This thesis discusses the earthquake reflecting ability of the observation well pattern system of Jiangsu Province, China, which has been digitally renovated, and probes into the cause of the major differences in the ...This thesis discusses the earthquake reflecting ability of the observation well pattern system of Jiangsu Province, China, which has been digitally renovated, and probes into the cause of the major differences in the earthquake reflecting abilities of well holes at different measurement points. This is achieved through the analysis of the co-seismic responses to the Wenchuan (2008; Ms8.0, China) and Tohoku (2011; Ms9.0, Japan) earthquakes. We found that the co-seismic response of water level from regional well holes in Jiangsu Province was stronger than that of water temperature. The water-level co-seismic response follows a consistent law and is closely related to the earthquake magnitude. The co-seismic response of water temperature strongly varied among well points, and was more often manifested as a slow restorative change. The co-seismic responses also varied based on tectonic elements. The response in central and northern Jiangsu was weaker than that of southern Jiangsu, possibly due to the thicker loess cover layer in central Jiangsu which makes it less effective at capturing the micro-changes of stress-strain states relative to the hilly land in the south. The more complicated geological structure in southern Jiangsu makes it contribute to greater changes in the state of underground water after a minor disturbance.展开更多
Climate warming profoundly affects plant biodiversity, community productivity, and soil properties in alpine and subalpine grassland ecosystems. However, these effects are poorly understood across elevational gradient...Climate warming profoundly affects plant biodiversity, community productivity, and soil properties in alpine and subalpine grassland ecosystems. However, these effects are poorly understood across elevational gradients in subalpine meadow ecosystems. To reveal the elevational patterns of warming effects on plant biodiversity, community structure, productivity, and soil properties, we conducted a warming experiment using open-top chambers from August 2019 to August 2022 at high(2764 m a. s. l.), medium(2631 m a. s. l.), and low(2544 m a. s. l.) elevational gradients on a subalpine meadow slope of Mount Wutai, Northern China. Our results showed that three years of warming significantly increased topsoil temperature but significantly decreased topsoil moisture at all elevations(P<0.05), and the percentage of increasing temperature and decreasing moisture both gradually raised with elevation lifting. Warming-induced decreasing proportions of soil organic carbon(SOC, by 19.24%), and total nitrogen(TN, by 24.56%) were the greatest at high elevational gradients. Experimental warming did not affect topsoil C: N, p H, NO_(3)^(-)-N, or NH_(4)^(+)-N at the three elevational gradients. Warming significantly increased species richness(P<0.01) and Shannon-Weiner index(P<0.05) at low elevational gradients but significantly decreased belowground biomass(P<0.05) at a depth of 0–10 cm at three elevational gradients. Warming caused significant increases in the aboveground biomass in the three elevational plots. Warming significantly increased the aboveground biomass of graminoids in medium(by 92.47%) and low(by 98.25%) elevational gradients, that of sedges in high(by 72.44%) and medium(by 57.16%) elevational plots, and that of forbs in high(by 75.88%), medium(by 34.38%), and low(by 74.95%) elevational plots. Species richness had significant linear correlations with SOC, TN, and C: N(P<0.05), but significant nonlinear responses to soil temperature and soil moisture in the warmed treatment(P<0.05). The warmed aboveground biomass had a significant nonlinear response to soil temperature and significant linear responses to soil moisture(P<0.05). This study provided evidence that altitude is a factor in sensitivity to climate warming, and these different parameters(e.g., plant species richness, Shannon-Weiner index, soil temperature, soil moisture, SOC, and TN) can be used to measure this sensitivity.展开更多
A prediction framework based on the evolution of pattern motion probability density is proposed for the output prediction and estimation problem of non-Newtonian mechanical systems,assuming that the system satisfies t...A prediction framework based on the evolution of pattern motion probability density is proposed for the output prediction and estimation problem of non-Newtonian mechanical systems,assuming that the system satisfies the generalized Lipschitz condition.As a complex nonlinear system primarily governed by statistical laws rather than Newtonian mechanics,the output of non-Newtonian mechanics systems is difficult to describe through deterministic variables such as state variables,which poses difficulties in predicting and estimating the system’s output.In this article,the temporal variation of the system is described by constructing pattern category variables,which are non-deterministic variables.Since pattern category variables have statistical attributes but not operational attributes,operational attributes are assigned to them by posterior probability density,and a method for analyzing their motion laws using probability density evolution is proposed.Furthermore,a data-driven form of pattern motion probabilistic density evolution prediction method is designed by combining pseudo partial derivative(PPD),achieving prediction of the probability density satisfying the system’s output uncertainty.Based on this,the final prediction estimation of the system’s output value is realized by minimum variance unbiased estimation.Finally,a corresponding PPD estimation algorithm is designed using an extended state observer(ESO)to estimate the parameters to be estimated in the proposed prediction method.The effectiveness of the parameter estimation algorithm and prediction method is demonstrated through theoretical analysis,and the accuracy of the algorithm is verified by two numerical simulation examples.展开更多
AIM:To determine the smartphone use patterns and effects of smartphone use on accommodation and convergence system of the eyes among Malaysian teenagers.METHODS:A total of 62 participants aged between 13 and 17y were ...AIM:To determine the smartphone use patterns and effects of smartphone use on accommodation and convergence system of the eyes among Malaysian teenagers.METHODS:A total of 62 participants aged between 13 and 17y were involved.A self-administered questionnaires containing 12 items was used to evaluate the smartphone usage patterns.This was followed by an eye examination,involving a battery of accommodation and convergence assessments before and after the smartphone use.The data analysis comprised descriptive statistics,paired t-test,and correlation coefficients.RESULTS:The use of smartphones is at a high level and at an optimal distance daily,with more than 6h a day watching video films,games,and completing school projects.Majority of the participants not reported eye strain factors and eye prescription changes with the use of digital devices.The use of a smartphone continuously for 30min was found to significantly decrease amplitude of accommodation,accommodative facility,and positive relative accommodation(P<0.001).Meanwhile,the lag of accommodation parameters and negative relative accommodation increased with the use of smartphones significantly(P<0.001).The near point of convergence(NPC)and distance and near negative fusional vergence decreased significantly(P<0.001).The NPC parameter was found to have a weak negative association with the frequency of smartphone use(R=-0.276,P<0.05).CONCLUSION:Frequent and continuous use of smartphones have increased visual stress and resulted in weakness of accommodation and vergence functions.Therefore,frequent break is mandatory when using a smartphone and appropriate visual hygiene,the 20-20-20 rule(every 20min,view something 20 feet away for 20s)are required during smartphone use to maintain visual function.展开更多
The Yellow River Delta(YRD), a critical economic zone along China's eastern coast, also functions as a vital ecological reserve in the lower Yellow River. Amidst rapid industrialization and urbanization, the regio...The Yellow River Delta(YRD), a critical economic zone along China's eastern coast, also functions as a vital ecological reserve in the lower Yellow River. Amidst rapid industrialization and urbanization, the region has witnessed significant land use/cover changes(LUCC), impacting ecosystem services(ES) and ecological security patterns(ESP). Investigating LUCC's effects on ES and ESP in the YRD is crucial for ecological security and sustainable development. This study utilized the PLUS model to simulate 2030 land use scenarios, including natural development(NDS), economic development(EDS), and ecological protection scenarios(EPS). Subsequently, the InVEST model and circuit theory were applied to assess ES and ESP under varying LUCC scenarios from 2010 to 2030. Findings indicate:(1) Notable LUCC from 2010 to 2030, marked by decreasing cropland and increasing construction land and water bodies.(2) From 2010 to 2020, improvements were observed in carbon storage,water yield, soil retention, and habitat quality, whereas 2020–2030 saw increases in water yield and soil retention but declines in habitat quality and carbon storage. Among the scenarios, EPS showed superior performance in all four ES.(3) Between 2010 and 2030, ecological sources, corridors, and pinchpoints expanded, displaying significant spatial heterogeneity. The EPS scenario yielded the most substantial increases in ecological sources,corridors, and pinchpoints, totaling 582.89 km^(2), 645.03 km^(2),and 64.43 km^(2), respectively. This study highlights the importance of EPS, offering insightful scientific guidance for the YRD's sustainable development.展开更多
The crack fault is one of the most common faults in the rotor system,and researchers have paid close attention to its fault diagnosis.However,most studies focus on discussing the dynamic response characteristics cause...The crack fault is one of the most common faults in the rotor system,and researchers have paid close attention to its fault diagnosis.However,most studies focus on discussing the dynamic response characteristics caused by the crack rather than estimating the crack depth and position based on the obtained vibration signals.In this paper,a novel crack fault diagnosis and location method for a dual-disk hollow shaft rotor system based on the Radial basis function(RBF)network and Pattern recognition neural network(PRNN)is presented.Firstly,a rotor system model with a breathing crack suitable for a short-thick hollow shaft rotor is established based on the finite element method,where the crack's periodic opening and closing pattern and different degrees of crack depth are considered.Then,the dynamic response is obtained by the harmonic balance method.By adjusting the crack parameters,the dynamic characteristics related to the crack depth and position are analyzed through the amplitude-frequency responses and waterfall plots.The analysis results show that the first critical speed,first subcritical speed,first critical speed amplitude,and super-harmonic resonance peak at the first subcritical speed can be utilized for the crack fault diagnosis.Based on this,the RBF network and PRNN are adopted to determine the depth and approximate location of the crack respectively by taking the above dynamic characteristics as input.Test results show that the proposed method has high fault diagnosis accuracy.This research proposes a crack detection method adequate for the hollow shaft rotor system,where the crack depth and position are both unknown.展开更多
Cymbidium(Orchidaceae:Epidendroideae),with around 60 species,is widely-distributed across Southeast Asia,providing a nice system for studying the processes that underlie patterns of biodiversity in the region.However,...Cymbidium(Orchidaceae:Epidendroideae),with around 60 species,is widely-distributed across Southeast Asia,providing a nice system for studying the processes that underlie patterns of biodiversity in the region.However,phylogenetic relationships of Cymbidium have not been well resolved,hampering investigations of species diversification and the biogeographical history of this genus.In this study,we construct a plastome phylogeny of 56 Cymbidium species,with four well-resolved major clades,which provides a framework for biogeographical and diversification rate analyses.Molecular dating and biogeographical analyses show that Cymbidium likely originated in the region spanning northern IndoBurma to the eastern Himalayas during the early Miocene(~21.10 Ma).It then rapidly diversified into four major clades in East Asia within approximately a million years during the middle Miocene.Cymbidium spp.migration to the adjacent regions(Borneo,Philippines,and Sulawesi)primarily occurred during the Pliocene-Pleistocene period.Our analyses indicate that the net diversification rate of Cymbidium has decreased since its origin,and is positively associated with changes in temperature and monsoon intensity.Favorable hydrothermal conditions brought by monsoon intensification in the early Miocene possibly contributed to the initial rapid diversification,after which the net diversification rate was reduced with the cooling climate after the middle Miocene.The transition from epiphytic to terrestrial habits may have enabled adaptation to cooler environments and colonization of northern niches,yet without a significant effect on diversification rates.This study provides new insights into how monsoon activity and temperature changes affected the diversification dynamics of plants in Southeast Asia.展开更多
BACKGROUND Although chronic erosive gastritis(CEG)is common,its clinical characteristics have not been fully elucidated.The lack of consensus regarding its treatment has resulted in varied treatment regimens.AIM To ex...BACKGROUND Although chronic erosive gastritis(CEG)is common,its clinical characteristics have not been fully elucidated.The lack of consensus regarding its treatment has resulted in varied treatment regimens.AIM To explore the clinical characteristics,treatment patterns,and short-term outcomes in CEG patients in China.METHODS We recruited patients with chronic non-atrophic or mild-to-moderate atrophic gastritis with erosion based on endoscopy and pathology.Patients and treating physicians completed a questionnaire regarding history,endoscopic findings,and treatment plans as well as a follow-up questionnaire to investigate changes in symptoms after 4 wk of treatment.RESULTS Three thousand five hundred sixty-three patients from 42 centers across 24 cities in China were included.Epigastric pain(68.0%),abdominal distension(62.6%),and postprandial fullness(47.5%)were the most common presenting symptoms.Gastritis was classified as chronic non-atrophic in 69.9%of patients.Among those with erosive lesions,72.1%of patients had lesions in the antrum,51.0%had multiple lesions,and 67.3%had superficial flat lesions.In patients with epigastric pain,the combination of a mucosal protective agent(MPA)and proton pump inhibitor was more effective.For those with postprandial fullness,acid regurgitation,early satiety,or nausea,a MPA appeared more promising.CONCLUSION CEG is a multifactorial disease which is common in Asian patients and has non-specific symptoms.Gastroscopy may play a major role in its detection and diagnosis.Treatment should be individualized based on symptom profile.展开更多
The undesirable dendrite growth induced by non-planar zinc(Zn)deposition and low Coulombic efficiency resulting from severe side reactions have been long-standing challenges for metallic Zn anodes and substantially im...The undesirable dendrite growth induced by non-planar zinc(Zn)deposition and low Coulombic efficiency resulting from severe side reactions have been long-standing challenges for metallic Zn anodes and substantially impede the practical application of rechargeable aqueous Zn metal batteries(ZMBs).Herein,we present a strategy for achieving a high-rate and long-cycle-life Zn metal anode by patterning Zn foil surfaces and endowing a Zn-Indium(Zn-In)interface in the microchannels.The accumulation of electrons in the microchannel and the zincophilicity of the Zn-In interface promote preferential heteroepitaxial Zn deposition in the microchannel region and enhance the tolerance of the electrode at high current densities.Meanwhile,electron aggregation accelerates the dissolution of non-(002)plane Zn atoms on the array surface,thereby directing the subsequent homoepitaxial Zn deposition on the array surface.Consequently,the planar dendrite-free Zn deposition and long-term cycling stability are achieved(5,050 h at 10.0 mA cm^(−2) and 27,000 cycles at 20.0 mA cm^(−2)).Furthermore,a Zn/I_(2) full cell assembled by pairing with such an anode can maintain good stability for 3,500 cycles at 5.0 C,demonstrating the application potential of the as-prepared ZnIn anode for high-performance aqueous ZMBs.展开更多
The World Journal of Cardiology published an article written by Kuwahara et al that we take the pleasure to comment on.We focused our attention on venous congestion.In intensive care settings,it is now widely accepted...The World Journal of Cardiology published an article written by Kuwahara et al that we take the pleasure to comment on.We focused our attention on venous congestion.In intensive care settings,it is now widely accepted that venous congestion is an important clinical feature worthy of investigation.Evaluating venous Doppler profile abnormalities at multiple sites could suggest adequate treatment and monitor its efficacy.Renal dysfunction could trigger or worsen fluid overload in heart disease,and cardio-renal syndrome is a well-characterized spectrum of disorders describing the complex interactions between heart and kidney diseases.Fluid overload and venous congestion,including renal venous hypertension,are major determinants of acute and chronic renal dysfunction arising in heart disease.Organ congestion from venous hypertension could be involved in the development of organ injury in several clinical situations,such as critical diseases,congestive heart failure,and chronic kidney disease.Ultrasonography and abnormal Doppler flow patterns diagnose clinically significant systemic venous congestion.Cardiologists and nephrologists might use this valuable,noninvasive,bedside diagnostic tool to establish fluid status and guide clinical choices.展开更多
A recommender system is an approach performed by e-commerce for increasing smooth users’experience.Sequential pattern mining is a technique of data mining used to identify the co-occurrence relationships by taking in...A recommender system is an approach performed by e-commerce for increasing smooth users’experience.Sequential pattern mining is a technique of data mining used to identify the co-occurrence relationships by taking into account the order of transactions.This work will present the implementation of sequence pattern mining for recommender systems within the domain of e-com-merce.This work will execute the Systolic tree algorithm for mining the frequent patterns to yield feasible rules for the recommender system.The feature selec-tion's objective is to pick a feature subset having the least feature similarity as well as highest relevancy with the target class.This will mitigate the feature vector's dimensionality by eliminating redundant,irrelevant,or noisy data.This work pre-sents a new hybrid recommender system based on optimized feature selection and systolic tree.The features were extracted using Term Frequency-Inverse Docu-ment Frequency(TF-IDF),feature selection with the utilization of River Forma-tion Dynamics(RFD),and the Particle Swarm Optimization(PSO)algorithm.The systolic tree is used for pattern mining,and based on this,the recommendations are given.The proposed methods were evaluated using the MovieLens dataset,and the experimental outcomes confirmed the efficiency of the techniques.It was observed that the RFD feature selection with systolic tree frequent pattern mining with collaborativefiltering,the precision of 0.89 was achieved.展开更多
The existence of thermal storage will correspondingly increase the temperature of surrounding strata and promote the continuous expansion,volatilization,upward migration,and loss of gas in the strata.As a result,a low...The existence of thermal storage will correspondingly increase the temperature of surrounding strata and promote the continuous expansion,volatilization,upward migration,and loss of gas in the strata.As a result,a low-concentration gas field will be formed in the strata above geothermal reservoirs.Geothermal reservoirs could in turn heat formation water and increase the solubility of soluble inorganic salts in the surrounding rocks and the total dissolved solids(TDS)content in the formation water.Since water can strongly wet and permeate strata,the dissolved inorganic salts migrate into upper strata along with water,giving rise to the formation of a high-concentration inorganic salt field in the strata above geothermal reservoirs.A higher geothermal reservoir temperature corresponds to more significant characteristics mentioned above.Therefore,a medium-to-high temperature geothermal system has a surface geochemical anomaly pattern of high inorganic salt concentrations and low gas concentrations(also referred to as the high-salt and low-gas pattern).This pattern is applied to the surface geochemical exploration of the two geothermal fields in Guangdong Province,i.e.,the Huangshadong geothermal field in Huizhou City and the Xinzhou geothermal field in Yangjiang City,revealing low-concentration gas fields above both.The application results also show that the exposed thermal spring water in both geological fields has higher concentration of dissolved inorganic salt than the surface water and nearby seawater,forming high-amplitude anomalies on the surface above geothermal reservoirs.These characteristics,as well as the measured temperature at known geothermal wells,verify the validity of the high-salt and low-gas pattern of medium-to-high temperature geothermal systems proposed in this study.Moreover,the high-salt and low-gas pattern proposed predicts three favorable medium-to-high temperature geothermal zones in the surface geochemical exploration of the Shiba Basin near the Huangshadong geothermal field.展开更多
Experiments are conducted on the evacuation rate of pedestrians through exits with queued evacuation pattern and random evacuation pattern. The experimental results show that the flow rate of pedestrians is larger wit...Experiments are conducted on the evacuation rate of pedestrians through exits with queued evacuation pattern and random evacuation pattern. The experimental results show that the flow rate of pedestrians is larger with the random evacuation pattern than with the queued evacuation pattern. Therefore, the exit width calculated based on the minimum evacuation clear width for every 100 persons, which is on the assumption that the pedestrians pass through the exit in one queue or several queues, is conservative. The number of people crossing the exit simultaneously is greater in the random evacuation experiments than in the queued evacuation experiments, and the time interval between the front row and rear row of people is shortened in large-exit conditions when pedestrians evacuate randomly. The difference between the flow rate with a queued evacuation pattern and the flow rate with a random evacuation pattern is related to the surplus width of the exit, which is greater than the total width of all accommodated people streams. Two dimensionless quantities are defined to explore this relationship. It is found that the difference in flow rate between the two evacuation patterns is stable at a low level when the surplus width of the exit is no more than 45% of the width of a single pedestrian stream. There is a great difference between the flow rate with the queued evacuation pattern and the flow rate with the random evacuation pattern in a scenario with a larger surplus width of the exit. Meanwhile, the pedestrians crowd extraordinarily at the exit in these conditions as well, since the number of pedestrians who want to evacuate through exit simultaneously greatly exceeds the accommodated level. Therefore, the surplus width of exit should be limited especially in the narrow exit condition, and the relationship between the two dimensionless quantities mentioned above could provide the basis to some extent.展开更多
Functional magnetic resonance imaging(fMRI)is a popular tool used to investigate not only how the brain responds to specific stimuli during sensorimotor or cognitive tasks,but also brain activity at rest.The physics b...Functional magnetic resonance imaging(fMRI)is a popular tool used to investigate not only how the brain responds to specific stimuli during sensorimotor or cognitive tasks,but also brain activity at rest.The physics beyond this approach is based on the analysis of the blood oxygenation level-dependent signal.展开更多
Metal halide perovskites have emerged as promising light-emitting materials for next-generation displays owing to their remarkable material characteristics including broad color tunability,pure color emission with rem...Metal halide perovskites have emerged as promising light-emitting materials for next-generation displays owing to their remarkable material characteristics including broad color tunability,pure color emission with remarkably narrow bandwidths,high quantum yield,and solution processability.Despite recent advances have pushed the luminance efficiency of monochromic perovskite light-emitting diodes(PeLEDs)to their theoretical limits,their current fabrication using the spincoating process poses limitations for fabrication of full-color displays.To integrate PeLEDs into full-color display panels,it is crucial to pattern red–green–blue(RGB)perovskite pixels,while mitigating issues such as cross-contamination and reductions in luminous efficiency.Herein,we present state-of-the-art patterning technologies for the development of full-color PeLEDs.First,we highlight recent advances in the development of efficient PeLEDs.Second,we discuss various patterning techniques of MPHs(i.e.,photolithography,inkjet printing,electron beam lithography and laserassisted lithography,electrohydrodynamic jet printing,thermal evaporation,and transfer printing)for fabrication of RGB pixelated displays.These patterning techniques can be classified into two distinct approaches:in situ crystallization patterning using perovskite precursors and patterning of colloidal perovskite nanocrystals.This review highlights advancements and limitations in patterning techniques for PeLEDs,paving the way for integrating PeLEDs into full-color panels.展开更多
Memristors are extensively used to estimate the external electromagnetic stimulation and synapses for neurons.In this paper,two distinct scenarios,i.e.,an ideal memristor serves as external electromagnetic stimulation...Memristors are extensively used to estimate the external electromagnetic stimulation and synapses for neurons.In this paper,two distinct scenarios,i.e.,an ideal memristor serves as external electromagnetic stimulation and a locally active memristor serves as a synapse,are formulated to investigate the impact of a memristor on a two-dimensional Hindmarsh-Rose neuron model.Numerical simulations show that the neuronal models in different scenarios have multiple burst firing patterns.The introduction of the memristor makes the neuronal model exhibit complex dynamical behaviors.Finally,the simulation circuit and DSP hardware implementation results validate the physical mechanism,as well as the reliability of the biological neuron model.展开更多
A combination of hydrogels and microfluidics allows the construction of biomimetic three-dimensional(3D)tissue models in vitro,which are also known as organ-on-a-chipmodels.The hydrogel patterningwith awell-controlled...A combination of hydrogels and microfluidics allows the construction of biomimetic three-dimensional(3D)tissue models in vitro,which are also known as organ-on-a-chipmodels.The hydrogel patterningwith awell-controlled spatial distribution is typically achieved by embedding sophisticated microstructures to act as a boundary.However,these physical barriers inevitably expose cells/tissues to a less physiologically relevant microenvironment than in vivo conditions.Herein,we present a novel dissolvable temporary barrier(DTB)strategy that allows robust and flexible hydrogel patterning with great freedom of design and desirable flow stimuli for cellular hydrogels.The key aspect of this approach is the patterning of a water-soluble rigid barrier as a guiding path for the hydrogel using stencil printing technology,followed by a barrier-free medium perfusion after the dissolution of the DTB.Single and multiple tissue compartments with different geometries can be established using either straight or curved DTB structures.The effectiveness of this strategy is further validated by generating a 3D vascular network through vasculogenesis and angiogenesis using a vascularized microtumor model.As a new proof-of-concept in vasculature-on-a-chip,DTB enables seamless contact between the hydrogel and the culture medium in closed microdevices,which is an improved protocol for the fabrication ofmultiorgan chips.Therefore,we expect it to serve as a promising paradigm for organ-on-a-chip devices for the development of tumor vascularization and drug evaluation in the future preclinical studies.展开更多
The China-Myanmar Economic Corridor(CMEC) is an important part of China's Belt and Road Initiative and an important area for global ecology and biodiversity. In this study, the annual and seasonal spatiotemporal p...The China-Myanmar Economic Corridor(CMEC) is an important part of China's Belt and Road Initiative and an important area for global ecology and biodiversity. In this study, the annual and seasonal spatiotemporal patterns of temperature and precipitation in the CMEC over the past century were investigated using linear tendency estimation, the Mann-Kendall mutation test, the T-test, and wavelet analysis based on the monthly mean climatic data from 1901 to 2018 released by the Climatic Research Unit(CRU) of the University of East Anglia, UK. The results show that the CMEC demonstrated a trend of warming and drying over the past 100 years, and the rate of change in Myanmar was stronger than that in Yunnan Province of China. The warming rate was 0.039 ℃/10a. Precipitation decreased at a rate of -6.1 mm/10a. From the perspective of spatial distribution, temperature was high in the central and southern, low in the north of the CMEC, and the high-temperature centers were mainly distributed in the southern plain and river valley. Precipitation decreased from west to east and from south to north of the CMEC. From the perspective of the rate of change, warming was stronger in central and northern CMEC than in southern and northeastern CMEC. The rate of precipitation decline was stronger in the central and western regions than in the eastern region. This study provides a scientific reference for the CMEC to address climate change and ensure sustainable social and economic development and ecological security.展开更多
Positional information encoded in spatial concentration patterns is crucial for the development of multicellular organisms.However,it is still unclear how such information is affected by the physically dissipative dif...Positional information encoded in spatial concentration patterns is crucial for the development of multicellular organisms.However,it is still unclear how such information is affected by the physically dissipative diffusion process.Here we study one-dimensional patterning systems with analytical derivation and numerical simulations.We find that the diffusion constant of the patterning molecules exhibits a nonmonotonic effect on the readout of the positional information from the concentration patterns.Specifically,there exists an optimal diffusion constant that maximizes the positional information.Moreover,we find that the energy dissipation due to the physical diffusion imposes a fundamental upper limit on the positional information.展开更多
基金supported by the Scientific and Technological Support Project of Jiangsu Province (No.BS2007084)Seismic Technology Spark Project (No.XH12020)
文摘This thesis discusses the earthquake reflecting ability of the observation well pattern system of Jiangsu Province, China, which has been digitally renovated, and probes into the cause of the major differences in the earthquake reflecting abilities of well holes at different measurement points. This is achieved through the analysis of the co-seismic responses to the Wenchuan (2008; Ms8.0, China) and Tohoku (2011; Ms9.0, Japan) earthquakes. We found that the co-seismic response of water level from regional well holes in Jiangsu Province was stronger than that of water temperature. The water-level co-seismic response follows a consistent law and is closely related to the earthquake magnitude. The co-seismic response of water temperature strongly varied among well points, and was more often manifested as a slow restorative change. The co-seismic responses also varied based on tectonic elements. The response in central and northern Jiangsu was weaker than that of southern Jiangsu, possibly due to the thicker loess cover layer in central Jiangsu which makes it less effective at capturing the micro-changes of stress-strain states relative to the hilly land in the south. The more complicated geological structure in southern Jiangsu makes it contribute to greater changes in the state of underground water after a minor disturbance.
基金carried out in the framework of the 1331 Project of Cultural Ecology Collaborative Innovation Center in Wutai Mountain (00000342)co-financed by Program for the Philosophy and Social Sciences Research of Higher Learning Institutions of Shanxi (2022J027)+1 种基金Applied Basic Research Project of Shanxi Province (202203021221225)Basic Research Project of Xinzhou Science and Technology Bureau (20230501)。
文摘Climate warming profoundly affects plant biodiversity, community productivity, and soil properties in alpine and subalpine grassland ecosystems. However, these effects are poorly understood across elevational gradients in subalpine meadow ecosystems. To reveal the elevational patterns of warming effects on plant biodiversity, community structure, productivity, and soil properties, we conducted a warming experiment using open-top chambers from August 2019 to August 2022 at high(2764 m a. s. l.), medium(2631 m a. s. l.), and low(2544 m a. s. l.) elevational gradients on a subalpine meadow slope of Mount Wutai, Northern China. Our results showed that three years of warming significantly increased topsoil temperature but significantly decreased topsoil moisture at all elevations(P<0.05), and the percentage of increasing temperature and decreasing moisture both gradually raised with elevation lifting. Warming-induced decreasing proportions of soil organic carbon(SOC, by 19.24%), and total nitrogen(TN, by 24.56%) were the greatest at high elevational gradients. Experimental warming did not affect topsoil C: N, p H, NO_(3)^(-)-N, or NH_(4)^(+)-N at the three elevational gradients. Warming significantly increased species richness(P<0.01) and Shannon-Weiner index(P<0.05) at low elevational gradients but significantly decreased belowground biomass(P<0.05) at a depth of 0–10 cm at three elevational gradients. Warming caused significant increases in the aboveground biomass in the three elevational plots. Warming significantly increased the aboveground biomass of graminoids in medium(by 92.47%) and low(by 98.25%) elevational gradients, that of sedges in high(by 72.44%) and medium(by 57.16%) elevational plots, and that of forbs in high(by 75.88%), medium(by 34.38%), and low(by 74.95%) elevational plots. Species richness had significant linear correlations with SOC, TN, and C: N(P<0.05), but significant nonlinear responses to soil temperature and soil moisture in the warmed treatment(P<0.05). The warmed aboveground biomass had a significant nonlinear response to soil temperature and significant linear responses to soil moisture(P<0.05). This study provided evidence that altitude is a factor in sensitivity to climate warming, and these different parameters(e.g., plant species richness, Shannon-Weiner index, soil temperature, soil moisture, SOC, and TN) can be used to measure this sensitivity.
文摘A prediction framework based on the evolution of pattern motion probability density is proposed for the output prediction and estimation problem of non-Newtonian mechanical systems,assuming that the system satisfies the generalized Lipschitz condition.As a complex nonlinear system primarily governed by statistical laws rather than Newtonian mechanics,the output of non-Newtonian mechanics systems is difficult to describe through deterministic variables such as state variables,which poses difficulties in predicting and estimating the system’s output.In this article,the temporal variation of the system is described by constructing pattern category variables,which are non-deterministic variables.Since pattern category variables have statistical attributes but not operational attributes,operational attributes are assigned to them by posterior probability density,and a method for analyzing their motion laws using probability density evolution is proposed.Furthermore,a data-driven form of pattern motion probabilistic density evolution prediction method is designed by combining pseudo partial derivative(PPD),achieving prediction of the probability density satisfying the system’s output uncertainty.Based on this,the final prediction estimation of the system’s output value is realized by minimum variance unbiased estimation.Finally,a corresponding PPD estimation algorithm is designed using an extended state observer(ESO)to estimate the parameters to be estimated in the proposed prediction method.The effectiveness of the parameter estimation algorithm and prediction method is demonstrated through theoretical analysis,and the accuracy of the algorithm is verified by two numerical simulation examples.
文摘AIM:To determine the smartphone use patterns and effects of smartphone use on accommodation and convergence system of the eyes among Malaysian teenagers.METHODS:A total of 62 participants aged between 13 and 17y were involved.A self-administered questionnaires containing 12 items was used to evaluate the smartphone usage patterns.This was followed by an eye examination,involving a battery of accommodation and convergence assessments before and after the smartphone use.The data analysis comprised descriptive statistics,paired t-test,and correlation coefficients.RESULTS:The use of smartphones is at a high level and at an optimal distance daily,with more than 6h a day watching video films,games,and completing school projects.Majority of the participants not reported eye strain factors and eye prescription changes with the use of digital devices.The use of a smartphone continuously for 30min was found to significantly decrease amplitude of accommodation,accommodative facility,and positive relative accommodation(P<0.001).Meanwhile,the lag of accommodation parameters and negative relative accommodation increased with the use of smartphones significantly(P<0.001).The near point of convergence(NPC)and distance and near negative fusional vergence decreased significantly(P<0.001).The NPC parameter was found to have a weak negative association with the frequency of smartphone use(R=-0.276,P<0.05).CONCLUSION:Frequent and continuous use of smartphones have increased visual stress and resulted in weakness of accommodation and vergence functions.Therefore,frequent break is mandatory when using a smartphone and appropriate visual hygiene,the 20-20-20 rule(every 20min,view something 20 feet away for 20s)are required during smartphone use to maintain visual function.
基金financially supported by the National Natural Science Foundation of China (Grant No. 41461011)。
文摘The Yellow River Delta(YRD), a critical economic zone along China's eastern coast, also functions as a vital ecological reserve in the lower Yellow River. Amidst rapid industrialization and urbanization, the region has witnessed significant land use/cover changes(LUCC), impacting ecosystem services(ES) and ecological security patterns(ESP). Investigating LUCC's effects on ES and ESP in the YRD is crucial for ecological security and sustainable development. This study utilized the PLUS model to simulate 2030 land use scenarios, including natural development(NDS), economic development(EDS), and ecological protection scenarios(EPS). Subsequently, the InVEST model and circuit theory were applied to assess ES and ESP under varying LUCC scenarios from 2010 to 2030. Findings indicate:(1) Notable LUCC from 2010 to 2030, marked by decreasing cropland and increasing construction land and water bodies.(2) From 2010 to 2020, improvements were observed in carbon storage,water yield, soil retention, and habitat quality, whereas 2020–2030 saw increases in water yield and soil retention but declines in habitat quality and carbon storage. Among the scenarios, EPS showed superior performance in all four ES.(3) Between 2010 and 2030, ecological sources, corridors, and pinchpoints expanded, displaying significant spatial heterogeneity. The EPS scenario yielded the most substantial increases in ecological sources,corridors, and pinchpoints, totaling 582.89 km^(2), 645.03 km^(2),and 64.43 km^(2), respectively. This study highlights the importance of EPS, offering insightful scientific guidance for the YRD's sustainable development.
基金Supported by National Natural Science Foundation of China (Grant No.11972129)National Science and Technology Major Project of China (Grant No.2017-IV-0008-0045)+1 种基金Heilongjiang Provincial Natural Science Foundation (Grant No.YQ2022A008)the Fundamental Research Funds for the Central Universities。
文摘The crack fault is one of the most common faults in the rotor system,and researchers have paid close attention to its fault diagnosis.However,most studies focus on discussing the dynamic response characteristics caused by the crack rather than estimating the crack depth and position based on the obtained vibration signals.In this paper,a novel crack fault diagnosis and location method for a dual-disk hollow shaft rotor system based on the Radial basis function(RBF)network and Pattern recognition neural network(PRNN)is presented.Firstly,a rotor system model with a breathing crack suitable for a short-thick hollow shaft rotor is established based on the finite element method,where the crack's periodic opening and closing pattern and different degrees of crack depth are considered.Then,the dynamic response is obtained by the harmonic balance method.By adjusting the crack parameters,the dynamic characteristics related to the crack depth and position are analyzed through the amplitude-frequency responses and waterfall plots.The analysis results show that the first critical speed,first subcritical speed,first critical speed amplitude,and super-harmonic resonance peak at the first subcritical speed can be utilized for the crack fault diagnosis.Based on this,the RBF network and PRNN are adopted to determine the depth and approximate location of the crack respectively by taking the above dynamic characteristics as input.Test results show that the proposed method has high fault diagnosis accuracy.This research proposes a crack detection method adequate for the hollow shaft rotor system,where the crack depth and position are both unknown.
基金supported by grants from the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB31000000)The 14th Five-Year Plan of the Xishuangbanna Tropical Botanical Garden,Chinese Academy of Sciences (XTBG-1450101)+3 种基金the Science and Technology Basic Resources Investigation Program of China (2021FY100200)the Key Basic Research Program of Yunnan Province,China (202101BC070003)the Yunnan Revitalization Talent Support Program"Young Talent"and"Innovation Team"ProjectsEcological and Environmental Conservation Program from the Department of Ecology and Environment of Yunnan Province。
文摘Cymbidium(Orchidaceae:Epidendroideae),with around 60 species,is widely-distributed across Southeast Asia,providing a nice system for studying the processes that underlie patterns of biodiversity in the region.However,phylogenetic relationships of Cymbidium have not been well resolved,hampering investigations of species diversification and the biogeographical history of this genus.In this study,we construct a plastome phylogeny of 56 Cymbidium species,with four well-resolved major clades,which provides a framework for biogeographical and diversification rate analyses.Molecular dating and biogeographical analyses show that Cymbidium likely originated in the region spanning northern IndoBurma to the eastern Himalayas during the early Miocene(~21.10 Ma).It then rapidly diversified into four major clades in East Asia within approximately a million years during the middle Miocene.Cymbidium spp.migration to the adjacent regions(Borneo,Philippines,and Sulawesi)primarily occurred during the Pliocene-Pleistocene period.Our analyses indicate that the net diversification rate of Cymbidium has decreased since its origin,and is positively associated with changes in temperature and monsoon intensity.Favorable hydrothermal conditions brought by monsoon intensification in the early Miocene possibly contributed to the initial rapid diversification,after which the net diversification rate was reduced with the cooling climate after the middle Miocene.The transition from epiphytic to terrestrial habits may have enabled adaptation to cooler environments and colonization of northern niches,yet without a significant effect on diversification rates.This study provides new insights into how monsoon activity and temperature changes affected the diversification dynamics of plants in Southeast Asia.
基金the National Key Clinical Specialty Construction Project,No.ZK108000CAMS Innovation Fund for Medical Sciences,No.2021-I2M-C&T-A-001 and No.2022-I2M-C&T-B-012.
文摘BACKGROUND Although chronic erosive gastritis(CEG)is common,its clinical characteristics have not been fully elucidated.The lack of consensus regarding its treatment has resulted in varied treatment regimens.AIM To explore the clinical characteristics,treatment patterns,and short-term outcomes in CEG patients in China.METHODS We recruited patients with chronic non-atrophic or mild-to-moderate atrophic gastritis with erosion based on endoscopy and pathology.Patients and treating physicians completed a questionnaire regarding history,endoscopic findings,and treatment plans as well as a follow-up questionnaire to investigate changes in symptoms after 4 wk of treatment.RESULTS Three thousand five hundred sixty-three patients from 42 centers across 24 cities in China were included.Epigastric pain(68.0%),abdominal distension(62.6%),and postprandial fullness(47.5%)were the most common presenting symptoms.Gastritis was classified as chronic non-atrophic in 69.9%of patients.Among those with erosive lesions,72.1%of patients had lesions in the antrum,51.0%had multiple lesions,and 67.3%had superficial flat lesions.In patients with epigastric pain,the combination of a mucosal protective agent(MPA)and proton pump inhibitor was more effective.For those with postprandial fullness,acid regurgitation,early satiety,or nausea,a MPA appeared more promising.CONCLUSION CEG is a multifactorial disease which is common in Asian patients and has non-specific symptoms.Gastroscopy may play a major role in its detection and diagnosis.Treatment should be individualized based on symptom profile.
基金supported by the National Research Foundation of Korea Grant funded by the Korean government(MSIP)(No.2018R1A6A1A03025708).
文摘The undesirable dendrite growth induced by non-planar zinc(Zn)deposition and low Coulombic efficiency resulting from severe side reactions have been long-standing challenges for metallic Zn anodes and substantially impede the practical application of rechargeable aqueous Zn metal batteries(ZMBs).Herein,we present a strategy for achieving a high-rate and long-cycle-life Zn metal anode by patterning Zn foil surfaces and endowing a Zn-Indium(Zn-In)interface in the microchannels.The accumulation of electrons in the microchannel and the zincophilicity of the Zn-In interface promote preferential heteroepitaxial Zn deposition in the microchannel region and enhance the tolerance of the electrode at high current densities.Meanwhile,electron aggregation accelerates the dissolution of non-(002)plane Zn atoms on the array surface,thereby directing the subsequent homoepitaxial Zn deposition on the array surface.Consequently,the planar dendrite-free Zn deposition and long-term cycling stability are achieved(5,050 h at 10.0 mA cm^(−2) and 27,000 cycles at 20.0 mA cm^(−2)).Furthermore,a Zn/I_(2) full cell assembled by pairing with such an anode can maintain good stability for 3,500 cycles at 5.0 C,demonstrating the application potential of the as-prepared ZnIn anode for high-performance aqueous ZMBs.
文摘The World Journal of Cardiology published an article written by Kuwahara et al that we take the pleasure to comment on.We focused our attention on venous congestion.In intensive care settings,it is now widely accepted that venous congestion is an important clinical feature worthy of investigation.Evaluating venous Doppler profile abnormalities at multiple sites could suggest adequate treatment and monitor its efficacy.Renal dysfunction could trigger or worsen fluid overload in heart disease,and cardio-renal syndrome is a well-characterized spectrum of disorders describing the complex interactions between heart and kidney diseases.Fluid overload and venous congestion,including renal venous hypertension,are major determinants of acute and chronic renal dysfunction arising in heart disease.Organ congestion from venous hypertension could be involved in the development of organ injury in several clinical situations,such as critical diseases,congestive heart failure,and chronic kidney disease.Ultrasonography and abnormal Doppler flow patterns diagnose clinically significant systemic venous congestion.Cardiologists and nephrologists might use this valuable,noninvasive,bedside diagnostic tool to establish fluid status and guide clinical choices.
文摘A recommender system is an approach performed by e-commerce for increasing smooth users’experience.Sequential pattern mining is a technique of data mining used to identify the co-occurrence relationships by taking into account the order of transactions.This work will present the implementation of sequence pattern mining for recommender systems within the domain of e-com-merce.This work will execute the Systolic tree algorithm for mining the frequent patterns to yield feasible rules for the recommender system.The feature selec-tion's objective is to pick a feature subset having the least feature similarity as well as highest relevancy with the target class.This will mitigate the feature vector's dimensionality by eliminating redundant,irrelevant,or noisy data.This work pre-sents a new hybrid recommender system based on optimized feature selection and systolic tree.The features were extracted using Term Frequency-Inverse Docu-ment Frequency(TF-IDF),feature selection with the utilization of River Forma-tion Dynamics(RFD),and the Particle Swarm Optimization(PSO)algorithm.The systolic tree is used for pattern mining,and based on this,the recommendations are given.The proposed methods were evaluated using the MovieLens dataset,and the experimental outcomes confirmed the efficiency of the techniques.It was observed that the RFD feature selection with systolic tree frequent pattern mining with collaborativefiltering,the precision of 0.89 was achieved.
基金This study was funded by the project entitled Exploration Technology for Deep Geothermal Resources in Igneous Rock Areas in South China(2019YFC0604902),Chinathe Ministry of Science and Technology of China,China+1 种基金the project entitled Research and Application of Key Technologies for Geophysical and Geochemical Exploration of Deep Geothermal Resources in Southeastern China(P20041-2),Chinathe Science and Technology Department of SINOPEC,China.
文摘The existence of thermal storage will correspondingly increase the temperature of surrounding strata and promote the continuous expansion,volatilization,upward migration,and loss of gas in the strata.As a result,a low-concentration gas field will be formed in the strata above geothermal reservoirs.Geothermal reservoirs could in turn heat formation water and increase the solubility of soluble inorganic salts in the surrounding rocks and the total dissolved solids(TDS)content in the formation water.Since water can strongly wet and permeate strata,the dissolved inorganic salts migrate into upper strata along with water,giving rise to the formation of a high-concentration inorganic salt field in the strata above geothermal reservoirs.A higher geothermal reservoir temperature corresponds to more significant characteristics mentioned above.Therefore,a medium-to-high temperature geothermal system has a surface geochemical anomaly pattern of high inorganic salt concentrations and low gas concentrations(also referred to as the high-salt and low-gas pattern).This pattern is applied to the surface geochemical exploration of the two geothermal fields in Guangdong Province,i.e.,the Huangshadong geothermal field in Huizhou City and the Xinzhou geothermal field in Yangjiang City,revealing low-concentration gas fields above both.The application results also show that the exposed thermal spring water in both geological fields has higher concentration of dissolved inorganic salt than the surface water and nearby seawater,forming high-amplitude anomalies on the surface above geothermal reservoirs.These characteristics,as well as the measured temperature at known geothermal wells,verify the validity of the high-salt and low-gas pattern of medium-to-high temperature geothermal systems proposed in this study.Moreover,the high-salt and low-gas pattern proposed predicts three favorable medium-to-high temperature geothermal zones in the surface geochemical exploration of the Shiba Basin near the Huangshadong geothermal field.
基金Project supported by the Special Funds for Basic Operating Expenses of the Centre University of China (Grant No.23ZYJS006)。
文摘Experiments are conducted on the evacuation rate of pedestrians through exits with queued evacuation pattern and random evacuation pattern. The experimental results show that the flow rate of pedestrians is larger with the random evacuation pattern than with the queued evacuation pattern. Therefore, the exit width calculated based on the minimum evacuation clear width for every 100 persons, which is on the assumption that the pedestrians pass through the exit in one queue or several queues, is conservative. The number of people crossing the exit simultaneously is greater in the random evacuation experiments than in the queued evacuation experiments, and the time interval between the front row and rear row of people is shortened in large-exit conditions when pedestrians evacuate randomly. The difference between the flow rate with a queued evacuation pattern and the flow rate with a random evacuation pattern is related to the surplus width of the exit, which is greater than the total width of all accommodated people streams. Two dimensionless quantities are defined to explore this relationship. It is found that the difference in flow rate between the two evacuation patterns is stable at a low level when the surplus width of the exit is no more than 45% of the width of a single pedestrian stream. There is a great difference between the flow rate with the queued evacuation pattern and the flow rate with the random evacuation pattern in a scenario with a larger surplus width of the exit. Meanwhile, the pedestrians crowd extraordinarily at the exit in these conditions as well, since the number of pedestrians who want to evacuate through exit simultaneously greatly exceeds the accommodated level. Therefore, the surplus width of exit should be limited especially in the narrow exit condition, and the relationship between the two dimensionless quantities mentioned above could provide the basis to some extent.
文摘Functional magnetic resonance imaging(fMRI)is a popular tool used to investigate not only how the brain responds to specific stimuli during sensorimotor or cognitive tasks,but also brain activity at rest.The physics beyond this approach is based on the analysis of the blood oxygenation level-dependent signal.
基金the National Research Foundation of Korea(NRF)grant funded by the Korean government(MSIT)(Grant No.2021R1C1C1007997).
文摘Metal halide perovskites have emerged as promising light-emitting materials for next-generation displays owing to their remarkable material characteristics including broad color tunability,pure color emission with remarkably narrow bandwidths,high quantum yield,and solution processability.Despite recent advances have pushed the luminance efficiency of monochromic perovskite light-emitting diodes(PeLEDs)to their theoretical limits,their current fabrication using the spincoating process poses limitations for fabrication of full-color displays.To integrate PeLEDs into full-color display panels,it is crucial to pattern red–green–blue(RGB)perovskite pixels,while mitigating issues such as cross-contamination and reductions in luminous efficiency.Herein,we present state-of-the-art patterning technologies for the development of full-color PeLEDs.First,we highlight recent advances in the development of efficient PeLEDs.Second,we discuss various patterning techniques of MPHs(i.e.,photolithography,inkjet printing,electron beam lithography and laserassisted lithography,electrohydrodynamic jet printing,thermal evaporation,and transfer printing)for fabrication of RGB pixelated displays.These patterning techniques can be classified into two distinct approaches:in situ crystallization patterning using perovskite precursors and patterning of colloidal perovskite nanocrystals.This review highlights advancements and limitations in patterning techniques for PeLEDs,paving the way for integrating PeLEDs into full-color panels.
基金supported by the National Natural Science Foundation of China(Grant No.62061014)Technological Innovation Projects in the Field of Artificial Intelligence in Liaoning province(Grant No.2023JH26/10300011)Basic Scientific Research Projects in Department of Education of Liaoning Province(Grant No.JYTZD2023021).
文摘Memristors are extensively used to estimate the external electromagnetic stimulation and synapses for neurons.In this paper,two distinct scenarios,i.e.,an ideal memristor serves as external electromagnetic stimulation and a locally active memristor serves as a synapse,are formulated to investigate the impact of a memristor on a two-dimensional Hindmarsh-Rose neuron model.Numerical simulations show that the neuronal models in different scenarios have multiple burst firing patterns.The introduction of the memristor makes the neuronal model exhibit complex dynamical behaviors.Finally,the simulation circuit and DSP hardware implementation results validate the physical mechanism,as well as the reliability of the biological neuron model.
基金supported by the National Natural Science Foundation of China(Nos.31972929 and 62231025)the Research Program of Shanghai Science and Technology Committee(Nos.21140901300 and 20DZ2220400)+3 种基金the Natural Science Foundation of Chongqing,China(No.CSTB2022NSCQ-MSX0767)the Interdisciplinary Program of Shanghai Jiao Tong University(Nos.YG2021ZD22 and YG2023LC04)the Foundation of National Center for Translational Medicine(Shanghai)SHU Branch(No.SUITM-2023008)the Cross-disciplinary Research Fund of Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine(No.JYJC202108).
文摘A combination of hydrogels and microfluidics allows the construction of biomimetic three-dimensional(3D)tissue models in vitro,which are also known as organ-on-a-chipmodels.The hydrogel patterningwith awell-controlled spatial distribution is typically achieved by embedding sophisticated microstructures to act as a boundary.However,these physical barriers inevitably expose cells/tissues to a less physiologically relevant microenvironment than in vivo conditions.Herein,we present a novel dissolvable temporary barrier(DTB)strategy that allows robust and flexible hydrogel patterning with great freedom of design and desirable flow stimuli for cellular hydrogels.The key aspect of this approach is the patterning of a water-soluble rigid barrier as a guiding path for the hydrogel using stencil printing technology,followed by a barrier-free medium perfusion after the dissolution of the DTB.Single and multiple tissue compartments with different geometries can be established using either straight or curved DTB structures.The effectiveness of this strategy is further validated by generating a 3D vascular network through vasculogenesis and angiogenesis using a vascularized microtumor model.As a new proof-of-concept in vasculature-on-a-chip,DTB enables seamless contact between the hydrogel and the culture medium in closed microdevices,which is an improved protocol for the fabrication ofmultiorgan chips.Therefore,we expect it to serve as a promising paradigm for organ-on-a-chip devices for the development of tumor vascularization and drug evaluation in the future preclinical studies.
基金funded by the Natural Science Foundation of China (Grant No. 42271030)Fujian Provincial Funds for Distinguished Young Scientists (Grant No. 2022J06018)Applied Basic Research Programs of Yunnan province (Grant No. 202001BB050073)。
文摘The China-Myanmar Economic Corridor(CMEC) is an important part of China's Belt and Road Initiative and an important area for global ecology and biodiversity. In this study, the annual and seasonal spatiotemporal patterns of temperature and precipitation in the CMEC over the past century were investigated using linear tendency estimation, the Mann-Kendall mutation test, the T-test, and wavelet analysis based on the monthly mean climatic data from 1901 to 2018 released by the Climatic Research Unit(CRU) of the University of East Anglia, UK. The results show that the CMEC demonstrated a trend of warming and drying over the past 100 years, and the rate of change in Myanmar was stronger than that in Yunnan Province of China. The warming rate was 0.039 ℃/10a. Precipitation decreased at a rate of -6.1 mm/10a. From the perspective of spatial distribution, temperature was high in the central and southern, low in the north of the CMEC, and the high-temperature centers were mainly distributed in the southern plain and river valley. Precipitation decreased from west to east and from south to north of the CMEC. From the perspective of the rate of change, warming was stronger in central and northern CMEC than in southern and northeastern CMEC. The rate of precipitation decline was stronger in the central and western regions than in the eastern region. This study provides a scientific reference for the CMEC to address climate change and ensure sustainable social and economic development and ecological security.
基金Project supported by the National Natural Science Foundation of China (Grant Nos.32271293 and 11875076)。
文摘Positional information encoded in spatial concentration patterns is crucial for the development of multicellular organisms.However,it is still unclear how such information is affected by the physically dissipative diffusion process.Here we study one-dimensional patterning systems with analytical derivation and numerical simulations.We find that the diffusion constant of the patterning molecules exhibits a nonmonotonic effect on the readout of the positional information from the concentration patterns.Specifically,there exists an optimal diffusion constant that maximizes the positional information.Moreover,we find that the energy dissipation due to the physical diffusion imposes a fundamental upper limit on the positional information.