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Micro-macro fracture mechanism of heterogeneous granite in percussive drilling
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作者 Wei-Ji Liu Yan-Fei Wang +1 位作者 Zhao-Wang Dan Xiao-Hua Zhu 《Petroleum Science》 SCIE EI CSCD 2023年第5期3131-3142,共12页
The conventional rotary rock breaking method faces a technical bottleneck in improving the rate of penetration(ROP)in deep hard formations.Percussive drilling is the most potential approach to increase rock-breaking e... The conventional rotary rock breaking method faces a technical bottleneck in improving the rate of penetration(ROP)in deep hard formations.Percussive drilling is the most potential approach to increase rock-breaking efficiency and ROP.However,the rock-breaking mechanism of percussive drilling is still unclear enough,especially the micro-fracture mechanism of rock under confining pressure(under lateral pressure and hydraulic pressure).In this paper,the impact rock breaking experiments by four kinds of Polycrystalline Diamond Compact(PDC)cutters are carried out using a drop-weight impact testing machine and an acoustic emission(AE)recording system,the influence of parameters such as cutter shape,rake angle,and impact energy on rock-breaking are systematically analyzed.This study includes a numerical simulation to examine the process of crack initiation,propagation,and cuttings formation during the impact process with the consideration of confining pressure.The results show the conicalshaped cutter is the most aggressive with high breaking efficiency.The penetration depth of the cutter is mainly influenced by the impact energy and cutter shape than the rake angle of the cutter.There exists critical impact energy makes the rock breaking efficiency the highest.The critical impact energy is about 40 J when using the conical-shaped cutter with a rake angle of 15°.The rock mainly failed in tensile mode,and the inter-grain crack is the main crack.Hydraulic pressure can inhibit the formation of horizontal cracks,while lateral pressure can inhibit the formation of vertical cracks and reduce the proportion of tensile cracks.The research results can provide some reference and basis for improving the rock-breaking efficiency in deep hard formations. 展开更多
关键词 percussive drilling PFC Rock fragmentation characteristics Rock breaking efficiency
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Bifurcations and the penetrating rate analysis of a model for percussive drilling 被引量:3
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作者 Qing-Jie Cao Marian Wiercigroch +1 位作者 Ekaterina Pavlovskaia Shao-Pu Yang 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 2010年第3期467-475,共9页
In this paper, we investigate a low dimensional model of percussive drilling with vibro-impact to mimic the nonlinear dynamics of the bounded progression. Non- holonomity which arises in the stick-slip caused by the i... In this paper, we investigate a low dimensional model of percussive drilling with vibro-impact to mimic the nonlinear dynamics of the bounded progression. Non- holonomity which arises in the stick-slip caused by the impact during drilling fails to be correctly identified via the classical techniques. A reduced model without non-holono- mity is derived by the introduction of a new state variable, of which averaging technique is employed successfully to detect the periodic motions. Local bifurcations are presented directly by using C-L method. Numerical simulations and the penetrating rate analysis along different choices of parame- ters have been carried out to probe the nonlinear behaviour and the optimal penetrating rate of the drilling system. 展开更多
关键词 BIFURCATION CHAOS Non-holonomity percussive drilling
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Evaluation of the energy efficiency of rotary percussive drilling using dimensionless energy index 被引量:3
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作者 V.N.Oparin V.N.Karpov +1 位作者 V.V.Timonin A.I.Konurin 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2022年第5期1486-1500,共15页
This paper sets forth a geomechanics framework for assessing the energy efficiency of rotary percussive drilling using the energy criterion, which has been proposed by Victor Oparin for volumetric destruction of high-... This paper sets forth a geomechanics framework for assessing the energy efficiency of rotary percussive drilling using the energy criterion, which has been proposed by Victor Oparin for volumetric destruction of high-stress rocks having nonuniform physico-mechanical properties. We review the long-term research and development in the specified area of science and technology, including research and development projects implemented at the Institute of Mining, Siberian Branch of the Russian Academy of Sciences. A new modified expression of Oparin’s dimensionless energy criterion of volumetric rock destruction k is introduced. The range of in situ values is determined for the energy criterion of volumetric rock destruction at the optimized energy efficiency of rotary percussive drilling. The temporospatial intervals of geotechnical monitoring are found to control pneumatic drilling energy efficiency at subsoil use objects in Russia. The integrated experimental, theoretical and geotechnical approach to the comprehensive investigation of real-time processes of rock fracture in rotary percussive drilling using the energy concept possesses the necessary geomechanical performance-and-technology potential to create the next level geotechnical monitoring of drilling systems for various purposes, including determination of physico-mechanical properties and the stress-strain analysis of rock mass in full-scale drilling. 展开更多
关键词 Rotary percussive drilling Geotechnical monitoring Drilling machine Energy criterion Energy efficiency
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Exploration and determination of the principles of rotary-percussive underground slimhole drilling 被引量:1
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作者 Shadrina Anastasija Saruev Lev 《International Journal of Mining Science and Technology》 SCIE EI 2014年第2期245-249,共5页
A possibility of the efficient use of rotary percussive drilling to provide drilling smaller diameter holes(40–70 mm) both in mining and prospecting is disclosed herein. A new construction designed for the nipple thr... A possibility of the efficient use of rotary percussive drilling to provide drilling smaller diameter holes(40–70 mm) both in mining and prospecting is disclosed herein. A new construction designed for the nipple thread connection is described. The relative amplitude variation, change of power pulse time and energy in their propagation throughout the drilling tool are determined. A possibility of the efficient power pulse transfer along the drill string to the rock destruction tools with new nipple connections which allow automating the make-up and breakout system of drill pipe was supported by experiments. 展开更多
关键词 Rotary-percussive drilling Smaller diameter holes Drill string Nipple thread connection Power pulse percussive energy
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Percussive Acupuncture and Cupping Treatment for the 28 Cases of the injury of the Flabs
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作者 Ye Lihan(No.1 People’s hospital, Zhao qing City.Guangdong) 《中国针灸》 CAS CSCD 北大核心 1995年第S2期291-291,共1页
PercussiveAcupunctureandCuppingTreatmentforthe28CasesoftheinjuryoftheFlabs¥YeLihan(No.1People'shospital,Zhao... PercussiveAcupunctureandCuppingTreatmentforthe28CasesoftheinjuryoftheFlabs¥YeLihan(No.1People'shospital,ZhaoqingCity.Guangdon... 展开更多
关键词 ACUPUNCTURE CASES CUPPING Flabs percussive TREATMENT and for INJURY of
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Study of Penetration Boundary Conditions in Percussive Rock Drilling
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作者 单仁亮 安保全 高文蛟 《International Journal of Mining Science and Technology》 SCIE EI 1998年第1期69-73,共5页
Tkis paper makes a synthetic analysis on the varying laws of four parameters of force, velocity, displacement and momentum, and indicates that rock fragmenting is not instantaneously produced but is by a process of ac... Tkis paper makes a synthetic analysis on the varying laws of four parameters of force, velocity, displacement and momentum, and indicates that rock fragmenting is not instantaneously produced but is by a process of accumulative damage. The relationship between incideut wave form and force-displacement ckaracteristfor is also inqulred into in this paper, and then it is proposed that conditions at the bit-rock interface cau be represeuted with displacement-impulse relationship. 展开更多
关键词 ROCK fragmenting percussive PENETRATION BOUNDARY CONDITION
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A novel experimental system for performance evaluation of water powered percussive rock drill
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作者 李夕兵 李志国 +1 位作者 周梓荣 刘希灵 《Journal of Central South University》 SCIE EI CAS 2011年第6期1902-1909,共8页
A set of water powered excavation test system was developed for the comprehensive performance testing and evaluation of water powered percussive rock drill indoors. The whole system contains hydraulic power section, e... A set of water powered excavation test system was developed for the comprehensive performance testing and evaluation of water powered percussive rock drill indoors. The whole system contains hydraulic power section, electronic control system, test and data acquisition system, and assistant devices, such as guideway and drilling bench. Parameters of the water powered percussive rock drill can be obtained by analyzing testing data, which contain impact energy, front and back cavity pressure, pressure and flow in each working part, drilling velocity, frequency and energy efficiency etc. The system is applied to test the self-designed water powered percussive rock drill SYYG65. The parameters of water powered percussive rock drill with impact pressure of about 8.9 MPa are 58.93 J for impact energy, and 8.97% for energy efficiency, which prove the effectiveness of system. 展开更多
关键词 water powered percussive rock drill performance test water powered excavation comprehensive evaluation
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Effects of intrapulmonary percussive ventilation on airway mucus clearance: A bench model 被引量:1
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作者 Lorena Fernandez-Restrepo Lauren Shaffer +3 位作者 Bravein Amalakuhan Marcos I Restrepo Jay Peters Ruben Restrepo 《World Journal of Critical Care Medicine》 2017年第3期164-171,共8页
AIM To determine the ability of intrapulmonary percussive ventilation(IPV) to promote airway clearance in spontaneously breathing patients and those on mechanical ventilation.METHODS An artificial lung was used to sim... AIM To determine the ability of intrapulmonary percussive ventilation(IPV) to promote airway clearance in spontaneously breathing patients and those on mechanical ventilation.METHODS An artificial lung was used to simulate a spontaneously breathing patient(Group 1), and was then connected to a mechanical ventilator to simulate a patient on mechanical ventilation(Group 2). An 8.5 mm endotracheal tube(ETT) connected to the test lung, simulated the patient airway. Artificial mucus was instilled into the mid-portion of the ETT. A filter was attached at both ends of the ETT to collect the mucus displaced proximally(mouth-piece filter) and distally(lung filter). The IPV machine was attached to the proximal end of the ETT and was applied for 10-min each to Group 1 and 2. After each experiment, the weight of the various circuit components were determined and compared to their dry weights to calculate the weight of the displaced mucus.RESULTS In Group 1(spontaneously breathing model), 26.8% ± 3.1% of the simulated mucus was displaced proximally, compared to 0% in Group 2(the mechanically ventilated model) with a P-value of < 0.01. In fact, 17% ± 1.5% of the mucus in Group 2 remained in the mid-portion of the ETT where it was initially instilled and 80% ± 4.2% was displaced distally back towards the lung(P < 0.01). There was an overall statistically significant amount of mucusmovement proximally towards the mouth-piece in the spontaneously breathing(SB) patient. There was also an overall statistically significant amount of mucus movement distally back towards the lung in the mechanically ventilated(MV) model. In the mechanically ventilated model, no mucus was observed to move towards the proximal/mouth piece section of the ETT. CONCLUSION This bench model suggests that IPV is associated with displacement of mucus towards the proximal mouthpiece in the SB patient, and distally in the MV model. 展开更多
关键词 MUCUS SPUTUM Mechanical VENTILATORS PERCUSSION Respiratory drainage Breathing EXERCISES
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Numerical Simulation of Impact on Pneumatic DTH Hammer Percussive Drilling 被引量:17
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作者 卜长根 瞿叶高 +1 位作者 程志强 刘宝林 《Journal of Earth Science》 SCIE CAS CSCD 2009年第5期868-878,共11页
The process of DTH(down-the-hole) hammer drilling has been characterized as a very complex phenomenon due to its high nonlinearity,large deformation and damage behaviors.Taking brittle materials(concrete,granite an... The process of DTH(down-the-hole) hammer drilling has been characterized as a very complex phenomenon due to its high nonlinearity,large deformation and damage behaviors.Taking brittle materials(concrete,granite and sandstone) as impact specimens,the explicit time integration nonlinear finite element code LS-DYNA was employed to analyze the impact process and the penetration boundary conditions of DTH hammer percussive drilling system.Compared with previous studies,the present model contains several new features.One is that the 3D effects of DTH hammer drilling system were considered.Another important feature is that it took the coupling effects of brittle materials into account to the bit-specimen boundary of the drilling system.This distinguishes it from the traditional approaches to the bit-rock intersection,in which nonlinear spring models are usually imposed.The impact forces,bit insert penetrations and force-penetration curves of concrete,granite and sandstone under DTH hammer impact have been recorded;the formation of craters and fractures has been also investigated.The impact loads of piston-bit interaction appear to be relatively sensitive to piston impact velocity.The impact between piston-bit interaction occurs at two times larger forces,whereas the duration of the first impact doesn't change with respect to the piston velocity.The material properties of impact specimen do not affect the first impact process between the piston and bit.However,the period between the two impacts and the magnitudes of the second impact forces greatly depend on the specimen material properties.It is found that the penetration depth of specimen is dependent on the impact force magnitude and the macro-mechanical properties of the brittle materials. 展开更多
关键词 pneumatic DTH hammer percussive drilling LS-DYNA brittle material impactforce-penetration curve.
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Framework on robotic percussive riveting for aircraft assembly automation 被引量:10
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作者 Feng-Feng Xi Lin Yu Xiao-Wei Tu 《Advances in Manufacturing》 SCIE CAS 2013年第2期112-122,共11页
Presented in this paper is a framework for the implementation of a robotic percussive riveting system, a new robot application for aircraft assembly. It is shown here that a successful robot application to the automat... Presented in this paper is a framework for the implementation of a robotic percussive riveting system, a new robot application for aircraft assembly. It is shown here that a successful robot application to the automation of a process requires in-depth research of the process and the interaction with the robot. For this purpose, a process plan- ning-driven approach is proposed to guide a robot applica- tion research. A typical process planning will involve a list of key considerations including: process sequence, process parameters, process tooling, and process control. Through this list, a number of key research issues are identified for robotic percussive riveting, such as rivet pattern planning, rivet time determination, rivet tooling design and rivet insertion control. The detailed research on these issues has effectively created know-how for the successful implemen- tation of our robotic percussive riveting system. 展开更多
关键词 Aircraft assembly Assembly automation Robotic riveting percussive riveting Process planning
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Research on Improvement Strategies of Psychological Training and Stage Expressiveness in Percussion Performance
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作者 Yu Yan 《Journal of Contemporary Educational Research》 2024年第10期240-246,共7页
With the continuous development of music education,percussion,as an important form of performance,has led to growing attention to the psychological training of its performers.This study aims to explore how psychologic... With the continuous development of music education,percussion,as an important form of performance,has led to growing attention to the psychological training of its performers.This study aims to explore how psychological factors in percussion performance impact stage expressiveness and to propose corresponding psychological training strategies.By analyzing relevant domestic and international literature,we found that psychological training not only enhances performers’confidence and alleviates performance anxiety but also contributes to an overall improvement in performance quality.This study shows that methods such as emotional management and cognitive restructuring exhibit promising application potential in practice.Therefore,exploring a systematic psychological training program is significant for improving the stage expressiveness of percussion performers. 展开更多
关键词 Percussion performance techniques Psychological training Stage expressiveness Emotional management Cognitive restructuring
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Experimental studies on rock failure mechanisms under impact load by single polycrystalline diamond compact cutter
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作者 Zhao-Sheng Ji Jin-Bao Jiang +1 位作者 Huai-Zhong Shi Bang-Min Li 《Petroleum Science》 SCIE EI CSCD 2023年第5期3100-3109,共10页
Percussive drilling shows excellent potential for promoting the rate of penetration(ROP)in drilling hard formations.Polycrystalline diamond compact(PDC)bits account for most of the footage drilled in the oil and gas f... Percussive drilling shows excellent potential for promoting the rate of penetration(ROP)in drilling hard formations.Polycrystalline diamond compact(PDC)bits account for most of the footage drilled in the oil and gas fields.To reveal the rock failure mechanisms under the impact load by PDC bits,a series of drop tests with a single PDC cutter were conducted to four kinds of rocks at different back rake angles,drop heights,drop mass,and drop times.Then the morphology characteristics of the craters were obtained and quantified by using a three-dimensional profilometer.The fracture micrographs can be observed by using scanning electron microscope(SEM).The distribution and propagation process of subsurface cracks were captured in rock-like silica glass by a high-speed photography system.The results can indicate that percussive drilling has a higher efficiency and ROP when the rock fractures in brittle mode.The failure mode of rock is related with the type of rock,the impact speed,and the back rake angle of the cutter.Both the penetration depth and fragmentation volume get the maximum values at a back rake angle of about 45°.Increasing the weight and speed of falling hammer is beneficial to improving the rock breaking effects and efficiency.The subsurface cracks under the impact load by a single PDC cutter is shaped like a clamshell,and its size is much larger than the crater volume.These findings can help to shed light on the rock failure mechanisms under the impact of load by a single PDC cutter and provide a theoretical explanation for better field application of percussive drilling. 展开更多
关键词 percussive drilling PDC cutter Drop test Failure mechanism Subsurface cracks
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Crack-free high-aspect ratio holes in glasses by top–down percussion drilling with infrared femtosecond laser GHz-bursts 被引量:3
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作者 Pierre Balage John Lopez +2 位作者 Guillaume Bonamis Clemens Hönninger Inka Manek-Hönninger 《International Journal of Extreme Manufacturing》 SCIE EI CAS CSCD 2023年第1期193-200,共8页
We report novel results on top-down percussion drilling in different glasses with femtosecond laser GHz-bursts.Thanks to this particular regime of light–matter interaction,combining non-linear absorption and thermal ... We report novel results on top-down percussion drilling in different glasses with femtosecond laser GHz-bursts.Thanks to this particular regime of light–matter interaction,combining non-linear absorption and thermal cumulative effects,we obtained crack-free holes of aspect ratios exceeding 30 in sodalime and 70 in fused silica.The results are discussed in terms of inner wall morphology,aspect ratio and drilling speed. 展开更多
关键词 femtosecond laser glass GHz-bursts percussion drilling
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Penetration and impact resistance of PDC cutters inclined at different attack angles 被引量:3
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作者 李夕兵 《中国有色金属学会会刊:英文版》 CSCD 2000年第2期275-279,共5页
In order to develop a rotary percussive bit with diamond enhanced cutters assisted by high pressure water jets, it is necessary to study the damage mechanism and the penetration properties of PDC cutters subject to di... In order to develop a rotary percussive bit with diamond enhanced cutters assisted by high pressure water jets, it is necessary to study the damage mechanism and the penetration properties of PDC cutters subject to different impact load level and rock types. Therefore the impact experiments of the single PDC cutters with different attack angles in four rocks: black basalt, Missouri red granite, Halston limestone, and a very soft (Roubidoux) sandstone were carried out, and the effects of rake angles of PDC cutters on both the penetration and impact resistance of PDC cutters have been discussed in detail. Test results show that a PDC insert can withstand a very strong impact in compression but is easily damaged by impact shearing, the PDC cutters are more easily damaged by shearing if the attack angles are relatively small, the 45? PDC cutters have the least penetration resistance among the cutters tested. Thus it is suggested that the attack angles of PDC cutters should be larger than 30? for bits which must withstand impact from a hammer. 展开更多
关键词 PDC cutters PENETRATION and impact RESISTANCE ROTARY percussive DRILL BITS
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East and West: Different Perceptions of Effective Ethos Exhibited in Chinese and American College Students' Persuasive Essays
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作者 LIU Ying-qin 《Sino-US English Teaching》 2013年第6期439-451,共13页
This paper studies how different cultural values and rhetorical traditions may influence students' perceptions and understanding of effective ethos in persuasive essays. Fifty Chinese EFL (English as a foreign langu... This paper studies how different cultural values and rhetorical traditions may influence students' perceptions and understanding of effective ethos in persuasive essays. Fifty Chinese EFL (English as a foreign language) college students and 50 American college students participated in writing English persuasive essays on the selected topics. The essays were then compared for similarities and differences in the use of rhetorical appeals with a focus on ethos, the credibility, and trustworthiness of an author. The study revealed that participants from both groups established ethos as an important rhetorical tool to persuade the audience to accept their viewpoints. However, they displayed different perceptions of what effective ethos entailed. For Chinese participants, effective ethos seemed to come from using detailed explanations that reflected an author's intention to advocate an ethical or moral message based on some Chinese cultural values. But, strong ethos for American participants appeared to mean the use of evidence--facts and personal testimony--to establish the writer's trustworthiness. The interpretation of the results from the perspective of different cultural value orientations was also discussed. 展开更多
关键词 ETHOS percussive essays cultural values intercultural rhetoric
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Polydatin prevents the induction of secondary brain injury after traumatic brain injury by protecting neuronal mitochondria 被引量:13
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作者 Li Li Hong-Ping Tan +8 位作者 Cheng-Yong Liu Lin-Tao Yu Da-Nian Wei Zi-Chen Zhang Kui Lu Ke-Sen Zhao Marc Maegele Dao-Zhang Cai Zheng-Tao Gu 《Neural Regeneration Research》 SCIE CAS CSCD 2019年第9期1573-1582,共10页
Polydatin is thought to protect mitochondria in different cell types in various diseases.Mitochondrial dysfunction is a major contributing factor in secondary brain injury resulting from traumatic brain injury.To inve... Polydatin is thought to protect mitochondria in different cell types in various diseases.Mitochondrial dysfunction is a major contributing factor in secondary brain injury resulting from traumatic brain injury.To investigate the protective effect of polydatin after traumatic brain injury,a rat brain injury model of lateral fluid percussion was established to mimic traumatic brain injury insults.Rat models were intraperitoneally injected with polydatin(30 mg/kg)or the SIRT1 activator SRT1720(20 mg/kg,as a positive control to polydatin).At 6 hours post-traumatic brain injury insults,western blot assay was used to detect the expression of SIRT1,endoplasmic reticulum stress related proteins and p38 phosphorylation in cerebral cortex on the injured side.Flow cytometry was used to analyze neuronal mitochondrial superoxide,mitochondrial membrane potential and mitochondrial permeability transition pore opened.Ultrastructural damage in neuronal mitochondria was measured by transmission electron microscopy.Our results showed that after treatment with polydatin,release of reactive oxygen species in neuronal mitochondria was markedly reduced;swelling of mitochondria was alleviated;mitochondrial membrane potential was maintained;mitochondrial permeability transition pore opened.Also endoplasmic reticulum stress related proteins were inhibited,including the activation of p-PERK,spliced XBP-1 and cleaved ATF6.SIRT1 expression and activity were increased;p38 phosphorylation and cleaved caspase-9/3 activation were inhibited.Neurological scores of treated rats were increased and the mortality was reduced compared with the rats only subjected to traumatic brain injury.These results indicated that polydatin protectrd rats from the consequences of traumatic brain injury and exerted a protective effect on neuronal mitochondria.The mechanisms may be linked to increased SIRT1 expression and activity,which inhibits the p38 phosphorylation-mediated mitochondrial apoptotic pathway.This study was approved by the Animal Care and Use Committee of the Southern Medical University,China(approval number:L2016113)on January 1,2016. 展开更多
关键词 nerve REGENERATION TRAUMATIC brain injury POLYDATIN MITOCHONDRIA endoplasmic reticulum stress SIRT1 reactive oxygen species p38 MITOCHONDRIAL membrane potential MITOCHONDRIAL permeability transition pore lateral fluid PERCUSSION neural REGENERATION
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The pig as a preclinical traumatic brain injury model:current models,functional outcome measures,and translational detection strategies 被引量:8
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作者 Holly A.Kinder Emily W.Baker Franklin D.West 《Neural Regeneration Research》 SCIE CAS CSCD 2019年第3期413-424,共12页
Traumatic brain injury(TBI) is a major contributor of long-term disability and a leading cause of death worldwide. A series of secondary injury cascades can contribute to cell death, tissue loss, and ultimately to the... Traumatic brain injury(TBI) is a major contributor of long-term disability and a leading cause of death worldwide. A series of secondary injury cascades can contribute to cell death, tissue loss, and ultimately to the development of functional impairments. However, there are currently no effective therapeutic interventions that improve brain outcomes following TBI. As a result, a number of experimental TBI models have been developed to recapitulate TBI injury mechanisms and to test the efficacy of potential therapeutics. The pig model has recently come to the forefront as the pig brain is closer in size, structure, and composition to the human brain compared to traditional rodent models, making it an ideal large animal model to study TBI pathophysiology and functional outcomes. This review will focus on the shared characteristics between humans and pigs that make them ideal for modeling TBI and will review the three most common pig TBI models–the diffuse axonal injury, the controlled cortical impact, and the fluid percussion models. It will also review current advances in functional outcome assessment measures and other non-invasive, translational TBI detection and measurement tools like biomarker analysis and magnetic resonance imaging. The use of pigs as TBI models and the continued development and improvement of translational assessment modalities have made significant contributions to unraveling the complex cascade of TBI sequela and provide an important means to study potential clinically relevant therapeutic interventions. 展开更多
关键词 traumatic brain INJURY large animal MODEL PIG MODEL diffuse AXONAL INJURY FUNCTIONAL outcome assessment measures controlled cortical impact MODEL fluid percussion INJURY MODEL magnetic resonance imaging biomarkers
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Selective CDK inhibitors:promising candidates for future clinical traumatic brain injury trials 被引量:4
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作者 Shruti V.Kabadi Alan I.Faden 《Neural Regeneration Research》 SCIE CAS CSCD 2014年第17期1578-1580,共3页
Traumatic brain injury induces secondary injury that contributes to neuroinflammation, neuronal loss, and neurological dysfunction. One important injury mechanism is cell cycle activation which causes neuronal apoptos... Traumatic brain injury induces secondary injury that contributes to neuroinflammation, neuronal loss, and neurological dysfunction. One important injury mechanism is cell cycle activation which causes neuronal apoptosis and glial activation. The neuroprotective effects of both non-selective (Flavopiridol) and selective (Roscovitine and CR-8) cyclin-dependent kinase inhibitors have been shown across mukiple experimental traumatic brain injury models and species. Cyclin-depen- dent kinaseinhibitors, administered as a single systemic dose up to 24 hours after traumatic brain injury, provide strong neuroprotection-reducing neuronal cell death, neuroinflammation and neurological dysfunction. Given their effectiveness and long therapeutic window, cyclin-dependent kinase inhibitors appear to be promising candidates for clinical traumatic brain injury trials. 展开更多
关键词 cell cycle inhibition lateral fluid percussion Roscovitine CR-8 behavior microglial activation NEURODEGENERATION
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Cold water swimming pretreatment reduces cognitive deficits in a rat model of traumatic brain injury 被引量:4
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作者 Zi-wei Zhou Ya-dan Li +3 位作者 Wei-wei Gao Jie-li Chen Shu-yuan Yue Jian-ning Zhang 《Neural Regeneration Research》 SCIE CAS CSCD 2017年第8期1322-1328,共7页
A moderate stress such as cold water swimming can raise the tolerance of the body to potentially injurious events. However, little is known about the mechanism of beneficial effects induced by moderate stress. In this... A moderate stress such as cold water swimming can raise the tolerance of the body to potentially injurious events. However, little is known about the mechanism of beneficial effects induced by moderate stress. In this study, we used a classic rat model of traumatic brain injury to test the hypothesis that cold water swimming preconditioning improved the recovery of cognitive functions and explored the mechanisms. Results showed that after traumatic brain injury, pre-conditioned rats(cold water swimming for 3 minutes at 4℃) spent a significantly higher percent of times in the goal quadrant of cold water swim, and escape latencies were shorter than for non-pretreated rats. The number of circulating endothelial progenitor cells was significantly higher in pre-conditioned rats than those without pretreatment at 0, 3, 6 and 24 hours after traumatic brain injury. Immunohistochemical staining and Von Willebrand factor staining demonstrated that the number of CD34~+ stem cells and new blood vessels in the injured hippocampus tissue increased significantly in pre-conditioned rats. These data suggest that pretreatment with cold water swimming could promote the proliferation of endothelial progenitor cells and angiogenesis in the peripheral blood and hippocampus. It also ameliorated cognitive deficits caused by experimental traumatic brain injury. 展开更多
关键词 nerve regeneration cold water swimming cognitive deficits endothelial progenitor cells angiogenesis neural repair stress Morriswater maze fluid percussion injury model CD34 Von Willebrand factor neural regeneration
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Capacitor discharge percussion welding of pure aluminum wire to pure copper sheet 被引量:2
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作者 赵麦群 铃木实平 +2 位作者 川上博士 松山文彦 康晶 《China Welding》 EI CAS 2008年第3期66-71,共6页
This paper presents the results of a research into capacitor discharge percussion welding (CDPW) of pure aluminum wires and pure copper sheets, using percussion welding power and special welding device. A lot of CDP... This paper presents the results of a research into capacitor discharge percussion welding (CDPW) of pure aluminum wires and pure copper sheets, using percussion welding power and special welding device. A lot of CDPW factors, which will affect aluminum and copper dissimilar bonding, are described and these parameters have also been optimized. The fracture pull, interface compounds, microstructure and hardness are all studied. The results show that aluminum wire welding to copper sheet can form a sound weld and in some conditions the fracture pull is similar to that of the pure aluminum wires. The capacitance, discharge voltage, wire taper angle and machine oil as welding assistant medium affect fracture pull. The intermetaUic compounds A12 Cu appears on the copper side of joint. Narrower heat-affected zone is observed. 展开更多
关键词 percussion welding capacitor discharge dissimilar metals weld fracture pull
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