A major advance was made to reduce the side effects of cancer therapy via the elucidation of the tumor-specific lytic path“hyperploid progression-mediated death”targeting retinoblastoma(Rb)or p53-mutants defective i...A major advance was made to reduce the side effects of cancer therapy via the elucidation of the tumor-specific lytic path“hyperploid progression-mediated death”targeting retinoblastoma(Rb)or p53-mutants defective in G1 DNA damage checkpoint.The genetic basis of human cancers was uncovered through the cloning of the tumor suppressor Rb gene.It encodes a nuclear DNA-binding protein whose self-interaction is regulated by cyclin-dependent kinases.A 3Dstructure of Rb dimer is shown,confirming its multimeric status.Rb assumes a central role in cell cycle regulation and the“Rb pathway”is universally inactivated in human cancers.Hyperploidy refers to a state in which cells contain one or more extra chromosomes.Hyperploid progression occurs due to continued cell-cycling without cytokinesis in G1 checkpoint-defective cancer cells.The evidence for the triggering of hyperploid progression-mediated death in RBmutant human retinoblastoma cells is shown.Hence,the very genetic mutation that predisposes to cancer can be exploited to induce lethality.The discovery helped to establish the principle of targeted cytotoxic cancer therapy at the mechanistic level.By triggering the lytic path,targeted therapy with tumor specificity at the genetic level can be developed.It sets the stage for systematically eliminating side effects for cytotoxic cancer therapy.展开更多
The developmental status of the Three Gorges Reservoir in the post-migration era is expounded.Firstly,positioning of ecological reservoir is incompatible with its development;secondly,adopting the market selection and...The developmental status of the Three Gorges Reservoir in the post-migration era is expounded.Firstly,positioning of ecological reservoir is incompatible with its development;secondly,adopting the market selection and government-directed migration mode;thirdly,tough task in the post-migration era;fourthly,prevention of geological disasters and environmental management.After the analyses,the adoptable approaches for developing the Three Gorges Reservoir are concluded.The approaches cover supporting migrants and trying to stabilize and enrich them;supporting the development of industries around the reservoir;intensifying the construction of ecological environment in the reservoir;and strengthening the support of central fiscal policies.The policies and suggestions on developing the Three Gorges Reservoir from the perspective of fiscal policies are put forward.Firstly,they include the fiscal and tax measures on prompting ecological migration and stabilizing and enriching migrants.The specific measures include the fiscal and tax measures on promoting the employment of migrants;measures on providing social security for migrants;fiscal subsidies and preferential policies and increasing the input on solving the problems left after reconstruction.Secondly,they are the fiscal and tax measures for promoting the industrial development in the reservoir.The specific contents include displaying the functions of industrial fund to optimize the industrial structure of the reservoir;providing preferential policies on taxes to attract capitals and intensifying the strength of local finance.展开更多
The Khondalite Belt within the Inner Mongolia Suture Zone (IMSZ) in the North China Craton is a classic example for Paleoproterozoic ultrahigh-temperature (UHT) metamorphism. Here we report new spinel-bearing meta...The Khondalite Belt within the Inner Mongolia Suture Zone (IMSZ) in the North China Craton is a classic example for Paleoproterozoic ultrahigh-temperature (UHT) metamorphism. Here we report new spinel-bearing metapelitic granulites from a new locality at Xumayao within the southern domain of the IMSZ. Petrological studies and thermodynamic modeling of the spinel -- quartz-bearing assemblage shows that these rocks experienced extreme metamorphism at UHT conditions. Spinel occurs in two textural settings:(1) high Xzn(Zn/(Mg + FeH -- Zn) = 0.071--0.232) spinel with perthitic K-feld- spar, sillimanite and quartz in the rock matrix; and (2)low Xzn (0.045-0.070) spinel as inclusions within garnet porphyroblasts in association with quartz and sillimanite. Our phase equilibria modeling indicates two main stages during the metamorphic evolution of these rocks:(l) near-isobaric cooling from 975 ℃ to 875 ℃ around 8 kbar, represented by the formation of garnet porphyroblasts from spinel and quartz; and(2)cooling and decompression from 850 ℃, 8 kbar to below 750 ℃- 6.5 kbar, represented by the break-down of garnet. The spinel + quartz assemblage is considered to have been stable at peak metamorphism, formed through the break-down of cordierite, indi- caring a near isothermal compression process. Our study confirms the regional extent of UHT metamor- phism within the IMSZ associated with the Paleoproterozoic subduction-collision process.展开更多
Mafic granulites have been found as structural lenses within the huge thrust system outcropping about 10 km west of Nam Co of the northern Lhasa Terrane, Tibetan Plateau. Petrological evidence from these rocks indicat...Mafic granulites have been found as structural lenses within the huge thrust system outcropping about 10 km west of Nam Co of the northern Lhasa Terrane, Tibetan Plateau. Petrological evidence from these rocks indicates four distinct metamorphic assemblages. The early metamorphic assemblage (M1) is preserved only in the granulites and represented by plagioclase+hornblende inclusions within the cores of garnet porphyroblasts. The peak assemblage (M2) consists of garnet+clinopyroxene+hornblende+plagioclase in the mafic granulites. The peak metamorphism was followed by near-isothermal decompression (M3), which resulted in the development of hornblende+plagioclase symplectites surrounding embayed garnet porphyroblasts, and decompression-cooling (M4) is represented by minerals of hornblende+plagioclase recrystallized during mylonization. The peak (M2) P-T conditions of garnet+ clinopyroxene+plagioclase+hornblende were estimated at 769-905℃ and 0.86-1.02 GPa based on the geothermometers and geobarometers. The P-T conditions of plagioclase+hornblende symplectites (M3) were estimated at 720-800℃ and 0.55-0.68 GPa, and recrystallized hornblende+plagioclase (M4) at 594-708℃ and 0.26-0.47 GPa. It is impossible to estimate the P-T conditions of the early metamorphic assemblage (M1) because of the absence of modal minerals. The combination of petrographic textures, metamorphic reaction history, thermobarometric data and corresponding isotopic ages defines a clockwise near-isothermal decompression metamorphic path, suggesting that the mafic granulites had undergone initial crustal thickening, subsequent exhumation, and cooling and retrogression. This tectonothermal path is considered to record two major phases of collision which resulted in both the assemblage of Gondwanaland during the Pan-African orogeny at 531 Ma and the collision of the Qiangtang and Lhasa Terranes at 174 Ma, respectively.展开更多
The garnet (Grt) and biotite (Bt) from gneisses of the Ji’ an Group are characterized by diffusion zoning at the rim, but equilibrium composition of metamorphic peak is usually remained in extensive interior area. Ga...The garnet (Grt) and biotite (Bt) from gneisses of the Ji’ an Group are characterized by diffusion zoning at the rim, but equilibrium composition of metamorphic peak is usually remained in extensive interior area. Garnet with growth zoning is also found in the kyanite zone.In the light of microarea compositional variation of Grt and Bt, the temperatuIe and pressuIe at the progressive, peak and post peak metamorphic stages are determined by correctly using GrtBt thermometer and GASP barometer. On this basis, a counterclockwise P-T-t path can be constructed, which reflects the closing process of an ensialic rift belt in this region during the Early Proterozoic.展开更多
After the integration of petrographic study, geothermobarometry and Gibbs method, the synthetic P-T paths for the rocks from different geological profiles in the North Qilian, China, have been derived. The composite P...After the integration of petrographic study, geothermobarometry and Gibbs method, the synthetic P-T paths for the rocks from different geological profiles in the North Qilian, China, have been derived. The composite P-T paths from different methods indicate that all the high-pressure rocks in the Qilian area recorded P-T paths with clockwise loops starting at the blueschist facies, later reaching peak metamorphism at the blueschist facies, eclogite fades or epidote-amphibolite facies and ending up with the greenschist facies. The incremental Ar-Ar dating shows that the plateau ages for the high-pressure rocks range from 410 to 443 Ma. The plateau ages could be used as a minimum age constraint for the subduction that resulted in the formation of these high-pressure rocks in the Qilian area. It is proposed that the late-stage decompressional and cooling P-T paths with ends at the greenschist facies for these high-pressure rocks probably reflect the uplift process which could occur after shifting the arc-trench tectonic system to the system of continental orogenic belts. The retrograde paths for the high-pressure rocks in the North Qilian tectonic belt are characterized by dramatic decompression with slight cooling, which suggests very rapid exhumation. Petrography supports that the mountain-building for the Qilian mountain range could undergo a very fast process which caused rapid uplift and denudation.展开更多
Through studies of P\|T\|t paths and decompressive retrograde metamorphic textures of metamorphic rocks in the East Qinling\|Dabieshan region, the authors determined the Mesozoic crust rapid uplifting age, and then in...Through studies of P\|T\|t paths and decompressive retrograde metamorphic textures of metamorphic rocks in the East Qinling\|Dabieshan region, the authors determined the Mesozoic crust rapid uplifting age, and then inferred that in the East Qinling\|Dabieshan region lithosphere delamination occurred from T\-3 to J\-1. The Yanshanian granites produced by delamination are developed well in the East Qinling\|Dabieshan region. But due to the Gondwana plate effect, magmatism in the region caused by delamination lagged until J\-3 when the northern Tibet terrane and the Eurasian plate completely amalgamated. Additionally, due to western Pacific plate subducting underneath the Eurasian plate, in the East Qinling\|Dabieshan region the stress state was transformed from compression to extension. So in the region from J\-3 to K\-2 magmatism was most intensive, and liberalization was also relatively strong. Geophysical data reflect that in the East Qinling\|Dabieshan region the asthenosphere rose to the shallow level, the Moho is flat with no mountain root, and the crustal thickness is less than 40 km on average. These features agree with those of collisional orogenes in which delamination has occurred. Through contrasting differences in surface and interior depth between east and west Qinling we believe that delamination proceeded from east to west.展开更多
A ophiolite belt associated with the tectonic melange is recoghzed in northern area of Mian-Lue, southern Qinling. The ophiolite is considered to originate in a island arc. The occurrence of the ophiolite indicates th...A ophiolite belt associated with the tectonic melange is recoghzed in northern area of Mian-Lue, southern Qinling. The ophiolite is considered to originate in a island arc. The occurrence of the ophiolite indicates that a paleo-ocean or finite oceanic basin existed POSt-Prot6rozoic in southern Qiuling, implying the difference of the continental basement of Southern Qinling from the Yangtze craton. The ophiolitc and themelange may mark the paleo-suture zoic between the two plates. The basic granulite is found in eastern area (Anzishan) of the ophiolite belt. The p-T path for metamorphism of the granulite demonstrates a process of continental collision.展开更多
The east sector of the southern Qinling belt is, lithologically, composed mainly of metapelites, ***qüartzites, marbles and small amount of metabasites and gneisses, whose protoliths are the Silurian, Devonian an...The east sector of the southern Qinling belt is, lithologically, composed mainly of metapelites, ***qüartzites, marbles and small amount of metabasites and gneisses, whose protoliths are the Silurian, Devonian and less commonly the Sinian and Upper Palaeozoic. They have been subjected at least to two epochs of metamorphism. The early epoch belongs to progressive metamorphism which is centered on high amphibolite-granulite fades in the Fuping area and changed outwards into low amphibolite facies (staurolite-kyanite zone), epidote amphibolite facies (garnet zone) and greenschist facies (chlorite and biotite zones), the metamorphic age of which is about 220–260 Ma. This early-epoch metamorphism belongs to different pressure types: the rocks from greenschist to low amphibolite facies belong to the typical medium-pressure type which shows geothermal gradients of about 17–20 ***C/km and was probably produced by a crustal thickening process related to continental collision, and the high amphibolite-granulite facies belongs to the low-pressure type which shows geothermal gradients of about 25–38 ***C/km and was probably affected by some magmatic heats. Based on the basic characteristics of the P-T paths of the different facies calculated from the garnet zonations, it can be deduced that the metamorphism of medium-pressure facies series took place during an imbricated thickening process, rather than during the uplifting process after thickening. The late-epoch metamorphism belongs to dynamic metamorphism of greenschist facies which is overprinted on the early-epoch metamorphic rocks and is Yanshanian or Himalayan in age, probably related to intracontinental orogeny.展开更多
Eclogitic garnet-amphibole rocks are scattered around me Songshugou ultramafic bodies in Qinling Mountains . Three metamorphic stages are recognized in terms of petrography, mineral chemistry and geothermobarometry . ...Eclogitic garnet-amphibole rocks are scattered around me Songshugou ultramafic bodies in Qinling Mountains . Three metamorphic stages are recognized in terms of petrography, mineral chemistry and geothermobarometry . The first alhite-amphibole stage was of greenschist facies metamorphism with typical mineral assemblage of actinolite+epidote+chlorite+albite ; the pressure and temperature conditions were equal to or lower than 500MPa and about 400 ℃ .The second prograde eclogitic garnet-amphibole stage was of amphibole-eclogite fades metamorphism with typical mineral assemblage of garnet+hornblende± clinopyroxene+ruffle without ptagioclase ,the pressure condition was at least 1000- 1200MPa and the temperature about 600 ℃ .The third retrograde epidote-amphibole stage was of epidote-amphibolite fecies with assemblage of plagioclase+hornblende+epidote+ilmenite/titanite , the temperature was 500-600 ℃ and the pressure from 800MPa down to 500MPa .All three stages took place in one single tectonothermal event called Jinningian movement at about 1000Ma .The p-T path shows a hairpin shape and thus indicates a metamorphism in the sobduction environment. The metamorphk processes of the garnet- amphibole rocks thus provides a significant evidence for the pbte tectonic movement prevailing in the late Middle Proterozoic period.展开更多
As a window of insight into the lower crust, high pressure granulite has received much attention since last decade. Yushugou high pressure granulite-peridotite Complex was located in the northeast margin of Southern T...As a window of insight into the lower crust, high pressure granulite has received much attention since last decade. Yushugou high pressure granulite-peridotite Complex was located in the northeast margin of Southern Tianshan, NW China. Previous ideas agreed that the peridotite unit in Yushugou, combined with the ultramafic rocks in Tonghuashan and Liuhuangshan, represent an ophiolite belt. However, the metamorphic evolution and tectonic mechanism of the Yushugou high pressure (HP) granulite remain controversial. Petrological investigations and phase equilibrium modelling for two representative fclsic granulitc samples suggest two stages metamorphism of the rocks in Yushugou Complex. Granulite facies metamorphism (Stage I) with P-T conditions of 9.8-10.4 kbar at 895-920℃ was recorded by the porphyroblastic garnet core; HP granulite facies metamorphism (Stage II) shows P-T conditions of 13.2-13.5 kbar at 845-860℃, based on the increasing grossular and decreasing pyrope contents of garnet rims. The Yushugou HP felsic granulites have recorded an anti- clockwise P-T path, characterized by the temperature decreasing and pressure increasing simultaneously. The LA-ICP-MS isotopic investigations on zircons from the felsic granulite show that the protolith ages of the granlulites are -430 Ma, with two age groups of-390 Ma and 340-350 Ma from the metamorphic rims of zircon, indicating the Stage I and II metamorphic events, respectively. A tectonic model was proposed to interpret the processes. The investigated felsic granulite was derived from deep rooted hanging wall, with Stage I granulite facies metamorphism of -390 Ma, which may he related to the Devonian arc magmatic intrusion; Stage II HP granulite facies metamorphism (340-350 Ma) may due to the involvement of being captured into the subducting slab and experienced the high pressure metamorphism.展开更多
Metamorphic provinces such as the^1 Ga Grenvillian,~400 Ma Caledonide and Triassic Qinling Provinces often contain rocks with high-pressure assemblages such as eclogites,which formed at mantle depths in subduction zon...Metamorphic provinces such as the^1 Ga Grenvillian,~400 Ma Caledonide and Triassic Qinling Provinces often contain rocks with high-pressure assemblages such as eclogites,which formed at mantle depths in subduction zones.These are evidence of the accretion of terranes by subduction of oceans and collision to form large tectonostratigraphic provinces.The Mesoproterozoic Namaqua-Natal Province comprises a number of terranes thought to have been assembled by plate-tectonic processes,but they have generally yielded metamorphic pressures below 5 kbar,corresponding to<20 km,crustal depths,lacking evidence for subduction processes.The Kaaien Terrane in the Namaqua Front contains two large garbenschiefer units with the unusual paragenesis garnet-hornblende-epidote-white mica-plagioclase-ilmenite-quartz.Their protoliths are graywackes influenced by andesitic volcanism during their deposition at^1870 Ma,in a passive margin of the Rehoboth Province or Kaapvaal Craton.Prograde garnet growth dated at 11655 Ma culminated in peak metamorphic conditions of 64530C and 10.40.7 kbar,corresponding to 40 km depth.This is attributed to subduction of these rocks before collision between the overriding arc-related Areachap Terrane,the Kaaien Terrane and the Kaapvaal-Rehoboth cratonic block during the Namaqua orogeny.Exhumation of the garbenschiefer slabs was followed by rapid cooling,as the 11435 Ma argon dates of hornblende and white mica,with closure temperatures^540C and^440C respectively,are the same within error.This was probably due to tectonic juxtaposition of the garbenschiefer slab with much cooler rock units.The exhumation was accommodated along the Trooilapspan-Brakbosch Shear Zone due to ongoing transpression.Other components of the Namaqua Front have distinctly different P-T-t paths,exemplified by greenschist metamorphism in the 1300 Ma Wilgenhoutsdrift Group,and medium-pressure metamorphism in the Areachap Terrane.They were juxtaposed by late-tectonic uplift and transpressional movements.The^40 km depth of garbenschiefer peak metamorphism is the deepest yet found in the Namaqua-Natal Province and strengthens the plate tectonic model of accretion by collision of terranes at the end of a Wilson cycle.The high pressure paragenesis of the garbenschiefer was preserved due to its location in the Namaqua Front,whereas most other parts of the Namaqua-Natal Province were overprinted by 1100–1020 Ma thermal events after the collision events.展开更多
Permo-Triassic high-pressure(HP) mafic granulites, together with the Bibong retrogressed eclogite,preserved along the central western Korean Peninsula provide important insights into the Late Permian to Triassic colli...Permo-Triassic high-pressure(HP) mafic granulites, together with the Bibong retrogressed eclogite,preserved along the central western Korean Peninsula provide important insights into the Late Permian to Triassic collisional orogeny in northeast Asia. The metamorphic pressureetemperatureetime(P-T-t)paths of these rocks, however, remain poorly constrained and even overestimated, owing to outdated geothermobarometers and inaccurate isopleth techniques. Here we evaluate the metamorphic Pe T conditions of Triassic HP mafic granulites including those in Baekdong, Sinri and Daepan and the Bibong Triassic retrogressed eclogite in the Hongseong area, and the Permo-Triassic Samgot mafic granulite in the Imjingang Belt of the central western Korean Peninsula through the application of modern phase equilibria techniques. The Baekdong and Samgot mafic granulites and the Bibong retrogressed eclogite yield a range of 12.0 -16.0 kbar and 800 -900℃, representing HP granulite facies conditions. The Sinri and Daepan granulites from the Hongseong area show relatively lower grade metamorphic conditions between HP granulite and normal granulite facies, and are characterized by sub-isothermal decompression during exhumation. The similarities in the metamorphic ages and the post-collisional igneous activity from the central western Korean Peninsula indicate that the Triassic ages represent the retrograde stage of the metamorphic Pe T paths. In contrast, the Late Permian metamorphic ages, which are older than protolith ages of the post-collisional igneous rocks, correspond to the possible prograde stage of metamorphism. The P-T-t paths presented in this paper, together with the metamorphic ages and post-orogenic igneous events reported from these areas suggest trace of the subduction, accretion and exhumation history, and indicate a tectonic linkage among the northeast Asian continents during the Paleo-Tethyan Ocean closure.展开更多
The Motuo area is located in the east of the Eastern Himalayan Syntaxis.There outcrops a sequence of high-grade metamorphic rocks,such as metapelites.Petrology and mineralogy data suggest that these rocks have experie...The Motuo area is located in the east of the Eastern Himalayan Syntaxis.There outcrops a sequence of high-grade metamorphic rocks,such as metapelites.Petrology and mineralogy data suggest that these rocks have experienced three stages of metamorphism.The prograde metamorphic mineral assemblages (M1) are mineral inclusions (biotite + plagioclase + quartz ± sillimanite ± Fe-Ti oxides) preserved in garnet porphyroblasts,and the peak metamorphic assemblages (M2) are represented by garnet with the lowest Xsps values and the lowest XFe# ratios and the matrix minerals (plagioclase + quartz ± K-feldspar + biotite + muscovite + kyanite ± siilimanite),whereas the retrograde assemblages (M3) are composed of biotite + plagioclase + quartz symplectites rimming the garnet porphyroblasts.Thermobarometric computation shows that the metamorphic conditions are 562-714℃ at 7.3-7.4 kbar for the M1 stage,661-800℃ at 9.4-11.6 kbar for the M2 stage,and 579-713℃ at 5.5-6.6 kbar for the M3 stage.These rocks are deciphered to have undergone metamorphism characterized by clockwise P-T paths involving nearly isothermal decompression (ITD) segments,which is inferred to be related to the collision of the India and Eurasia plates.展开更多
In this study, we investigate the possible record of a Late Mesoproterozoic paired metamorphic belt in the Aravalli-Delhi Mobile Belt(ADMB), NW India using a suite of supracrustal and metaigneous granulites from the P...In this study, we investigate the possible record of a Late Mesoproterozoic paired metamorphic belt in the Aravalli-Delhi Mobile Belt(ADMB), NW India using a suite of supracrustal and metaigneous granulites from the Pilwa-Chinwali granulite terrain at the north-western margin of the ADMB. Using metamorphic reaction textures, mineral chemistry, metamorphic reaction history, geothermobarometric computations and electron microprobe dating of monazite in 5 samples of pelitic granulite, leptynite gneiss, enderbite and charnockite, we have deduced a medium-pressure granulite facies metamorphism(P between 4.9 and 6.8 kbar, T> 760-815℃) along a heating-cooling, counterclockwise P-T path between 1.09 and 1.01 Ga. When collated with published metamorphic and chronological constraints and geological settings of the adjoining crustal domains of the ADMB, these findings provide new insights into the developments of two tectonic domains of contrasting thermal gradients at ca. 1.0 Ga, consistent with metamorphic transformations in tectonically thickened middle-lower crustal sections during continental collision to continental subduction and in the root zones of spatially adjacent island arc, as part of the Rodinia supercontinent assembly event.展开更多
The investigation of the structure and thermoelectric properties of nanostructured solid solutions (Bi, Sb)2Te3 p-type has been carried out. The samples were obtained by grinding of original compositions in a planetar...The investigation of the structure and thermoelectric properties of nanostructured solid solutions (Bi, Sb)2Te3 p-type has been carried out. The samples were obtained by grinding of original compositions in a planetary ball mill and by spark plasma sintering (SPS). Initial powder has an average particle size of 10 - 12 nm according to transmission electron microscopy, and the size of the coherent scattering region (CSR) obtained by X-ray line broadening. During sintering at Ts = 250°C - 400°C, the grain size and CSR increased, which was associated with the processes of recrystallization. The maximum of size distribution of CSR shifts to larger sizes when Ts increases so that no broadening of X-ray lines at Ts = 400°C can take place. At higher Ts, the emergence of new nanograins is observed. The formation of nanograins is conditioned by reducing of quantity of the intrinsic point defects produced in the grinding of the source materials. The study of the electrical conductivity and the Hall effect in a single crystal allows to estimate the mean free path of the holes-L in the single crystal Bi0.5Sb1.5Te3 which at room temperature is 2 - 5 nm (it is much smaller than the dimensions of CSR in the samples). The method for evaluation of L in polycrystalline samples is proposed. At room temperature, L is close to the mean free path in single crystals. Scattering parameter holes in SPS samples obtained from the temperature dependence of the Seebeck coefficient are within the measurement error equal to the parameter of the scattering of holes in a single crystal. The figure of merit ZT of SPS samples as a function of composition and sintering temperature has been investigated. Maximum ZT, equal to 1.05 at room temperature, is obtained for the composition Bi0.4Sb1.6Te3 at Ts = 500°C and a pressure of 50 MPa. The causes of an apparent increase in thermoelectric efficiency are discussed.展开更多
基金We are grateful to Tri Ngo for assistance with computer-based molecular modeling.Also acknowledged are the faculties at Johns Hopkins University,U.C.Berkeley,Baylor University,Davidson College(alma mater of United States president Woodrow Wilson,Nobel Prize 1919),Hollywood High School(alma mater of Hollywood classics actors,ex.Judy Garland in″The Wizard of Oz″),clinical staff(U.C.San Francisco),and actress in‘The Flying Nun’(Warner Bros.Pictures,Hollywood).City of Hope National Medical Center(National Comprehensive Cancer Network member)was established partly through the assistance of Hollywood's film industries(ex.Warner Bros.Pictures),supported by Hollywood’s renown figures(Frank Sinatra,Bob Hope,Ella Fitzgerald,etc.),visited by United States First Lady Eleanor(Franklin D.Roosevelt presidency),United States presidential candidate Robert F.Kennedy,Queen Elizabeth II(United Kingdom),graced by Pope John Paul II(Vatican,Italy),and supported by numerous distinguished individuals/industries.Its Beckman Research Institute was established by A.Beckman(California Institute of TechnologyBeckman Instruments).
文摘A major advance was made to reduce the side effects of cancer therapy via the elucidation of the tumor-specific lytic path“hyperploid progression-mediated death”targeting retinoblastoma(Rb)or p53-mutants defective in G1 DNA damage checkpoint.The genetic basis of human cancers was uncovered through the cloning of the tumor suppressor Rb gene.It encodes a nuclear DNA-binding protein whose self-interaction is regulated by cyclin-dependent kinases.A 3Dstructure of Rb dimer is shown,confirming its multimeric status.Rb assumes a central role in cell cycle regulation and the“Rb pathway”is universally inactivated in human cancers.Hyperploidy refers to a state in which cells contain one or more extra chromosomes.Hyperploid progression occurs due to continued cell-cycling without cytokinesis in G1 checkpoint-defective cancer cells.The evidence for the triggering of hyperploid progression-mediated death in RBmutant human retinoblastoma cells is shown.Hence,the very genetic mutation that predisposes to cancer can be exploited to induce lethality.The discovery helped to establish the principle of targeted cytotoxic cancer therapy at the mechanistic level.By triggering the lytic path,targeted therapy with tumor specificity at the genetic level can be developed.It sets the stage for systematically eliminating side effects for cytotoxic cancer therapy.
基金Supported by "Chunhui Project" of Ministry of Education (S2007-1-63002)
文摘The developmental status of the Three Gorges Reservoir in the post-migration era is expounded.Firstly,positioning of ecological reservoir is incompatible with its development;secondly,adopting the market selection and government-directed migration mode;thirdly,tough task in the post-migration era;fourthly,prevention of geological disasters and environmental management.After the analyses,the adoptable approaches for developing the Three Gorges Reservoir are concluded.The approaches cover supporting migrants and trying to stabilize and enrich them;supporting the development of industries around the reservoir;intensifying the construction of ecological environment in the reservoir;and strengthening the support of central fiscal policies.The policies and suggestions on developing the Three Gorges Reservoir from the perspective of fiscal policies are put forward.Firstly,they include the fiscal and tax measures on prompting ecological migration and stabilizing and enriching migrants.The specific measures include the fiscal and tax measures on promoting the employment of migrants;measures on providing social security for migrants;fiscal subsidies and preferential policies and increasing the input on solving the problems left after reconstruction.Secondly,they are the fiscal and tax measures for promoting the industrial development in the reservoir.The specific contents include displaying the functions of industrial fund to optimize the industrial structure of the reservoir;providing preferential policies on taxes to attract capitals and intensifying the strength of local finance.
文摘The Khondalite Belt within the Inner Mongolia Suture Zone (IMSZ) in the North China Craton is a classic example for Paleoproterozoic ultrahigh-temperature (UHT) metamorphism. Here we report new spinel-bearing metapelitic granulites from a new locality at Xumayao within the southern domain of the IMSZ. Petrological studies and thermodynamic modeling of the spinel -- quartz-bearing assemblage shows that these rocks experienced extreme metamorphism at UHT conditions. Spinel occurs in two textural settings:(1) high Xzn(Zn/(Mg + FeH -- Zn) = 0.071--0.232) spinel with perthitic K-feld- spar, sillimanite and quartz in the rock matrix; and (2)low Xzn (0.045-0.070) spinel as inclusions within garnet porphyroblasts in association with quartz and sillimanite. Our phase equilibria modeling indicates two main stages during the metamorphic evolution of these rocks:(l) near-isobaric cooling from 975 ℃ to 875 ℃ around 8 kbar, represented by the formation of garnet porphyroblasts from spinel and quartz; and(2)cooling and decompression from 850 ℃, 8 kbar to below 750 ℃- 6.5 kbar, represented by the break-down of garnet. The spinel + quartz assemblage is considered to have been stable at peak metamorphism, formed through the break-down of cordierite, indi- caring a near isothermal compression process. Our study confirms the regional extent of UHT metamor- phism within the IMSZ associated with the Paleoproterozoic subduction-collision process.
基金China Geological Survey(Grant No.20013000166) Natural Science Foundation of China(Grant No.49902006).
文摘Mafic granulites have been found as structural lenses within the huge thrust system outcropping about 10 km west of Nam Co of the northern Lhasa Terrane, Tibetan Plateau. Petrological evidence from these rocks indicates four distinct metamorphic assemblages. The early metamorphic assemblage (M1) is preserved only in the granulites and represented by plagioclase+hornblende inclusions within the cores of garnet porphyroblasts. The peak assemblage (M2) consists of garnet+clinopyroxene+hornblende+plagioclase in the mafic granulites. The peak metamorphism was followed by near-isothermal decompression (M3), which resulted in the development of hornblende+plagioclase symplectites surrounding embayed garnet porphyroblasts, and decompression-cooling (M4) is represented by minerals of hornblende+plagioclase recrystallized during mylonization. The peak (M2) P-T conditions of garnet+ clinopyroxene+plagioclase+hornblende were estimated at 769-905℃ and 0.86-1.02 GPa based on the geothermometers and geobarometers. The P-T conditions of plagioclase+hornblende symplectites (M3) were estimated at 720-800℃ and 0.55-0.68 GPa, and recrystallized hornblende+plagioclase (M4) at 594-708℃ and 0.26-0.47 GPa. It is impossible to estimate the P-T conditions of the early metamorphic assemblage (M1) because of the absence of modal minerals. The combination of petrographic textures, metamorphic reaction history, thermobarometric data and corresponding isotopic ages defines a clockwise near-isothermal decompression metamorphic path, suggesting that the mafic granulites had undergone initial crustal thickening, subsequent exhumation, and cooling and retrogression. This tectonothermal path is considered to record two major phases of collision which resulted in both the assemblage of Gondwanaland during the Pan-African orogeny at 531 Ma and the collision of the Qiangtang and Lhasa Terranes at 174 Ma, respectively.
文摘The garnet (Grt) and biotite (Bt) from gneisses of the Ji’ an Group are characterized by diffusion zoning at the rim, but equilibrium composition of metamorphic peak is usually remained in extensive interior area. Garnet with growth zoning is also found in the kyanite zone.In the light of microarea compositional variation of Grt and Bt, the temperatuIe and pressuIe at the progressive, peak and post peak metamorphic stages are determined by correctly using GrtBt thermometer and GASP barometer. On this basis, a counterclockwise P-T-t path can be constructed, which reflects the closing process of an ensialic rift belt in this region during the Early Proterozoic.
文摘After the integration of petrographic study, geothermobarometry and Gibbs method, the synthetic P-T paths for the rocks from different geological profiles in the North Qilian, China, have been derived. The composite P-T paths from different methods indicate that all the high-pressure rocks in the Qilian area recorded P-T paths with clockwise loops starting at the blueschist facies, later reaching peak metamorphism at the blueschist facies, eclogite fades or epidote-amphibolite facies and ending up with the greenschist facies. The incremental Ar-Ar dating shows that the plateau ages for the high-pressure rocks range from 410 to 443 Ma. The plateau ages could be used as a minimum age constraint for the subduction that resulted in the formation of these high-pressure rocks in the Qilian area. It is proposed that the late-stage decompressional and cooling P-T paths with ends at the greenschist facies for these high-pressure rocks probably reflect the uplift process which could occur after shifting the arc-trench tectonic system to the system of continental orogenic belts. The retrograde paths for the high-pressure rocks in the North Qilian tectonic belt are characterized by dramatic decompression with slight cooling, which suggests very rapid exhumation. Petrography supports that the mountain-building for the Qilian mountain range could undergo a very fast process which caused rapid uplift and denudation.
文摘Through studies of P\|T\|t paths and decompressive retrograde metamorphic textures of metamorphic rocks in the East Qinling\|Dabieshan region, the authors determined the Mesozoic crust rapid uplifting age, and then inferred that in the East Qinling\|Dabieshan region lithosphere delamination occurred from T\-3 to J\-1. The Yanshanian granites produced by delamination are developed well in the East Qinling\|Dabieshan region. But due to the Gondwana plate effect, magmatism in the region caused by delamination lagged until J\-3 when the northern Tibet terrane and the Eurasian plate completely amalgamated. Additionally, due to western Pacific plate subducting underneath the Eurasian plate, in the East Qinling\|Dabieshan region the stress state was transformed from compression to extension. So in the region from J\-3 to K\-2 magmatism was most intensive, and liberalization was also relatively strong. Geophysical data reflect that in the East Qinling\|Dabieshan region the asthenosphere rose to the shallow level, the Moho is flat with no mountain root, and the crustal thickness is less than 40 km on average. These features agree with those of collisional orogenes in which delamination has occurred. Through contrasting differences in surface and interior depth between east and west Qinling we believe that delamination proceeded from east to west.
文摘A ophiolite belt associated with the tectonic melange is recoghzed in northern area of Mian-Lue, southern Qinling. The ophiolite is considered to originate in a island arc. The occurrence of the ophiolite indicates that a paleo-ocean or finite oceanic basin existed POSt-Prot6rozoic in southern Qiuling, implying the difference of the continental basement of Southern Qinling from the Yangtze craton. The ophiolitc and themelange may mark the paleo-suture zoic between the two plates. The basic granulite is found in eastern area (Anzishan) of the ophiolite belt. The p-T path for metamorphism of the granulite demonstrates a process of continental collision.
文摘The east sector of the southern Qinling belt is, lithologically, composed mainly of metapelites, ***qüartzites, marbles and small amount of metabasites and gneisses, whose protoliths are the Silurian, Devonian and less commonly the Sinian and Upper Palaeozoic. They have been subjected at least to two epochs of metamorphism. The early epoch belongs to progressive metamorphism which is centered on high amphibolite-granulite fades in the Fuping area and changed outwards into low amphibolite facies (staurolite-kyanite zone), epidote amphibolite facies (garnet zone) and greenschist facies (chlorite and biotite zones), the metamorphic age of which is about 220–260 Ma. This early-epoch metamorphism belongs to different pressure types: the rocks from greenschist to low amphibolite facies belong to the typical medium-pressure type which shows geothermal gradients of about 17–20 ***C/km and was probably produced by a crustal thickening process related to continental collision, and the high amphibolite-granulite facies belongs to the low-pressure type which shows geothermal gradients of about 25–38 ***C/km and was probably affected by some magmatic heats. Based on the basic characteristics of the P-T paths of the different facies calculated from the garnet zonations, it can be deduced that the metamorphism of medium-pressure facies series took place during an imbricated thickening process, rather than during the uplifting process after thickening. The late-epoch metamorphism belongs to dynamic metamorphism of greenschist facies which is overprinted on the early-epoch metamorphic rocks and is Yanshanian or Himalayan in age, probably related to intracontinental orogeny.
基金The project is supported by National Nature Science Fountation of China No.48900015
文摘Eclogitic garnet-amphibole rocks are scattered around me Songshugou ultramafic bodies in Qinling Mountains . Three metamorphic stages are recognized in terms of petrography, mineral chemistry and geothermobarometry . The first alhite-amphibole stage was of greenschist facies metamorphism with typical mineral assemblage of actinolite+epidote+chlorite+albite ; the pressure and temperature conditions were equal to or lower than 500MPa and about 400 ℃ .The second prograde eclogitic garnet-amphibole stage was of amphibole-eclogite fades metamorphism with typical mineral assemblage of garnet+hornblende± clinopyroxene+ruffle without ptagioclase ,the pressure condition was at least 1000- 1200MPa and the temperature about 600 ℃ .The third retrograde epidote-amphibole stage was of epidote-amphibolite fecies with assemblage of plagioclase+hornblende+epidote+ilmenite/titanite , the temperature was 500-600 ℃ and the pressure from 800MPa down to 500MPa .All three stages took place in one single tectonothermal event called Jinningian movement at about 1000Ma .The p-T path shows a hairpin shape and thus indicates a metamorphism in the sobduction environment. The metamorphk processes of the garnet- amphibole rocks thus provides a significant evidence for the pbte tectonic movement prevailing in the late Middle Proterozoic period.
基金financially supported by the National Natural Science Foundation of China(Grants 41330210,41520104004)
文摘As a window of insight into the lower crust, high pressure granulite has received much attention since last decade. Yushugou high pressure granulite-peridotite Complex was located in the northeast margin of Southern Tianshan, NW China. Previous ideas agreed that the peridotite unit in Yushugou, combined with the ultramafic rocks in Tonghuashan and Liuhuangshan, represent an ophiolite belt. However, the metamorphic evolution and tectonic mechanism of the Yushugou high pressure (HP) granulite remain controversial. Petrological investigations and phase equilibrium modelling for two representative fclsic granulitc samples suggest two stages metamorphism of the rocks in Yushugou Complex. Granulite facies metamorphism (Stage I) with P-T conditions of 9.8-10.4 kbar at 895-920℃ was recorded by the porphyroblastic garnet core; HP granulite facies metamorphism (Stage II) shows P-T conditions of 13.2-13.5 kbar at 845-860℃, based on the increasing grossular and decreasing pyrope contents of garnet rims. The Yushugou HP felsic granulites have recorded an anti- clockwise P-T path, characterized by the temperature decreasing and pressure increasing simultaneously. The LA-ICP-MS isotopic investigations on zircons from the felsic granulite show that the protolith ages of the granlulites are -430 Ma, with two age groups of-390 Ma and 340-350 Ma from the metamorphic rims of zircon, indicating the Stage I and II metamorphic events, respectively. A tectonic model was proposed to interpret the processes. The investigated felsic granulite was derived from deep rooted hanging wall, with Stage I granulite facies metamorphism of -390 Ma, which may he related to the Devonian arc magmatic intrusion; Stage II HP granulite facies metamorphism (340-350 Ma) may due to the involvement of being captured into the subducting slab and experienced the high pressure metamorphism.
基金supported by a Swedish VR grant 2006-2402 to DHC
文摘Metamorphic provinces such as the^1 Ga Grenvillian,~400 Ma Caledonide and Triassic Qinling Provinces often contain rocks with high-pressure assemblages such as eclogites,which formed at mantle depths in subduction zones.These are evidence of the accretion of terranes by subduction of oceans and collision to form large tectonostratigraphic provinces.The Mesoproterozoic Namaqua-Natal Province comprises a number of terranes thought to have been assembled by plate-tectonic processes,but they have generally yielded metamorphic pressures below 5 kbar,corresponding to<20 km,crustal depths,lacking evidence for subduction processes.The Kaaien Terrane in the Namaqua Front contains two large garbenschiefer units with the unusual paragenesis garnet-hornblende-epidote-white mica-plagioclase-ilmenite-quartz.Their protoliths are graywackes influenced by andesitic volcanism during their deposition at^1870 Ma,in a passive margin of the Rehoboth Province or Kaapvaal Craton.Prograde garnet growth dated at 11655 Ma culminated in peak metamorphic conditions of 64530C and 10.40.7 kbar,corresponding to 40 km depth.This is attributed to subduction of these rocks before collision between the overriding arc-related Areachap Terrane,the Kaaien Terrane and the Kaapvaal-Rehoboth cratonic block during the Namaqua orogeny.Exhumation of the garbenschiefer slabs was followed by rapid cooling,as the 11435 Ma argon dates of hornblende and white mica,with closure temperatures^540C and^440C respectively,are the same within error.This was probably due to tectonic juxtaposition of the garbenschiefer slab with much cooler rock units.The exhumation was accommodated along the Trooilapspan-Brakbosch Shear Zone due to ongoing transpression.Other components of the Namaqua Front have distinctly different P-T-t paths,exemplified by greenschist metamorphism in the 1300 Ma Wilgenhoutsdrift Group,and medium-pressure metamorphism in the Areachap Terrane.They were juxtaposed by late-tectonic uplift and transpressional movements.The^40 km depth of garbenschiefer peak metamorphism is the deepest yet found in the Namaqua-Natal Province and strengthens the plate tectonic model of accretion by collision of terranes at the end of a Wilson cycle.The high pressure paragenesis of the garbenschiefer was preserved due to its location in the Namaqua Front,whereas most other parts of the Namaqua-Natal Province were overprinted by 1100–1020 Ma thermal events after the collision events.
基金supported by a Basic Research Project (GP2017021 Development of integrated geological information based on digital mapping) of the Korea Institute of Geoscience and Mineral Resources (KIGAM)+1 种基金funded by the Ministry of Science, Information, Communication and Technology (ICT),and Future Planning, Koreasupported partially by the Basic Science Research Program through the National Research Foundation (NRF) funded by the Ministry of Science and ICT 2013R1A1A2058070, 2017R1D1A1B04028521 to H.S. Kim, and 2015R1D1A1A09058914, 2017R1A6A1A07015374 to S. Kwon
文摘Permo-Triassic high-pressure(HP) mafic granulites, together with the Bibong retrogressed eclogite,preserved along the central western Korean Peninsula provide important insights into the Late Permian to Triassic collisional orogeny in northeast Asia. The metamorphic pressureetemperatureetime(P-T-t)paths of these rocks, however, remain poorly constrained and even overestimated, owing to outdated geothermobarometers and inaccurate isopleth techniques. Here we evaluate the metamorphic Pe T conditions of Triassic HP mafic granulites including those in Baekdong, Sinri and Daepan and the Bibong Triassic retrogressed eclogite in the Hongseong area, and the Permo-Triassic Samgot mafic granulite in the Imjingang Belt of the central western Korean Peninsula through the application of modern phase equilibria techniques. The Baekdong and Samgot mafic granulites and the Bibong retrogressed eclogite yield a range of 12.0 -16.0 kbar and 800 -900℃, representing HP granulite facies conditions. The Sinri and Daepan granulites from the Hongseong area show relatively lower grade metamorphic conditions between HP granulite and normal granulite facies, and are characterized by sub-isothermal decompression during exhumation. The similarities in the metamorphic ages and the post-collisional igneous activity from the central western Korean Peninsula indicate that the Triassic ages represent the retrograde stage of the metamorphic Pe T paths. In contrast, the Late Permian metamorphic ages, which are older than protolith ages of the post-collisional igneous rocks, correspond to the possible prograde stage of metamorphism. The P-T-t paths presented in this paper, together with the metamorphic ages and post-orogenic igneous events reported from these areas suggest trace of the subduction, accretion and exhumation history, and indicate a tectonic linkage among the northeast Asian continents during the Paleo-Tethyan Ocean closure.
基金supported by the National Natural Science Foundation of China (40921001)the Geological Survey of China (1212010818094)
文摘The Motuo area is located in the east of the Eastern Himalayan Syntaxis.There outcrops a sequence of high-grade metamorphic rocks,such as metapelites.Petrology and mineralogy data suggest that these rocks have experienced three stages of metamorphism.The prograde metamorphic mineral assemblages (M1) are mineral inclusions (biotite + plagioclase + quartz ± sillimanite ± Fe-Ti oxides) preserved in garnet porphyroblasts,and the peak metamorphic assemblages (M2) are represented by garnet with the lowest Xsps values and the lowest XFe# ratios and the matrix minerals (plagioclase + quartz ± K-feldspar + biotite + muscovite + kyanite ± siilimanite),whereas the retrograde assemblages (M3) are composed of biotite + plagioclase + quartz symplectites rimming the garnet porphyroblasts.Thermobarometric computation shows that the metamorphic conditions are 562-714℃ at 7.3-7.4 kbar for the M1 stage,661-800℃ at 9.4-11.6 kbar for the M2 stage,and 579-713℃ at 5.5-6.6 kbar for the M3 stage.These rocks are deciphered to have undergone metamorphism characterized by clockwise P-T paths involving nearly isothermal decompression (ITD) segments,which is inferred to be related to the collision of the India and Eurasia plates.
基金financial support from the Indian Institute of Technology(IIT)Kharagpur in the form of a Cumulative Professional Development Allowance
文摘In this study, we investigate the possible record of a Late Mesoproterozoic paired metamorphic belt in the Aravalli-Delhi Mobile Belt(ADMB), NW India using a suite of supracrustal and metaigneous granulites from the Pilwa-Chinwali granulite terrain at the north-western margin of the ADMB. Using metamorphic reaction textures, mineral chemistry, metamorphic reaction history, geothermobarometric computations and electron microprobe dating of monazite in 5 samples of pelitic granulite, leptynite gneiss, enderbite and charnockite, we have deduced a medium-pressure granulite facies metamorphism(P between 4.9 and 6.8 kbar, T> 760-815℃) along a heating-cooling, counterclockwise P-T path between 1.09 and 1.01 Ga. When collated with published metamorphic and chronological constraints and geological settings of the adjoining crustal domains of the ADMB, these findings provide new insights into the developments of two tectonic domains of contrasting thermal gradients at ca. 1.0 Ga, consistent with metamorphic transformations in tectonically thickened middle-lower crustal sections during continental collision to continental subduction and in the root zones of spatially adjacent island arc, as part of the Rodinia supercontinent assembly event.
文摘The investigation of the structure and thermoelectric properties of nanostructured solid solutions (Bi, Sb)2Te3 p-type has been carried out. The samples were obtained by grinding of original compositions in a planetary ball mill and by spark plasma sintering (SPS). Initial powder has an average particle size of 10 - 12 nm according to transmission electron microscopy, and the size of the coherent scattering region (CSR) obtained by X-ray line broadening. During sintering at Ts = 250°C - 400°C, the grain size and CSR increased, which was associated with the processes of recrystallization. The maximum of size distribution of CSR shifts to larger sizes when Ts increases so that no broadening of X-ray lines at Ts = 400°C can take place. At higher Ts, the emergence of new nanograins is observed. The formation of nanograins is conditioned by reducing of quantity of the intrinsic point defects produced in the grinding of the source materials. The study of the electrical conductivity and the Hall effect in a single crystal allows to estimate the mean free path of the holes-L in the single crystal Bi0.5Sb1.5Te3 which at room temperature is 2 - 5 nm (it is much smaller than the dimensions of CSR in the samples). The method for evaluation of L in polycrystalline samples is proposed. At room temperature, L is close to the mean free path in single crystals. Scattering parameter holes in SPS samples obtained from the temperature dependence of the Seebeck coefficient are within the measurement error equal to the parameter of the scattering of holes in a single crystal. The figure of merit ZT of SPS samples as a function of composition and sintering temperature has been investigated. Maximum ZT, equal to 1.05 at room temperature, is obtained for the composition Bi0.4Sb1.6Te3 at Ts = 500°C and a pressure of 50 MPa. The causes of an apparent increase in thermoelectric efficiency are discussed.