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Research Progress in Early-onset Colorectal Cancer
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作者 Jing Li Haoyuan Guo +1 位作者 Jing Yu Zhibo Gai 《Journal of Clinical and Nursing Research》 2024年第6期201-205,共5页
Colorectal cancer used to be a common disease among middle-aged and elderly people.In recent years,the incidence of colorectal cancer(Early-onset colorectal cancer,EOCRC)under 50 years old has increased year by year.D... Colorectal cancer used to be a common disease among middle-aged and elderly people.In recent years,the incidence of colorectal cancer(Early-onset colorectal cancer,EOCRC)under 50 years old has increased year by year.Different from the traditional late-onset colon cancer(LOCRC),the diagnosis stage of EOCRC is mostly in the late stage,with poor cell differentiation and poor diagnosis,and there is a layer of consensus and guidance on the diagnosis,treatment or screening of EOCRC at presentation.Therefore,fully understanding the disease characteristics and risk exposure factors of EOCRC is helpful to guide early screening and treatment,which ultimately reduces the mortality of EOCRC.In this review article,we summarized the epidemiology,physiology,risk exposure factors and pathological diagnosis of EOCRC,and discussed the diagnosis and treatment prospect of EOCRC. 展开更多
关键词 Early-onset colorectal cancer Epidemiological investigation PHYLOGENY Exposure factors pathological prognosis
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Clinical characteristics and prognostic analysis of gastroenteropancreatic neuroendocrine neoplasm(GEP-NEN) 被引量:1
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作者 Ping Yang Jie Liu +6 位作者 Dongliang Lin Haiyang Fu Jing Chu Feng Li Guiyan Han Yujun Li Weiwei Fu 《The Chinese-German Journal of Clinical Oncology》 CAS 2014年第12期578-583,共6页
Objective: The aim of the study was to analyze the clinicopathologic characteristics of gastroenteropancreatic neuroendocrine neoplasm (GEP-NEN) and to explore the prognostic factors for patients and differences of... Objective: The aim of the study was to analyze the clinicopathologic characteristics of gastroenteropancreatic neuroendocrine neoplasm (GEP-NEN) and to explore the prognostic factors for patients and differences of immunohisto- chemical markers between neuroendocrine tumor (NET) and neuroendocrine carcinoma (NEC). Methods: Retrospective reviews were conducted for the charts of 119 patients with GEP-NEN at the Affiliated Hospital of Qingdao University (China) from August 2003 to December 2013. Kaplan-Meier method was used to do the overall survivals analysis for the patients at different levels of predictive factors. Meanwhile, Cox proportional hazard model was used to select independent risk factors of surJival. Analysis of variance was used to compare the expression of immunohistochemical markers among different patho- logical grades. Results:Among 119 patients, pancreas (45/119, 37.82%) and rectum (33/119, 27.73%) were mostly involved. The onset age of GEP-NEN in female group was younger than that of the male group. There were 13 deaths (10.92%) during 18.9 (0.1-133.4) months follow-up period. Multivariate analysis indicated that neural invasion, gender and pathological grades of NET and NEC were independent risk factors. In neuroendocrine neoplasm (NEN), Syn expression in G2 was higher than G1 and G3, while CgA showed no significant difference. All markers showed no significant differences between NET and NEC. Conclusion: GEP-NEN may occur at multiple sites of digestive system and lack specific clinical manifestations. Syn expression detected for the prognosis of G1, G2 and G3 tumors have clinical significance. Neural invasion, sex and patho- logical grades were independent prognostic factors for GEP-NEN patients. No significant difference was found in different pathological grades of NET and NEC. 展开更多
关键词 neuroendocrine neoplasm (NEN) pathology prognosis multiple factor analysis
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DIAGNOSIS AND SURGICAL MANAGEMENT FOR RETROSTERNAL THYROID MASS
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作者 崔玉尚 张志庸 +3 位作者 李单青 李力 张恒 李泽坚 《Chinese Medical Sciences Journal》 CAS CSCD 2002年第3期173-177,共5页
<Abstract
关键词 retrosternal goiter thyroid carcinoma DIAGNOSIS surgeryObjective. To understand the clinical manifestations diagnostic methods surgical management and prognosis of retrosternal thyroid masses in various pathological types. Methods. Sixty
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