Pediatric Clinical Pharmacology and Child Health:A Canadian Perspective

Introduction Canadian academic centres and children’s hospitals have had a longstanding interest in the improvement of drug therapy for children through research conducted across the four pillars of activity identified as being of

Recent landscape and trends for industry-sponsored pediatric clinical trials in China from 2013 to 2022

Importance:Pediatric medication is a challenging issue globally.Promoting trials of medications for children and implementing measures to encourage innovation for addressing unmet medical and health needs are important.Objective:To explore the recent landscape of pediatric clinical trials of new investigational drugs conducted by pharmaceutical enterprises in China from 2013 to 2022 to provide insight into pediatric drug development in the pharmaceutical industry and regulatory policy formulation.Methods:We performed a cross-sectional observational investigation of pediatric clinical trials registered from January 1,2013,to December 31,2022,on the Registration and Information Disclosure Platform for Drug Clinical Trials,the official registration platform established in 2013 for trials of new investigational drugs initiated by biopharmaceutical enterprises.Trials that included pediatric participants(under 18 years old)were retrieved,and their relevant characteristics were extracted and analyzed.Results:In total,895 pediatric clinical trials were collected,accounting for 5.1%of the total registered clinical trials initiated prior to January 1,2023.The overall average annual growth rate for the number of pediatric clinical trials was 12%(P<0.001).Phase III trials accounted for the highest proportion(49.1%,439).Of the 895 trials included,736(82.2%)were domestic trials,and 159(17.8%)were international multicenter trials.In terms of tested drugs,investigations of biological products accounted for the largest proportion of trials(67.4%,603).Among pediatric clinical trials,studies of vaccines accounted for the largest proportion of trials(41.0%,367),followed by trials for rare diseases(17.2%,154).Furthermore,geographical distribution analysis revealed that the largest and smallest numbers of trials were conducted in North China(35.7%,320)and Northeast China(0.8%,7),respectively.Interpretation:The growth trends for industry-sponsored clinical trials involving children illustrate the progress and increasing capability of pediatric drug development achieved in China since 2013.Current challenges and potential areas of focus for policymakers and stakeholders include investigating orphan drugs for rare diseases according to the unique epidemiological characteristics of Chinese children,expanding the scope of pediatric clinical trials,and improving the uneven geographical distribution of leading research centers.

Determination of the Relationship between Empathy and Compassion Fatigue in Pediatric Clinic Nurses

Background:This study aimed to determine the relationship between compassion fatigue and empathic disposition and skill levels of pediatric clinic nurses.Methods:This research was carried out as a descriptive and cross-sectional study.The research was carried out with 233 nurses determined by using a stratified sampling method from 648 nurses working in two University Hospital and two City Hospital children’s clinics.Data were collected using the“Personal Information Form”,“Compassion Scale(CS)”,“Empathic Tendency Scale(ETS)”and“Empathic Skill Scale(ESS)”.Pearson Correlation test,Student’s t-test,ANOVA test,and Scheffe test were used in the analysis of the data.Results:The mean age of the nurses participating in the study was 30.93±6.23 years,81.1%were women and 54.9%were married.Pediatric clinic nurses’mean compassion score was 96.29±11.64,empathic tendency mean score was 69.30±8.39,and empathic skill mean score was 140.82±23.15.According to the findings obtained,the mean compassion score of the male,married,and nurses who were not satisfied with working in the pediatric clinics and working in the pediatric emergency clinics was found to be the lowest(p<0.05,p<0.01,p<0.001).The empathic disposition mean scores of the nurses working in the pediatric inpatient clinics,who were satisfied with working in the pediatric clinic,and who did not have the thought of moving to another clinic,were found to be significantly higher(p<0.01,p<0.001).The mean scores of empathic skills of nurses working only during the daytime were found to be significantly higher(p<0.001).Conclusion:This study confirms that pediatric clinic nurses are experiencing compassion fatigue at the end of COVID-19 and how this situation negatively affects their empathic tendencies and skills.The study highlights the need for both clinical and management-based planning to prevent compassion fatigue and increase empathic tendencies and skills in Pediatric clinic nurses.

Quick-impact Tuina for 38 cases of pediatric muscular torticollis

Objective To observe the therapeutic effect of quick-impact Tuina method on treatment of pediatric muscular torticollis.Methods Pushing,kneading,and grasping manipulations combined with traction and flicking method were applied at sternocleidomastoid on the affected side for 38 cases of pediatric muscular torticollis.The treatment was given 1 time a day,10 times as a course.The therapeutic effect was evaluated after 3 courses of treatment.Results Thirty-four cases was evaluated as full recovery,3 cases as remarkable effectiveness,1 case as effectiveness,0 case as ineffectiveness,the total effective rate was 100.0%.Conclusion The combined method treating pediatric muscular torticollis regulated tendons and relieved blood stasis,improved muscular spasm,and dispersed mass,so as to enhance and restore the regular neck function with significant therapeutic effect.