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Time derivative of earthquake acceleration 被引量:5
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作者 George C. Lee 《Earthquake Engineering and Engineering Vibration》 SCIE EI CSCD 2005年第1期1-16,共16页
Unlike acceleration, velocity, and displacement, the time derivative ofacceleration (TDoA) of ground motion has not been extensively studied. In this paper, the basiccharacteristics of TDoA are evaluated based on reco... Unlike acceleration, velocity, and displacement, the time derivative ofacceleration (TDoA) of ground motion has not been extensively studied. In this paper, the basiccharacteristics of TDoA are evaluated based on records from the 1999 Chi-Chi, earthquake (Mw 7.6)and one of its aftershocks (Mw 6.2). It is found that the maximum TDoA at a free-field station wasover 31,200 cm/s3 (31.8 g/s); and the duration of 'strong' TDoA, between the first and the last timepoints exceeding 2,000 cm/s3 (2 g/s), was almost one minute near the epicenter area. Since groundTDoA sensors are not commonly available, the time series are calculated by direct numericaldifferentiation of acceleration time series. Relative error analysis shows that the error isnon-transitive and total error is within 4%. The density function of TDoA amplitude, frequencycontent and spatial distribution of peak ground jerk (PGJ) are evaluated. The study also includesexamination of some TDoA responses from a seven-story building and comparison of ground TDoA withthe limit TDoA used in the transportation industry for ride comfort. Some potential impacts of TDoAon humans have also been reviewed. 展开更多
关键词 time derivation of acceleration peak ground jerk acceleration time series earthquake ground motion earthquake effect on human activities
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Upper bound for the time derivative of entropy for a stochastic dynamical system with double singularities driven by non-Gaussian noise 被引量:2
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作者 郭培荣 徐伟 刘迪 《Chinese Physics B》 SCIE EI CAS CSCD 2010年第3期233-238,共6页
A stochastic dynamical system with double singularities driven by non-Gaussian noise is investigated. The Fokker Plank equation of the system is obtained through the path-integral approach and the method of transforma... A stochastic dynamical system with double singularities driven by non-Gaussian noise is investigated. The Fokker Plank equation of the system is obtained through the path-integral approach and the method of transformation. Based on the definition of Shannon's information entropy and the Schwartz inequality principle, the upper bound for the time derivative of entropy is calculated both in the absence and in the presence of non-equilibrium constraint. The present calculations can be used to interpret the effects of the system dissipative parameter, the system singularity strength parameter, the noise correlation time and the noise deviation parameter on the upper bound. 展开更多
关键词 non-Gaussian noise stochastic dynamical system with double singularities informationentropy upper bound for the time derivative of entropy
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DIRECTIONAL DERIVATIVE OF VECTOR FIELD AND REGULAR CURVES ON TIME SCALES
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作者 Emin zyilmaz 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI 2006年第10期1349-1360,共12页
The general idea in this paper is to study curves of the parametric equations where the parameter varies in a so-called time scale, which may be an arbitrary closed subset of the set of all real numbers. We introduce ... The general idea in this paper is to study curves of the parametric equations where the parameter varies in a so-called time scale, which may be an arbitrary closed subset of the set of all real numbers. We introduce the directional derivative according to the vector fields. 展开更多
关键词 time scale nabla derivative regular curve tangent line vector field
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On Conformable Delta Fractional Derivative on Time Scales
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作者 YOU Xue-xiao ZHAO Da-fang CHENG Jian 《Chinese Quarterly Journal of Mathematics》 2017年第2期208-215,共8页
In this paper, we introduce and investigate the concept of conformable delta fractional derivative on time scales. By using the theory of time scales, we obtain some basic properties of the conformable delta fractiona... In this paper, we introduce and investigate the concept of conformable delta fractional derivative on time scales. By using the theory of time scales, we obtain some basic properties of the conformable delta fractional derivative. Our results extend and improve both the results in [9] and the usual delta derivative. 展开更多
关键词 conformable delta fractional derivative delta derivative time scales
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PRECISE MOMENT ASYMPTOTICS FOR THE STOCHASTIC HEAT EQUATION OF A TIME-DERIVATIVE GAUSSIAN NOISE 被引量:1
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作者 Heyu LI Xia CHEN 《Acta Mathematica Scientia》 SCIE CSCD 2019年第3期629-644,共16页
This article establishes the precise asymptotics Eu^m(t, x)(t → ∞ or m → ∞) for the stochastic heat equation ?u/?t(t, x) =1/2?u(t, x) + u(t, x)(t, x)?W/?t(t, x) with the time-derivative Gaussian noise W?/?t(t, x) ... This article establishes the precise asymptotics Eu^m(t, x)(t → ∞ or m → ∞) for the stochastic heat equation ?u/?t(t, x) =1/2?u(t, x) + u(t, x)(t, x)?W/?t(t, x) with the time-derivative Gaussian noise W?/?t(t, x) that is fractional in time and homogeneous in space. 展开更多
关键词 STO chastic HEA t equation t ime-deriva tive Gaussian noise BROWNIAN MOT ion Feynman-Kac representation Schilder's large deviation
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IMPULSIVE EXPONENTIAL SYNCHRONIZATION OF FRACTIONAL-ORDER COMPLEX DYNAMICAL NETWORKS WITH DERIVATIVE COUPLINGS VIA FEEDBACK CONTROL BASED ON DISCRETE TIME STATE OBSERVATIONS
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作者 Ruihong LI Huaiqin WU Jinde CAO 《Acta Mathematica Scientia》 SCIE CSCD 2022年第2期737-754,共18页
This article aims to address the global exponential synchronization problem for fractional-order complex dynamical networks(FCDNs)with derivative couplings and impulse effects via designing an appropriate feedback con... This article aims to address the global exponential synchronization problem for fractional-order complex dynamical networks(FCDNs)with derivative couplings and impulse effects via designing an appropriate feedback control based on discrete time state observations.In contrast to the existing works on integer-order derivative couplings,fractional derivative couplings are introduced into FCDNs.First,a useful lemma with respect to the relationship between the discrete time observations term and a continuous term is developed.Second,by utilizing an inequality technique and auxiliary functions,the rigorous global exponential synchronization analysis is given and synchronization criterions are achieved in terms of linear matrix inequalities(LMIs).Finally,two examples are provided to illustrate the correctness of the obtained results. 展开更多
关键词 Fractional-order complex dynamical networks fractional derivative couplings IMPULSES discrete time state observations
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ANN-Time Varying GARCH Model: Simulations and Application in Modelling Temperature for Weather Derivatives
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作者 Elias K. Karuiru John Mwaniki Kihoro +1 位作者 Thomas Mageto Anthony Gichuhi Waititu 《Open Journal of Statistics》 2022年第3期433-441,共9页
In economics and finance, minimising errors while building an abstract representation of financial assets plays a critical role due to its application in areas such as risk management, decision making and option prici... In economics and finance, minimising errors while building an abstract representation of financial assets plays a critical role due to its application in areas such as risk management, decision making and option pricing. Despite the many methods developed to handle this problem, modelling processes with fixed and random periodicity still remains a major challenge. Such methods include Artificial Neural networks (ANN), Fuzzy Inference system (FIS), GARCH models and their hybrids. This study seeks to extend literature of hybrid ANN-Time Varying GARCH model through simulations and application in modelling weather derivatives. The study models daily temperature of Kenya using ANN-Time Varying GARCH (1, 1), Time Lagged Feedforward neural network (TLNN) and periodic GARCH family models. Mean square error (MSE) and coefficient of determination R<sup>2</sup> were used to determine performance of the models under study. Results obtained show that the ANN-Time Varying GARCH model gives the best results. 展开更多
关键词 Artificial Neural Network time Varying GARCH Weather derivatives TEMPERATURE
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肉中猪源性成分Real-time PCR定量检测技术 被引量:3
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作者 翟晓虎 李翎旭 +3 位作者 陈小竹 蒋怀德 贺卫华 姚大伟 《中国农业科学》 CAS CSCD 北大核心 2023年第1期156-164,共9页
【目的】建立一种快速、准确的肉中猪源性成分定量检测方法。【方法】首先从GenBank数据库中筛选猪特异性的微卫星DNA,根据微卫星DNA核酸序列设计引物,对常见10种动物基因组DNA进行PCR扩增,通过有无扩增产物判断筛选的微卫星DNA对猪源... 【目的】建立一种快速、准确的肉中猪源性成分定量检测方法。【方法】首先从GenBank数据库中筛选猪特异性的微卫星DNA,根据微卫星DNA核酸序列设计引物,对常见10种动物基因组DNA进行PCR扩增,通过有无扩增产物判断筛选的微卫星DNA对猪源性成分的特异性。然后根据微卫星DNA核酸序列,设计特异性引物和探针,建立猪源性成分Real-time PCR检测方法,采用双标准曲线分别对猪源性成分和总动物源性成分进行定量,计算猪源性成分的百分含量。【结果】筛选到猪特异性微卫星DNA(Accession EF172428),根据其序列设计的引物SEQ-sus2-F/R只能从猪基因组DNA中扩增出目的条带,其他动物的基因组均无目的条带扩增。建立的Real-time PCR检测方法灵敏度为0.02 ng/25μL反应体系。该方法能够准确检测出混合DNA样品中猪源性成分和混合肉样品中猪源性成分,百分误差分别约为1.32%和1.06%-7.12%。【结论】本研究利用Real-time PCR技术建立的定量猪源性成分的检测方法可以用来检测猪源性成分在混合样品中的百分含量。 展开更多
关键词 动物源性成分 Real-time PCR 定量
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Derivation and application of time step model in solidification process simulation
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作者 GONG Wen-bang CHEN Li-liang +1 位作者 LIU Rui-xiang HAO Jing 《China Foundry》 SCIE CAS 2007年第3期206-209,共4页
The heat transfer during the casting solidification process includes the heat radiation of the high temperature casting and the mold,the heat convection between the casting and the mold,and the heat conduction inside ... The heat transfer during the casting solidification process includes the heat radiation of the high temperature casting and the mold,the heat convection between the casting and the mold,and the heat conduction inside the casting and from the casting to the mold. In this paper,a formula of time step in simulation of solidification is derived,considering the heat radiation,convection and conduction based on the conservation of energy. The different heat transfer conditions between the conventional sand casting and the permanent mold casting are taken into account in this formula. The characteristics of heat transfer in the interior and surface of the casting are also considered. The numerical experiments show that this formula can avoid computational dispersion,and improve the computational efficiency by about 20% in the simulation of solidification process. 展开更多
关键词 castina solidification SIMULATION time step formula derivation
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A Paradoxical Consistency Between Dynamic and Conventional Derivatives on Hybrid Grids
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作者 Qin Sheng 《Numerical Mathematics(Theory,Methods and Applications)》 SCIE 2008年第2期198-213,共16页
It has been evident that the theory and methods of dynamic derivatives are playing an increasingly important role in hybrid modeling and computations. Being constructed on various kinds of hybrid grids, that is, tim... It has been evident that the theory and methods of dynamic derivatives are playing an increasingly important role in hybrid modeling and computations. Being constructed on various kinds of hybrid grids, that is, time scales, dynamic derivatives offer superior accuracy and flexibility in approximating mathematically important natural processes with hard-to-predict singularities, such as the epidemic growth with unpredictable jump sizes and option market changes with high uncertainties, as compared with conventional derivatives. In this article, we shall review the novel new concepts, explore delicate relations between the most frequently used second-order dynamic derivatives and conventional derivatives. We shall investigate necessary conditions for guaranteeing the consistency between the two derivatives. We will show that such a consistency may never exist in general. This implies that the dynamic derivatives provide entirely different new tools for sensitive modeling and approximations on hybrid grids. Rigorous error analysis will be given via asymptotic expansions for further modeling and computational applications. Numerical experiments will also be given. 展开更多
关键词 Dynamic derivatives conventional derivatives time scale theory APPROXIMATIONS error estimates hybrid grids uniform and nonuniform grids asymptotic expansions
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TD-DFT Study on Pyrazoline Derivatives 被引量:1
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作者 MIAO Ti-Fang ZHANG Jian-Fu LI Shuang 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 北大核心 2005年第10期1169-1175,共7页
The molecular structures of ground state and first single excited state for pyrazoline derivatives are optimized with DFT B3LYP method and ab initio “configuration interaction with single excitations”(CIS) method,... The molecular structures of ground state and first single excited state for pyrazoline derivatives are optimized with DFT B3LYP method and ab initio “configuration interaction with single excitations”(CIS) method, respectively. The frontier molecular orbital characteristics have been analyzed systematically, and the electronic transition mechanism has been discussed. Electronic spectra are calculated by using TD-DFT method. These results are consistent with those from the experiment. 展开更多
关键词 pyrazoline derivatives electron transfer time-dependent density functional theory (TD-DFT) electronic spectrum
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Exact Solutions and Finite Time Stability of Linear Conformable Fractional Systems with Pure Delay
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作者 Ahmed M.Elshenhab Xingtao Wang +1 位作者 Fatemah Mofarreh Omar Bazighifan 《Computer Modeling in Engineering & Sciences》 SCIE EI 2023年第2期927-940,共14页
We study nonhomogeneous systems of linear conformable fractional differential equations with pure delay.By using new conformable delayed matrix functions and the method of variation,we obtain a representation of their... We study nonhomogeneous systems of linear conformable fractional differential equations with pure delay.By using new conformable delayed matrix functions and the method of variation,we obtain a representation of their solutions.As an application,we derive a finite time stability result using the representation of solutions and a norm estimation of the conformable delayedmatrix functions.The obtained results are new,and they extend and improve some existing ones.Finally,an example is presented to illustrate the validity of our theoretical results. 展开更多
关键词 Representation of solutions conformable fractional derivative conformable delayed matrix function conformable fractional delay differential equations finite time stability
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Time, Length, and Mass Are Derived Quantities
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作者 Tower Chen Zeon Chen 《Journal of Modern Physics》 2016年第10期1192-1199,共8页
Fundamental units of measurements are kilograms, meters, and seconds—in regards to mass length, and time. All other measurements in mechanical quantities including kinetic quantities and dynamic quantities are called... Fundamental units of measurements are kilograms, meters, and seconds—in regards to mass length, and time. All other measurements in mechanical quantities including kinetic quantities and dynamic quantities are called derived units. These derived units can be expressed in terms of fundamental units, such as acceleration, area, energy, force, power, velocity and volume. Derived quantities will be referred to as time, length, and mass. In order to explain that fundamental units are not equivalent with fundamental quantities, we need to understand the contraction of time and length in Special Relativity. If we choose the velocity of light as fundamental quantity and length and time as derived quantities, then we are able to construct three-dimensional space-time frames. Three-dimensional space-time frames representing time with polar coordination, time contraction and length contraction can be shown graphically. 展开更多
关键词 Fundamental Units Fundamental Quantities derived Units derived Quantities Special Relativity Constant Velocity of Light Three-Dimensional Space-time Frame
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产教融合理念下化工仪表及自动化课程教学改革探究
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作者 潘赛虎 朱冬森 +4 位作者 王雪 郝振华 金立强 蒋建明 吕继东 《广东化工》 CAS 2024年第4期164-166,175,共4页
本文以产教融合理念为基础,针对化工仪表及自动化课程教学进行改革研究。以学生学习反应釜温度PID控制参数整定设置知识点为例,从理论教学和产业应用两个角度分析微分时间常数TD取值对温控系统过渡过程特性影响及调节阀流量特性和控制... 本文以产教融合理念为基础,针对化工仪表及自动化课程教学进行改革研究。以学生学习反应釜温度PID控制参数整定设置知识点为例,从理论教学和产业应用两个角度分析微分时间常数TD取值对温控系统过渡过程特性影响及调节阀流量特性和控制死区等因素对TD值的限制问题,提升学生深刻理解TD常数意义。在此基础上,提出教学改革措施,旨在提高学生的实践能力和创新意识。本研究表明,通过产教融合的教学模式和教学方法,可以显著提高学生的对化工自动化课程的学习效果,为其未来的职业发展打下坚实的基础。 展开更多
关键词 产教融合 化工仪表及自动化 教学改革 PID调节 微分时间常数
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联合激励下分数阶非线性系统非平稳响应的半解析方法
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作者 孔凡 廖海君 +2 位作者 韩仁杰 张义 洪旭 《振动工程学报》 EI CSCD 北大核心 2024年第8期1339-1348,共10页
确定性和随机激励联合作用下的非线性动力系统具有特殊的动力响应特征。本文提出一种用于计算联合激励下含分数阶阻尼的非线性系统非平稳响应的半解析方法。将系统响应表示为确定性响应和零均值随机响应之和,则原分数阶非线性运动微分... 确定性和随机激励联合作用下的非线性动力系统具有特殊的动力响应特征。本文提出一种用于计算联合激励下含分数阶阻尼的非线性系统非平稳响应的半解析方法。将系统响应表示为确定性响应和零均值随机响应之和,则原分数阶非线性运动微分方程可等效地化为分数阶确定性微分方程和随机子微分方程的组合。利用时变谐波平衡法处理非线性确定性微分方程,利用统计线性化处理非线性随机子微分方程。对于后者,结合Prony‐SS算法和Laplace变换得到其分数阶等效线性方程的半解析解。联立得到的相关耦合方程,通过数值算法迭代求解响应未知量。蒙特卡罗模拟验证了此方法的适用性和精度。 展开更多
关键词 统计线性化 时变谐波平衡法 分数阶导数 非线性系统 Prony‐SS算法
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经典导数的拓展——时间尺度上求导
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作者 宋传静 翟相华 《河南财政金融学院学报(自然科学版)》 2024年第3期36-41,共6页
在微积分的教学中,学生对微积分的认识不应该止于经典积分的思想与内容。教师可为学生介绍时间尺度微积分的概念,拓展教学内容。首先介绍时间尺度的背景,然后给出时间尺度上常用的基本符号及时间尺度上函数可微的定义,更有利于学生理解... 在微积分的教学中,学生对微积分的认识不应该止于经典积分的思想与内容。教师可为学生介绍时间尺度微积分的概念,拓展教学内容。首先介绍时间尺度的背景,然后给出时间尺度上常用的基本符号及时间尺度上函数可微的定义,更有利于学生理解相关概念,激发继续探索微积分的兴趣。 展开更多
关键词 时间尺度 微积分 微分学 基本符号 导数
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车辆轨迹数据驱动的急弯路段追尾冲突风险时空演化规律
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作者 王永岗 李晓坤 +1 位作者 宋杰 李德林 《哈尔滨工业大学学报》 EI CAS CSCD 北大核心 2024年第3期38-45,共8页
为有效揭示急弯路段上车辆间追尾冲突风险的形成与变化态势,选取典型事故多发急弯路段使用无人机航拍等方式采集交通流数据,利用Tracker软件提取车辆轨迹信息,构建急弯路段追尾冲突后侵入时间PET判别指标,结合冲突先导车LV与跟随车FV的... 为有效揭示急弯路段上车辆间追尾冲突风险的形成与变化态势,选取典型事故多发急弯路段使用无人机航拍等方式采集交通流数据,利用Tracker软件提取车辆轨迹信息,构建急弯路段追尾冲突后侵入时间PET判别指标,结合冲突先导车LV与跟随车FV的速度、加速度变化划分追尾冲突模式,进而界定临界冲突点、冲突风险范围及PET变化率指标DPET,运用回归分析量化LV与FV的速度、加速度、速度差及加速度差对DPET的影响,阐明临界冲突点及主要追尾冲突模式的微观变化特性及时空演化规律。结果表明:车辆追尾冲突存在空间集聚性,主要集中在入弯缓和曲线上游、曲中标志断面下游及出弯缓和曲线下游;在潜在追尾冲突的九大类别中发生频率最高的四大类冲突数量占比高达83.24%;PET在冲突临界点和冲突风险范围内均下降,导致DPET均为负值,在冲突临界点PET快速下降,其下降程度显著大于冲突风险范围;FV速度、加速度及LV、FV间速度差、加速度差四个指标显著影响追尾冲突临界点的DPET变化;T10模式(LV减速、FV加速)冲突过程中的DPET均值最小,PET序列下降最为剧烈,危险性显著高于其他冲突模式。 展开更多
关键词 急弯路段 追尾冲突风险 时空演化 后侵入时间PET DPET 车辆轨迹
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脑源性神经营养因子在牦牛与黄牛端脑不同区域的表达与分布
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作者 郑丽平 刘霞 +2 位作者 杜晓华 吴亚娟 刘珊珊 《解剖学报》 CAS CSCD 2024年第1期10-16,共7页
目的探讨高原牦牛与平原黄牛端脑中脑源性神经营养因子(BDNF)表达与分布,探讨BDNF功能发挥与高原低氧适应性之间的关联。方法选取牦牛和黄牛各5只,应用Real-time PCR、Western blotting及免疫组织化学技术对BDNF在牦牛和黄牛端脑的额叶... 目的探讨高原牦牛与平原黄牛端脑中脑源性神经营养因子(BDNF)表达与分布,探讨BDNF功能发挥与高原低氧适应性之间的关联。方法选取牦牛和黄牛各5只,应用Real-time PCR、Western blotting及免疫组织化学技术对BDNF在牦牛和黄牛端脑的额叶、颞叶、顶叶、枕叶、大脑白质以及海马中的含量与分布进行了定量与定性分析。结果Real-time PCR结果表明,在牦牛与黄牛端脑中,BDNF mRNA均在颞叶皮质中的表达量最高,海马次之,其后依序为顶叶皮质,枕叶皮质和额叶皮质,在大脑白质中的表达量最低。Western blotting结果表明,BDNF蛋白在牦牛颞叶皮质中含量最高,海马次之,其他组织含量由高到低依次为顶叶皮质、额叶皮质、大脑白质,枕叶皮质中含量最低。BDNF蛋白在黄牛端脑颞叶皮质中含量最高,海马次之,其余组织含量由高及低依次为顶叶皮质、枕叶皮质、额叶皮质,大脑白质中蛋白含量最低。免疫组织化学结果表明,BDNF蛋白在牦牛和黄牛端脑中的阳性表达情况基本相似,主要分布在额叶皮质、颞叶皮质、顶叶皮质、枕叶皮质的颗粒细胞和神经胶质细胞,大脑白质的神经胶质细胞以及海马的锥体细胞层和多形细胞层,在端脑皮质区的马丁诺提细胞和海马的分子细胞层中有少量分布。结论BDNF mRNA和蛋白在牦牛和黄牛端脑不同区域中均有表达,但表达量存在差异,推测与端脑不同分区的特定功能密切相关。牦牛端脑中的表达水平除枕叶皮质外,均高于黄牛,推测与其生存的高原低氧环境有关,BDNF在动物机体适应低氧环境过程中可能发挥着增强低氧耐受性和保护机体内环境稳态等重要功能。 展开更多
关键词 脑源性神经营养因子 端脑 实时定量聚合酶链反应 免疫印迹法 免疫组织化学 牦牛 黄牛
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大跨度桥梁非线性颤振理论与试验研究
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作者 李凯 蔡春声 +1 位作者 韩艳 宋俊 《工程力学》 EI CSCD 北大核心 2024年第2期1-24,共24页
目前,在线性颤振设防标准下,大跨桥梁的设计与建设成本巨幅增加,严重阻碍了大跨度桥梁的进一步发展,亟需研究大跨度桥梁的非线性颤振特性并构建相关非线性颤振分析理论,为后颤振设防标准的构建提供理论依据。该研究发展了基于自由振动... 目前,在线性颤振设防标准下,大跨桥梁的设计与建设成本巨幅增加,严重阻碍了大跨度桥梁的进一步发展,亟需研究大跨度桥梁的非线性颤振特性并构建相关非线性颤振分析理论,为后颤振设防标准的构建提供理论依据。该研究发展了基于自由振动风洞试验识别幅变颤振导数的方法,建立了多/全模态耦合三维非线性颤振频域快速分析方法和能够考虑气动与结构双重非线性效应的三维时域分析方法,拓展了桥梁断面节段模型大振幅非线性颤振研究的风洞试验技术。基于发展的非线性颤振分析方法,以国内某四主缆双层桁架主梁断面悬索桥为背景,研究了该桥主梁断面的非线性颤振特性,量化了竖向自由度对该断面非线性颤振的影响,探究了多模态耦合效应对该桥非线性颤振的影响规律,发现了几何非线性效应诱发的超谐共振行为,并据此揭示了几何非线性效应对该桥非线性颤振的影响机制。该文方便读者对非线性颤振理论与分析方法有比较全面的了解,研究可为今后建立大跨桥梁的韧性抗风设计标准提供理论支撑和技术保障。 展开更多
关键词 大跨度桥梁 幅变颤振导数 三维非线性颤振分析 时域非线性自激力模型 几何非线性
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凝血指标与PDGF-BB、ET-1在不同严重程度子痫前期中的水平及对妊娠结局的预测价值
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作者 孙莉莉 唐显赫 宁书芬 《检验医学与临床》 CAS 2024年第16期2406-2410,2416,共6页
目的 探讨凝血指标[部分凝血活酶时间(APTT)、凝血酶原时间(PT)、纤维蛋白原(FIB)、D-二聚体(D-D)]与血小板衍生生长因子-BB(PDGF-BB)、内皮素-1(ET-1)在不同严重程度子痫前期(PE)孕妇中的水平及对妊娠结局的预测价值。方法 选取2021年... 目的 探讨凝血指标[部分凝血活酶时间(APTT)、凝血酶原时间(PT)、纤维蛋白原(FIB)、D-二聚体(D-D)]与血小板衍生生长因子-BB(PDGF-BB)、内皮素-1(ET-1)在不同严重程度子痫前期(PE)孕妇中的水平及对妊娠结局的预测价值。方法 选取2021年1月至2023年3月该院收治的PE孕妇118例作为研究对象,根据病情严重程度分为PE组(71例)与重度PE组(47例);另选取同期在该院产检的健康孕妇59例作为对照组。对比3组APTT、PT、FIB、D-D、PDGF-BB、ET-1水平;分析APTT、PT、D-D、FIB、PDGF-BB、ET-1水平与PE严重程度的相关性。PE患者均随访至分娩,并根据妊娠结局将其分为妊娠结局良好组和妊娠结局不良组;采用受试者工作特征(ROC)曲线分析APTT、PT、D-D、FIB、PDGF-BB、ET-1对PE患者妊娠结局的预测效能;分析APTT、PT、D-D、FIB、PDGF-BB、ET-1对妊娠结局的影响。结果 重度PE组与PE组APTT、PT短于对照组,FIB、D-D、PDGF-BB、ET-1水平高于对照组,差异均有统计学意义(P<0.05);而重度PE组APTT、PT短于PE组,FIB、D-D、PDGF-BB、ET-1水平高于PE组,差异均有统计学意义(P<0.05)。Spearman相关分析结果显示,APTT、PT与PE严重程度呈负相关(r=-0.505、-0.513,P<0.05),而FIB、D-D、PDGF-BB、ET-1水平与PE严重程度呈正相关(r=0.559、0.607、0.618、0.642,P<0.05)。118例PE患者均完成了随访,其中妊娠结局良好组92例,妊娠结局不良组26例。妊娠结局不良组APTT、PT短于妊娠结局良好组,FIB、D-D、PDGF-BB、ET-1水平高于妊娠结局良好组,差异均有统计学意义(P<0.05)。ROC曲线分析结果显示,APTT、PT、FIB、D-D、PDGF-BB、ET-1预测PE患者妊娠结局不良的曲线下面积分别为0.849、0.767、0.828、0.768、0.743、0.763,最佳截断值分别为29.39 s、11.85 s、5.44 g/L、0.93 mg/L、116.29 ng/L、2.24 mg/L;以ROC曲线获取的最佳截断值为分界值分为低值与高值,其中APTT、PT低值PE患者妊娠结局不良的风险是高值患者的15.231、7.411倍;FIB、D-D、PDGF-BB、ET-1高值PE患者妊娠结局不良的风险是低值患者的7.398、4.861、4.565、6.300倍。结论 APTT、PT、FIB、D-D、PDGF-BB、ET-1与PE病情程度显著相关,可作为PE患者妊娠结局的独立预测因子。 展开更多
关键词 子痫前期 部分凝血活酶时间 凝血酶原时间 纤维蛋白原 D-二聚体 血小板衍生生长因子-BB 内皮素-1 妊娠结局 预测价值
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