Purpose: To study the effects of perfluorodecalin on the cornea of the rabbit eyes. Methods: Perfluorodecalin (0.05 ml/each) was injected into the anterior chambers of eighteen rabbit eyes. Corneal morphology and endo...Purpose: To study the effects of perfluorodecalin on the cornea of the rabbit eyes. Methods: Perfluorodecalin (0.05 ml/each) was injected into the anterior chambers of eighteen rabbit eyes. Corneal morphology and endothelial cells were monitored clinically by slit-lamp biomicroscope and specular microscope for 26 weeks. Animals were sacrificed in 1 st, 2nd, 4th, 10th, 16th, 22nd, and 26th week after injection, respectively, and the corneas were examined under the light microscope. Results: Perfluorodecalin droplets looking like “ fish eggs ” were found at about 1/4-1/2 of the corneal height in the inferior anterior chamber. Corneal opacification on the area contacted with perfluorodecalin was observed in five eyes five weeks after injection, and all in the 22nd week. Mutton fat KPs in one eye were seen in the 6th week firstly, and in all eyes in the 7th week. Corneal pannus formation in one eye was present in the 4th week, two eyes in the 5th week and three eyes in the 6th week. Retrocorneal fibrous membrane in one eye was detected at the 6th week and 3 eyes at the 7th week respectively. After injection of perfluorodecalin, endothelial cell density was sighificantly decreased (2789 ± 192 vs. 2341 ± 658, P < O. O1 ) and corneal thickness was increased. Conclusions: Perfluorodecalin injected into anterior chamber can lead to corneal damage and inflammatory reaction. Eye Sciemce 2001; 17:16 - 20.展开更多
Objective To explore the methods of lens sparing (without lensectomy), non silicone oil tamponade and no scleral buckling for treatment of early giant retinal tears. Methods Thirteen cases of early retinal detachm...Objective To explore the methods of lens sparing (without lensectomy), non silicone oil tamponade and no scleral buckling for treatment of early giant retinal tears. Methods Thirteen cases of early retinal detachment of proliferative vitreoretinopathy (PVR) grade C 2 D 1, with giant tear extending from 135°to 270° were chosen. Transscleral cryotherapy was first applied to treat each end of the giant tear up to the oral serrate. And then conventional three port pars plana vitrectomy was performed. Perfluorodecalin liquid was injected to manipulate the flap of the retinal tear. The flap with no cryotherapy before was treated with endolaser or cryotherapy under optimal visual condition, then air fluid was exchanged completely and C 3F 8 was injected properly.Results With a mean follow up of 8.2 months, the retina was reattached completely in 12 eyes. Success rate was 92.3%, and visual acuity improved. Most postoperative complications were slight. The retina failed to reattach only in 1 case with severe vitreous blood. Conclusions In treating early retinal giant tears without severe PVR, the lens sparing, non silicone oil tamponade and no scleral bucking are helpful to simplify operation and to improve the success rate of the retinal surgery and to yield satisfactory outcome of visual acuity. Besides, it can also avoid the initial side effects of silicone oil tamponade and diopter irregularity after lensectomy.展开更多
Perfluoronaphthenes,with inert chemical and biological properties and ability to dissolve large amounts of oxygen,have received the most attention in medical applications.However,the excessive anion contained may caus...Perfluoronaphthenes,with inert chemical and biological properties and ability to dissolve large amounts of oxygen,have received the most attention in medical applications.However,the excessive anion contained may cause some side effects.Herein,liquid-liquid extraction technique with shaking and ultrasonic extraction was used for the trace analysis of five anions(F^(-),Cl^(-),NO_(3)^(-),PO_(4)^(3-),SO_(4)^(2-))in perfluorodecalin using water as green extractant.The optimum pretreatment technology and ion chromatography detection conditions were established.Good linearity was observed in each concentration range,and the linear correlation coefficient(R^(2))was better than 0.997.The limits of detection(S/N=3)of five anions from perfluorodecalin were 3.2,5.5,14.2,23.2 and 29.5μg/L,respectively.The established method with high sensitivity and accuracy has been successfully appliedfor the determination of five anions in three perfluorodecalin products,which provides a basis for further development of green detection and quality standard formulation in perfluorodecalin and other fluorocarbon solvents.展开更多
The chemical reduction and electro reduction behavior of perfluorodecalin have been investigated under the illumination of UV light. The IR spectra of the resulting products showed that the same functional group, acyl...The chemical reduction and electro reduction behavior of perfluorodecalin have been investigated under the illumination of UV light. The IR spectra of the resulting products showed that the same functional group, acyl fluoride, could be formed in both reduction processes. The results of 19 F NMR and UV vis spectra revealed that there were other different functional groups formed in the two reduction processes. In the electro chemical reduction , conjunctive double bonds could be formed in the same and different carbon ring. In the chemical reduction, using Zn and Mg as reducing agents, aromatic structure was formed in the products.展开更多
目的探讨全氟萘烷（Perfluorodecalin，PFDL）在睫状体扁平部玻璃体切除术（Pars Plana Vitrectormy，PPV）中的独特作用及在眼内长期残留时对眼组织的影响。方法回顾分析在PPV中应用PFDL的临床病例239例239只眼，其中裂孔源性视网膜脱...目的探讨全氟萘烷（Perfluorodecalin，PFDL）在睫状体扁平部玻璃体切除术（Pars Plana Vitrectormy，PPV）中的独特作用及在眼内长期残留时对眼组织的影响。方法回顾分析在PPV中应用PFDL的临床病例239例239只眼，其中裂孔源性视网膜脱离（retinal detachment，RD）130例，晶状体脱位于玻璃体腔4例，外伤性RD41例，增殖性糖尿病性视网膜病变导致玻璃体出血合并牵拉性RD21例，视网膜静脉栓塞和视网膜静脉周围炎导致玻璃体腔出血合并牵拉性RD27例，陈旧性脉络膜出血1例，急性视网膜坏死合并视网膜脱离2例，眼内炎3例，Coats病合并牵拉裂孔性RD1例，眼内填充硅油合并RD9例。采用PPV，膜剥离，PFDL使用，眼内激光，气液交换，惰性气体及硅油眼内填充。探讨防止PFDL眼内残留的方法，对黄斑裂孔或后极部裂孔采用“气液交换后置换PFDL法”，对巨大裂孔性视网膜脱离采用“PFDL联合部份气液交换法”，对360。视网膜切开采用“逐步使用PFDL法”。结果随访12～15个月，212例212只眼获得随访，视网膜复位181例181只眼，有效率85-37％，术后PFDL残留22只眼，随访期间，角膜、前房及视网膜均未见功能及结构上的改变。结论PFDL可有效地应用于PPV中，提高治疗巨大裂孔性视网膜脱离、外伤性视网膜脱离、眼内填充硅油合并RD等复杂性视网膜脱离的手术成功率，PFDL小滴在眼内长期存留，临床上未观察到明显眼部损害。展开更多
Hafnium（Ⅳ） bis（perfluorooctanesulfonyl）imide complex is found to be an efficient catalyst for the multicomponent condensation ofβ-naphthol,aromatic aldehydes and urea or amides in perfluorodecalin to afford the ...Hafnium（Ⅳ） bis（perfluorooctanesulfonyl）imide complex is found to be an efficient catalyst for the multicomponent condensation ofβ-naphthol,aromatic aldehydes and urea or amides in perfluorodecalin to afford the corresponding substituted amidomethyl naphthols in good yields.The remarkable features of this new procedure are high yields,shorter reaction times, reusability of catalyst and simple work-up procedures.展开更多
基金This Work was Supported by the Scientific Fund Of the Ministrv of Health of China.
文摘Purpose: To study the effects of perfluorodecalin on the cornea of the rabbit eyes. Methods: Perfluorodecalin (0.05 ml/each) was injected into the anterior chambers of eighteen rabbit eyes. Corneal morphology and endothelial cells were monitored clinically by slit-lamp biomicroscope and specular microscope for 26 weeks. Animals were sacrificed in 1 st, 2nd, 4th, 10th, 16th, 22nd, and 26th week after injection, respectively, and the corneas were examined under the light microscope. Results: Perfluorodecalin droplets looking like “ fish eggs ” were found at about 1/4-1/2 of the corneal height in the inferior anterior chamber. Corneal opacification on the area contacted with perfluorodecalin was observed in five eyes five weeks after injection, and all in the 22nd week. Mutton fat KPs in one eye were seen in the 6th week firstly, and in all eyes in the 7th week. Corneal pannus formation in one eye was present in the 4th week, two eyes in the 5th week and three eyes in the 6th week. Retrocorneal fibrous membrane in one eye was detected at the 6th week and 3 eyes at the 7th week respectively. After injection of perfluorodecalin, endothelial cell density was sighificantly decreased (2789 ± 192 vs. 2341 ± 658, P < O. O1 ) and corneal thickness was increased. Conclusions: Perfluorodecalin injected into anterior chamber can lead to corneal damage and inflammatory reaction. Eye Sciemce 2001; 17:16 - 20.
文摘Objective To explore the methods of lens sparing (without lensectomy), non silicone oil tamponade and no scleral buckling for treatment of early giant retinal tears. Methods Thirteen cases of early retinal detachment of proliferative vitreoretinopathy (PVR) grade C 2 D 1, with giant tear extending from 135°to 270° were chosen. Transscleral cryotherapy was first applied to treat each end of the giant tear up to the oral serrate. And then conventional three port pars plana vitrectomy was performed. Perfluorodecalin liquid was injected to manipulate the flap of the retinal tear. The flap with no cryotherapy before was treated with endolaser or cryotherapy under optimal visual condition, then air fluid was exchanged completely and C 3F 8 was injected properly.Results With a mean follow up of 8.2 months, the retina was reattached completely in 12 eyes. Success rate was 92.3%, and visual acuity improved. Most postoperative complications were slight. The retina failed to reattach only in 1 case with severe vitreous blood. Conclusions In treating early retinal giant tears without severe PVR, the lens sparing, non silicone oil tamponade and no scleral bucking are helpful to simplify operation and to improve the success rate of the retinal surgery and to yield satisfactory outcome of visual acuity. Besides, it can also avoid the initial side effects of silicone oil tamponade and diopter irregularity after lensectomy.
基金supported by the Zibo Key Scientific Research program(2019gy010020)the Jinan Customs Science and Technology Plan(2020JK012)
文摘Perfluoronaphthenes,with inert chemical and biological properties and ability to dissolve large amounts of oxygen,have received the most attention in medical applications.However,the excessive anion contained may cause some side effects.Herein,liquid-liquid extraction technique with shaking and ultrasonic extraction was used for the trace analysis of five anions(F^(-),Cl^(-),NO_(3)^(-),PO_(4)^(3-),SO_(4)^(2-))in perfluorodecalin using water as green extractant.The optimum pretreatment technology and ion chromatography detection conditions were established.Good linearity was observed in each concentration range,and the linear correlation coefficient(R^(2))was better than 0.997.The limits of detection(S/N=3)of five anions from perfluorodecalin were 3.2,5.5,14.2,23.2 and 29.5μg/L,respectively.The established method with high sensitivity and accuracy has been successfully appliedfor the determination of five anions in three perfluorodecalin products,which provides a basis for further development of green detection and quality standard formulation in perfluorodecalin and other fluorocarbon solvents.
文摘The chemical reduction and electro reduction behavior of perfluorodecalin have been investigated under the illumination of UV light. The IR spectra of the resulting products showed that the same functional group, acyl fluoride, could be formed in both reduction processes. The results of 19 F NMR and UV vis spectra revealed that there were other different functional groups formed in the two reduction processes. In the electro chemical reduction , conjunctive double bonds could be formed in the same and different carbon ring. In the chemical reduction, using Zn and Mg as reducing agents, aromatic structure was formed in the products.
文摘目的探讨全氟萘烷（Perfluorodecalin，PFDL）在睫状体扁平部玻璃体切除术（Pars Plana Vitrectormy，PPV）中的独特作用及在眼内长期残留时对眼组织的影响。方法回顾分析在PPV中应用PFDL的临床病例239例239只眼，其中裂孔源性视网膜脱离（retinal detachment，RD）130例，晶状体脱位于玻璃体腔4例，外伤性RD41例，增殖性糖尿病性视网膜病变导致玻璃体出血合并牵拉性RD21例，视网膜静脉栓塞和视网膜静脉周围炎导致玻璃体腔出血合并牵拉性RD27例，陈旧性脉络膜出血1例，急性视网膜坏死合并视网膜脱离2例，眼内炎3例，Coats病合并牵拉裂孔性RD1例，眼内填充硅油合并RD9例。采用PPV，膜剥离，PFDL使用，眼内激光，气液交换，惰性气体及硅油眼内填充。探讨防止PFDL眼内残留的方法，对黄斑裂孔或后极部裂孔采用“气液交换后置换PFDL法”，对巨大裂孔性视网膜脱离采用“PFDL联合部份气液交换法”，对360。视网膜切开采用“逐步使用PFDL法”。结果随访12～15个月，212例212只眼获得随访，视网膜复位181例181只眼，有效率85-37％，术后PFDL残留22只眼，随访期间，角膜、前房及视网膜均未见功能及结构上的改变。结论PFDL可有效地应用于PPV中，提高治疗巨大裂孔性视网膜脱离、外伤性视网膜脱离、眼内填充硅油合并RD等复杂性视网膜脱离的手术成功率，PFDL小滴在眼内长期存留，临床上未观察到明显眼部损害。
基金the project of"Excellence Initiative"and"Zijin Star"in NJUST for financial support
文摘Hafnium（Ⅳ） bis（perfluorooctanesulfonyl）imide complex is found to be an efficient catalyst for the multicomponent condensation ofβ-naphthol,aromatic aldehydes and urea or amides in perfluorodecalin to afford the corresponding substituted amidomethyl naphthols in good yields.The remarkable features of this new procedure are high yields,shorter reaction times, reusability of catalyst and simple work-up procedures.
