A Study of the People’s Nature in Woodcuts During the Anti-Japanese War in Shanxi

The anti-Japanese woodcuts focus on the red revolutionary culture and describe the connotation of the Anti-Japanese War era,which is self-evident in the commemorative value of China’s revolutionary struggle history.For example,in Shanxi,China,woodcut art activities and social practice promotion activities organized around the theme of the Anti-Japanese War are also everywhere,which all show the people’s nature of the Chinese people during the revolutionary struggle from the two aspects of the red culture of the Anti-Japanese War and traditional art and culture,and its humanistic connotation is quite profound.In this paper,we first introduce the historical origin of woodcut during the Anti-Japanese War,and then show the people’s value connotation of woodcut art activities in Shanxi.This paper mainly discusses the image narration,language and picture narration and construction significance of woodcuts in Shanxi’s War of Resistance,fully reveals the narrative nature of image media,strives to arouse people’s recognition of this period of Shanxi’s War of Resistance culture and history,and reflects the realistic value and significance of Shanxi’s War of Resistance Woodcuts art activities.

Natural products and food components with anti-Helicobacter pylori activities

The bacterial pathogen Helicobacter pylori (H. pylori) colonizes in over half of the world’s population. H. pylori that establishes life-long infection in the stomach is definitely associated with gastro-duodenal diseases and a wide variety of non-gastrointestinal tract conditions such as immune thrombocytopenia. Triple therapy which consists of a proton pump inhibitor and combinations of two antibiotics (amoxicillin, clarithromycin or amoxicillin, metronidazol) is commonly used for H. pylori eradication. Recently, the occurrence of drug-resistant H. pylori and the adverse effect of antibiotics have severely weakened eradication therapy. Generally antibiotics induce the disturbance of human gastrointestinal microflora. Furthermore, there are inappropriate cases of triple therapy such as allergy to antibiotics, severe complications (liver and/or kidney dysfunction), the aged and people who reject the triple therapy. These prompt us to seek alterative agents instead of antibiotics and to develop more effective and safe therapy with these agents. The combination of these agents actually may result in lower a dose of antibiotics. There are many reports world-wide that non-antibiotic substances from natural products potentially have an anti-H. pylori agent. We briefly review the constituents derived from nature that fight against H. pylori in the literature with our studies.

Therapeutic potential of thymoquinone in combination therapy against cancer and cancer stem cells

The long-term success of standard anticancer monotherapeutic strategies has been hampered by intolerable side effects,resistance to treatment and cancer relapse.These monotherapeutic strategies shrink the tumor bulk but do not effectively eliminate the population of self-renewing cancer stem cells(CSCs)that are normally present within the tumor.These surviving CSCs develop mechanisms of resistance to treatment and refuel the tumor,thus causing cancer relapse.To ensure durable tumor control,research has moved away from adopting the monotreatment paradigm towards developing and using combination therapy.Combining different therapeutic modalities has demonstrated significant therapeutic outcomes by strengthening the anti-tumor potential of monotreatment against cancer and cancer stem cells,mitigating their toxic adverse effects,and ultimately overcoming resistance.Recently,there has been growing interest in combining natural products from different sources or with clinically used chemotherapeutics to further improve treatment efficacy and tolerability.Thymoquinone(TQ),the main bioactive constituent of Nigella sativa,has gained great attention in combination therapy research after demonstrating its low toxicity to normal cells and remarkable anticancer efficacy in extensive preclinical studies in addition to its ability to target chemoresistant CSCs.Here,we provide an overview of the therapeutic responses resulting from combining TQ with conventional therapeutic agents such as alkylating agents,antimetabolites and antimicrotubules as well as with topoisomerase inhibitors and non-coding RNA.We also review data on anticancer effects of TQ when combined with ionizing radiation and several natural products such as vitamin D3,melatonin and other compounds derived from Chinese medicinal plants.The focus of this review is on two outcomes of TQ combination therapy,namely eradicating CSCs and treating various types of cancers.In conclusion,the ability of TQ to potentiate the anticancer activity of many chemotherapeutic agents and sensitize cancer cells to radiotherapy makes it a promising molecule that could be used in combination therapy to overcome resistance to standard chemotherapeutic agents and reduce their associated toxicities.

A Study of Xi Jinping Thought on Governing the Country Based on the Unity of “Party Spirit-People’s Nature”

The unity of “party spirit-people’s nature” is the basic proposition of Xi Jinping’s governance.Deng Xiaoping summarized the experience and lessons in the early days of reform and opening up,and put forward the basic line of the “leadership and unity” of the party in the early stage of socialism around “one center,two basic points”;Xi Jinping’s so-called “unification”,which is based on the the basic line of Deng Xiaoping’s initial stage of building a socialist country that is “rich,strong,democratic,civilized,harmonious and beautiful”,has further established the importance of “people as the center” and “party’s leadership”.Therefore,the “people-centered” and “the party’s overall leadership” are unified and become the basic idea of General Secretary Xi Jinping’s governance of the country.Xi Jinping has put forward the unity of “party spirit-people’s nature”,the “consistency” between governing the country and politics,and the “integration” between the people’s interests and the party’s leadership,thus forming “persistence”,“comprehensive”,“confidence”,“maintenance” and other assertions.

Numerical Investigation of Combined Production of Natural Gas Hydrate and Conventional Gas

Natural gas hydrate(NGH)is generally produced and accumulated together with the underlying conventional gas.Therefore,optimizing the production technology of these two gases should be seen as a relevant way to effectively reduce the exploitation cost of the gas hydrate.In this study,three types of models accounting for the coexistence of these gases are considered.Type A considers the upper hydrate-bearing layer(HBL)adjacent to the lower conventional gas layer(CGL);with the Type B a permeable interlayer exists between the upper HBL and the lower CGL;with the type C there is an impermeable interlayer between the upper HBL and the lower CGL.The production performances associated with the above three models are calculated under different conditions,including only a depressurized HBL(only HBL DP);only a depressurized CGL(only CGL DP);and both the HBL and the CGL being depressurized(HBL+CGL DP).The results show that for Type A and Type B coexistence accumulation models,when only HBL or CGL is depressurized,the gas from the other layer will flow into the production layer due to the pressure difference between the two layers.In the coexistence accumulation model of type C,the cumulative gas production is much lower than that of Type A and Type B,regardless of whether only HBL DP,only CGL DP,or HBL+CGL DP are considered.This indicates that the impermeable interlayer restricts the cross-flow of gas between HBL and CGL.For three different coexistence accumulation models,CGL DP has the largest gas-to-water ratio.

Antitumor effect of thymoquinone combined with resveratrol on mice transplanted with breast cancer

Objective:To test the anticancer potential activity of the combination of thymoquinone(TQ)and resveratrol(RES) against breast cancer in mice.Methods:The antiproliferative activity of TQ.RES and their combination was assessed against three breast cancer cell lines and one normal cells using MTT assay.The combination index was calculated using isobolographic method.Balb/C mice were inoculated with EMT6/P cells and in vivo antitumor activity was evaluated.Results:The combination therapy caused significant decrease in tumor size with a percentage cure of 60%.The combination therapy induced geographic necrosis,enhanced apoptosis,and decreased VEGF expression.Serum levels of IFN-y were elevated in mice treated with combination therapy with no liver and kidney toxicity.Conclusions:The combination of TQ and RES against breast cancer in mice can work synergistically.The anticancer effect of this combination is mediated by apoptosis induction,angiogenesis inhibition and immune modulation.

Natural Products in Cancer Therapy: Past, Present and Future

Natural products,with remarkable chemical diversity,have been extensively investigated for their anticancer potential for more than a half-century.The collective efforts of the community have achieved the tremendous advancements,bringing natural products to clinical use and discovering new therapeutic opportunities,yet the challenges remain ahead.With remarkable changes in the landscape of cancer therapy and growing role of cutting-edge technologies,we may have come to a crossroads to revisit the strategies to understand nature products and to explore their therapeutic utility.This review summarizes the key advancements in nature product-centered cancer research and calls for the implementation of systematic approaches,new pharmacological models,and exploration of emerging directions to revitalize natural products search in cancer therapy.

Thermodynamic analysis and combined cycle research on recoverable pressure energy in natural gas pipeline

Current research and ways of capturing mechanical energy are discussed in this paper. By the aid of the comprehensive thermodynamic analysis and Aspen simulation tool, the amount of a vailable work that can be produced from capturing the pressure energy has been calculated. Based on the comprehensive thermodynamic analysis, two systems have been proposed to capture pressure energy of natural gas to generate electricity. In this study, the expression of exergy is given which can be used in evaluating purposes. A problem with this multidisciplinary study is the complicated boundary condition. In conclusion, a technical prospect on recoverable natural gas pressure energy has been presented based on total energy system theory.

Immune evasion and therapeutic opportunities based on natural killer cells

Natural killer(NK)cells can elicit an immune response against malignantly transformed cells without recognizing antigens,and they also exhibit cytotoxic effects and immune surveillance functions in tumor immunotherapy.Although several studies have shown the promising antitumor effects of NK cells in immunotherapy,their function is often limited in the tumor microenvironment because tumor cells can easily escape NK cell-induced death.Thus,for efficient tumor immunotherapy,the mechanism by which tumor cells escape NK cell-induced cytotoxicity must be fully understood.Various novel molecules and checkpoint receptors that mediate the disruption of NK cells in the tumor microenvironment have been discovered.In this review,we analyze and detail the major activating and inhibitory receptors on the surface of NK cells to delineate the mechanism by which tumor cells suppress NKG2D ligand expression and increase tumor receptor and inhibitory receptor expression[NKG2A,programmed cell death1(PD-1),and T-cell immunoglobulin and immunoreceptor tyrosine inhibitory motif(TIGIT)]on the NK cell surface,and thus inhibit NK cell activity.We also reviewed the current status of treatments based on these surface molecules.By comparing the therapeutic effects related to the treatment status and bypass mechanisms,we attempt to identify optimal single or combined treatments to suggest new treatment strategies for tumor immunotherapy.

Inorganic phosphate in the development and treatment of cancer:A Janus Bifrons?

Inorganic phosphate(Pi) is an essential nutrient to living organisms. It is required as a component of the energy metabolism,kinase/phosphatase signaling and in the formation and function of lipids,carbohydrates and nucleic acids and,at systemic level,it plays a key role for normal skeletal and dentin mineralization. Pi represents an abundant dietary element and its intestinal absorption is efficient,minimally regulated and typically extends to approximately 70%. Maintenance of proper Pi homeostasis is a critical event and serum Pi level is maintained within a narrow range through an elaborate network of humoral interactions and feedback loops involving intestine,kidney,parathyroid gland and bone,and depends on the activity of a number of hormones,including parathyroid hormone,1,25-dihydroxy vitamin D,and fibroblast growth factor 23 as major regulators of Pi homeostasis. Notably,Pi intake seemingly continues to increase as a consequence of chronic high-phosphorus(P) diets deriving from the growing consumption of highly processed foods,especially restaurant meals,fast foods,and convenience foods. Several recent reports have generated significant associations between high-P intake or high-serum Pi concentration and morbidity and mortality. Many chronic diseases,including cardiovascular diseases,obesity and even cancer have been proposed to be associated with high-P intakes and high-serum Pi concentrations. On the other hand,there is also evidence that Pi can have antiproliferative effects on some cancer cell types,depending on cell status and genetic background and achieve additive cytotoxic effects when combined with doxorubicin,illustrating its potential for clinical applications and suggesting that up-regulating Pi levels at local sites for brief times,might contribute to the development of novel and cheap modalities for therapeutic intervention in some tumours. Overall,the influence of Pi on cell function and the possible relationship to cancer have to be fully understood and investigated further.

Formation conditions and exploration direction of large and medium gas reservoirs in the Junggar Basin, NW China

The Junggar Basin is rich in oil but lacks natural gas, which is inconsistent with its geological background of natural gas. Based on the analysis of main source kitchens, and the evaluation of geological setting and controlling factors of gas accumulation, it is proposed that three significant fields for gas exploration should be emphasized. The first field is the Carboniferous volcanic rocks. The Carboniferous residual sags and large-scale reservoirs were developed in three active continental margins, i.e., the southeastern, northeastern and northwestern active continental margins. Gas accumulation is controlled by the favorable reservoir-caprock combinations composed of volcanic rocks and their superimposed lacustrine mudstones in the Upper Wuerhe Formation. Dinan, Eastern and Zhongguai uplifts are three favorable directions for natural gas exploration. The second field is the Lower combinations in the southern margin of Junggar Basin. Rows of structural traps were developed in this area with ideal preservation conditions and space-time configuration for trap-source combinations. Sets of clastic reservoirs and overpressured mudstones formed perfect reservoir-caprock combinations which are the main exploration direction for Jurassic coal-type gas reservoirs in this area. The seven large structural traps in the middle-east section are recently the most significant targets. The last field is the Central Depression. Large hydrocarbon generating centers, i.e., Mahu, Fukang and Shawan sags, were developed in this area, their source rocks were deeply buried and at highly-mature stage. Thus the Central Depression is a favorable exploration direction for Permian high-over mature gas fields(reservoirs). Great attentions should be paid to two types of targets, the deeply–buried structures and structural-lithologic traps. Based on three main gas systems, gas exploration is suggested be strengthened within three fields and on three levels.

Phenotypic Characteristics and Function of NK Cell Subsets in cART-Treated HIV-1-Infected Individuals

Natural killer (NK) cell plays an important role in an innate immune response against viral infection. The kinetics regulation and functional consequences of NK cells in the pathogeneses of diseases are uncertain. We analyzed NK cell distribution and function of successfully combination antiretroviral therapy (cART)-treated HIV-1 infected individuals in Khon Kaen Regional Hospital, Thailand. The results demonstrated that increased percentage and the total number of NK cell in cART-treated HIV-1 infected patients with preferential high levels of CD56dimCD16+ and CD56-CD16+ subsets when compared with a control group even in undetectable viral load (<40 copies per milliliter). Concomitantly, decreased cytotoxic activity measured by CD107asurface expression with maintained IFN-γ production implied the impairment of cytolytic activity was not recovered after cART treatment. Thus, altered NK cell frequency and function by HIV-1 infection are not completely recovered with cART, which may contribute to impaired cellular immune response and persistence of HIV-1.

Effects of combined spinal-epidural anesthesia on anxiety,labor analgesia and motor blocks in women during natural delivery

BACKGROUND The background of this study was analgesia in natural delivery.The combined spinal-epidural anesthesia has obvious analgesic effect on the parturients in natural labor,and combined spinal-epidural anesthesia has been widely used in anesthesia for various diseases.AIM To study the effects of combined spinal-epidural anesthesia on anxiety,labor analgesia,and motor blocks in parturients during natural delivery.METHODS A total of 120 women who gave birth at Changning District Maternal and Child Health Hospital between December 2021 to December 2022 were included;a random number table approach was employed to divide the women into a control group and a joint group,with each group consisting of 60 women.The control group was given epidural anesthesia,while the joint group was given combined spinal-epidural anesthesia.The visual analog scale(VAS)was used to evaluate the degree of maternal pain.Comparisons were made between the two groups’conditions of childbirth and the duration of labor.Apgar scores were used to evaluate the status of the newborns at birth;Self-rating Anxiety Scale(SAS)and General Self-Efficacy Scale(GSES)scores,umbilical artery blood gas analysis indices and stress indices were compared between the two groups;and the frequencies of motor block and postpartum complications were analyzed.RESULTS In comparison to the control group,in the joint group,the VAS scores for the first,second,and third stages of labor were lower(P<0.05).The rates of conversion to cesarean section and postpartum blood loss in the joint group were lower than those in the control group(P<0.05).No significant differences were observed in the Apgar score,the duration of the first stage of labor,or the total duration of labor between the two groups(P>0.05).The second and third stages of labor in the joint group were shorter than those in the control group(P<0.05).When compared to the control group,the postpartum SAS score of the joint group was lower,while the GSES score was greater(P<0.05).Between the control group and the joint group,the differences observed in pH,arterial carbon dioxide partial pressure,arterial oxygen partial pressure,or arterial hydrogen ion concentration were not significant(P>0.05).Nitric oxide,cortisol,and adrenaline levels were lower in the joint group than in the control group(P<0.05).There were no substantial differences in Bromage grade or rate of complications between the two groups(P>0.05).CONCLUSION For parturients during natural delivery,combined spinal-epidural anesthesia can reduce anxiety,provide labor analgesia,shorten labor time,and reduce postoperative stress levels but did not result in a motor block.

Integration Possibility of Urban Public Bus System and Cable Car in Maribor

Combination of a bus system and cable car system can reduce the overall congestion of traffic in urban areas, where surrounding hills or mountains hold larger settlements or tourist and recreational infrastructure. With this kind of integration number of individual car trips can be significantly reduced. In this paper, the authors present an analysis of the pilot project implementation, which was held in Maribor. The authors conducted a limited test trial of two means of transportation, combining them into a single operating transport offer for inhabitants and tourists. Combined transport option proved to be a good starting point for reduction of traffic and parking congestion during winter tourist season and beyond. Method used in the research, in order to gain actual potential of integrating two systems and improving public transport offer, was establishment and implementation of the pilot project in Maribor during January 2011. Data was gathered through interviews of two interest groups. The first covered the users who were brought to the foothills of Pohorje＇s ski center by bus. The second covered the cable car users that were traveling to the top of Pohorje. For a limited time period, a trial principle of a single ticket was established, which gave ski-pass holders free bus ride on bus line No. 6. With the aim of reducing CO2, test drives of hybrid bus and compressed natural gas bus were conducted alongside many promotional activities with which users were informed of importance of environmentally friendly mobility options.

Technical and Economic Aspects and Experience from 6 Years of Operating the Technology Using the Waste Heat from the Exhaust Gases of Heat Sources and 3 Years of Operating a Heating Plant in an Autonomous, Island Regime

This article is focused on technical and economic evaluation of more than 6-years experiences of operating the Waste Heat Recovery technology—the manner and system of flue gas processing generated in the combustion process in heat & power plants, cogeneration units, etc., which burn the gaseous fuel, primarily natural gas, or methane, biogas, geothermal gas, or other gaseous mixtures containing hydrogen. The solution proposes a more effective and non-traditional use of gaseous fuel for heating, the flue gases of which are processed in order to extract additional utilisable heat, with potential elimination of CO2 from them. Deploying of the heating plant in an island regime (OFF-GRID) enables definition of the benefits brought by the 3 years of operational experience and presents visions for the future offering the possibility to utilise the support energy services at the municipal as well as regional level.

A Hierarchical Combination Method for Computer Understanding of Chinese Language

On the basis of the characteristics of Chinese language such.as simple and uniform structure, distinct hierarchy and construction by word order and function words, and in the view of the human cognitive mechanism, a hierarchical combination method for computer understanding of Chinese language is put forward in this paper. By this method, the whole information of a sentence is hierarchically combined from the partial information of the basic units of it, with the unification operation under attribute description frames. This method is perfect in combining syntax analysis with semantic analysis, easy to implement, and very suitable for the computer understanding system for processing Chinese language.

Thymoquinone anticancer activity is enhanced when combined with royal jelly in human breast cancer

BACKGROUND Breast cancer is the most common cause of the majority of cancer-related deaths in women,among which triple-negative breast cancer is the most aggressive type of breast cancer diagnosed with limited treatment options.Thymoquinone(TQ),the main bioactive constituent of Nigella sativa,has been extensively studied as a potent anticancer molecule against various types of cancers.Honeybee products such as the royal jelly(RJ),the nutritive secretion fed to honeybee queens,exhibit a variety of biological activities besides its anticancer effect.However,the anticancer activity of the combination of TQ and RJ against breast cancer is still unknown.AIM To investigate cytotoxicity of RJ in FHs 74 Int cells and the anticancer effects of TQ,RJ,and their combinations in the MDA-MB-231 cell line.METHODS Cells were treated with TQ,RJ,and their combinations for 24 h.Using 3-(4,5 dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay,we determined the half-maximal inhibitory concentration of TQ.Trypan blue and 3-(4,5 dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays were then performed to assess the cell viability in response to different treatment conditions.Cell death and cycle regulation were investigated using propidium iodide deoxyribonucleic acid staining followed by flow cytometry in response to a single dose of TQ,RJ,and their combination.Immunostaining for cleaved caspase 3 and Ki67 expression was used to determine apoptosis induction and changes in cell proliferation.RESULTS TQ alone inhibited cell viability in a dose-dependent manner at concentrations below and above the half-maximal inhibitory concentration.RJ exhibited relatively nontoxic effects against MDA-MB-231 cells and FHs 74 Int small intestinal cells at concentrations below 5μg/mL.High doses of RJ(200μg/mL)had greater toxicity against MDA-MB-231 cells.Interestingly,the inhibition of cell viability was most pronounced in response to 15μmol/L TQ and 5μg/mL RJ.A dose of 15μmol/L TQ caused a significant increase in the PreG1 population,while a more pronounced effect on cell viability inhibition and PreG1 increase was observed in response to TQ and RJ combinations.TQ was the main inducer of caspase 3-dependent apoptosis when applied alone and in combination with RJ.In contrast,no significant regulation of Ki67 expression was observed,indicating that the decrease in cell viability was due to apoptosis induction rather than to inhibition of cell proliferation.CONCLUSION This study is the first to report enhanced anticancer effects of TQ and RJ combination against MDA-MB-231 breast cancer cells,which could confer an advantage for cancer therapy.

Historical Course Follows Climate Change: Patterns of the Northern Hemisphere — From Peoples’ Migration until the Industrial Revolution (3^rd-18^thCentury)

This paper relates to the statement that the so-called “Little Ice Age” (RCC 6: 1.350-1.800 A.D.) represents—besides the 8k-Event (8.200-8.000 yr cal. B.P.)—the fastest and strongest onset in Holocene History [1]. Its intention focuses on the correlation of interplaying natural processes (i.e. solar energy variation, aerosols, oceanic currents, volcanism as part of plate tectonics, heat flow) with social/political evidence through the time-span of Peoples’ Migration until Industrial Revolution (3rd-18th Century). The time-span comprises the cool/wet/respectively dry climate phase of the P.M. (260-550), a Climate Optimum (600-1.100 A.D.) owning a final Thermal Maximum (1.100-1.260 A.D.) and the “little Ice Age” (1.350-1.800 A.D.), the latter intercalated by the Sp&#246;rer Minimum (1.460-1.550 A.D.) and the Maunder Minimum (1.650-1.720 A.D.). Thereby, an average temperature difference of 1.0&#176;C - 2.0&#176;C seems sufficient for incising climatic/cultural consequences [2]. It has become obvious that a Climate Optimum primarily provides constructive life conditions;however with a problematic final as the following “Effect-Chain” tells: balanced agricultural/cultural population growth → rich harvests → satisfying nourishment → health, encouragement → overpopulation under favorable materialistic conditions → increasing stress → lack of food, high prices → revolts → migration. In contrast, cool/wet/resp. dry conditions originate destructive/depressive conditions (see Peoples’ Migration) which initiate the following “Effect Chain”: bad agricultural conditions → poor/no harvesting → famine → disease, growing death rate → social, political revolts, wars → human cruelties with psychic/religious background (inquisition, witch-combustion → general chaos (30 yr-war) → death, migration (maritime endeavors, colonization). Furthermore, it should be stressed that volcanic aerosols play besides the solar influx variation—an important role on climate/cultural change [3]. However, the effects of oceanic currents’ heat flow of Mid-Oceanic Ridges and Hot Spots, as well as Earth-Magnetism and Sun/Earth Geometry are poorly understood in this context (Example: Iceland as hot spot situated on the Mid-Atlantic Ridge having been working since 40 Ma). The Chapter-introducing citations play a challenging role in regard to Science Criticism and touch the so-called 95% Confidence line (accepted realm of causal interrelation and according recommendation to Society [4]).

Dynamic simulation of hydrodynamic model of drum level wave action and sloshing

In order to build the model of the drum level wave action and sloshing, based on the method of modularization modeling, the hydrodynamic model of drum level wave action and sloshing was developed, and dynamic simulation researches were carried out based on the model. The results indicate that both drum level and drum length have functional relations with period of drum level wave action and sloshing. When the drum level decreases or drum length increases, the period of drum level wave action and sloshing increases, density of liquid and number of sub-module division have little influence on the period of drum level wave action and sloshing. The model was validated by the analytical solution theory of liquid’s wave action and sloshing in cuboid container, and the 3D graphics of drum level wave action and sloshing was also obtained. The model can dynamically reflect the rules of wave action and sloshing of water in the container exactly.

Theory of pleiotropic action of biologically active compounds and medicines—Basic principles and practical application

This article represents the main positions of the theory of pleiotropic action of biologically active compounds (BACs) and medicines, which has been designed by the author based on her own experimental researches. The term “pleiotropy” means the ability of the BACs and medicines to implement more than one mechanism of action resulting in the specific biological (pharmacological) effect. The interaction of these mechanisms forms a distinct pattern of biological response (pleiotropic pattern), which reflects the change in his character with the increased dose (concentration)-dependent efficacy of BACs and medicines. The article consists of description of different pleiotropic patterns established in experiments on the model of reactive oxygen species (ROS) generation by macrophages dependent on activity of specialized enzyme called Nox2-NAD(P)H oxidase (Nox2, EC 1.6.3.1). Moreover, it consists of explanation of pharmacodynamic nature of pleiotropic patterns by means of application Chou-Talalay median effect equalization and combination index (CI) theory. The novel theory explains unsolved until now universal aspects of activity BACs and medicines, such as slope angles of “dose-effect” dependences in the conditions relevant in vivo, and it is of fundamental interest. However, it has applications in experimental pharmacology, as it allows defining the choice of the individual compounds and combinations, modulating the trust effect selectively and efficiently. This knowledge opens up new approaches to medicines discovery and evaluation, their rational dosing and combining.