iFlow彩色血流编码成像技术在下肢动脉硬化闭塞症诊断中的应用价值

目的研究iFlow彩色血流编码成像技术在下肢动脉硬化闭塞症(LEASO)诊断中的应用价值。方法选择2022年3月至2023年10月期间确诊的106例LEASO患者作为本研究的LEASO组,以一般资料与LEASO组匹配且无动脉病变的80例志愿者作为对照组。两组受试者均进行数字减影血管造影(DSA)并采用iFlow彩色血流编码成像技术检测股骨头区域和踝关节区域达峰时间(TTP)、计算踝关节区域与股骨头区域TTP的差值,测量踝肱指数(ABI)。结果两组研究对象年龄、性别、体质量指数、吸烟史、高血压病史、糖尿病史、冠心病史、股骨头区域TTP的比较,差异无统计学意义(P>0.05);LEASO组踝关节区域TTP及TTP差值均高于对照组,差异有统计学意义(P<0.05);LEASO组中不同Rutherford分类患者股骨头区域TTP的比较以及左侧病变患者与右侧病变患者股骨头区域TTP、踝关节区域TTP、TTP差值的比较,差异无统计学意义(P>0.05),Rutherford分类越高,踝关节区域TTP及TTP差值越低(P<0.05);经Pearson检验,LEASO患者的踝关节区域TTP、TTP差值与ABI呈负相关(P<0.05);经受试者工作特征(ROC)曲线分析,踝关节区域TTP、TTP差值对LEASO具有诊断效能;经Delong检验,TTP差值诊断的ROC曲线下面积高于踝关节区域TTP(P<0.05)。结论iFlow彩色血流编码成像技术测定踝关节区TTP及TTP差值是诊断LEASO的量化指标。

Relationship between the transition frequency of local fluid flow and the peak frequency of attenuation

Local fluid flow（LFF） at the mesoscopic scale is the main dissipation mechanism of seismic waves in heterogeneous porous media within the seismic frequency band.LFF is easily influenced by the structure and boundary conditions of the porous media,which leads to different behaviors of the peak frequency of attenuation.The associated transition frequency can provide detailed information about the trend of LFF;therefore,research on the transition frequency of LFF and its relationship with the peak frequency of the corresponding attenuation（i.e.,inverse of quality factor） facilitates the detailed understanding of the effect of inner structures and boundary conditions in porous media.In this study,we firstly obtain the transition frequency of fluid flux based on Biot＇s theory of poroelasticity and the fast Fourier transform algorithm in a sample containing one repeating unit cell（RUC）.We then analyze changes of these two frequencies in porous media with different porous properties.Finally,we extend our analysis to the influence of the undrained boundary condition on the transition frequency and peak frequency in porous media with multiple RUCs.This setup can facilitate the understanding of the effect from the undrained boundary condition.Results demonstrate that these two frequencies have the same trend at low water saturation,but amplitude variations differ between the frequencies as the amount of saturation increases.However,for cases of high water saturation,both the trend and the amplitude variation of these two frequencies fit well with each other.

Using Path Analysis to Identify the Influence of Climatic Factors on Spring Peak Flow Dominated by Snowmelt in an Alpine Watershed

Spring snowmelt peak flow （SSPF） can cause serious damage. Precipitation as rainfall directly contributes to the SSPF and influences the characteristics of the SSPF, while temperature indirectly impacts the SSPF by shaping snowmelt rate and determining the soil frozen state which partitions snowmelt water into surface runoff and soil infiltration water in spring. It is necessary to identify the important and significant paths of climatic factors influencing the SSPF and provide estimates of the magnitude and significance of hypothesized causal connections between climatic factors and the SSPF. This study used path analysis with a selection of five factors - the antecedent precipitation index （API）, spring precipitation （SP）, winter precipitation as snowfall （WS）, 〈0℃ temperature accumulation in winter （[ATNI）, and average 〉0℃temperature accumulation in spring （AT） - to analyze their influences on the SSPF in the Kaidu River in Xinjiang, China. The results show that {ATN}, AT and WS have a significant correlation with the SSPF, while API and SP do not show a significant correlation. AT and WS directly influence the SSPF, while as the influence of[ATN] on SSPF is indirect through WS and AT. The indirect influence of [ATN[ on SSPF through WS accounts for 69% of the total influence of [ATN] on SSPF. Compared to the multiple linear regression method, path analysis provides additional valuable information, including influencing paths from independent variables to the dependent variable as well as direct and indirect impacts of external variables on the internal variable. This information can help improve the description of snow melt and spring runoff in hydrologic models as well as the planning and management of water resources.

The effects of rainfall regimes and rainfall characteristics on peak discharge in a small debris flow-prone catchment

Peak discharge plays an important role in triggering channelized debris flows.The rainfall regimes and rainfall characteristics have been demonstrated to have important influences on peak discharge.In order to explore the relationship between rainfall regimes and peak discharge,a measuring system was placed at the outlet of a small,debris flow-prone catchment.The facility consisted of an approximately rectangular stilling basin,ending with a sharp-crested weir.Six runoff events were recorded which provided a unique opportunity for characterizing the hydrological response of the debris flow-prone catchment.Then,a rainfall–runoff model was tested against the flow discharge measurements to have a deep understanding of hydrological response.Based on the calibrated rainfall-runoff model,twelve different artificially set rainfall patterns were regarded as the input parameters to investigate the effect of rainfall regimes on peak discharge.The results show that the rainfall patterns have a significant effect on peak discharge.The rainfall regimes which have higher peak rainfall intensity and peak rainfall point occur at the later part of rainfall process are easy to generate larger peak discharge in the condition of the same cumulative rainfall and duration.Then,in order to explore the relationship between rainfall characteristics and peak discharge under different cumulative precipitation and different duration,167 measured rainfall events were also collected.On the basis of rainfall depth,rainfall duration,and maximum hourly intensity,all the rainfall events were classified into four categories by using K-mean clustering.Rainfall regime 1 was composed of rainfall events with a moderate mean P(precipitation),a moderate D(duration),and a moderate I60(maximum hourly intensity).Rainfall regime 2 was the group of rainfall events with a high mean P,long D.Rainfall regime 3,however,had a low P and a long D.The characteristic of Rainfall regime 4 was high I60 and short duration with large P.The results show that the rainfall regime 2 and 4 are easier to generate peak discharge as the rainfall intensity plays an important role in generating peak discharge.The results in this study have implications for improving peak discharge prediction accuracy in debris flow gully.

Trans-Thoracic Echocardiographic Aortic Blood Flow Peak Velocity Variation, Distance Minute, Aortic Velocity Time Integral and Postoperative Outcome in Pediatric Surgical Patients—An Observational Pilot Study Protocol

Background: A Randomized Controlled Trial (RCT) has been elaborated where goal directed fluid and hemodynamic therapy (GDFHT) will be realized with trans-thoracic echocardiographic aortic blood flow peak velocity variation (ΔVpeak) and distance minute (DM) to guide fluid therapy and hemodynamics in high risk pediatric surgical patients. This RCT will clarify the impact of GDFHT with ΔVpeak and DM on postoperative outcome in terms of morbidity, length of stay in the intensive care unit (LOSICU), length of mechanical ventilation (LMV) and length of hospital stay (LOS) in children. To determine values of ΔVpeak, DM and VTI predictive of these postoperative outcomes, an observational pilot study will be realized. This pilot study is described here. The primary objective of this study is to determine values of ΔVpeak, DM and ITV predictive of postoperative outcome in children in terms of morbidity. The secondary objectives are to determine values of ΔVpeak, DM and ITV predictive of LOSICU, LMV, LOS, intraoperative, postoperative fluid administration and vasoactive-inotropic therapy. Methods: 500 - 1000 children aged less than 18 years will be included prospectively. Statistic analysis will be realized with XLSTAT 2019.4.2 software or plus. Results and Conclusions: This trial protocol will determine values of ΔVpeak, DM and ITV with echocardiography predictive of postoperative outcome in children.

Development of Upstream Data-Input Models to Estimate Downstream Peak Flow in Two Mediterranean River Basins of Chile

Accurate flood prediction is an important tool for risk management and hydraulic works design on a watershed scale. The objective of this study was to calibrate and validate 24 linear and non-linear regression models, using only upstream data to estimate real-time downstream flooding. Four critical downstream estimation points in the Mataquito and Maule river basins located in central Chile were selected to estimate peak flows using data from one, two, or three upstream stations. More than one thousand paper-based storm hydrographs were manually analyzed for rainfall events that occurred between 1999 and 2006, in order to determine the best models for predicting downstream peak flow. The Peak Flow Index (IQP) (defined as the quotient between upstream and downstream data) and the Transit Times (TT) between upstream and downstream points were also obtained and analyzed for each river basin. The Coefficients of Determination (R2), the Standard Error of the Estimate (SEE), and the Bland-Altman test (ACBA) were used to calibrate and validate the best selected model at each basin. Despite the high variability observed in peak flow data, the developed models were able to accurately estimate downstream peak flows using only upstream flow data.

Impact of E×B flow shear stabilization on particle confinement and density peaking at JET

The impact of the E×B flow shear stabilization on particle transport and density peaking at JET is analyzed in the framework of integrated modelling with the CRONOS code.For that purpose,plasmas from a power scan which show a significant increasing of density peaking with the injected neutral beam injection power have been used as a modeling basis.By means of simulations with the quasilinear model GLF23 for the heat and particle transport,a strong link between the particle confinement and E×B flow shear stabilization is found.This is particularly important close to the pedestal region where the particle pinch direction becomes strongly inward for high E×B flow shear values.Such impact introduces some non-negligible deviation from the well-known collisonality dependence of the density peaking,whose general trend has been also obtained in the framework of this modelling by performing pedestal density scans.

超临界循环流化床锅炉深度调峰时水冷壁流动不稳定特性计算分析

针对深度调峰时超临界循环流化床锅炉水冷壁管道内的汽液两相流动不稳定问题,提出了一种适用于不同工况的频域法数学模型。通过对质量、能量、动量方程进行小扰动线性化后经拉普拉斯变换得到了用于描述管道内汽液流体流动稳定性的传递函数,通过图解奈奎斯特图的方法判断管内工质流动的稳定性。然后,通过该模型计算了某350 MW超临界循环流化床锅炉水冷壁管段的不稳定边界并研究了不同参数对流动不稳定特性的影响。计算结果表明:所选回路在20%和50%锅炉最大连续蒸发量负荷发生流动不稳定时,热负荷分别为76.09 kW·m^(-2)和113.52 kW·m^(-2),水冷壁管道流动稳定且安全;入口过冷度对临界热流密度的影响呈非单值性;增大质量流速使流体的进口和出口密度差减小,有利于流动的稳定;增大入口节流系数,可以抑制入口处流量的脉动,有利于流动的稳定;在不同的工况条件下,改变管段倾斜角度会对流动稳定性产生不同的影响。

利用Flow-3D软件数值模拟堰塞坝溃决过程

利用Autodesk Civil3D软件,根据卫星遥感测绘获取的高程数据,建立唐家山堰塞坝三维数值模型,运用Flow-3D软件,模拟堰塞坝溃决过程,并通过与现场测量的溃口流量过程对比验证模型的合理性。堰塞坝漫顶冲蚀分3个阶段:快速溃口发展阶段、洪峰阶段、溃口发展减缓阶段。在溃决过程中,泄流渠中陡坎处的流速较快,泄流渠两岸冲蚀最深;唐家山堰塞坝溃决过程中,泄流渠有溯源侵蚀现象出现。参数敏感性分析表明:起溃水位对溃决过程影响显著;开挖泄流渠可有效降低堰塞坝溃决时的库水位,从而降低溃口的峰值流量,是控制危害损失的有效方案。

基于多源数据的福州地铁车站高峰客流预测研究

为提高地铁车站高峰客流预测精度,基于多源数据和统计学规律,分析了地铁车站高峰时段乘客进站特性,以此建立人岗比—高峰小时流量—超高峰小时系数三维模型和人口—岗位—高峰小时偏差系数三维模型。以福建省福州市目前已开通运营的站点为研究对象,分析其AFC数据,获取乘客进站和换乘信息,结合站点周边不同用地性质,对影响因素和关键参数进行研究,建立超高峰小时系数模型和高峰小时偏差系数模型。

Resistance Measured by Airflow Perturbation Compared with Standard Pulmonary Function Measures

Background: Routine lung function testing requires expensive equipment, or requires maximum expiratory effort. The airflow perturbation device (APD) is a light handheld device, allowing for serial measures of respiratory resistance noninvasively and effortlessly. Methods: In a convenience sample of 398 patients undergoing pulmonary function testing, we compared routine spirometric indices (forced expired volume in 1 second (FEV1), peak expiratory flow (PEF)), and airways resistance (Raw-272 patients), to measures of respiratory resistance measured with the APD including inspiratory (IR), expiratory (ER) and averaged (AR) resistance. Results: Measures of lung function were significantly correlated (p 0.001). On regression analysis, between 7% - 17% of the variance (R2) for FEV1, PEF, and Raw was explained by APD measurements. Approximately 2/3 of the variance in FEV1 was explained by PEF measurements. Conclusions: APD measurements of lung function correlate with conventional measures. Future studies should be directed at exploring the use of the APD device in serial measures of lung function in patients with lung disease.

渤海油田噪声-流量测井与PEAK工具组合找漏堵漏技术

油套管漏失和管外窜槽等问题影响油气水井正常生产,特别是海上平台井筒发生漏失,大修费用高、周期长。噪声-流量测井可获取井下各深度处的噪声和流量数据,对噪声数据进行傅里叶变换,得到不同深度位置频率和幅值的对应关系,再通过流体流经不同部位时频率和幅值的响应特征,辅以流量数据,实现准确定位井筒管漏的目的;PEAK跨隔堵漏工具可以坐封在任意深度,基于它的中通特性,跨隔工具坐封堵漏后,管道上下空间正常连通。在渤海油田S4井应用,通过对噪声频谱和流量数据的分析,确定油管漏点在1494.0 m附近,下入PEAK跨隔工具封堵漏点上下各6 m范围,成功实现精准找漏堵漏并恢复正常生产,初期日产液180 m^3。该方案可避免大修作业,为今后油套管管漏问题提供有效应对方案。

Combination of diaphragmatic breathing with therapeutic walking exercise to increase peak expiratory flow rate in asthma patients

Objective:This study aimed to determine the effect of combined diaphragmatic breathing and therapeutic walking exercise on peak expiratory flow in asthma patients.Methods:The research design used a quasi-experiment nonequivalent pretest and posttest design.The research sample contained 38 respondents divided into intervention and control groups,selected by simple random sampling.The control group received standard drug therapy,while the intervention group received standard drug therapy and a combination of diaphragmatic breathing and therapeutic walking exercise for 2 weeks.This exercise was carried out in the morning,6 times a week,with 5 diaphragmatic breathing and exhalations per exercise.After that,a 1-min break was followed by a therapeutic walking exercise of 5–15 min,with an increased duration.Both groups measured the peak expiratory flow before and after the intervention using a peak flow meter.The data analysis used central tendency and t-test.Results:The results showed that the mean peak expiratory flow in the intervention group was 306.84,while in the control group,it was 232.63,with the value of the t-test being-14.17(P<0.0001).Conclusions:Diaphragmatic breathing and therapeutic walking exercise significantly increased the peak expiratory flow in asthma patients.

Evaluating Functions of Reservoirs'Storage Capacities and Locations on Daily Peak Attenuation for Ganjiang River Basin Using Xinanjiang Model

Flooding is the most prevalent and costly natural disaster in the world and building reservoirs is one of the major structural measures for flood control and management. In this paper, a framework was proposed to evaluate functions of reservoirs′ locations and magnitudes on daily peak flow attenuation for a large basin of China, namely Ganjiang River Basin. In this study, the Xinanjiang model was adopted to simulate inflows of the reservoirs and flood hydrographs of all sub-catchments of the basin, and simple reservoir operation rules were established for calculating outflows of the reservoirs. Four reservoirs scenarios were established to analyze reservoirs′ locations on daily peak flow attenuation. The results showed that: 1) reservoirs attenuated the peak discharges for all simulated floods, when the flood storage capacities increase as new reservoirs were built, the peak discharge attenuation by reservoirs showed an increasing tendency both in absolute and relative measures; 2) reservoirs attenuated more peak discharge relatively for small floods than for large ones; 3) reservoirs reduced the peak discharge more efficiently for the floods with single peak or multi peaks with main peak occurred first; and 4) effect of upstream reservoirs on peak attenuation decreased from upper reaches to lower reaches; upstream and midstream reservoirs played important roles in decreasing peak discharge both at middle and lower reaches, and downstream reservoirs had less effect on large peak discharge attenuation at outlet of the basin. The proposed framework of evaluating functions of multiple reservoirs′ storage capacities and locations on peak attenuation is valuable for flood control planning and management at basin scale.

Modeling of breaching parameters for debris flow dams

The debris flow dam is a common type of barrier dams,which shows significant differences from other types of barrier dam such as landslide dam,moraine dam in their formation processes,dam body shapes,and internal compositions.The basic breaching parameters such as flood peak discharge are vital indicators of risk assessment.In this study,we elucidated the failure process of the debris flow dam through the flume experiment,and built the calculation equation of the breaching parameters by selecting critical factors.The result shows that the overtopping failure process of the debris flow dam is capable of forming significantly retrogressive scarps,and the failure process experiences three stages,the formation of the retrogressive scarp,the erosion of the retrogressive scarp,and the decline of the retrogressive scarp.Five factors used for establishing the calculation equations for peak discharge(Qp),final width(Wb)of the breach,and duration(T)of the debris flow dam failure are dam height(h),reservoir capacity(V),the fine grain content(P0.075)of the soil,the nonuniformity coefficient(Cu)of the soil,and the upper limit grain size(D90)of the soil,respectively.In the three equations,the correlation coefficients between Qp,Wb,T and the five factors were 0.86,0.70,0.63,respectively.The equations still need to be modified and verified in actual cases.

Novel extended C-m models of flow stress for accurate mechanical and metallurgical calculations and comparison with traditional flow models

Here,we developed novel extended piecewise bilinear power law(C-m)models to describe flow stresses under broad ranges of strain,strain rate,and temperature for mechanical and metallurgical calculations during metal forming at elevated temperatures.The traditional C-m model is improved upon by formulating the material parameters C and m,defined at sample strains and temperatures as functions of the strain rate.The coefficients are described as a linear combination of the basis functions defined in piecewise patches of the sample strain and temperature domain.A comparison with traditional closed-form function flow models revealed that our approach using the extended piecewise bilinear C-m model is superior in terms of accuracy,ease of use,and adaptability;additionally,the extended C-m model was applicable to numerical analysis of mechanical,metallurgical,and microstructural problems.Moreover,metallurgy-related values can be calculated directly from the flow stress information.Although the proposed model was developed for materials at elevated temperatures,it can be applied over a broad temperature range.

乌东德水电站日调峰对下游裂腹鱼类栖息地的影响

日调峰是乌东德水电站日常运行的主要出力约束和调度目标。为了探讨电站调度引起的出库流量大幅涨落对下游生态环境的不利影响,采用河道内流量增量法,通过构建二维水动力模型,研究了乌东德水电站日调峰引起的下游河段水文水动力条件波动对裂腹鱼类繁殖期栖息地适宜性的影响,并分析了2023年电站基荷发电生态调度试验效果。结果表明,乌东德电站下泄流量低于1160 m^(3)/s,坝下江段裂腹鱼类潜在产卵场面积相对较大;流量高于2000 m^(3)/s,裂腹鱼类潜在的产卵场面积显著减少。电站日调峰结束时,出库流量降幅越大,裂腹鱼类潜在产卵场脱水面积及鱼卵脱水风险越大。乌东德电站基荷发电生态调度期间,坝下江段裂腹鱼类潜在产卵场的加权面积有所减少,但潜在产卵场和鱼卵早期的脱水风险显著降低。为提高繁殖期裂腹鱼类生境适宜性和持续性,有必要进一步减少电站日调峰频率,降低出库流量至适宜区间。

咳嗽峰流量在临床中的应用现状及未来研究方向展望

咳嗽是一种正常的保护机制,用于清除气管或支气管中的分泌物和吸入的异物,有效的咳嗽可有效预防肺部感染和肺不张,然而目前临床较少有指标可用以客观评价病人的咳嗽能力。咳嗽峰流量凭借测量的可重复性、经济性和易用性已经在多个领域展现了它的应用价值,主要综述咳嗽峰流量在临床的应用现状,并对其未来的研究方向做出展望。

森林结构差异对大兴安岭森林小流域径流情势和退水特征的影响

径流情势和流域退水是反映水文过程至关重要的指标,除气候因素外,主要受到下垫面和流域水文地质特征的影响。利用准配对流域法,对比大兴安岭地区森林结构不同的2个小流域(老爷岭流域、圣诞村流域),排除气候和地形地貌的干扰,探究森林结构变化对流域径流情势及退水过程的影响。结果表明:老爷岭流域的全年洪峰历时比圣诞村流域延长5 h、平均洪峰滞时推迟2 h,洪峰径流量、变异系数均无显著差异。随着森林平均蓄积量、树种组成、郁闭度等森林结构指标的提高,老爷岭流域(森林结构综合指数较高)较圣诞村流域(森林结构综合指数低)的枯水径流时间低4 h,平均枯水径流深提高0.65 mm(是圣诞村流域3倍),平均枯水径流变异系数低33%,且流域间差异均达到了极显著水平(P<0.01)。通过退水分析,结果表明:老爷岭流域和圣诞村流域退水系数(k)的均值分别为16.9、8.5 d,退水常数(α)均值分别为0.909 4、0.862 6,老爷岭流域的平均退水时间比圣诞村流域延缓了8.4 d。该地区流域水文特征受森林植被变化的影响明显,森林结构复杂、森林质量高的老爷岭流域枯水径流量高并且稳定,退水过程更慢,水源涵养功能更好。

床旁即时超声测量动脉峰流速呼吸变异度评价危重症患者容量反应性的临床价值

目的评估床旁即时超声(POCUS)测量动脉峰流速呼吸变异度(△Vpeak)评价危重症患者容量反应性的临床价值。方法回顾性选取川北医学院附属医院于2021年1月至2023年6月收治的100例危重症患者作为研究对象,所有患者均接受容量负荷(VE)试验,根据患者容量反应性分为有反应组[容量负荷后心脏每搏量(SV)增加≥15%,n=56]与无反应组(心脏指数增加<15%,n=44)。容量负荷前后均对患者实施床旁即时超声测量及中心静脉压(CVP)、脉压变异率(PPV)检测,比较两组容量负荷前后△Vpeak[主动脉血流峰流速(△Vpeak-AO)、颈总动脉血流峰流速(△Vpeak-CA)、肱动脉血流峰流速(△Vpeak-BA)、股动脉血流峰流速(△Vpeak-FA)]、CVP、PPV指标,并绘制受试者工作特征(ROC)曲线分析△Vpeak对危重症患者容量反应性的预测价值。结果容量负荷前,有反应组患者的△Vpeak-AO、△Vpeak-CA、△Vpeak-BA、△Vpeak-FA以及PPV分别为(15.42±4.24)%、(14.24±3.24)%、(13.29±2.54)%、(12.35±2.24)%、(13.32±2.53)%,均高于无反应组[(10.93±4.63)%、(10.48±3.16)%、(9.48±2.68)%、(7.84±2.16)%、(9.35±1.27)%],差异均有统计学意义(P<0.05),两组患者CVP比较差异无统计学意义(P>0.05);容量负荷后,有反应组与无反应组各项△Vpeak指标与PPV、CVP比较差异均无统计学意义(P>0.05)。△Vpeak-AO、△Vpeak-CA、△Vpeak-BA、△Vpeak-FA对危重症患者容量反应性敏感度、特异度及曲线下面积高于PPV。结论床旁即时超声测量△Vpeak能够有效预测危重症患者容量反应性,为临床诊断及治疗提供指导,具有较高临床价值。