BACKGROUND Studies with large size samples on the liver histological changes of indeterminate phase chronic hepatitis B(CHB)patients were not previously conducted.AIM To assess the liver histological changes in the in...BACKGROUND Studies with large size samples on the liver histological changes of indeterminate phase chronic hepatitis B(CHB)patients were not previously conducted.AIM To assess the liver histological changes in the indeterminate phase CHB patients using liver biopsy.METHODS The clinical and laboratory data of 1532 untreated CHB patients were collected,and all patients had least once liver biopsy from January 2015 to December 2021.The significant differences among different phases of CHB infection were compared with t-test,and the risk factors of significant liver histological changes were analyzed by the multivariate logistic regression analysis.RESULTS Among 1532 untreated CHB patients,814(53.13%)patients were in the indeterminate phase.Significant liver histological changes(defined as biopsy score≥G2 and/or≥S2)were found in 488/814(59.95%)CHB patients in the indete-rminate phase.Significant liver histological changes were significant differences among different age,platelets(PLTs),and alanine aminotransferase(ALT)subgroup in indeterminate patient.Multivariate logistic regression analysis indicated that age≥40 years old[adjust odd risk(aOR),1.44;95%confidence interval(CI):1.06-1.97;P=0.02],PLTs≤150×10^(9)/L(aOR,2.99;95%CI:1.85-4.83;P<0.0001),and ALT≥upper limits of normal(aOR,1.48;95%CI:1.08,2.05,P=0.0163)were independent risk factors for significant liver histological changes in CHB patients in the indeterminate phase.CONCLUSION Our results suggested that significant liver histological changes were not rare among the untreated CHB patients in indeterminate phase,and additional strategies are urgently required for the management of these patients.展开更多
A high-speed digital acquisition and wide-band measurement system was used to acquiring and recording the ultrasonic pulse waveforms backscattered from normal and several pathological pig's fresh liver tissues (in...A high-speed digital acquisition and wide-band measurement system was used to acquiring and recording the ultrasonic pulse waveforms backscattered from normal and several pathological pig's fresh liver tissues (including ballooning degeneration, fatty degeneration, cirrhosis) in vitro. Some frequency-domain analyses were performed in which integrated backscattering coefficient (IBSC), frequency dependence of backscattering coefficient (FDBSC),and mean spacing (MS) among adjacent scatterers of the tissues were determined.In the experiments the frequency domain was from 3MHz to 7 MHz. The obtained results show that the differences among normal and various pathological tissues cause distinct changes of the measured parameters. The results show that the ultrasonic spectum technique, which can be used in tissue characterization for pathological liver in clinical, has an exciting prospect.展开更多
基金Supported by Construction of Key Medical Disciplines in Shenzhen,No.SZXK076.
文摘BACKGROUND Studies with large size samples on the liver histological changes of indeterminate phase chronic hepatitis B(CHB)patients were not previously conducted.AIM To assess the liver histological changes in the indeterminate phase CHB patients using liver biopsy.METHODS The clinical and laboratory data of 1532 untreated CHB patients were collected,and all patients had least once liver biopsy from January 2015 to December 2021.The significant differences among different phases of CHB infection were compared with t-test,and the risk factors of significant liver histological changes were analyzed by the multivariate logistic regression analysis.RESULTS Among 1532 untreated CHB patients,814(53.13%)patients were in the indeterminate phase.Significant liver histological changes(defined as biopsy score≥G2 and/or≥S2)were found in 488/814(59.95%)CHB patients in the indete-rminate phase.Significant liver histological changes were significant differences among different age,platelets(PLTs),and alanine aminotransferase(ALT)subgroup in indeterminate patient.Multivariate logistic regression analysis indicated that age≥40 years old[adjust odd risk(aOR),1.44;95%confidence interval(CI):1.06-1.97;P=0.02],PLTs≤150×10^(9)/L(aOR,2.99;95%CI:1.85-4.83;P<0.0001),and ALT≥upper limits of normal(aOR,1.48;95%CI:1.08,2.05,P=0.0163)were independent risk factors for significant liver histological changes in CHB patients in the indeterminate phase.CONCLUSION Our results suggested that significant liver histological changes were not rare among the untreated CHB patients in indeterminate phase,and additional strategies are urgently required for the management of these patients.
文摘A high-speed digital acquisition and wide-band measurement system was used to acquiring and recording the ultrasonic pulse waveforms backscattered from normal and several pathological pig's fresh liver tissues (including ballooning degeneration, fatty degeneration, cirrhosis) in vitro. Some frequency-domain analyses were performed in which integrated backscattering coefficient (IBSC), frequency dependence of backscattering coefficient (FDBSC),and mean spacing (MS) among adjacent scatterers of the tissues were determined.In the experiments the frequency domain was from 3MHz to 7 MHz. The obtained results show that the differences among normal and various pathological tissues cause distinct changes of the measured parameters. The results show that the ultrasonic spectum technique, which can be used in tissue characterization for pathological liver in clinical, has an exciting prospect.
