A Clinical Study on the Treat ment of Chronic Pelvic Inflammation of Qi-stagnation with Blood Stasis Syndrome by Penyanqing Capsule (盆炎清胶囊)

Objective： To observe the clinical efficacy of Penyanqing Capsule （盆炎清胶囊, PYQC） in treating pelvic inflammation of Qi-stagnation with blood stasis syndrome. Methods： The randomized, single blinded, parallel positive drug controlled method was adopted, with 82 patients assigned into two groups by envelop method. The 42 patients in the treated group received PYQC 3 times a day, 4 capsules each time taken orally; the 40 patients in the control group were given orally Fuyankang tablets （妇炎康片, FYKT） 3 times a day, 6 tablets each time. The therapeutic course for both groups was 2 months, and 2 courses of treatment were given successively to observe the comprehensive effect, changes of symptoms and signs before and after treatment. The effects of PYQC on hemorrheological character in part of the patients and on the pathogenetic chlamydia and mycoplasma were also observed. Results： The total effective rate in the treated group was 83.3%, which was insignificantly different from that in the control group （77.5%, P〉0.05）. However, PYQC could significantly lower the hemorrheologic indexes in patients and showed definite influence on the pathogenetic chlamydia and mycoplasma. Conclusion： PYQC has good therapeutic effect in treating chronic pelvic inflammation of Qi-stagnation with blood stasis syndrome, and showed definite effect on chlamydia and mycoplasma.

Systematic Review and Meta-Analysis of Fuke Qianjin Tablets(妇科千金片)in the Treatment of Chronic Pelvic Inflammation

Objective:To systematically evaluate the efficacy and safety of Fuke Qianjin Tablets(妇科千金片)in the treatment of chronic pelvic inflammation.Methods:A systematically and comprehensively search was conducted in 4 Chinese databases of CNKI,VIP,Wan Fang and CBM and the foreign language databases of Pubmed,EMbase and The Cochrane Library.The retrieval time was from database establishment to March 2019.The randomized controlled trials of Fuke Qianjin Tablets(妇科千金片)in the treatment of chronic pelvic inflammation were selected according to the predetermined criteria.The quality of the included study was evaluated by Cochrane collaborative network bias risk evaluation tool,and the meta-analysis was performed by Rev Man5.3 software.Results:A total of 1009 related literatures were searched.After initial screening and strict evaluation,55 studies were included,with a total sample size of 6826 cases,including 3416 cases in the experiment group and 3410 cases in the control group.The results of meta-analysis showed that the total effective rate of Fuke Qianjin Tablets(妇科千金片)combined with antibiotics in the treatment of chronic pelvic inflammation was better than that of antibiotics alone(RR=1.20,95%CI[1.17,1.22],P<0.00001).Fuke Qianjin Tablets(妇科千金片)combined with antibiotics was better than that of antibiotics alone in the improvement of abdominal pain symptoms(RR=1.40,95%CI[1.04,1.88],P<0.00001),leukorrhea abnormality(RR=1.38,95%CI[1.16,1.65],P<0.0004).In terms of safety,Fuke Qianjin Tablets(妇科千金片)combined with antibiotics could reduce the incidence of adverse reactions(RR=0.67,95%CI[0.48,0.93],P<0.02).The main adverse reactions were nausea and vomiting,bitterness and astringency in the mouth,rash and so on.All of them could be tolerated and the symptoms could disappear in the short term,and had no effect on the treatment.Conclusion:Fuke Qianjin Tablets(妇科千金片)combined with antibiotics in the treatment of chronic pelvic inflammation can improve the total effective rate,relieve abdominal pain and abnormal leukorrhea and other clinical discomfort symptoms,improve the quality of life of patients to a certain extent,and no serious adverse reactions are found.Due to the limitation of the quality and quantity of the included literature,the above conclusions need to be further studied and verified by high-quality research.

Identification of major compounds of total flavonoids from Smilax china and evaluation of anti-inflammatory effect on phenol mucilage-induced pelvic inflammation in rats

As a Chinese medicinal plant,Smilax china is traditionally used in the treatment of pelvic inflammatory disease(PID).Flavonoids have been identified as the anti-inflammatory bioactive fraction.However,the high content of total flavonoids has not been extracted from S.china.The therapeutic effects and mechanisms of total flavonoids are still unknown.In the present study,we aimed to obtain the effective parts of flavonoids in S.china,and elucidate the mechanism of action on PID.The anti-inflammatory effect was evaluated on phenol mucilage-induced pelvic inflammation in rats.This was the first time that total flavonoids in high concentration(up to 55.6%)were obtained in S.china.A total of 15 compounds were separated and identified by NMR,and the total flavonoids were detected with HPLC.TFSC caused a reduction in serum levels of IL-6 and IL-1β.These results suggested that TFSC had a significant anti-PID effect,probably due to inhibition of the inflammatory reaction.

Forty five cases of chronic pelvic inflammation treated by electroacupuncture combined with TDP

Objective To observe the effect of electro acupuncture combined with TDP on chronic pelvic inflammation. Methods Electroacupuncture combined with TDP were used in all the forty five cases of chronic pelvic inflammation. The acupoints included Guānyuán （关元 CV 4）, Zhōngjí （中极 CV 3）, Shuǐdào （水道 ST 28）, Guīlaí （归来 ST 29）, Zúsānlǐ （足三里 ST 36）, Sānyīnjiāo （三阴交 SP 6） and Tàichōng （太冲 LR 3）, and the low frequency therapeutic instrument in type of G9805-C was used in Shuǐdào （水道 ST 28） and Guīlaí （归来 ST 29） on the same side. Retain needles for 30min, and put TDP directly above patients’ lower abdomen at the same time. The treatment frequency was once every other day, and 1 course included 5 times. Evaluate the effect after 3 courses. Results There were 10 cases of recovery, 18 cases of obvious improvement and 17 cases of improvement. There was no adverse reaction or complication during treatment. Conclusion Electroacupuncture combined with TDP is effective on chronic pelvic inflammation.

Abdominal acupuncture in combination with Chinese herbal bag hot compress in the treatment of chronic pelvic inflammation

Objective To observe the clinical effect of abdominal acupuncture in combination with Chinese herbal bag hot compress in the treatment of chronic pelvic inflammation. Methods Fifty patients with chronic pelvic inflammation were treated with abdominal acupuncture and Chinese herbal bag hot compress. The following points were selected as Zhongwan （中脘 CV 12）, Xiawan （下脘 CV 10）, Qihai （气海 CV 6）, Guanyuan （关元 CV 4）, Huaroumen （滑肉门 ST 24）, Wailing （外陵 ST 26）, Daheng （大横 SP 15）, and abdominal acupuncture was given once every other day and Chinese herbal bag hot compress was given once a day and 15 days were one course. The clinical effect was observed after two courses of treatment. The observation data included clinical effect, the scoring comparison of main symptoms and signs before and after the treatment. Results Among 50 patients with chronic pelvic inflammation, 11 cases got clinically cured, 15 were markedly effective, and 20 effective and the total effective rate was 92.0%; dropping pain in the lower abdomen, abnormal leukorrhea and gynecological signs were significantly improved after the treatment （P〈0.05）. Conclusion Abdominal acupuncture combined with Chinese herbal bag hot compress have the exact effect on the chronic pelvic inflammation.

Analysis of the pain threshold at the acupoints on the medial crus in pelvic inflammatory disease

Objective： To explore the tenderness response at the acupoints on the medial crus in the patients of pelvic inflammatory disease.Methods： A total of 30 patients of pelvic inflammation and 30 healthy people were included. WAGNER FDX body mechanics algometer was used to determine the score of the visual analogue scale（VAS） and tenderness threshold value at Yīnlíngquán（阴陵泉 SP 9）, Sānyīnjiāo（三阴交SP 6） and Lígōu（蠡沟 LR 5）.The changes in the tenderness on the body surface at the relevant acupoints were compared and analyzed in the patients of pelvic inflammation.Results： The occurrence rate of tenderness at LR 5 at the pelvic inflammation group was higher significantly than the health group（86% Vs 42%, P0.01）. In SP 9, SP 6 and LR 5,the VAS scores at the acupoints in the pelvic inflammation group were higher significantly than the health group（test 1：55.00± 15.12 vs 27.25 ± 10.31,47.07 ± 18.38 vs 29.75 ± 14.30, 47.16 ± 19.4 vs 20.16 ±10.76; test2：53.40± 17.23 vs 33.42± 13.07, 45.95 ± 15.74 vs 29.15± 11.97, 42.50± 21.67 vs 21.05 ± 11.97; test 3：48.50± 14.97 vs 40.08 ± 13.20, 38.24± 15.29 vs 29.29± 12.37, 37.93± 19.17 vs 23.09± 12.26）, P〈0.01,P〈0.05.In SP 9, SP 6 and LR 5,the tenderness threshold values at the acupoints in the pelvic inflammation group were higher significantly than the health group（test 1：0.86 ± 0.95 vs 0.53 ± 0.39, 0.86 士 0.95 vs 0.53 ±0.39, 0.85 ± 0.77 vs 0.47 ± 0.47; test 2：0.88 ± 0.81 vs 0.44 ± 0.32, 0.98 ± 0.83 vs 0. 44 ± 0. 32,0.85±0.77 vs 0.47±0.47; test 3：0.98±0.80 vs 0.36±0.26, 1.11 ±0.92 vs 0. 36±0. 26,0.85±0.77 vs0.47 ± 0.47）, P〈0.01,P〈0.05（P〈0.05）.Conclusion： The VAS scores and tenderness threshold values at SP 9, SP 6 and LR 5 in the patients of pelvic inflammation are higher significantly than those in the healthy people. The occurrence rate of tenderness at LR 5 is higher significantly as compared with the healthy people.