Despite its abundant vascularization and extensive circulatory communication with neighboring organs, metastases to the penis are a rare event. A 57-yearold male, who had undergone total pelvic exenteration for rectal...Despite its abundant vascularization and extensive circulatory communication with neighboring organs, metastases to the penis are a rare event. A 57-yearold male, who had undergone total pelvic exenteration for rectal cancer sixteen months earlier, demonstrated an abnormal uptake within his penis by positron emission tomography/computed tomography. A single elastic nodule of the middle penis shaft was noted deep within Bucks fascia. No other obvious recurrent site was noted except the penile lesion. Total penectomy was performed as a curative resection based on a diagnosis of isolated penile metastasis from rectal cancer. A histopathological examination revealed an increase of well differentiated adenocarcinoma in the corpus spongiosum consistent with his primary rectal tumor. The immunohistochemistry of the tumor cells demonstrated positive staining for cytokeratin 20 and negative staining for cytokeratin 7, which strongly supported a diagnosis of penile metastasis from the rectum. The patient is alive more than two years without any recurrence.展开更多
BACKGROUND Metastasis to the penis is an unusual event,and penile metastasis from rectal carcinoma(PMRC)is extremely rare and associated with a dismal prognosis.Thus far,approximately 80 cases have been reported.CASE ...BACKGROUND Metastasis to the penis is an unusual event,and penile metastasis from rectal carcinoma(PMRC)is extremely rare and associated with a dismal prognosis.Thus far,approximately 80 cases have been reported.CASE SUMMARY Herein,we report the case of a 49-year-old man with PMRC.The patient presented to the urology clinic with a complaint of penile pain during urination.The patient underwent the Dixon operation for rectal carcinoma 2 mo before the presentation.During hospitalisation,abdominal computed tomography revealed a nodular lesion on the left penis.The postoperative pathological examination revealed a typical intestinal-type adenocarcinoma.Previous cases of PMRC were retrieved from PubMed to characterise the clinicopathological features and identify the prognostic factors of PMRC.CONCLUSION The analysis suggested that approximately 24 mo is the median time to metastasis occurrence and 150 d is the survival time after diagnosis.Furthermore,poor pathological differentiation,lymph node involvement of the primary RC,metastasis time<6 mo,penile metastatic nodule diameter>1 cm,and treatment abandonment are negative predictors of survival outcomes.Close follow-up,surgical resection,chemotherapy,and radiotherapy may potentially improve the prognosis of patients.展开更多
Two cases of penile metastasis from primary prostate cancer in a single center are presented,along with a literature review and description of the excision technique.Despite its rich vascularization,penile metastasis ...Two cases of penile metastasis from primary prostate cancer in a single center are presented,along with a literature review and description of the excision technique.Despite its rich vascularization,penile metastasis is rare,with 72 new cases from September 2006 to March 2021.There is a wide variety of diagnoses,treatments,and prognoses for penile metastatic lesions.Ga-68 prostatespecific membrane antigen positron emission tomography/computed tomography is the most sensitive imaging tool for detecting metastasis from primary prostate cancer.Magnetic resonance imaging of the penis is the most reliable technique for differentiating penile lesions.Histological diagnosis is mostly performed using fine-needle biopsy aspiration.Metastasis-directed treatment is not considered to contribute to prolonged survival.Local treatment is feasible and can be offered to symptomatic patients.Owing to a heterogeneous group,defining overall survival is difficult.Survival until 46months after detecting penile metastases is described.展开更多
Malignant priapism is an uncommon clinical disease .characterized by prolonged erection secondary to the invasion of malignant neoplasm into corpora cavernosa） Penile metastasis of malignant tumors is relatively rare...Malignant priapism is an uncommon clinical disease .characterized by prolonged erection secondary to the invasion of malignant neoplasm into corpora cavernosa） Penile metastasis of malignant tumors is relatively rare, and only approximately 370 cases were reported by 2006 from a wide range of primary sites with a descending order of the prostate 125 （34%）, bladder 112 （30%） and recto-sigmoid ＋ rectum 48 （13%）; only 11 cases of malignant priapisms （3%） were attributed to penile metastasis of testicular tumors. Here, we present an interesting case of malignant priapism caused by penile metastasis of a mixed germ cell tumor of the testes in a 25-year-old man.展开更多
文摘Despite its abundant vascularization and extensive circulatory communication with neighboring organs, metastases to the penis are a rare event. A 57-yearold male, who had undergone total pelvic exenteration for rectal cancer sixteen months earlier, demonstrated an abnormal uptake within his penis by positron emission tomography/computed tomography. A single elastic nodule of the middle penis shaft was noted deep within Bucks fascia. No other obvious recurrent site was noted except the penile lesion. Total penectomy was performed as a curative resection based on a diagnosis of isolated penile metastasis from rectal cancer. A histopathological examination revealed an increase of well differentiated adenocarcinoma in the corpus spongiosum consistent with his primary rectal tumor. The immunohistochemistry of the tumor cells demonstrated positive staining for cytokeratin 20 and negative staining for cytokeratin 7, which strongly supported a diagnosis of penile metastasis from the rectum. The patient is alive more than two years without any recurrence.
文摘BACKGROUND Metastasis to the penis is an unusual event,and penile metastasis from rectal carcinoma(PMRC)is extremely rare and associated with a dismal prognosis.Thus far,approximately 80 cases have been reported.CASE SUMMARY Herein,we report the case of a 49-year-old man with PMRC.The patient presented to the urology clinic with a complaint of penile pain during urination.The patient underwent the Dixon operation for rectal carcinoma 2 mo before the presentation.During hospitalisation,abdominal computed tomography revealed a nodular lesion on the left penis.The postoperative pathological examination revealed a typical intestinal-type adenocarcinoma.Previous cases of PMRC were retrieved from PubMed to characterise the clinicopathological features and identify the prognostic factors of PMRC.CONCLUSION The analysis suggested that approximately 24 mo is the median time to metastasis occurrence and 150 d is the survival time after diagnosis.Furthermore,poor pathological differentiation,lymph node involvement of the primary RC,metastasis time<6 mo,penile metastatic nodule diameter>1 cm,and treatment abandonment are negative predictors of survival outcomes.Close follow-up,surgical resection,chemotherapy,and radiotherapy may potentially improve the prognosis of patients.
文摘Two cases of penile metastasis from primary prostate cancer in a single center are presented,along with a literature review and description of the excision technique.Despite its rich vascularization,penile metastasis is rare,with 72 new cases from September 2006 to March 2021.There is a wide variety of diagnoses,treatments,and prognoses for penile metastatic lesions.Ga-68 prostatespecific membrane antigen positron emission tomography/computed tomography is the most sensitive imaging tool for detecting metastasis from primary prostate cancer.Magnetic resonance imaging of the penis is the most reliable technique for differentiating penile lesions.Histological diagnosis is mostly performed using fine-needle biopsy aspiration.Metastasis-directed treatment is not considered to contribute to prolonged survival.Local treatment is feasible and can be offered to symptomatic patients.Owing to a heterogeneous group,defining overall survival is difficult.Survival until 46months after detecting penile metastases is described.
文摘Malignant priapism is an uncommon clinical disease .characterized by prolonged erection secondary to the invasion of malignant neoplasm into corpora cavernosa） Penile metastasis of malignant tumors is relatively rare, and only approximately 370 cases were reported by 2006 from a wide range of primary sites with a descending order of the prostate 125 （34%）, bladder 112 （30%） and recto-sigmoid ＋ rectum 48 （13%）; only 11 cases of malignant priapisms （3%） were attributed to penile metastasis of testicular tumors. Here, we present an interesting case of malignant priapism caused by penile metastasis of a mixed germ cell tumor of the testes in a 25-year-old man.
