Comparing the effectiveness of pattern differentiation treatment and fixed formula treatment for perimenopausal syndrome with Chinese herbal medicine:A study protocol

Objective:To further understand and compare the effectiveness of pattern differentiation treatment and fixed prescription treatment in perimenopausal syndrome.Methods:The study will be conducted in the Hong Kong Federation of Trade Unions Workers'Medical Clinics,Hong Kong Baptist University Chinese Medicine Clinic cum Training and Research Centre(Hong Kong,China).One hundred Chinese women,aged 45-55 years,will be recruited.The participants will be randomized into 2 groups.The intervention group will be administered medication,based on pattern differentiation,by qualified traditional Chinese medicine(TCM)practitioners.After each evaluation,TCM practitioners will evaluate and revise the prescription,based on the participants'patterns.The control group will be given the standard formula,i.e.,the Erxian decoction,which contains 6 herbs.The treatment period and the follow-up period will be 8 weeks each.The primary assessment outcome measure will be the Kupperman Index,and the secondary outcome measure will be the Menopause-specific Quality of Life Questionnaire score.Conclusion:Pattern-differentiated treatment is the basic principle of TCM to understand and treat diseases.The study will show the pattern-differentiated treatment is effectiveness than the fixed prescription.

Guidelines on common cold for Traditional Chinese Medicine based on pattern differentiation

OBJECTIVE: To establish the guidelines on common cold treated with Traditional Chinese Medicine (TCM) in terms of pattern identification. METHODS: The guidelines were formulated by using the basic patterns of common cold in ChinaPharmacopeia integrated with findings from systematic literature review and the experts' consensus on the issue in question. RESULTS: Common cold was divided into four patterns in the guidelines. The medications were recommended respectively: Ganmaoqingre granule for wind-cold exterior syndrome,Yinqiaojiedu granule for wind-heat exterior syndrome, Huoxiangzhengqi Wan for summer-heat dampness exterior syndrome and Shensu Wan for wind-cold exterior syndrome accompanied with Qi deficiency. CONCLUSION: The guidelines were primarily derived from the practice experience of TCM and the experts' consensus. The process was not strictly evidence-based because of lacking enough clinical studies. Further refinement of the guidelines should be needed as more studies are available.

Logical thinking in pattern differentiation of Traditional Chinese Medicine

OBJECTIVE: To discuss the application of logic to pattern differentiation for treatment in Traditional Chinese Medicine (TCM). METHODS: Comparing logic reasoning of syllogism with the logical thinking ofTCM pattern differentiation for treatment. RESULTS:TCM logical thinking depends on symbolic and intuitive judgment with abstractive reasoning integrated into the process. Although it lacks quantitative measurement, it pays great attention to the comprehensive analysis of a disease's cause and its development patterns to get insight into the essence of illness. CONCLUSION: TCM diagnosis reasoning methodmay lack rigorousness, continuity, systematic induction and deduction, but its logical thinking still can attain its goal following a process with rigorous, regulated and scientific formal logic.

Spatial differentiation pattern of interregional migration in ethnic minority areas of Yunnan Province, China

Interregional migration has broad and far-reaching impacts on regional urbanization process in ethnic minority areas of Southwest China.The previous literature of interregional migration paid less attention on the ethnic minority areas with fragile geographical feature and marginal socio-economic context in the developing world due to the dearth of reliable data.Based on the 2015 national 1%population sampling survey at the village/community scale,taking Yulong Naxi Autonomous County,Yunnan Province,China as the case study,this paper analyzed the spatial differentiation pattern.The results showed that:(1)migration in Yulong Naxi Autonomous County exhibited obvious spatial differentiation characteristics in terms of population aggregation,population loss,migration direction,and migration activity;(2)the overall spatial differentiation of migration exhibited a"layer+sector"pattern in Yulong Naxi Autonomous County:the first layer was active areas with net inflows(<20 km from the seat of the county government),the second layer was inactive areas(within 20–60 km of the seat of the county government),and the third layer was a mixed"layer+sector"zone(>60 km to the seat of the county government),comprised of inactive areas and active areas with net outflows;(3)the spatial differentiation pattern of migration was highly correlated with the regional contexts including the regional economic development,regional transportation accessibility and regional social development,while regional physical geographical factors had insignificant relationships with the migration pattern.

Spatial and Temporal Pattern of Urban Smart Development in China and Its Driving Mechanism

Smart urban development is an inevitable choice, and is essential to overall strength improvement. It is important to explore an urban smart development path which unites smart growth with driving shrinkage perfectly in forming scientific and sustainable development concept and responding to new normal strategic opportunities. Based on statistic data of 294 prefecture-level cities and above in China from 2000 to 2015, we analyzed spatial and temporal evolution of urban smart development in China by constructing a dynamic fitting model of urban land expansion, population growth, and economic development as well as the coefficient of variation of urban smart development(CVSD). Further efforts were then made to consider differential distribution regularity of urban smart development so as to understand the driving mechanisms of heterogeneous classification of urban smart development in China from different scales and scale variation. Our results indicate that: 1) the disordered growth tendency of urban cities in China is overall well controlled in the middle, and late research and it mainly presented a doublet coexistence of shrinkage disordered cities and smart developing cities. It is particularly obvious that Northeast China and East China have regarded shrinkage disordered cities and smart developing cities as main development tendency separately. 2) Areas with basic stability and relative variation were relatively dispersed across the time period, but the proportion was far beyond areas with significant variation. It demonstrates a relative equilibrium spatial and temporal differential evolution pattern of prefecture-level cities and above in China, except for Tongling, Lanzhou and Chaoyang. 3) prefecture-level cities and above in China are mostly characterized by shrinkage disordered and smart development classification under the background of different scale and scale variation from 2000–2015; however, the spatial resonance relation is not obvious. 4) There are many interaction factors forming an important driving mechanism in developing the spatial and temporal pattern of urban smart development in China, including natural geographical factors, industrial structure adjustment, human capital radiation, regional traffic accessibility, and government decision-making intervention.

A Research Review of the ＂Differential Pattern＂ Theory and Its Contemporary Value

The ＂differential pattern＂ is an important thesis raised by Fei Xiaotong in his early sociology theory and possesses unique theoretical intension and practical value. From different dimensions, the study of the ＂differential pattern＂ theory and its contemporary value has been one of the hot issues in domestic sociology. With these studies, the contents of the ＂differential pattern＂ theory are enriched, and also its value boundary and contemporary significance are revealed.

Traditional Medicine Diagnostic Codes in ICD-11 and Alternative Diagnostic Classifications in the Mainstream Healthcare

In 2018,the 11^(th) Edition of the International Classification of Diseases(ICD-11)defined a diagnostic code list for standard traditional medicine(TM)conditions.The codes improve patient safety by providing more comprehensive and accurate medical records for hospitals in the Western Pacific Region.In these facilities,TM is often a standard of care for those populations.In several mainstream media sources,writers are circumventing evidence-based peer-reviewed medical literature by unduly influencing public opinion and,in this case,against the new ICD-11 codes.The dangers imposed by the transgression of popular writing onto the discipline of peer-reviewed works are present since best practices in medical record-keeping will fail without the inclusion of TM in the ICD-11 codes.Such failures directly affect the health of the patients and policymakers in regions where TM and conventional medicine are combined.This article investigates the boundaries between substantial evidence and popular opinion.In this era where media is used to manipulate evidence,the reader’s use of sound judgment and critical thought are thwarted.This article also challenges three controversial themes in pop literature,including the threat to endangered species,increased patient risk,and contaminants in the TM.These themes are made without evidence and are,in fact,of flawed logic.There is no reason to assume that improved medical record-keeping and knowledge of patient cases increase risks.

Relationship Between Differential Gene Expression and Heterosis During Ear Development in Maize (Zea mays L.)

Maize （Zea raays L.） is one of the most important crops because of the remarkable properties of its hybrid, which is responsible for the high commercial value of hybrid maize. The genetic basis of heterosis （hybrid vigor） is not well understood. A differential display technique was performed to identify genes with differential expression across twelve maize inbred lines and thirty-three hybrids during ear development. An incomplete diallel design was used to investigate the relationship between the global framework of differential gene expression and heterosis. It was found that the genes belonging to MONO pattern （i.e., genes expressed in both parental lines and in hybrid） was the highest in percentage among the total five patterns and illustrated that the properties of differentially expressed genes are not entirely responsible for heterosis. Furthermore,a larger number of differentially expressed genes in hybrid, which serves as a major reservoir for generating novel phenotypes that exhibit heterosis of certain agronomic traits during early development and differentiation of maize ear. Moreover, there were some silent genesin hybrids that are responsible for the arrest or abortion of spikelets and for the increase in kernels weight.

Spatial Differentiation Pattern of Habitat Quality and Mechanism of Factors Influencing in Resource-based Cities:A Case Study of Tangshan City,China

The degradation of the eco-environment has been a challenge for sustainability in resource-based cities around the world.Although much attention has been drawn to this issue,few insights have been acquired regarding the spatial differentiation and mechanism of the factors influencing habitat quality in resource-based cities from the perspective of the interactions of natural and human factors.Using Tangshan City as a case study,this paper evaluates habitat quality by integrating Ecosystem Service Value Assessment and the InVEST-HQ model,identifies the spatial distribution of Tangshan’s habitat quality with spatial auto-correlation,and explores the influencing factors and their mechanism of influence on the spatial differentiation with the geographical detector model and Space production theory.The results show that:(1)The total value of the habitat quality in Tangshan City in 2019 was 3.45×10^(10) yuan,and the habitat quality value was 24435.05 yuan ha-1.The habitat quality value presents a clustered distribution pattern of"hot in the north and the south,cold from the center to the west".(2)On the county scale,Qianxi County had the best habitat quality and Lubei District had the worst habitat quality;Shangying Township had the highest average habitat quality and Kaiping Street had the lowest average habitat quality in the township unit.(3)The results of geographical detectors show that natural environmental conditions are the important basic factors affecting the spatial differentiation of habitat quality in Tangshan City,while urbanization and industrialization factors are the most important external forces driving the spatial differentiation of habitat quality.The contributions of average elevation,average slope,raw material industrial density,and population density to the spatial differentiation of habitat quality are all above 0.40.The interactions of any two factors on habitat quality are enhanced.Areas with concentrated populations,rich industrial resources,and convenient transportation become low-value habitat quality areas;while areas with beautiful landscape patterns,abundant precipitation,and a comfortable climate become high-value habitat quality areas.Space production theory can be used to explain the mechanism of the formation of the spatial differentiation of habitat quality.

Acupuncture Points Used in the Prophylaxis against Recurrent Uncomplicated Cystitis, Patterns Identified and Their Possible Relationship to Physiological Measurements

Objective： To explore the correlation between single acupoints used and the recurrence rate of cystitis among cystitis-prone women receiving acupuncture as a prophylactic treatment. Methods： In all, 58 cystitis-prone women were included in the analysis. Customised acupuncture treatments were given twice a week, over 4 weeks. The main effect parameter was the number of cystitis episodes during the 6-month observation time. Residual urine was measured at baseline, 2, 4 and 6 months using portable ultrasound equipment. Sympathetic and vagotone nerve activities were measured by using skin conductance and respiratory sinus arrhythmia, respectively. Results： The main acupoints used for patients with Kidney （Shen） qi/yang deficiency were Shenshu （BL23）, Taixi （KI3）, Zhongji （CV3）, Sanyinjiao （SP6） and Pangguangshu （BL2.8）, compared with Taichong （LR3）, CV3, BL28, Yinlingquan （SP9） and SP6 for Liver （Gan） qi stagnation, and SP6, CV3, BL28, Zusanli （ST36） and SP9 for Spleen （Pi） qi/yang deficiency patients. The combination BL23 and KI3 were used in 16 women, 13 of which were Kidney pattern related patients. When used, the number of symptomatic episodes were reduced to a third compared with what occurred in the 42 women where this combination was not used （3/16 vs. 28/42, P〈0.05）. BL23 application correlated to a significant reduction in residual urine measured a few days after treatment. Patients with the pattern of Spleen qi/yang deficiency had an initial increase in residual urine after treatments. Conclusion： Treating Kidney pattern related patients with the combination of BL23 and KI3 resulted in far better outcome than other points/combination of points for other Chinese medicine diagnoses. The acupoint SP6 may be less indicated than previously assumed when treating cvstitis-Drone women DroDhvlacticalIv.

Parametric array differential Pattern time delay shift coding underwater acoustic communication in the under-ice environment

In order to meet the demands of underwater acoustic communication in under ice environment,a differential Pattern time delay shift coding underwater acoustic communication method based on parametric array is introduced in this paper.The under ice underwater acoustic channel is characterized by heavy multipath transmission.Under this model,a parametric array emission method of Pattern signal is derived and the system performance is analyzed.A broadband low frequency sound waves with narrow beam-pattern,which will reduce the interface reflections and suppress the effects of multipath transmission,can be obtained by the emission method.The Songhua River under ice trial results show that there is an anti-multipath property and a higher data rate in the under-ice acoustic channel in proposed approach.

Comparison of efficacy of treating obese patients with endocrine-metabolic abnormity by electroacupuncture of different types of wave modes

Objective To compare the efficacy of treating obese patients with abnormity of lipids and serum leptin by dilatational wave or continuous wave of electroacupuncture combined with thunder-fire moxibustion in order to provide a clinical basis for selecting wave types of electroacupuncture for different patterns of obesity. Methods Sixty obese patients with abnormal lipids and serum leptin were randomly divided into a dilatational wave group and a continuous wave group via random number table, with 30 cases in each group. They were divided by TCM differentiation into three types： stomachintestine excessive heat, weakness of the spleen-stomach and spleen-kidney yang deficiency, treated by electroacupuncture on Tianshu （天枢 ST 25）, Daheng （大横 SP 15）, Zusanli （足三里ST 36）, Shangjuxu （上巨虚 ST 37）, Fanglong （丰隆 ST 40）, Yinlingquan （阴陵泉 SP 9）, Quchi （曲池 LI 11）, Zhigou （支沟 TE 6） and Hegu （合谷 LI 4） along with thunder-fire moxibustion. The frequency of electro-acupuncture in the dilatational wave group and the continuous wave group was 2 Hz/100 Hz and 2 Hz, respectively. Patients in the two groups were treated once a day, six times a week. The treatment lasted for 4 weeks with 3-month follow-up. Body mass and body fat percentage before and after the treatment, as well as during the follow-up, were compared. The effectiveness rates in the two groups were compared, and the efficacy statistics of patients with different TCM patterns in the dilatational wave group were also analyzed. Lipid levels of the patients in two groups before and after the treatment were measured with an automatic biochemical analyzer, and serum leptin levels were detected with flow cytometry system. Results After the treatment, the patients＇ blood lipids, serum leptin levels, body mass and body fat percentage were effectively reduced in the two groups; three months＇ follow-up witnessed continuous decline of obesity indicators （P〈0.01 or P〈0.05）, and patients in the dilatat-ional wave group improved more significantly than those in continuous wave group （P〈0.05 or P〈0.01）. The efficacy in the dilatational wave group was superior to that in the continuous wave group （P〈0.01）. The best efficacy could be found among patients with weakness of the spleen and the stomach in the dilatational wave group. Conclusion Efficacy of treating obese patients with abnormity of lipids and serum leptin by electro-acupuncture combined with thunder-fire moxibustion in the dilatational wave group was significantly better than that of the continuous wave group, and efficacy for obese patients with weakness of the spleen and the stomach was superior to that of those with stomach-intestine excessive heat and spleen-kidney yang deficiency.