Objective： To observe the efficacy and safety of Jingui Shengqi Pill （金匮肾气丸, JSP） in treating partial androgen deficiency in aging males （PADAM）, and to explore the new approach in improving the quality of l...Objective： To observe the efficacy and safety of Jingui Shengqi Pill （金匮肾气丸, JSP） in treating partial androgen deficiency in aging males （PADAM）, and to explore the new approach in improving the quality of life in PADAM patients. Methods： Forty patients with PADAM were treated with JSP, the efficacy was evaluated with international index of erectile function （IIEF） scoring, PADAM questionnaire scoring, hormone, prostatic specific antigen （PSA）, etc., and the data before treatment were compared with those after treatment in the same group. Results： After 3 months of treatment, PADAM scoring and IIEF scoring were all significantly improved. Symptoms regarding physical ability, vasomotion, and psychical and mental condition all got improved more markedly than symptoms regarding sexual hypofunction. The serum level of testosterone was 3.85±0.36 before treatment and 5.02±0.83 after treatmnet （P〈0.05）; luteinizing hormone of 7.33±2.14 and 4.84±1.43 （P〈0.01）, follicule-stimulating hormone of 10.22±4.48 and 6.47±3.28 （P〈0.01）, respectively. The level of PSA failed to change significantly （1.94±0.55 and 2.06±0.47, P〉0.05）. Conclusion： JSP is effective and safe in treating PADAM, the mechanism of it is different from supplementing extrinsic androgen. It may have produced the effect by means of favorably regulating the condition of sex hormone to improve the balance of pituitary-sex gland axis, so it has more extensive clinical application.展开更多
目的:探索应用中医药治疗中老年男性部分雄激素缺乏综合征(PADAM)的有效性及安全性。方法:对30例PADAM患者予口服中和汤煎剂,于治疗前后记录症状评分、血清TT、FT及PSA水平。结果:治疗后体能和血管症状、精神症状及性功能减退症状评分...目的:探索应用中医药治疗中老年男性部分雄激素缺乏综合征(PADAM)的有效性及安全性。方法:对30例PADAM患者予口服中和汤煎剂,于治疗前后记录症状评分、血清TT、FT及PSA水平。结果:治疗后体能和血管症状、精神症状及性功能减退症状评分均有明显改善(P<0.001),TT、FT水平均有升高(P分别<0.001、0.002),PSA水平无明显变化(P>0.05),除轻微消化道症状外,未发生明显的毒、副作用。结论:中和汤有较好的治疗P A D A M的作用,且无雄激素补充治疗所常有的副作用及禁忌症。展开更多
文摘Objective： To observe the efficacy and safety of Jingui Shengqi Pill （金匮肾气丸, JSP） in treating partial androgen deficiency in aging males （PADAM）, and to explore the new approach in improving the quality of life in PADAM patients. Methods： Forty patients with PADAM were treated with JSP, the efficacy was evaluated with international index of erectile function （IIEF） scoring, PADAM questionnaire scoring, hormone, prostatic specific antigen （PSA）, etc., and the data before treatment were compared with those after treatment in the same group. Results： After 3 months of treatment, PADAM scoring and IIEF scoring were all significantly improved. Symptoms regarding physical ability, vasomotion, and psychical and mental condition all got improved more markedly than symptoms regarding sexual hypofunction. The serum level of testosterone was 3.85±0.36 before treatment and 5.02±0.83 after treatmnet （P〈0.05）; luteinizing hormone of 7.33±2.14 and 4.84±1.43 （P〈0.01）, follicule-stimulating hormone of 10.22±4.48 and 6.47±3.28 （P〈0.01）, respectively. The level of PSA failed to change significantly （1.94±0.55 and 2.06±0.47, P〉0.05）. Conclusion： JSP is effective and safe in treating PADAM, the mechanism of it is different from supplementing extrinsic androgen. It may have produced the effect by means of favorably regulating the condition of sex hormone to improve the balance of pituitary-sex gland axis, so it has more extensive clinical application.
文摘目的:探索应用中医药治疗中老年男性部分雄激素缺乏综合征(PADAM)的有效性及安全性。方法:对30例PADAM患者予口服中和汤煎剂,于治疗前后记录症状评分、血清TT、FT及PSA水平。结果:治疗后体能和血管症状、精神症状及性功能减退症状评分均有明显改善(P<0.001),TT、FT水平均有升高(P分别<0.001、0.002),PSA水平无明显变化(P>0.05),除轻微消化道症状外,未发生明显的毒、副作用。结论:中和汤有较好的治疗P A D A M的作用,且无雄激素补充治疗所常有的副作用及禁忌症。
