbers for these amino acids were calculated.The transfer volumes from water to aqueous(D-xylose) solutions were obtained and discussed in terms of the structural hydration interaction model.The results show that all of the transfer volumes are positive,and increase with increasing xylose concentration;the side-chain contributions to the transfer volumes are highly related to the nature of side-chain groups;the hydration numbers for the three amino acids in solutions decrease with increasing xylose concentration.展开更多
文摘目的探究D-二聚体、C肽水平结合经皮氧分压对糖尿病周围神经病变(DPN)的诊断价值。方法选取2022年1月至2023年1月于安徽省皖南医学院附属太和医院接受治疗的60例2型糖尿病合并DPN患者作为研究组,另纳入60例同期未合并DPN的2型糖尿病患者作为对照组。收集两组患者临床资料、生化指标等进行比较,多因素Logistic回归分析糖尿病患者周围神经病变的危险因素,并通过受试者临床特征(ROC)曲线分析D-二聚体、C肽水平结合经皮氧分压(TcPO_(2))对糖尿病周围神经病变的诊断价值。结果研究组患者BMI、进食后2 h C肽及TcPO_(2)水平明显低于对照组,差异有统计学意义(t=2.435、6.215、5.849,P<0.05)。糖尿病病程、血清尿酸(SUA)、糖化血红蛋白(HbA1c)、D-二聚体数值高于对照组,差异有统计学意义(t=6.677、5.789、5.621、5.285,P<0.05);多因素Logistics回归分析结果显示糖尿病病程、HbA1c、D-二聚体、进食后2hC肽、TcPO_(2)均是糖尿病患者周围神经病变的独立影响因素(P<0.05);ROC曲线分析结果显示D-二聚体、C肽水平、经皮氧分压三者单独检测及联合检测的曲线下面积(AUC)分别为:0.752、0.784、0.769、0.861,三者联合检测的诊断价值优于单一指标(P<0.05)。结论糖尿病患者血清C肽、经皮氧分压及血清D-二聚体三者联合检测对其是否发生周围神经病变具有较高诊断价值。
文摘Densities of glycine,L-alanine and L-serine in various aqueous D-xylose solutions were measured at 298.15 K by an Anton Paar Model 55 densimeter.Apparent molar volumes,limiting partial molar volumes and hydration numbers for these amino acids were calculated.The transfer volumes from water to aqueous(D-xylose) solutions were obtained and discussed in terms of the structural hydration interaction model.The results show that all of the transfer volumes are positive,and increase with increasing xylose concentration;the side-chain contributions to the transfer volumes are highly related to the nature of side-chain groups;the hydration numbers for the three amino acids in solutions decrease with increasing xylose concentration.
