The main sources of nssSO 2- 4 and NO - 3 were summarized in this paper. By analyzing the spatial distribution features of major ions in Antarctic ice sheet and studying on the different time of the same volca...The main sources of nssSO 2- 4 and NO - 3 were summarized in this paper. By analyzing the spatial distribution features of major ions in Antarctic ice sheet and studying on the different time of the same volcanic event recorded by different ice cores from different regions in Antarctica, this paper intends to study the transmission path of nssSO 2- 4 and NO - 3. Results show that nssSO 2- 4 and NO - 3 are transmitted to the ice sheet through long distance and high altitude. The procedure of the transmission is that nssSO 2- 4 and NO - 3 are transmitted to the level between the top of troposphere and the bottom of stratosphere, then subsided to the ice sheet surface and spread to other regions.展开更多
In the present work we study the Hamiltonian, path integral and BRST formulations of the Chern-Simons-Higgs theory in two-space one-time dimensions, in the so-called broken symmetry phase of the Higgs potential (where...In the present work we study the Hamiltonian, path integral and BRST formulations of the Chern-Simons-Higgs theory in two-space one-time dimensions, in the so-called broken symmetry phase of the Higgs potential (where the phase φ(xμ) of the complex matter field Φ(xμ) carries the charge degree of freedom of the complex matter field and is akin to the Goldstone boson) on the light-front (i.e., on the hyperplanes defined by the fixed light-cone time). The theory is seen to possess a set of first-class constraints and the local vector gauge symmetry. The theory being gauge-invariant is quantized under appropriate gauge-fixing conditions. The explicit Hamiltonian and path integral quantization is achieved under the above light-cone gauges. The Heisenberg equations of motion of the system are derived for the physical degrees of freedom of the system. Finally the BRST quantization of the system is achieved under appropriate BRST gauge-fixing, where the BRST symmetry is maintained even under the BRST light-cone gauge-fixing.展开更多
Benzene is an established leukotoxin and leukemogen in humans. We have previously re- ported that exposure of workers to benzene and to benzene metabolite hydroquinone in cultured cells induced DNA-dependent protein k...Benzene is an established leukotoxin and leukemogen in humans. We have previously re- ported that exposure of workers to benzene and to benzene metabolite hydroquinone in cultured cells induced DNA-dependent protein kinase catalytic subunit (DNA-PKcs) to mediate the cellular response to DNA double strand break (DSB) caused by DNA-damaging metabolites. In this study, we used a new, small molecule, a selective inhibitor of DNA-PKcs, 2-(morpholin-4-yl)-benzo[h]chomen-4-one (NU7026), as a probe to analyze the molecular events and pathways in hydroquinone-induced DNA DSB repair and apoptosis. Inhibition of DNA-PKcs by NU7026 markedly potentiated the apoptotic and growth inhibitory effects of hydroquinone in proerythroid leukemic K562 cells in a dose-dependent manner. Treatment with NU7026 did not alter the production of reactive oxygen species and oxidative stress by hydroquinone but repressed the protein level of DNA-PKcs and blocked the induction of the kinase mRNA and protein expression by hydroquinone. Moreover, hydroquinone increased the phos- phorylation of Akt to activate Akt, whereas co-treatment with NU7026 prevented the activation of Akt by hydroquinone. Lastly, hydroquinone and NU7026 exhibited synergistic effects on promoting apop- tosis by increasing the protein levels of pro-apoptotic proteins Bax and caspase-3 but decreasing the protein expression of anti-apoptotic protein Bcl-2. Taken together, the findings reveal a central role of DNA-PKcs in hydroquinone-induced hematotoxicity in which it coordinates DNA DSB repair, cell cycle progression, and apoptosis to regulate the response to hydroquinone-induced DNA damage.展开更多
Changes in requirements may result in the increasing of product development project cost and lead time, therefore, it is important to understand how require- ment changes propagate in the design of complex product sys...Changes in requirements may result in the increasing of product development project cost and lead time, therefore, it is important to understand how require- ment changes propagate in the design of complex product systems and be able to select best options to guide design. Currently, a most approach for design change is lack of take the multi-disciplinary coupling relationships and the number of parameters into account integrally. A new design change model is presented to systematically analyze and search change propagation paths. Firstly, a PDS-Be- havior-Structure-based design change model is established to describe requirement changes causing the design change propagation in behavior and structure domains. Secondly, a multi-disciplinary oriented behavior matrix is utilized to support change propagation analysis of complex product systems, and the interaction relationships of the matrix elements are used to obtain an initial set of change paths. Finally, a rough set-based propagation space reducing tool is developed to assist in narrowing change propagation paths by computing the importance of the design change parameters. The proposed new design change model and its associated tools have been demonstrated by the scheduling change propagation paths of high speed train's bogie to show its feasibility and effectiveness. This model is not only supportive to response quickly to diversified market requirements, but also helpful to satisfy customer require- ments and reduce product development lead time. The proposed new design change model can be applied in a wide range of engineering systems design with improved efficiency.展开更多
The mixed propagator (MP) approach to ρ-ω mixing is discussed. It is found that under the pole-approximation assumption the results of MP approach is not compatible both with the effective Lagrangian theory andwith ...The mixed propagator (MP) approach to ρ-ω mixing is discussed. It is found that under the pole-approximation assumption the results of MP approach is not compatible both with the effective Lagrangian theory andwith the experiment measurement criterion. To overcome these inconsistent, we propose a new MP approach in whichthe physical states of ρ and ω are determined by the requirement of experimental measurement to meson resonance. Interms of this new MP approach, the EM pion form factor Fπ and form factors of ρo →π0γ and of ω→πo γ are derived.The results of Fπ are in good agreement with data. The form factor of ρo →π0γ exhibits a hidden charge-asymmetryenhancement effect which agrees with the prediction of the effective Lagrangian theory.展开更多
The UAVs (unmanned aerial vehicles) and the use of graphical data files of extension KML (keyhole markup language) have become popular nowadays. The KML files are associated to the Google Earth applications. Devel...The UAVs (unmanned aerial vehicles) and the use of graphical data files of extension KML (keyhole markup language) have become popular nowadays. The KML files are associated to the Google Earth applications. Developed by Microdrone company for planning, overflight simulation and data flight analysis, the program mdCockpit was used in this experiment. The UAV Microdrone's flight path was programmed in two ways: using geo referenced images from Google Earth and entering points coordinates into the program. These points have had their geographical decimal coordinates collected by GPS (global positioning system) (RTK (real time kinematic)) method. The aim here is to describe a way of evaluating the difference between the alternatives of flight planning. A flight path, defined a route with 22 points, was also simulated in the program mdCockpit. The points were collected and saved, while the images captured by the program went automatically forming a georeferenced mosaic. A comparison between the differences of coordinates to each point was made by choosing on the images and also by a RTK positioning. The result was up to 14.20 m to a 100 m flight height. There is a significant change of position and this can result in unwanted over flights in locations or even jeopardizing the safety of air activity.展开更多
文摘The main sources of nssSO 2- 4 and NO - 3 were summarized in this paper. By analyzing the spatial distribution features of major ions in Antarctic ice sheet and studying on the different time of the same volcanic event recorded by different ice cores from different regions in Antarctica, this paper intends to study the transmission path of nssSO 2- 4 and NO - 3. Results show that nssSO 2- 4 and NO - 3 are transmitted to the ice sheet through long distance and high altitude. The procedure of the transmission is that nssSO 2- 4 and NO - 3 are transmitted to the level between the top of troposphere and the bottom of stratosphere, then subsided to the ice sheet surface and spread to other regions.
文摘In the present work we study the Hamiltonian, path integral and BRST formulations of the Chern-Simons-Higgs theory in two-space one-time dimensions, in the so-called broken symmetry phase of the Higgs potential (where the phase φ(xμ) of the complex matter field Φ(xμ) carries the charge degree of freedom of the complex matter field and is akin to the Goldstone boson) on the light-front (i.e., on the hyperplanes defined by the fixed light-cone time). The theory is seen to possess a set of first-class constraints and the local vector gauge symmetry. The theory being gauge-invariant is quantized under appropriate gauge-fixing conditions. The explicit Hamiltonian and path integral quantization is achieved under the above light-cone gauges. The Heisenberg equations of motion of the system are derived for the physical degrees of freedom of the system. Finally the BRST quantization of the system is achieved under appropriate BRST gauge-fixing, where the BRST symmetry is maintained even under the BRST light-cone gauge-fixing.
文摘Benzene is an established leukotoxin and leukemogen in humans. We have previously re- ported that exposure of workers to benzene and to benzene metabolite hydroquinone in cultured cells induced DNA-dependent protein kinase catalytic subunit (DNA-PKcs) to mediate the cellular response to DNA double strand break (DSB) caused by DNA-damaging metabolites. In this study, we used a new, small molecule, a selective inhibitor of DNA-PKcs, 2-(morpholin-4-yl)-benzo[h]chomen-4-one (NU7026), as a probe to analyze the molecular events and pathways in hydroquinone-induced DNA DSB repair and apoptosis. Inhibition of DNA-PKcs by NU7026 markedly potentiated the apoptotic and growth inhibitory effects of hydroquinone in proerythroid leukemic K562 cells in a dose-dependent manner. Treatment with NU7026 did not alter the production of reactive oxygen species and oxidative stress by hydroquinone but repressed the protein level of DNA-PKcs and blocked the induction of the kinase mRNA and protein expression by hydroquinone. Moreover, hydroquinone increased the phos- phorylation of Akt to activate Akt, whereas co-treatment with NU7026 prevented the activation of Akt by hydroquinone. Lastly, hydroquinone and NU7026 exhibited synergistic effects on promoting apop- tosis by increasing the protein levels of pro-apoptotic proteins Bax and caspase-3 but decreasing the protein expression of anti-apoptotic protein Bcl-2. Taken together, the findings reveal a central role of DNA-PKcs in hydroquinone-induced hematotoxicity in which it coordinates DNA DSB repair, cell cycle progression, and apoptosis to regulate the response to hydroquinone-induced DNA damage.
基金Supported by National Natural Science Foundation of China(Grant Nos.51305367,51575461)Doctoral Student Innovation Funds for Hai-Zhu Zhang from Southwest Jiaotong University,China
文摘Changes in requirements may result in the increasing of product development project cost and lead time, therefore, it is important to understand how require- ment changes propagate in the design of complex product systems and be able to select best options to guide design. Currently, a most approach for design change is lack of take the multi-disciplinary coupling relationships and the number of parameters into account integrally. A new design change model is presented to systematically analyze and search change propagation paths. Firstly, a PDS-Be- havior-Structure-based design change model is established to describe requirement changes causing the design change propagation in behavior and structure domains. Secondly, a multi-disciplinary oriented behavior matrix is utilized to support change propagation analysis of complex product systems, and the interaction relationships of the matrix elements are used to obtain an initial set of change paths. Finally, a rough set-based propagation space reducing tool is developed to assist in narrowing change propagation paths by computing the importance of the design change parameters. The proposed new design change model and its associated tools have been demonstrated by the scheduling change propagation paths of high speed train's bogie to show its feasibility and effectiveness. This model is not only supportive to response quickly to diversified market requirements, but also helpful to satisfy customer require- ments and reduce product development lead time. The proposed new design change model can be applied in a wide range of engineering systems design with improved efficiency.
文摘The mixed propagator (MP) approach to ρ-ω mixing is discussed. It is found that under the pole-approximation assumption the results of MP approach is not compatible both with the effective Lagrangian theory andwith the experiment measurement criterion. To overcome these inconsistent, we propose a new MP approach in whichthe physical states of ρ and ω are determined by the requirement of experimental measurement to meson resonance. Interms of this new MP approach, the EM pion form factor Fπ and form factors of ρo →π0γ and of ω→πo γ are derived.The results of Fπ are in good agreement with data. The form factor of ρo →π0γ exhibits a hidden charge-asymmetryenhancement effect which agrees with the prediction of the effective Lagrangian theory.
文摘The UAVs (unmanned aerial vehicles) and the use of graphical data files of extension KML (keyhole markup language) have become popular nowadays. The KML files are associated to the Google Earth applications. Developed by Microdrone company for planning, overflight simulation and data flight analysis, the program mdCockpit was used in this experiment. The UAV Microdrone's flight path was programmed in two ways: using geo referenced images from Google Earth and entering points coordinates into the program. These points have had their geographical decimal coordinates collected by GPS (global positioning system) (RTK (real time kinematic)) method. The aim here is to describe a way of evaluating the difference between the alternatives of flight planning. A flight path, defined a route with 22 points, was also simulated in the program mdCockpit. The points were collected and saved, while the images captured by the program went automatically forming a georeferenced mosaic. A comparison between the differences of coordinates to each point was made by choosing on the images and also by a RTK positioning. The result was up to 14.20 m to a 100 m flight height. There is a significant change of position and this can result in unwanted over flights in locations or even jeopardizing the safety of air activity.