A knowledge of soil permeability is essential to evaluate hydrologic characteristics of soil, such as water storage and water movement, and soil permeability coefficient is an important parameter that reflects soil pe...A knowledge of soil permeability is essential to evaluate hydrologic characteristics of soil, such as water storage and water movement, and soil permeability coefficient is an important parameter that reflects soil permeability. In order to confirm the acceptability of the one-dimensional horizontal infiltration method(one-D method) for simultaneously determining both the saturated and unsaturated permeability coefficients of loamy sand, we first measured the cumulative infiltration and the wetting front distance under various infiltration heads through a series of one-dimensional horizontal infiltration experiments, and then analyzed the relationships of the cumulative horizontal infiltration with the wetting front distance and the square root of infiltration time. We finally compared the permeability results from Gardner model based on the one-D method with the results from other two commonly-used methods(i.e., constant head method and van Genuchten model) to evaluate the acceptability and applicability of the one-D method. The results showed that there was a robust linear relationship between the cumulative horizontal infiltration and the wetting front distance, suggesting that it is more appropriate to take the soil moisture content after infiltration in the entire wetted zone as the average soil moisture content than as the saturated soil moisture content. The results also showed that there was a robust linear relationship between the cumulative horizontal infiltration and the square root of infiltration time, suggesting that the Philip infiltration formula can better reflect the characteristics of cumulative horizontal infiltration under different infiltration heads. The following two facts indicate that it is feasible to use the one-D method for simultaneously determining the saturated and unsaturated permeability coefficients of loamy sand. First, the saturated permeability coefficient(prescribed in the Gardner model) of loamy sand obtained from the one-D method well agreed with the value obtained from the constant head method. Second, the relationship of unsaturated permeability coefficient with soil water suction for loamy sand calculated using Gardner model based on the one-D method was nearly identical with the same relationship calculated using van Genuchten model.展开更多
The steel slag (SS) permeable concrete was prepared by SS. The influences of the aggregate-cement rate, the aggregate particle size, the water-cement rate, the admixture dosage and other factors on the permeability ...The steel slag (SS) permeable concrete was prepared by SS. The influences of the aggregate-cement rate, the aggregate particle size, the water-cement rate, the admixture dosage and other factors on the permeability coefficient of SS permeable concrete were analyzed. The law of influence was also investigated. The study serves as a technological reference for the construction and design of SS permeable concrete.展开更多
The factors influencing the permeability coefficient of gravelly soils used for the development of embankment dams(core wall)are analyzed.Such factors include(but are not limited to)soil size,anisotropy,density and bo...The factors influencing the permeability coefficient of gravelly soils used for the development of embankment dams(core wall)are analyzed.Such factors include(but are not limited to)soil size,anisotropy,density and boundary effects.A review of the literature is conducted and new directions of research are proposed.In such a framework,it is shown that gravelly soil with controlled density and vertical stress should be used to optimize the measurement of the vertical and horizontal permeability coefficients,respectively.展开更多
A study evaluating the relationship between porosity and permeability coefficient for pervious concrete (PC) is presented. In addition, the effect of mixture design parameters particularly, water-to-cement ratio (W/C)...A study evaluating the relationship between porosity and permeability coefficient for pervious concrete (PC) is presented. In addition, the effect of mixture design parameters particularly, water-to-cement ratio (W/C) and size of aggregate on the permeability coefficient of PC was investigated. The PC mixtures were made with 4 range of W/C and 2 range size of aggregate. PC mixes were made from each aggregate and were tested. The results showed that the W/C and aggregate size are key parameters which significantly affect the characteristic performance of PC. Permeability coefficient of coarse pervious concrete (CPC) is bigger than fine pervious concrete (FPC) and the porosity of CPC are bigger than porosity of FPC. A regression model (RM) along with analysis of variance (ANOVA) was conducted to study the significance of porosity distribution on permeability coefficient of PC. The statistical model developed in this study can facilitate prediction permeability coefficient of CPC and FPC as the sustainable pavements.展开更多
Compressive stress and tensile stress were applied to concrete specimens using test rigs designed by RILEM TC 246-TDC. Ultrasonic wave velocity and autoclam permeability system were used to characterize the damage var...Compressive stress and tensile stress were applied to concrete specimens using test rigs designed by RILEM TC 246-TDC. Ultrasonic wave velocity and autoclam permeability system were used to characterize the damage variable and gas permeability coefficient of concrete, respectively. The experimental results show that the strain value of concrete increases with the increasing of stress level and loading time. The damage variable and gas permeability coefficient of concrete under compressive stress decrease at first and increase after a threshold value between 0 and 0.6. When the concrete is under tensile load, the damage variable and gas permeability coefficient increase with tensile stress, with a significant increase from 0.3 to 0.6 tensile stress. There is a strong linear relationship between the damage variable and the gas permeability coefficient, suggesting both as good indicators to characterize the damage of concrete under stress.展开更多
Owing to the fact that the conventional deterministic back analysis of the permeability coefficient cannot reflect the uncertainties of parameters, including the hydraulic head at the boundary, the permeability coeffi...Owing to the fact that the conventional deterministic back analysis of the permeability coefficient cannot reflect the uncertainties of parameters, including the hydraulic head at the boundary, the permeability coefficient and measured hydraulic head, a stochastic back analysis taking consideration of uncertainties of parameters was performed using the generalized Bayesian method. Based on the stochastic finite element method (SFEM) for a seepage field, the variable metric algorithm and the generalized Bayesian method, formulas for stochastic back analysis of the permeability coefficient were derived. A case study of seepage analysis of a sluice foundation was performed to illustrate the proposed method. The results indicate that, with the generalized Bayesian method that considers the uncertainties of measured hydraulic head, the permeability coefficient and the hydraulic head at the boundary, both the mean and standard deviation of the permeability coefficient can be obtained and the standard deviation is less than that obtained by the conventional Bayesian method. Therefore, the present method is valid and applicable.展开更多
Transdermal drug delivery not only has contributed immensely to medical practice, but has enjoyed enormous interest in the field of cosmetic and pharmaceutical industries. Nevirapine, a non‐nucleoside reverse transcr...Transdermal drug delivery not only has contributed immensely to medical practice, but has enjoyed enormous interest in the field of cosmetic and pharmaceutical industries. Nevirapine, a non‐nucleoside reverse transcriptase inhibitor (NNRTI) is used clinically for the treatment of HIV‐ 1 infection. The aim of the present study is to investigate the influence of cosolvents (glycerol, propylene glycol, ethanol, polyethylene glycol 400) and surfactants (polysorbate 20, polysorbate 80, sodium lauryl sulfate, sodium cholate and cetrimide) on the dermal permeability coefficient of nevirapine by utilizing established and recognized mathematical model that employs partition coefficient as one of its molecular descriptors. The partition coefficient of nevirapine is determined in chloroform-water system at room temperature using the shake flask method. The results show that all the cosolvents used in this study decrease the partition coefficient of nevirapine. The same decrease in the partition coefficient of nevirapine is observed with all the surfactants investigated. The order of dermal enhancement potential of the vehicles studied based on the predicted permeability coefficient is glycerol > propylene glycol > ethanol > polyethylene glycol 400 for the cosolvents while tween 20 > tween 80 > sodium lauryl sulfate > sodium cholate > cetrimide for the surfactants. The maximum predicted flux through skin was obtained by multiplying the predicted permeability coefficient and the drug aqueous solubility. As the rate of penetration into the skin is quantitatively assessed by the use of permeability coefficient, the findings suggest that for dermal formulation of nevirapine, glycerol and tween 20 are the most preferred vehicles out of the vehicles investigated. Furthermore, the results of the correlation coefficients obtained by plotting permeability coefficient or maximum predicted flux, versus logarithm partition coefficient indicate that permeability coefficient can be a more reliable parameter to predict transdermal absorption of nevirapine than flux.展开更多
During the operation of compressed air storage energy system,the rapid change of air pressure in a cavern will cause drastic changes in air density and permeability coefficient of sealing layer.To calculate and proper...During the operation of compressed air storage energy system,the rapid change of air pressure in a cavern will cause drastic changes in air density and permeability coefficient of sealing layer.To calculate and properly evaluate air tightness of polymer sealing caverns,the air-pressure-related air density and permeability must be considered.In this context,the high-pressure air penetration in the polymer sealing layer is studied in consideration of thermodynamic change of the cavern structure during the system operation.The air tightness model of compressed air storage energy caverns is then established.In the model,the permeability coefficient and air density of sealing layer vary with air pressure,and the effectiveness of the model is verified by field data in two test caverns.Finally,a compressed air storage energy cavern is taken as an example to understand the air tightness.The air leakage rate in the caverns is larger than that using air-pressure-independent permeability coefficient and air density,which is constant and small in the previous leakage rate calculation.Under the operating pressure of 4.5-10 MPa,the daily air leakage in the compressed air storage energy cavern of Yungang Mine with high polymer butyl rubber as the sealing material is 0.62%,which can meet the sealing requirements of compressed air storage energy caverns.The air tightness of the polymer sealing cavern is mainly affected by the cavern operating pressure,injected air temperature,cavern radius,and sealing layer thickness.The cavern air leakage rate will be decreased to reduce the cavern operating pressure the injection air temperature,or the cavern radius and sealing layer thickness will be increased.展开更多
The spewing of a screw conveyor easily occurs from the earth pressure balance(called EPB)shield in a water-rich sand stratum.This may lead to the collapse of the tunnel face and even serious subsidence of the ground s...The spewing of a screw conveyor easily occurs from the earth pressure balance(called EPB)shield in a water-rich sand stratum.This may lead to the collapse of the tunnel face and even serious subsidence of the ground surface.To understand the spewing mechanism of the shield screw conveyor and explore the critical hydraulic condition of soil spewing in a shield–soil chamber,a simplified theoretical model for the spewing of the screw conveyor was developed based on the equation of groundwater flow in the screw conveyor under turbulent state.Thus,coupling Darcy's law with Brinkman's equation,this model was implemented within the COMSOL Multiphysics framework.The underground water flow in the shield screw conveyor was simulated so as to obtain its velocity and flow rate.Numerical simulations show that the water pressure distribution is concentrated in the lower part of the soil chamber after the groundwater enters the soil chamber.When the groundwater enters the screw conveyor,its pressure gradually decreases along the direction of the screw conveyor.When the water flow reaches the stratum–shield interface,the flow velocity changes markedly:first increases and concentrates at the entrance of the lower soil chamber,plummets and stabilizes gradually,and increases again at the exit.The soil chamber and screw conveyor are significantly depressurized.It is also found that the soil permeability coefficient can be reduced to k<2.6×10^(−4)cm/s through appropriate soil improvement,which can effectively prevent the occurrence of spewing disasters.展开更多
To solve the cryogenic temperature problems faced by all-concrete liquefied natural gas(ACLNG)storage tanks during servicing,a low temperature resistant and high strength concrete(LHC)was designed from the perspective...To solve the cryogenic temperature problems faced by all-concrete liquefied natural gas(ACLNG)storage tanks during servicing,a low temperature resistant and high strength concrete(LHC)was designed from the perspectives of reducing water-binder ratio,removing coarse aggregates,optimizing composite mineral admixture and utilizing steel fibers.The variation laws of compressive and tensile strength,elastic modulus and Poisson’s ratio for C60 concrete and LHC were compared and analyzed under the temperatures from 10 to-165℃through uniaxial compression and tensile tests.The rapid freezing method was adopted to analyze the evolution process of mass and relative dynamic elastic modulus loss rates for C60 and LHC in 0-300 freeze-thaw cycles.The gas permeability test was carried out,and the laws of gas permeability coefficient varied with temperature and cryogenic freeze-thaw cycles were obtained.Then,the grey dynamic model GM(1,1)was used to predict the variation laws of physical and mechanical parameters on the basis of the test data.The test results demonstrate that the compressive strength,elastic modulus and Poisson’s ratio for both C60 and LHC increase significantly from 10 to-165℃,but the specific variation laws are difierent,and there is a phenomenon that some parameters decrease after reaching a critical temperature range for C60.The uniaxial tensile strength increases first and then decreases as temperature decreases,and finally increases slightly at-165℃for both C60 and LHC.The mass and relative dynamic elastic modulus loss rates of LHC are much lower than that of C60 under different freeze-thaw cycles.The gas permeability coefficient of C60 declines gradually with the drop of temperature,and increases gradually with the number of freeze-thaw cycles while the gas permeability coefficient of LHC basically remains stable and is much lower than that of C60.Therefore,such a conclusion can be drawn that LHC has better properties at cryogenic temperature.On the premise of providing consistent functional mode,GM(1,1)can predict the test data with high accuracy,which well reflects the variation laws of relevant parameters.展开更多
High-strength pervious concrete(HSPC) with porosity ranging from 0.08% to 2.011% was prepared. The mechanical properties and rainstorm waterlogging resistance of HSPC were evaluated,and a design method of HSPC pore ch...High-strength pervious concrete(HSPC) with porosity ranging from 0.08% to 2.011% was prepared. The mechanical properties and rainstorm waterlogging resistance of HSPC were evaluated,and a design method of HSPC pore characteristics(porosity and pore diameter) based on the mechanical properties and rainstorm waterlogging resistance was proposed. The results showed that the reduction of effective cross-sectional area caused by artificial channels was the main factor affecting flexural strength but had limited influence on compressive strength. Compared with the concrete matrix without artificial channels,the compressive strength of HSPC with porosity of 2.011% decreased by 7.4%, while the flexural strength decreased by 48.3%. The permeability coefficient of HSPC can reach 16.35 mm/s even at low porosity(2.011%).HSPC can meet the requirements of no rainstorm waterlogging, even if exposed to 100-year rainstorms. When the mechanical properties and rainstorm waterlogging resistance are compromised, the recommended porosity ranges from 1.1% to 3.5%, and the recommended pore diameter ranges from 0.8 to 2.7 mm.展开更多
Municipal sludge is a sedimentation waste produced during the wastewater process in sewage treatment plants.Among recent studies,pilot and field tests showed that chemical conditioning combined with vacuum preloading ...Municipal sludge is a sedimentation waste produced during the wastewater process in sewage treatment plants.Among recent studies,pilot and field tests showed that chemical conditioning combined with vacuum preloading can effectively treat municipal sludge.To further understand the drainage and consolidation characteristics of the conditioning sludge during vacuum preloading,a large deformation nonlinear numerical simulation model based on the equal strain condition was developed to simulate and analyze the pilot and field tests,whereas the simulation results were not satisfactory.The results of the numerical analysis of the pilot test showed that the predicted consolidation degree was greater than that measured by the field tests,which is attributed to the relatively low permeability layer formed during the preloading process of the prefabricated vertical drain.To better reflect the consolidation process of the conditioned sludge,a simplified analysis method considering the low permeability layer around the prefabricated vertical drain was proposed.The initial permeability coefficient of the low permeability layer is determined via numerical simulations using finite difference method.The predicted settlement curve was in good agreement with the measured results,which indicated that the numerical simulation based on the equal strain condition considering the relatively low permeability layer can better analyze the consolidation process of ferric chloride-conditioning sludge with vacuum preloading.展开更多
A high sensitive method based on liquid chromatography tandem mass spectrometry(LC-MS/MS) was developed and validated for the study of permeability of danshensu(DS) and paeoniflorin(PF) in Caco-2 intestinal abso...A high sensitive method based on liquid chromatography tandem mass spectrometry(LC-MS/MS) was developed and validated for the study of permeability of danshensu(DS) and paeoniflorin(PF) in Caco-2 intestinal absorption model. The DS and PF were extracted from cell culture by vacuum-lyophilizing and then separated on a Zorbax Stable Bond C18 column with 0.1% acetic acid aqueous solution and methanol as mobile phase. Detection was carried out by negative electrospray ionization(ESI ) with selected reaction monitoring(SRM) mode. The apparent permeability coefficients(Papp) of DS and PF in Caco-2 cell medium were calculated and the effects of verapamil on the coefficients Papp of the two test compounds were also illustrated. The permeability of PF was much better than that of DS when the two compounds were administrated individually. Co-administration of DS and PF led to the decrease of the transport from apical side to basolateral side for both the compounds. However, the transport in the contrary direction were accelerated. It was also observed that verapamil could accelerate the transport of the test compounds from apical side to basolateral side. However, the absorption-enhanced effect of verapamil was attenuated when DS and PF were co-administrated. These observations suggest that both passive diffusion and active efflux involved in P-gp would effect the passage of DS and PF across Caco-2 cell monolayer. At the same time, the co-administration of DS and PF to an alteration of transport behavior, which suggests that the interaction must be taken into account when ‘n-in-one' samples were used in Caco-2 intestinal model.展开更多
Ported wall extensions are important hydraulic structures used to reduce crosscurrents in upper approaches to locks.The effect of such extensions located upstream of a solid guard wall on flow characteristics depends ...Ported wall extensions are important hydraulic structures used to reduce crosscurrents in upper approaches to locks.The effect of such extensions located upstream of a solid guard wall on flow characteristics depends on many factors,including geometric and hydraulic parameters.In this study,the hydraulic performance of ported wall extensions was experimentally investigated in terms of the permeability coefficient,expanding angle,extension length,and flow depth.The results demonstrate that the dimensionless maximum transverse velocity is closely related to the permeability coefficient,expanding angle,and flow depth.By contrast,the dimensionless eddy length mainly depends on the permeability coefficient,expanding angle,and extension length.Furthermore,the optimum permeability coefficient increases with the expanding angle or flow depth,and it is approximately constant for different extension lengths.These results have the potential to provide direct guidance for the design of effective ported wall extensions in upper approaches to locks.展开更多
This paper suggested a modified model of SLM which could improve its stability.In the model, an organic solution was sandwiched between two layers of supported film,which we called sandwich supported liquid membrane(S...This paper suggested a modified model of SLM which could improve its stability.In the model, an organic solution was sandwiched between two layers of supported film,which we called sandwich supported liquid membrane(SSLM).The transport experiments of La3+ were performed with SSLM containing HEH(EHP)as a carrier. The permeability coefficient (p) of La3+ were measured and some factors affecting the p were investigated. The results showed that if the pH of the feed was below 4.0,the p was increased with increasing in pH. The p was also increased when the strip acidity increases.Inspite of not enough satisfactory reproducibility on test result, the stability of the model was improved.展开更多
The extraction of La ̄(3+) with hollow fiber sandwich liquid membrane was described in present paper. The theoretical equations of mass transport for this system were deduced. The permeability coefficient p of mass tr...The extraction of La ̄(3+) with hollow fiber sandwich liquid membrane was described in present paper. The theoretical equations of mass transport for this system were deduced. The permeability coefficient p of mass transport and its related factors were observed experimentally. The p value was increased with increase of pH in the feed and became constant under the condition of pH over 4. The p value was the highest when the flow rate was at 30 ml/min. The value of the coefficient was lower than that of single hollow fiber supported liquid membrane under the same conditions, but the stability and concentrated capacity of the sandwich membrane was better.展开更多
Fine-grained sediments are Quaternary sediments with grain sizes of not more than 2 mm.They startfirst when meeting water,their stability is related to the initial water volume triggering debrisflow,and thus plays an ...Fine-grained sediments are Quaternary sediments with grain sizes of not more than 2 mm.They startfirst when meeting water,their stability is related to the initial water volume triggering debrisflow,and thus plays an important role in debrisflow hazards early warning.The permeability coefficient is the inter-controlled factor offine-grained sediment stability.However,there is no hyperspectral model for detecting thefine-grained sediment permeability coefficient in large areas,which seriously affects the progress of debrisflow hazards early warning.Therefore,it is of great significance to establish a hyperspectral detection model for the permeability coefficient offine-grained sediments.Taking Beichuan County,Southwestern China as the case,a permeability coefficient hyperspectral detection model was established.The results show that eight bands are sensitive to the permeability coefficient with correlation coefficient(R)of 0.6343.T-test on the model shows that P-a values for sensitive bands are all less than 0.05,indicating the established model has a good prediction ability with a precision of 85.83%.These sensitive bands also indicate the spectral characteristics of the permeability coefficient.Therefore,it provides a scientific basis forfine-grained sediment stability detection in large areas and lays a theoretical foundation for debrisflow hazards’early warning.展开更多
The building construction throughout world faces the defects from normal to heavy and destructive like cracks and fractures which cause damages and eventually collapses to heavy life losses alongside economical and fi...The building construction throughout world faces the defects from normal to heavy and destructive like cracks and fractures which cause damages and eventually collapses to heavy life losses alongside economical and financial.The cracks like structures are found in wall and columns also.For the aim of the study,the international experts have classified the minimum allowable standards of those defects which can not be harmful to buildings and other people living there.This research study has been administered to research the most reasons to research the causes of cracks during a newly completed and used buildings in where some distinct cracks appeared immediately and after some years.Often these cracks seem in almost in walls,columns,beams,and so-like structures having different patterns.the foremost useful and customary methods consisting of reconnaissance survey;building inspection and laboratory testing were wont to investigate the causes of those distinct cracks which will cause the formation of cracks were considered and analyzed by the utilization of reconnaissance survey,factors like width,pattern,and conditions of the cracks were identified during the building inspection stage and therefore the soil properties associated with the creation of cracks were determined during the laboratory test.supported the results of the study;there was no distinct evidence of things like a matured system which will cause the creation of cracks within the building;The pore water pressure during this sort of soil takes longer time to fade,which may be expressed by the very low value of the coefficient of permeability(1.90x 10-7 to 2.15 x 10-7 m/s)acquired from different soil samples collected from the study area.Hence the cracks during this sort of building were found to be caused by the settlement of the building thanks to the character of the predominant soil type that was found within the study area,all the cracks are active cracks with their width increasing with time and therefore the soils within the entire block of the building possessed high percentage of fine materials with high moisture content and plasticity indices.展开更多
The determination of inhomogeneous permeability coefficient was studied as a parameter-control inverse problem for parabolic-type equation in this paper. By virtue of PST, the solution of the inverse problem is conver...The determination of inhomogeneous permeability coefficient was studied as a parameter-control inverse problem for parabolic-type equation in this paper. By virtue of PST, the solution of the inverse problem is converted into an iteration procedure of solving a direct problem and solving a Fredholm integral equation of the first kind. Besides, Tikhonov normalization method is introduced to treat the uncertainty caused by the integral equation. Thus an algorithm for determining inhomogeneous permeability coefficient has been formulated and implemented. Numerical results show: (1) The algorithm presented in the paper is suitable to strongly inhomogeneous seepagel; (2) The additional information needed for solution is merely the seepage velocity on partical boundary, so that drill works can be reduced remarkably; (3) The algorithm is applicable to determining inhomogeneous transmission coefficients in groundwater engineering or other engineering.展开更多
基金funded by the National Basic Research Program of China (2013CB429902)the National Natural Science Foundation of China (U1303181, 41671032)
文摘A knowledge of soil permeability is essential to evaluate hydrologic characteristics of soil, such as water storage and water movement, and soil permeability coefficient is an important parameter that reflects soil permeability. In order to confirm the acceptability of the one-dimensional horizontal infiltration method(one-D method) for simultaneously determining both the saturated and unsaturated permeability coefficients of loamy sand, we first measured the cumulative infiltration and the wetting front distance under various infiltration heads through a series of one-dimensional horizontal infiltration experiments, and then analyzed the relationships of the cumulative horizontal infiltration with the wetting front distance and the square root of infiltration time. We finally compared the permeability results from Gardner model based on the one-D method with the results from other two commonly-used methods(i.e., constant head method and van Genuchten model) to evaluate the acceptability and applicability of the one-D method. The results showed that there was a robust linear relationship between the cumulative horizontal infiltration and the wetting front distance, suggesting that it is more appropriate to take the soil moisture content after infiltration in the entire wetted zone as the average soil moisture content than as the saturated soil moisture content. The results also showed that there was a robust linear relationship between the cumulative horizontal infiltration and the square root of infiltration time, suggesting that the Philip infiltration formula can better reflect the characteristics of cumulative horizontal infiltration under different infiltration heads. The following two facts indicate that it is feasible to use the one-D method for simultaneously determining the saturated and unsaturated permeability coefficients of loamy sand. First, the saturated permeability coefficient(prescribed in the Gardner model) of loamy sand obtained from the one-D method well agreed with the value obtained from the constant head method. Second, the relationship of unsaturated permeability coefficient with soil water suction for loamy sand calculated using Gardner model based on the one-D method was nearly identical with the same relationship calculated using van Genuchten model.
文摘The steel slag (SS) permeable concrete was prepared by SS. The influences of the aggregate-cement rate, the aggregate particle size, the water-cement rate, the admixture dosage and other factors on the permeability coefficient of SS permeable concrete were analyzed. The law of influence was also investigated. The study serves as a technological reference for the construction and design of SS permeable concrete.
基金The work is supported by National Key Research and Development Program of China(No.2017YFC0404803)Guizhou High-Level Innovative Talents Project[2018](No.5630)+2 种基金Guizhou Science and Support[2019](No.2869)State Key Laboratory of Simulation and Regulation of Water Cycle in River Basin(No.SKL2020ZY09)Science and Technology Project of Huaneng Group Headquarters(HNKJ17-H18).
文摘The factors influencing the permeability coefficient of gravelly soils used for the development of embankment dams(core wall)are analyzed.Such factors include(but are not limited to)soil size,anisotropy,density and boundary effects.A review of the literature is conducted and new directions of research are proposed.In such a framework,it is shown that gravelly soil with controlled density and vertical stress should be used to optimize the measurement of the vertical and horizontal permeability coefficients,respectively.
文摘A study evaluating the relationship between porosity and permeability coefficient for pervious concrete (PC) is presented. In addition, the effect of mixture design parameters particularly, water-to-cement ratio (W/C) and size of aggregate on the permeability coefficient of PC was investigated. The PC mixtures were made with 4 range of W/C and 2 range size of aggregate. PC mixes were made from each aggregate and were tested. The results showed that the W/C and aggregate size are key parameters which significantly affect the characteristic performance of PC. Permeability coefficient of coarse pervious concrete (CPC) is bigger than fine pervious concrete (FPC) and the porosity of CPC are bigger than porosity of FPC. A regression model (RM) along with analysis of variance (ANOVA) was conducted to study the significance of porosity distribution on permeability coefficient of PC. The statistical model developed in this study can facilitate prediction permeability coefficient of CPC and FPC as the sustainable pavements.
基金Funded by the National Natural Science Foundation of China(No.51320105016)
文摘Compressive stress and tensile stress were applied to concrete specimens using test rigs designed by RILEM TC 246-TDC. Ultrasonic wave velocity and autoclam permeability system were used to characterize the damage variable and gas permeability coefficient of concrete, respectively. The experimental results show that the strain value of concrete increases with the increasing of stress level and loading time. The damage variable and gas permeability coefficient of concrete under compressive stress decrease at first and increase after a threshold value between 0 and 0.6. When the concrete is under tensile load, the damage variable and gas permeability coefficient increase with tensile stress, with a significant increase from 0.3 to 0.6 tensile stress. There is a strong linear relationship between the damage variable and the gas permeability coefficient, suggesting both as good indicators to characterize the damage of concrete under stress.
基金supported by the National Natural Science Foundation of China (Grant No. 50579090)the National Basic Research Program of China (973 Program, Grant No. 2007CB714102)National Science and Technology Support Program of China (Program for the Eleventh Five-Year Plan, Grant No. 2006BAB04A06)
文摘Owing to the fact that the conventional deterministic back analysis of the permeability coefficient cannot reflect the uncertainties of parameters, including the hydraulic head at the boundary, the permeability coefficient and measured hydraulic head, a stochastic back analysis taking consideration of uncertainties of parameters was performed using the generalized Bayesian method. Based on the stochastic finite element method (SFEM) for a seepage field, the variable metric algorithm and the generalized Bayesian method, formulas for stochastic back analysis of the permeability coefficient were derived. A case study of seepage analysis of a sluice foundation was performed to illustrate the proposed method. The results indicate that, with the generalized Bayesian method that considers the uncertainties of measured hydraulic head, the permeability coefficient and the hydraulic head at the boundary, both the mean and standard deviation of the permeability coefficient can be obtained and the standard deviation is less than that obtained by the conventional Bayesian method. Therefore, the present method is valid and applicable.
文摘Transdermal drug delivery not only has contributed immensely to medical practice, but has enjoyed enormous interest in the field of cosmetic and pharmaceutical industries. Nevirapine, a non‐nucleoside reverse transcriptase inhibitor (NNRTI) is used clinically for the treatment of HIV‐ 1 infection. The aim of the present study is to investigate the influence of cosolvents (glycerol, propylene glycol, ethanol, polyethylene glycol 400) and surfactants (polysorbate 20, polysorbate 80, sodium lauryl sulfate, sodium cholate and cetrimide) on the dermal permeability coefficient of nevirapine by utilizing established and recognized mathematical model that employs partition coefficient as one of its molecular descriptors. The partition coefficient of nevirapine is determined in chloroform-water system at room temperature using the shake flask method. The results show that all the cosolvents used in this study decrease the partition coefficient of nevirapine. The same decrease in the partition coefficient of nevirapine is observed with all the surfactants investigated. The order of dermal enhancement potential of the vehicles studied based on the predicted permeability coefficient is glycerol > propylene glycol > ethanol > polyethylene glycol 400 for the cosolvents while tween 20 > tween 80 > sodium lauryl sulfate > sodium cholate > cetrimide for the surfactants. The maximum predicted flux through skin was obtained by multiplying the predicted permeability coefficient and the drug aqueous solubility. As the rate of penetration into the skin is quantitatively assessed by the use of permeability coefficient, the findings suggest that for dermal formulation of nevirapine, glycerol and tween 20 are the most preferred vehicles out of the vehicles investigated. Furthermore, the results of the correlation coefficients obtained by plotting permeability coefficient or maximum predicted flux, versus logarithm partition coefficient indicate that permeability coefficient can be a more reliable parameter to predict transdermal absorption of nevirapine than flux.
基金We acknowledge the funding support from the National Science Foundation of China(Grant No.52278402)the Young Scientist Project of the National Key Research and Development Program of China(Grant No.2021YFC2900600)the Fundamental Research Funds for the Central Universities of China(Grant No.22120220117).
文摘During the operation of compressed air storage energy system,the rapid change of air pressure in a cavern will cause drastic changes in air density and permeability coefficient of sealing layer.To calculate and properly evaluate air tightness of polymer sealing caverns,the air-pressure-related air density and permeability must be considered.In this context,the high-pressure air penetration in the polymer sealing layer is studied in consideration of thermodynamic change of the cavern structure during the system operation.The air tightness model of compressed air storage energy caverns is then established.In the model,the permeability coefficient and air density of sealing layer vary with air pressure,and the effectiveness of the model is verified by field data in two test caverns.Finally,a compressed air storage energy cavern is taken as an example to understand the air tightness.The air leakage rate in the caverns is larger than that using air-pressure-independent permeability coefficient and air density,which is constant and small in the previous leakage rate calculation.Under the operating pressure of 4.5-10 MPa,the daily air leakage in the compressed air storage energy cavern of Yungang Mine with high polymer butyl rubber as the sealing material is 0.62%,which can meet the sealing requirements of compressed air storage energy caverns.The air tightness of the polymer sealing cavern is mainly affected by the cavern operating pressure,injected air temperature,cavern radius,and sealing layer thickness.The cavern air leakage rate will be decreased to reduce the cavern operating pressure the injection air temperature,or the cavern radius and sealing layer thickness will be increased.
基金National Natural Science Foundation of China,Grant/Award Number:U1261212。
文摘The spewing of a screw conveyor easily occurs from the earth pressure balance(called EPB)shield in a water-rich sand stratum.This may lead to the collapse of the tunnel face and even serious subsidence of the ground surface.To understand the spewing mechanism of the shield screw conveyor and explore the critical hydraulic condition of soil spewing in a shield–soil chamber,a simplified theoretical model for the spewing of the screw conveyor was developed based on the equation of groundwater flow in the screw conveyor under turbulent state.Thus,coupling Darcy's law with Brinkman's equation,this model was implemented within the COMSOL Multiphysics framework.The underground water flow in the shield screw conveyor was simulated so as to obtain its velocity and flow rate.Numerical simulations show that the water pressure distribution is concentrated in the lower part of the soil chamber after the groundwater enters the soil chamber.When the groundwater enters the screw conveyor,its pressure gradually decreases along the direction of the screw conveyor.When the water flow reaches the stratum–shield interface,the flow velocity changes markedly:first increases and concentrates at the entrance of the lower soil chamber,plummets and stabilizes gradually,and increases again at the exit.The soil chamber and screw conveyor are significantly depressurized.It is also found that the soil permeability coefficient can be reduced to k<2.6×10^(−4)cm/s through appropriate soil improvement,which can effectively prevent the occurrence of spewing disasters.
基金National Key Research and Development Projects of China(No.2022YFB2602605)。
文摘To solve the cryogenic temperature problems faced by all-concrete liquefied natural gas(ACLNG)storage tanks during servicing,a low temperature resistant and high strength concrete(LHC)was designed from the perspectives of reducing water-binder ratio,removing coarse aggregates,optimizing composite mineral admixture and utilizing steel fibers.The variation laws of compressive and tensile strength,elastic modulus and Poisson’s ratio for C60 concrete and LHC were compared and analyzed under the temperatures from 10 to-165℃through uniaxial compression and tensile tests.The rapid freezing method was adopted to analyze the evolution process of mass and relative dynamic elastic modulus loss rates for C60 and LHC in 0-300 freeze-thaw cycles.The gas permeability test was carried out,and the laws of gas permeability coefficient varied with temperature and cryogenic freeze-thaw cycles were obtained.Then,the grey dynamic model GM(1,1)was used to predict the variation laws of physical and mechanical parameters on the basis of the test data.The test results demonstrate that the compressive strength,elastic modulus and Poisson’s ratio for both C60 and LHC increase significantly from 10 to-165℃,but the specific variation laws are difierent,and there is a phenomenon that some parameters decrease after reaching a critical temperature range for C60.The uniaxial tensile strength increases first and then decreases as temperature decreases,and finally increases slightly at-165℃for both C60 and LHC.The mass and relative dynamic elastic modulus loss rates of LHC are much lower than that of C60 under different freeze-thaw cycles.The gas permeability coefficient of C60 declines gradually with the drop of temperature,and increases gradually with the number of freeze-thaw cycles while the gas permeability coefficient of LHC basically remains stable and is much lower than that of C60.Therefore,such a conclusion can be drawn that LHC has better properties at cryogenic temperature.On the premise of providing consistent functional mode,GM(1,1)can predict the test data with high accuracy,which well reflects the variation laws of relevant parameters.
基金Funded by the National Natural Science Foundation of China (No. 51878081)Natural Science Foundation of Jiangsu Province (No. BK20220626)+1 种基金Changzhou Leading Innovative Talent Introduction and Cultivation Project (No. CQ20210085)Postgraduate Research and Practice Innovation Program of Jiangsu Province (No. KYCX21_2847)。
文摘High-strength pervious concrete(HSPC) with porosity ranging from 0.08% to 2.011% was prepared. The mechanical properties and rainstorm waterlogging resistance of HSPC were evaluated,and a design method of HSPC pore characteristics(porosity and pore diameter) based on the mechanical properties and rainstorm waterlogging resistance was proposed. The results showed that the reduction of effective cross-sectional area caused by artificial channels was the main factor affecting flexural strength but had limited influence on compressive strength. Compared with the concrete matrix without artificial channels,the compressive strength of HSPC with porosity of 2.011% decreased by 7.4%, while the flexural strength decreased by 48.3%. The permeability coefficient of HSPC can reach 16.35 mm/s even at low porosity(2.011%).HSPC can meet the requirements of no rainstorm waterlogging, even if exposed to 100-year rainstorms. When the mechanical properties and rainstorm waterlogging resistance are compromised, the recommended porosity ranges from 1.1% to 3.5%, and the recommended pore diameter ranges from 0.8 to 2.7 mm.
基金acknowledge the financial support from The National Natural Science Foundation No.Gk321002Foundation of Nanjing Hydraulic Research Institute No.Y320012.
文摘Municipal sludge is a sedimentation waste produced during the wastewater process in sewage treatment plants.Among recent studies,pilot and field tests showed that chemical conditioning combined with vacuum preloading can effectively treat municipal sludge.To further understand the drainage and consolidation characteristics of the conditioning sludge during vacuum preloading,a large deformation nonlinear numerical simulation model based on the equal strain condition was developed to simulate and analyze the pilot and field tests,whereas the simulation results were not satisfactory.The results of the numerical analysis of the pilot test showed that the predicted consolidation degree was greater than that measured by the field tests,which is attributed to the relatively low permeability layer formed during the preloading process of the prefabricated vertical drain.To better reflect the consolidation process of the conditioned sludge,a simplified analysis method considering the low permeability layer around the prefabricated vertical drain was proposed.The initial permeability coefficient of the low permeability layer is determined via numerical simulations using finite difference method.The predicted settlement curve was in good agreement with the measured results,which indicated that the numerical simulation based on the equal strain condition considering the relatively low permeability layer can better analyze the consolidation process of ferric chloride-conditioning sludge with vacuum preloading.
基金the National Basic Research Priorities Program of China(No. 2005CB523402)the Natural Science Foundation of Zhejiang Province,China(No.Y204418)the Program for New Century Excellent Talents in University of China (No.NCET-06-0515)
文摘A high sensitive method based on liquid chromatography tandem mass spectrometry(LC-MS/MS) was developed and validated for the study of permeability of danshensu(DS) and paeoniflorin(PF) in Caco-2 intestinal absorption model. The DS and PF were extracted from cell culture by vacuum-lyophilizing and then separated on a Zorbax Stable Bond C18 column with 0.1% acetic acid aqueous solution and methanol as mobile phase. Detection was carried out by negative electrospray ionization(ESI ) with selected reaction monitoring(SRM) mode. The apparent permeability coefficients(Papp) of DS and PF in Caco-2 cell medium were calculated and the effects of verapamil on the coefficients Papp of the two test compounds were also illustrated. The permeability of PF was much better than that of DS when the two compounds were administrated individually. Co-administration of DS and PF led to the decrease of the transport from apical side to basolateral side for both the compounds. However, the transport in the contrary direction were accelerated. It was also observed that verapamil could accelerate the transport of the test compounds from apical side to basolateral side. However, the absorption-enhanced effect of verapamil was attenuated when DS and PF were co-administrated. These observations suggest that both passive diffusion and active efflux involved in P-gp would effect the passage of DS and PF across Caco-2 cell monolayer. At the same time, the co-administration of DS and PF to an alteration of transport behavior, which suggests that the interaction must be taken into account when ‘n-in-one' samples were used in Caco-2 intestinal model.
基金This work was supported by the National Key Research and Development Program of China(Grant No.2018YFB1600403)the Natural Science Foundation of Chongqing,China(Grant No.cstc2020jcyj-bshX0043).
文摘Ported wall extensions are important hydraulic structures used to reduce crosscurrents in upper approaches to locks.The effect of such extensions located upstream of a solid guard wall on flow characteristics depends on many factors,including geometric and hydraulic parameters.In this study,the hydraulic performance of ported wall extensions was experimentally investigated in terms of the permeability coefficient,expanding angle,extension length,and flow depth.The results demonstrate that the dimensionless maximum transverse velocity is closely related to the permeability coefficient,expanding angle,and flow depth.By contrast,the dimensionless eddy length mainly depends on the permeability coefficient,expanding angle,and extension length.Furthermore,the optimum permeability coefficient increases with the expanding angle or flow depth,and it is approximately constant for different extension lengths.These results have the potential to provide direct guidance for the design of effective ported wall extensions in upper approaches to locks.
文摘This paper suggested a modified model of SLM which could improve its stability.In the model, an organic solution was sandwiched between two layers of supported film,which we called sandwich supported liquid membrane(SSLM).The transport experiments of La3+ were performed with SSLM containing HEH(EHP)as a carrier. The permeability coefficient (p) of La3+ were measured and some factors affecting the p were investigated. The results showed that if the pH of the feed was below 4.0,the p was increased with increasing in pH. The p was also increased when the strip acidity increases.Inspite of not enough satisfactory reproducibility on test result, the stability of the model was improved.
文摘The extraction of La ̄(3+) with hollow fiber sandwich liquid membrane was described in present paper. The theoretical equations of mass transport for this system were deduced. The permeability coefficient p of mass transport and its related factors were observed experimentally. The p value was increased with increase of pH in the feed and became constant under the condition of pH over 4. The p value was the highest when the flow rate was at 30 ml/min. The value of the coefficient was lower than that of single hollow fiber supported liquid membrane under the same conditions, but the stability and concentrated capacity of the sandwich membrane was better.
基金supported by the National Natural Science Foundation of China (Grant No. 50379046)the Doctoral Fund of the Ministry of Education of China (Grant No. A50221)
基金funded in part by the Innovative Research Program of the International Research Center of Big Data for Sustainable Development Goals[grant number CBAS2022IRP03]the National Natural Science Foundation of China[grant number 42071312]the Hainan Hundred Special Project[grant number 31,JTT[2018]].
文摘Fine-grained sediments are Quaternary sediments with grain sizes of not more than 2 mm.They startfirst when meeting water,their stability is related to the initial water volume triggering debrisflow,and thus plays an important role in debrisflow hazards early warning.The permeability coefficient is the inter-controlled factor offine-grained sediment stability.However,there is no hyperspectral model for detecting thefine-grained sediment permeability coefficient in large areas,which seriously affects the progress of debrisflow hazards early warning.Therefore,it is of great significance to establish a hyperspectral detection model for the permeability coefficient offine-grained sediments.Taking Beichuan County,Southwestern China as the case,a permeability coefficient hyperspectral detection model was established.The results show that eight bands are sensitive to the permeability coefficient with correlation coefficient(R)of 0.6343.T-test on the model shows that P-a values for sensitive bands are all less than 0.05,indicating the established model has a good prediction ability with a precision of 85.83%.These sensitive bands also indicate the spectral characteristics of the permeability coefficient.Therefore,it provides a scientific basis forfine-grained sediment stability detection in large areas and lays a theoretical foundation for debrisflow hazards’early warning.
文摘The building construction throughout world faces the defects from normal to heavy and destructive like cracks and fractures which cause damages and eventually collapses to heavy life losses alongside economical and financial.The cracks like structures are found in wall and columns also.For the aim of the study,the international experts have classified the minimum allowable standards of those defects which can not be harmful to buildings and other people living there.This research study has been administered to research the most reasons to research the causes of cracks during a newly completed and used buildings in where some distinct cracks appeared immediately and after some years.Often these cracks seem in almost in walls,columns,beams,and so-like structures having different patterns.the foremost useful and customary methods consisting of reconnaissance survey;building inspection and laboratory testing were wont to investigate the causes of those distinct cracks which will cause the formation of cracks were considered and analyzed by the utilization of reconnaissance survey,factors like width,pattern,and conditions of the cracks were identified during the building inspection stage and therefore the soil properties associated with the creation of cracks were determined during the laboratory test.supported the results of the study;there was no distinct evidence of things like a matured system which will cause the creation of cracks within the building;The pore water pressure during this sort of soil takes longer time to fade,which may be expressed by the very low value of the coefficient of permeability(1.90x 10-7 to 2.15 x 10-7 m/s)acquired from different soil samples collected from the study area.Hence the cracks during this sort of building were found to be caused by the settlement of the building thanks to the character of the predominant soil type that was found within the study area,all the cracks are active cracks with their width increasing with time and therefore the soils within the entire block of the building possessed high percentage of fine materials with high moisture content and plasticity indices.
文摘The determination of inhomogeneous permeability coefficient was studied as a parameter-control inverse problem for parabolic-type equation in this paper. By virtue of PST, the solution of the inverse problem is converted into an iteration procedure of solving a direct problem and solving a Fredholm integral equation of the first kind. Besides, Tikhonov normalization method is introduced to treat the uncertainty caused by the integral equation. Thus an algorithm for determining inhomogeneous permeability coefficient has been formulated and implemented. Numerical results show: (1) The algorithm presented in the paper is suitable to strongly inhomogeneous seepagel; (2) The additional information needed for solution is merely the seepage velocity on partical boundary, so that drill works can be reduced remarkably; (3) The algorithm is applicable to determining inhomogeneous transmission coefficients in groundwater engineering or other engineering.