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Practice of Barrier Measures against COVID-19 Among Diabetic People Followed at Departmental University Hospital Center Ouémé-Plateau, Benin, in 2021
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作者 Yèssito Corine Nadège Houehanou Armand Wanvoègbe +4 位作者 Akouodé Thomas Hounto Luc Béhanzin Maurice Agonnoudé David Houéto Thierry Adoukonou 《Open Journal of Epidemiology》 2024年第2期249-259,共11页
Introduction: COVID-19 is a pandemic disease caused by the coronavirus SARS-COV2 appeared in China in 2019. The aim of the study was to evaluate the practice of barrier measures against COVID-19 and to identify associ... Introduction: COVID-19 is a pandemic disease caused by the coronavirus SARS-COV2 appeared in China in 2019. The aim of the study was to evaluate the practice of barrier measures against COVID-19 and to identify associated factors among diabetics followed at Departmental University Hospital Center Ouémé-Plateau, Benin, in 2021. Methods: This was a cross-sectional study conducted from June to August 2021, including diabetics aged 18 and over, hospitalized or received for medical visits in the department of medicine at the target hospital. Data were collected during an interview with each participant thanks to a questionnaire. “Good practice” was defined as regular practice of at least two of three barrier measures: hand washing, physical distancing and mask-wearing. Results: A total of 110 diabetics were included with a female predominance (55.5%) and a mean age of 57 ± 11.3 years. Among them, 89.1% washed their hands, 41.8% respected physical distancing and 12.7% wore a mask. The proportion of good practice was 47.3%. Only 5 practiced the three barrier measures. Only age group was associated with good practice. Conclusion: The study showed a low proportion of good practice of barrier measures against COVID-19 among diabetic people surveyed. It is important to continue the action for COVID-19 prevention among diabetic people in the targeted hospital and in other hospitals in Benin. 展开更多
关键词 COVID-19 Barrier Measures PRACTICE Diabetic people BENIN
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Understanding Behavioral Manifestations of Obsessive-Compulsive Disorder in People with Intellectual Disabilities—A Qualitative Study
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作者 Lena Grüter Matthias Grünke 《Open Journal of Psychiatry》 2024年第2期67-90,共24页
Background: There is limited knowledge about obsessive-compulsive disorder (OCD) in people with intellectual disabilities (IDs). This paper describes the manifestation of compulsive behaviors associated with OCD at th... Background: There is limited knowledge about obsessive-compulsive disorder (OCD) in people with intellectual disabilities (IDs). This paper describes the manifestation of compulsive behaviors associated with OCD at the behavioral level in people with ID in institutionalized settings. The aim was to gain nuanced insight into appropriate understanding and classification in this specific context, and derive implications for research and practice. Methods: Individual cases of people with ID (n = 7) were studied to assess compulsive symptoms through two days of on-site observation of the person with ID within the institution, guided group discussions (n = 28), and semi-structured interviews with key informants and caregivers of the person with ID (n = 20). Caregiver ratings of the compulsive behavior checklist were compiled. Data were analyzed using qualitative content analysis. Results: All forms of OCD were present. Characteristics of compulsive behaviors in people with ID at the behavioral level included less complex and more obvious compulsive acts, immediate responses, signs of tension, motor restlessness, facial expression changes, repetition, need for predictability, time-consuming behaviors, and aggressive reactions when these acts were interrupted. Some of the compulsive behaviors corresponded to the ICD-11 OCD code 6B20, and others to compulsions as a psychological symptom (MB23.4). Conclusions: OCD may manifest atypically at the behavioral level in people with ID, posing significant challenges for accurate classification due to symptom ambiguity. Follow-up differential diagnostic studies are needed to more accurately identify and differentiate OCD symptoms in people with ID. Further, disorder-specific guidelines for recognizing OCD in people with ID are needed for institutionalized settings without psychiatric-psychotherapeutic expertise. 展开更多
关键词 people with Intellectual Disabilities Obsessive-Compulsive Disorder Compulsive Behavior DIAGNOSTICS Differential Diagnosis
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Towards complex scenes: A deep learning-based camouflaged people detection method for snapshot multispectral images
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作者 Shu Wang Dawei Zeng +3 位作者 Yixuan Xu Gonghan Yang Feng Huang Liqiong Chen 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第4期269-281,共13页
Camouflaged people are extremely expert in actively concealing themselves by effectively utilizing cover and the surrounding environment. Despite advancements in optical detection capabilities through imaging systems,... Camouflaged people are extremely expert in actively concealing themselves by effectively utilizing cover and the surrounding environment. Despite advancements in optical detection capabilities through imaging systems, including spectral, polarization, and infrared technologies, there is still a lack of effective real-time method for accurately detecting small-size and high-efficient camouflaged people in complex real-world scenes. Here, this study proposes a snapshot multispectral image-based camouflaged detection model, multispectral YOLO(MS-YOLO), which utilizes the SPD-Conv and Sim AM modules to effectively represent targets and suppress background interference by exploiting the spatial-spectral target information. Besides, the study constructs the first real-shot multispectral camouflaged people dataset(MSCPD), which encompasses diverse scenes, target scales, and attitudes. To minimize information redundancy, MS-YOLO selects an optimal subset of 12 bands with strong feature representation and minimal inter-band correlation as input. Through experiments on the MSCPD, MS-YOLO achieves a mean Average Precision of 94.31% and real-time detection at 65 frames per second, which confirms the effectiveness and efficiency of our method in detecting camouflaged people in various typical desert and forest scenes. Our approach offers valuable support to improve the perception capabilities of unmanned aerial vehicles in detecting enemy forces and rescuing personnel in battlefield. 展开更多
关键词 Camouflaged people detection Snapshot multispectral imaging Optimal band selection MS-YOLO Complex remote sensing scenes
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Associations of PNPLA3 and LEP genetic polymorphisms with metabolic-associated fatty liver disease in Thai people living with human immunodeficiency virus
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作者 Kanuengnit Choochuay Punna Kunhapan +6 位作者 Apichaya Puangpetch Sissades Tongsima Pornpen Srisawasdi Abhasnee Sobhonslidsuk Somnuek Sungkanuparph Mohitosh Biswas Chonlaphat Sukasem 《World Journal of Hepatology》 2024年第3期366-378,共13页
BACKGROUND The prevalence of metabolic-associated fatty liver disease(MAFLD)is a growing public health issue in people living with human immunodeficiency virus(PLWH).However,the pathophysiology of MAFLD is still unkno... BACKGROUND The prevalence of metabolic-associated fatty liver disease(MAFLD)is a growing public health issue in people living with human immunodeficiency virus(PLWH).However,the pathophysiology of MAFLD is still unknown,and the role of genetic variables is only now becoming evident.AIM To evaluate the associations of gene-polymorphism-related MAFLD in PLWH.METHODS The study employed transient elastography with a controlled attenuation parameter≥248 dB/m to identify MAFLD in patients from a Super Tertiary Hospital in central Thailand.Candidate single-nucleotide polymorphisms(SNPs)were genotyped using TaqMan®MGB probe 5'nuclease assays for seven MAFLD-related genes.Statistical analyses included SNP frequency analysis,Fisher's Exact and Chi-square tests,odds ratio calculations,and multivariable logistic regression.RESULTS The G-allele carriers of PNPLA3(rs738409)exhibited a two-fold rise in MAFLD,increasing by 2.5 times in MAFLD with human immunodeficiency virus infection.The clinical features and genetic patterns imply that LEP rs7799039 A-allele carriers had a nine times(P=0.001)more significant chance of developing aberrant triglyceride among PLWH.CONCLUSION The current study shows an association between PNPLA3 rs738409 and LEP rs7799039 with MAFLD in PLWH. 展开更多
关键词 PNPLA3 LEP Metabolic-associated fatty liver disease people living with HIV THAI
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Narrative Empathy and Patriotism--An Analysis of the Chinese“Main-Melody”Film My People,My Country
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作者 WANG Zi-ying 《Journal of Literature and Art Studies》 2024年第3期226-238,共13页
Narrative empathy is a relatively new theory and it can guide researchers in the studies of main-melody films so as to promote the communication of the core values of the society.The rhetorical mechanism of narrative ... Narrative empathy is a relatively new theory and it can guide researchers in the studies of main-melody films so as to promote the communication of the core values of the society.The rhetorical mechanism of narrative empathy can be illustrated from five rhetorical elements,including rhetor,rhetorical goal,rhetorical situation,rhetorical strategy and audience.The theory of narrative empathy can be applied to the case study of the film My People,My Country.In the production of this film,the directors are the rhetors.The rhetors uphold the tenet of closeness,choose the right rhetorical situation as the 70th birthday of the People’s Republic of China,and use appropriate rhetorical strategies in order to realize the rhetorical goals of evoking empathy and inspiring patriotic feelings in the audience’s minds.An exploration and application of narrative empathy can be conducive to the empathic communication of Chinese main-melody films in order to achieve better communication effect. 展开更多
关键词 narrative empathy main-melody films My people My Country
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A Study of the People’s Nature in Woodcuts During the Anti-Japanese War in Shanxi
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作者 ZHANG Tong-yuan 《Journal of Literature and Art Studies》 2024年第11期1032-1040,共9页
The anti-Japanese woodcuts focus on the red revolutionary culture and describe the connotation of the Anti-Japanese War era,which is self-evident in the commemorative value of China’s revolutionary struggle history.F... The anti-Japanese woodcuts focus on the red revolutionary culture and describe the connotation of the Anti-Japanese War era,which is self-evident in the commemorative value of China’s revolutionary struggle history.For example,in Shanxi,China,woodcut art activities and social practice promotion activities organized around the theme of the Anti-Japanese War are also everywhere,which all show the people’s nature of the Chinese people during the revolutionary struggle from the two aspects of the red culture of the Anti-Japanese War and traditional art and culture,and its humanistic connotation is quite profound.In this paper,we first introduce the historical origin of woodcut during the Anti-Japanese War,and then show the people’s value connotation of woodcut art activities in Shanxi.This paper mainly discusses the image narration,language and picture narration and construction significance of woodcuts in Shanxi’s War of Resistance,fully reveals the narrative nature of image media,strives to arouse people’s recognition of this period of Shanxi’s War of Resistance culture and history,and reflects the realistic value and significance of Shanxi’s War of Resistance Woodcuts art activities. 展开更多
关键词 people’s nature Shanxi anti-Japanese woodcarving image media narrative synergistic effect construction significance humanistic cultural identity
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The Relationship Between Social Isolation, Psychological Resilience, and Psychological Well- Being Among Older People in the Community
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作者 Lijing Wang Zhaoyu Bi +3 位作者 Hongying Tian Liping Xu Yanling Li Hongyun Cai 《Journal of Clinical and Nursing Research》 2024年第10期36-44,共9页
Objective:To explore the relationship between social isolation,psychological resilience,and psychological well-being in community-dwelling older adults.Methods:A questionnaire survey was conducted with 265 community-d... Objective:To explore the relationship between social isolation,psychological resilience,and psychological well-being in community-dwelling older adults.Methods:A questionnaire survey was conducted with 265 community-dwelling older adults using the Social Isolation Scale for the Elderly(C-SIS),the 10-item Brief Psychological Resilience Scale,and the Comprehensive Happiness Questionnaire(MHQ).The results were statistically analyzed using SPSS 27.0.Results:The highest score on the Social Isolation Scale for Community Elderly was 23,with a mean entry score of 2.36±0.62.A score of 14 was the cut-off point,with scores of≤14 classified as social isolation.There were 136 cases with scores below 14,resulting in a social isolation incidence rate of 51.3%.The median(P50)psychological resilience score was 27,indicating a higher level of resilience.The total score on the Psychological Well-being Scale was 161,suggesting a moderate to slightly higher level of well-being.Social isolation had a direct negative effect on psychological well-being,while psychological resilience had a positive effect.Conclusion:Older adults should be supported in reducing the incidence of social isolation and increasing psychological resilience to enhance psychological well-being and promote successful aging. 展开更多
关键词 COMMUNITY Older people Social isolation Psychological resilience Psychological well-being
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Coping review of dementia fear studies among middle-aged and elderly people in the community
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作者 Hui Ren Gui-Meng Wang +3 位作者 Wen-Jing Yu Meng-Yuan Teng Jing-Mei Li Xiang-Shu Cui 《Nursing Communications》 2024年第22期1-9,共9页
This study used Arksey and O’Malley’s scoping review methodology as a framework and searched the following databases:PubMed,Embase,EBSCO,CINAHL,Web of Science,Cochrane Library,Scopus,CNKI,Wanfang,VIP,and the Chinese... This study used Arksey and O’Malley’s scoping review methodology as a framework and searched the following databases:PubMed,Embase,EBSCO,CINAHL,Web of Science,Cochrane Library,Scopus,CNKI,Wanfang,VIP,and the Chinese Biomedical Literature Database.The database is open to December 20,2023,and documents related to the fear of dementia among the elderly in the community are described and analyzed to provide a reference for future research in this field.At the same time,we screened,extracted,and summarized relevant information from 21 included documents(16 in English and 5 in Chinese),which consisted of 16 cross-sectional studies,2 quasi-experimental studies,2 randomized controlled studies,and 1 longitudinal study.Sixteen of the included documents mentioned the incidence or level of dementia fear among the elderly in the community,2 addressed the adverse effects of dementia fear,and 4 reported prevention and intervention measures for dementia fear.In total,there are 8 assessment tools,and the influencing factors are categorized into sociodemographic characteristics,psychological and behavioral characteristics,sociocultural background factors,and health and dementia-related factors.The final conclusion is that the fear of dementia is common among the elderly in the community.In the future,the application of research tools should be expanded among middle-aged individuals,with considerations for other types of dementia in mind.It is recommended to conduct large-scale,multi-center randomized controlled trials while confirming the intervention’s effect on different types of middle-aged and elderly individuals,focusing on the long-term impact of these intervention measures to promote healthy aging. 展开更多
关键词 dementia fear middle-aged and elderly people COMMUNITY scope review
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基于“微生物-肠-脑轴”探讨补肾通腑方对APP/PS1小鼠肠道菌群及LPS/TLR4/NF-κB通路的影响
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作者 王旭 张杰 +2 位作者 赵敏 宋晓雨 段建平 《中国药理学通报》 CAS 北大核心 2025年第1期171-178,共8页
目的探讨补肾通腑方调控肠道菌群,改善阿尔茨海默病(Alzheimer’s disease,AD)模型小鼠学习记忆能力的作用机制。方法以APP/PS1小鼠为研究对象,给予补肾通腑方治疗8周,采用Morris水迷宫法观察小鼠空间学习记忆能力变化;16S rDNA检测小... 目的探讨补肾通腑方调控肠道菌群,改善阿尔茨海默病(Alzheimer’s disease,AD)模型小鼠学习记忆能力的作用机制。方法以APP/PS1小鼠为研究对象,给予补肾通腑方治疗8周,采用Morris水迷宫法观察小鼠空间学习记忆能力变化;16S rDNA检测小鼠肠道菌群丰度、多样性变化;HE染色观察海马病理形态学变化;免疫荧光检测海马区小胶质细胞活化情况;Western blot检测TLR4、NF-κB、IL-6等炎症因子表达。结果与模型组相比,补肾通腑方可以缩短AD模型小鼠逃避潜伏期、游泳路径,增加跨越平台次数(P<0.05),提升肠道菌群多样性,调节肠道菌群丰度,促进海马神经元细胞损伤修复,降低iNOS/Iba1共表达,提高Arg1/Iba1共表达(P<0.01),促进小胶质细胞从M1型向M2型转化,下调TLR4、NF-κB、IL-6等促炎因子的表达。结论补肾通腑方改善AD模型小鼠学习记忆能力的作用机制可能与调节肠道菌群介导的LPS/TLR4/NF-κB通路,从而抑制促炎型小胶质细胞活化、减轻中枢神经系统炎症、改善海马区神经元细胞损伤有关。 展开更多
关键词 阿尔茨海默病 补肾通腑方 肠道菌群 LPS/TLR4/NF-κB通路 16S rDNA 微生物--脑轴
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需求不确定下的两阶段应急物流选址-路径研究
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作者 王庆荣 王雪娜 +1 位作者 朱昌锋 李裕杰 《灾害学》 北大核心 2025年第1期160-166,共7页
针对灾后应急救援在需求不确定和资源受限方面的问题,以多级应急物流网络为背景,构建了一个需求不确定下的两阶段应急选址-路径规划模型。该模型以总成本最小和救援车辆运输总距离最短为目标,采用三角模糊数刻画受灾点的不确定需求,并... 针对灾后应急救援在需求不确定和资源受限方面的问题,以多级应急物流网络为背景,构建了一个需求不确定下的两阶段应急选址-路径规划模型。该模型以总成本最小和救援车辆运输总距离最短为目标,采用三角模糊数刻画受灾点的不确定需求,并采用基于可信性的模糊机会约束规划方法,以消除约束条件中的不确定参数。模型第一阶段调用Gurobi求解器,求解得到应急配送中心选址结果和对受灾点的分配方案;第二阶段将选址及分配结果作为输入进行路径规划,并提出一种改进的自适应遗传算法(IAGA)对算例进行求解。然后采用自适应遗传算法(AGA)与之对比,并进行灵敏度分析。结果表明:IAGA在目标值、收敛速度和运行时间等方面均优于AGA,证明了IAGA具有一定的可行性和有效性,且可以为决策者提供较优的应急选址-路径规划方案,从而提升灾后救援的效率。 展开更多
关键词 应急物流 选址-路径问题 Gurobi 模糊需求 改进的自适应遗传算法
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SPME-Arrow/GC-MS结合多元统计分析研究不同批次爆珠香精组分差异
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作者 刘琪 张华 +4 位作者 叶远青 刘昌泽 袁益来 廖惠云 吴君章 《分析测试学报》 CAS 北大核心 2025年第1期135-144,共10页
以箭型固相微萃取(SPME-Arrow)为样品萃取手段,通过优化萃取头种类、氯化钠添加量、萃取温度、平衡时间及萃取时间等条件,构建了高效鉴定爆珠香精中挥发性及半挥发性化合物的箭型固相微萃取结合气相色谱-质谱联用(SPME-Arrow/GC-MS)法... 以箭型固相微萃取(SPME-Arrow)为样品萃取手段,通过优化萃取头种类、氯化钠添加量、萃取温度、平衡时间及萃取时间等条件,构建了高效鉴定爆珠香精中挥发性及半挥发性化合物的箭型固相微萃取结合气相色谱-质谱联用(SPME-Arrow/GC-MS)法。采用该方法对不同批次爆珠香精进行分析,结合主成分分析(PCA)、正交偏最小二乘-判别分析(OPLS-DA)及显著性F检验等多元统计分析手段,筛选显著性差异成分。结果表明:最佳萃取条件为优选DVB/CAR/PDMS萃取头,添加2.0 g氯化钠,在60℃下平衡50 min,萃取时间为40 min;经谱库检索结合保留指数辅助定性,共鉴定出96种挥发性、半挥发性组分,目标物峰面积的日间相对标准偏差(RSD)小于10%的色谱峰数量占总峰数量的92.7%,表明方法的重复性较好;从不同批次爆珠香精中共筛选出17个潜在差异化合物,通过显著性检验,确定10种显著性差异化合物,分别为α-蒎烯、柠檬烯、桉叶油醇、异胡薄荷醇、薄荷酮(含异构体)、新异薄荷醇、乙酸新薄荷酯、三辛酸甘油酯和二辛酸单癸酸甘油酯。该法可有效区分不同批次爆珠样品的组分差异,具有客观真实、准确可靠、可视化强等特点,能够为爆珠产品质量检验提供技术支持。 展开更多
关键词 箭型固相微萃取 气相色谱-质谱联用 多元统计分析 爆珠香精 差异化合物
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法舒地尔缓解β-淀粉样蛋白1-42诱导的SH-SY5Y细胞凋亡
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作者 郭敏芳 张慧宇 +3 位作者 章培军 苏琴 贾思玮 尉杰忠 《中国组织工程研究》 CAS 北大核心 2025年第23期4939-4946,共8页
背景:法舒地尔对阿尔茨海默病小鼠脑内的线粒体动力学有调节作用,并且可以抑制神经炎症,但能否调节线粒体自噬和NLRP3炎症小体进而减轻β-淀粉样蛋白毒性尚不清楚。目的:探究法舒地尔对β-淀粉样蛋白1-42诱导的人源神经母细胞瘤细胞株SH... 背景:法舒地尔对阿尔茨海默病小鼠脑内的线粒体动力学有调节作用,并且可以抑制神经炎症,但能否调节线粒体自噬和NLRP3炎症小体进而减轻β-淀粉样蛋白毒性尚不清楚。目的:探究法舒地尔对β-淀粉样蛋白1-42诱导的人源神经母细胞瘤细胞株SH-SY5Y凋亡和线粒体自噬以及NLRP3炎症小体的调节作用。方法:将SH-SY5Y细胞接种于孔板内,细胞贴壁后分3组干预:对照组不加入任何药物,模型组加入20μmol/L β-淀粉样蛋白1-42,法舒地尔组同时加入20μmol/L β-淀粉样蛋白1-42与15 mg/L法舒地尔,干预24 h后,采用MTT法检测细胞活性,TUNEL染色检测细胞凋亡,qRT-PCR和Western blot检测凋亡相关蛋白表达,免疫荧光染色和Western blot检测线粒体自噬相关蛋白表达,免疫荧光染色和Western blot检测NLRP3炎症小体相关蛋白表达。结果与结论:(1)与对照组比较,模型组细胞活性降低、凋亡率升高(P<0.05);与模型组比较,法舒地尔组细胞活性升高、凋亡率降低(P<0.05);(2)qRT-PCR和Western blot检测结果显示,与对照组比较,模型组细胞Bax mRNA与蛋白表达升高(P<0.05),Bcl-2 mRNA与蛋白表达降低(P<0.05);与模型组比较,法舒地尔组细胞Bax mRNA与蛋白表达降低(P<0.05),Bcl-2 mRNA与蛋白表达升高(P<0.05);(3)免疫荧光染色和Western blot检测结果显示,与对照组相比,模型组细胞PINK1、帕金森病蛋白和LC3蛋白表达降低(P<0.05),p62蛋白表达升高(P<0.05);与模型组相比,法舒地尔组细胞PINK1、帕金森病蛋白和LC3蛋白表达升高(P<0.05),p62蛋白表达降低(P<0.05);(4)免疫荧光染色和Western blot检测结果显示,与对照组相比,模型组细胞NLRP3、ASC、Caspase-1和白细胞介素1β蛋白表达升高(P<0.05);与模型组相比,法舒地尔组细胞NLRP3、ASC、Caspase-1和白细胞介素1β蛋白表达降低(P<0.05);(5)结果表明,法舒地尔可以减轻β-淀粉样蛋白1-42诱导的SH-SY5Y细胞凋亡,其机制可能与激活线粒体自噬且抑制NLRP3炎症小体激活有关。 展开更多
关键词 法舒地尔 Β-淀粉样蛋白 神经细胞 细胞凋亡 线粒体自噬 炎症小体
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Yield Increasing and Quality Improving Effects of Smash-ridging Method("4453" Effects) and Its Potential in Benefiting the Nation and the People 被引量:4
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作者 韦本辉 《Agricultural Science & Technology》 CAS 2014年第10期1767-1769,共3页
Yuan Longping proposed that smash-ridging technology could be extend-ed widely nationwide. ln the research, smash-ridging technology reconstruct cultiva-tion layers with loose soils in agricultural fields, creating "... Yuan Longping proposed that smash-ridging technology could be extend-ed widely nationwide. ln the research, smash-ridging technology reconstruct cultiva-tion layers with loose soils in agricultural fields, creating "4453" effects, as fol ows: "Four increases" include to increase loosen soil quantity in cultivation layers, soil nutri-ents use, "water pool" in soils, and "oxygen pool" in soils. Four reductions are to reduce soil erosion, carbon emission, salt content and heavy metal in soils. Five resistances refer to improve crop resistance capacity in terms of drought, high tem-perature, lower temperature, disease and lodging. Three improvements indicate to enhance photosynthetic efficiency over 10%, yield in 10%-30% and quality over 5%. lt is researched that without additional chemical fertilizer, yield could increase by 10% by labor force, animal, tractor or smash-ridging machine. What’s more, by smash-ridging cultivation, the depth can be 20 times or higher compared with tractor cultivation, with looser soils. lt is estimated that if smash-ridging cultivation is applied once in agricultural lands in China, present soil layers can be twice as deep as present. Specifical y, the thickness of loose soil-layers could be extended from 10-18 cm at present to 25-35 cm, and natural rainfal would increase by 40 bil ion cm3. After vitalization of soil nutrients, chemical fertilizer would decrease by 7 bil ion kg, and the increased c rops would feed more than 300 mil ion population as per yield at 7 50 kg/hm2. 展开更多
关键词 Smash-ridging technology Extension nationwide lncrease range in 10%-30% Supporting more 300 mil ion population"4453" effects Development potential
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真武汤介导lncRNA NEAT1/miR-31-5p/IGFBP7分子轴抑制慢性心力衰竭进程的机制研究
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作者 宁小康 张迎 +1 位作者 周永学 张立 《陕西中医》 CAS 2025年第1期8-12,共5页
目的:探讨真武汤通过lncRNA NEAT1/miR-31-5p/IGFBP7分子轴抑制慢性心力衰竭(CHF)进程的机制。方法:将雄性SD大鼠分为对照组、模型组、阳性对照组和真武汤低、中、高剂量组,每组各10只。除对照组外,其余各组采用腹腔注射阿霉素的方法建... 目的:探讨真武汤通过lncRNA NEAT1/miR-31-5p/IGFBP7分子轴抑制慢性心力衰竭(CHF)进程的机制。方法:将雄性SD大鼠分为对照组、模型组、阳性对照组和真武汤低、中、高剂量组,每组各10只。除对照组外,其余各组采用腹腔注射阿霉素的方法建立CHF模型,阳性对照组给予美托洛尔灌胃,真武汤低、中、高剂量组给予真武汤(生药含量6、12、18 g/kg)灌胃。检测各组大鼠左心室射血分数(LVEF)、左心室短轴缩短率(LVFS),血清脑钠肽(BNP)水平,心脏体重比,心肌病理改变,心肌中肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)、丙二醛(MDA)、超氧化物歧化酶(SOD)水平及lncRNA NEAT1、miR-31-5p、IGFBP7表达水平。培养大鼠心肌H9c2细胞,采用双荧光素酶报告基因实验检测lncRNA NEAT1靶向miR-31-5p、miR-31-5p靶向IGFBP7。结果:与模型组比较,真武汤低、中、高剂量组的LVEF、LVFS增加,血清BNP水平降低(P<0.05);与模型组比较,真武汤低、中、高剂量组的心肌TNF-α、IL-1β、MDA水平降低,SOD水平增加(P<0.05);与模型组比较,真武汤低、中、高剂量组的心肌lncRNA NEAT1、IGFBP7表达降低,miR-31-5p表达增加(P<0.05)。H9c2心肌细胞中,lncRNA NEAT1靶向miR-31-5p、miR-31-5p靶向IGFBP7。结论:真武汤可能通过lncRNA NEAT1/miR-31-5p/IGFBP7分子轴改善CHF大鼠心功能并减轻炎症反应、氧化应激反应。 展开更多
关键词 慢性心力衰竭 真武汤 超氧化物歧化酶 miR-31-5p 丙二醛
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ANGPTL4 TSP-1及CyPA与脑卒中后癫痫患者认知功能的关系
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作者 高灵利 方建 +2 位作者 李晓晖 李延红 耿智凡 《中国实用神经疾病杂志》 2025年第1期63-67,共5页
目的探讨血管生成素样蛋白4(ANGPTL4)、凝血酶敏感蛋白-1(TSP-1)、亲环素A(CyPA与脑卒中后癫痫患者认知功能的关系。方法选取2021-01—2022-12河南大学第一附属医院神经内科收治的100例脑卒中后癫痫病例进行观察,按简易精神状态量表(MM... 目的探讨血管生成素样蛋白4(ANGPTL4)、凝血酶敏感蛋白-1(TSP-1)、亲环素A(CyPA与脑卒中后癫痫患者认知功能的关系。方法选取2021-01—2022-12河南大学第一附属医院神经内科收治的100例脑卒中后癫痫病例进行观察,按简易精神状态量表(MMSE)划分认知障碍标准将患者分为认知障碍组(50例)和认知正常组(50例),应用酶联免疫吸附试验(ELISA)检测2组患者的血清ANGPTL4、TSP-1、CyPA水平,MMSE量表测评2组患者的认知功能。结果与认知正常组比较,认知障碍组患者MMSE评分降低,ANGPTL4、TSP-1、CyPA水平升高(P<0.05);与轻度认知障碍患者比较,中度认知障碍患者血清ANGPTL4、TSP-1、CyPA水平升高(P<0.05);与中度认知障碍患者比较,重度认知障碍患者血清ANGPTL4、TSP-1、CyPA水平升高(P<0.05)。在脑卒中后癫痫患者中,血清ANGPTL4、TSP-1、Cy PA与MMSE评分各维度均呈负相关(P<0.05)。结论脑卒中后癫痫会降低MMSE评分,提高患者血清ANGPTL4、TSP-1、CyPA水平。ANGPTL4、TSP-1、CyPA水平越高,患者认知功能障碍越严重。 展开更多
关键词 脑卒中后癫痫 血管生成素样蛋白4 凝血酶敏感蛋白-1 亲环素A 认知功能
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写作教学如何有效落实“教-学-评”一致性的原则?--以说明文写作为例
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作者 莫先武 《小学教学研究》 2025年第1期8-13,共6页
“教-学-评”一致性的原则既是现代“促进学生学习课程”的具体体现,也是核心素养时代课程标准的基本要求。写作教学因其复杂性与特殊性,落实“教-学-评”一致性原则时存在着诸多困难。文章以程序说明文为例,探讨写作的教学内容、学习... “教-学-评”一致性的原则既是现代“促进学生学习课程”的具体体现,也是核心素养时代课程标准的基本要求。写作教学因其复杂性与特殊性,落实“教-学-评”一致性原则时存在着诸多困难。文章以程序说明文为例,探讨写作的教学内容、学习方式与评价问题,以及如何在写作教学中切实有效地落实“教-学-评”一致性的原则。 展开更多
关键词 “教--评”一致性 写作关键知识 长程写作实践 动态评价
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金(Ⅰ)-膦炔配合物设计合成及其光学性质研究
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作者 杜静 范维 +1 位作者 卓灏 徐海兵 《湖北大学学报(自然科学版)》 CAS 2025年第1期8-14,共7页
为了构建不同拓扑结构诱导的丰富发光行为,本研究利用萘环替代已报道的相似有机磷配体L中的联苯基团,利用构-效关系,实现有机金配合物不同光谱性能调控。为此,我们通过分步组装或炔金聚合物解聚分别获得了含萘环有机膦配体(L1)及9-乙炔... 为了构建不同拓扑结构诱导的丰富发光行为,本研究利用萘环替代已报道的相似有机磷配体L中的联苯基团,利用构-效关系,实现有机金配合物不同光谱性能调控。为此,我们通过分步组装或炔金聚合物解聚分别获得了含萘环有机膦配体(L1)及9-乙炔基蒽(L2)构建的前驱物L1AuCl(1)和金(I)配合物L1AuL2(2)。通过单晶衍射确定了晶体结构及其堆积模式,利用紫外可见吸收光谱及荧光光谱研究其在固、液中不同的光学性质与构-效关系。研究发现,含萘环的1发光行为完全不同于含联苯的1’。而2中,由于L2的引入带来的空间位阻扭曲了L1中萘环基团的空间伸展方向,诱导π…π堆积和氢键作用,不仅增强了其固态发光强度,而且使其激发发射窗口红移。 展开更多
关键词 炔膦金(Ⅰ)配合物 -效关系 刚化结构 荧光
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lncRNA-BBOX1-2通过调控成纤维细胞生长因子受体1促进胃癌的发生和发展
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作者 孙颖 顾玮 +1 位作者 王吉 郑雄 《安徽医药》 CAS 2025年第1期57-62,I0002,共7页
目的探讨长链非编码RNA(long non-coding RNA,lncRNA)BBOX1-2通过调控成纤维细胞生长因子受体1(fibroblast growth factor receptor 1,FGFR1)对胃癌的发生发展机制的影响。方法回顾性选取2017年4月至2019年1月于上海交通大学医学院附属... 目的探讨长链非编码RNA(long non-coding RNA,lncRNA)BBOX1-2通过调控成纤维细胞生长因子受体1(fibroblast growth factor receptor 1,FGFR1)对胃癌的发生发展机制的影响。方法回顾性选取2017年4月至2019年1月于上海交通大学医学院附属瑞金医院卢湾分院接受胃癌根治术30例病人肿瘤组织及癌旁相应正常组织作为研究对象,采用实时定量PCT(real-time PCR,RT-PCR)检测lncRNA-BBOX1-2和FGFR1表达;si-linc-BBOX1-2转染SGC-7901细胞后,通过蛋白质印迹法/细胞存活率分析(MTT)、细胞迁移和侵袭(Transwell)实验、细胞划痕、平板克隆一系列生物学功能实验,检测肿瘤细胞生物学功能及FGFR1表达的变化。结果胃癌组织中的lncRNA-BBOX1-2(3.68±0.58比1.15±0.11)和FGFR1(4.26±0.71比1.19±0.18)表达显著高于癌旁正常组织(P<0.05);si-linc-BBOX1-2转染SGC-7901细胞后,FGFR1表达下调,细胞活力、迁移、侵袭和生存能力明显下降。结论LincRNA-BBOX1-2可通过调控FGFR1的表达介导胃癌细胞的增殖、凋亡、迁移和侵袭,可能为胃癌的治疗提供了新的靶点和潜在的生物学标志物。 展开更多
关键词 胃肿瘤 长链非编码RNA BBOX1-2 成纤维细胞生长因子受体1 调控 增殖 凋亡
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A descriptive-comparative study of medications used by older people prior to and following admission to a continuing care facility 被引量:9
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作者 Alysha Visram Donna Wilson 《Open Journal of Nursing》 2012年第1期8-14,共7页
Medications are beneficial for curing or managing acute and chronic illnesses. Medications typically have positive outcomes, although older people are prone to drug-related problems. Community-dwelling seniors are at ... Medications are beneficial for curing or managing acute and chronic illnesses. Medications typically have positive outcomes, although older people are prone to drug-related problems. Community-dwelling seniors are at particularly high risk of polypharmacy, as they tend to receive many prescriptions over time and from different care providers. Continuing-care facility admission presents an excellent opportunity for a comprehensive medication review. A research study was conducted to describe and compare medications taken by community-dwelling seniors prior to and following admission to a continuing-care facility. This pilot project involved data being gathered from the charts of deceased residents, as required by a University Health Research Ethics Board, who had been cared for at one large local continuing-care facility. The facility administrators also approved this study, in part to evaluate their policy to conduct a medication review for all new residents within six weeks of entry. This study revealed a slight but statistically significant reduction in the number of medications following this review. Other issues such as medication interactions and required dosage changes were addressed by this medication review. Although this study was confined to one continuing-care facility and a small number of residents, the findings suggest medication reviews would be beneficial upon admission to all continuing-care facilities, and annually perhaps through other means for older persons living in the community. 展开更多
关键词 POLYPHARMACY Drug Interactions OLDER people Aging Nursing Homes CONTINUING Care Comparative Research
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自旋-轨道耦合作用下极化激元凝聚中的调制不稳定性
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作者 陈海军 《原子与分子物理学报》 CAS 北大核心 2025年第6期136-143,共8页
利用线性稳定性分析方法,对存在自旋-轨道耦合(SOS)作用的二维极化激元玻色-爱因斯坦凝聚(BEC)系统中的调制不稳定性(MI)进行了研究.分析了组分内部,组分之间以及SOC相互作用对系统调制不稳定性的影响.结果显示,当系统内部不存在SOC作用... 利用线性稳定性分析方法,对存在自旋-轨道耦合(SOS)作用的二维极化激元玻色-爱因斯坦凝聚(BEC)系统中的调制不稳定性(MI)进行了研究.分析了组分内部,组分之间以及SOC相互作用对系统调制不稳定性的影响.结果显示,当系统内部不存在SOC作用,组分之间的相互作用为0,组分内部存在排斥作用时,不会出现调制不稳定性,组分内部存在吸引作用时,会出现调制不稳定性,并且调制不稳定性区间长度随吸引作用的增强而增加;组分之间相互作用不为0时,组分之间的相互作用以平方形式出现,其正负不会对调制不稳定性产生实质性影响.存在SOC相互作用时,SOC相互作用会引起增益谱曲线的不规则振荡,破坏原来的调制不稳定性区间. 展开更多
关键词 极化激元凝聚 调制不稳定性 自旋-轨道耦合 双分量
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