The issue of education for people with disabilities has become of increasing concern. How can we effectively guarantee the basic right to education for persons with disabilities? Will the revised Regulation on Educati...The issue of education for people with disabilities has become of increasing concern. How can we effectively guarantee the basic right to education for persons with disabilities? Will the revised Regulation on Education for Persons with Disabilities meet their needs? This article takes the Regulation on Education for Persons with Disabilities as the core and compares it with the related special educational laws of the United States, Britain and Japan. The following conclusions were drawn from this study: In terms of educational concept, the three countries follow the concept of inclusive education, and pursue equity and educational justice. They not only pay attention to inclusive education but also focus on improving the quality of education for students with disabilities. All three countries focus on accommodating children with special needs, but each implements its programs in a different way. These practices can be used as reference for the development of a special needs education law in China.展开更多
Autoimmune hepatitis is an uncommon condition that affects both adults and children and is characterized by chronic and recurrent inflammatory activity in the liver.This inflammation is accompanied by elevated IgG and...Autoimmune hepatitis is an uncommon condition that affects both adults and children and is characterized by chronic and recurrent inflammatory activity in the liver.This inflammation is accompanied by elevated IgG and autoantibody levels.Historically,treatment consists of steroids with the addition of azathioprine,which results in remission in approximately 80%of patients.Despite significant advancements in our understanding of the immune system over the past two decades,few modifications have been made to treatment algorithms,which have remained largely unchanged since they were first proposed more than 40 years ago.This review summarized the various treatment options currently available as well as our experiences using them.Although steroids are the standard treatment for induction therapy,other medications may be considered.Cyclosporin A,a calcineurin inhibitor that decreases T cell activation,has proven effective for induction of remission,but its long-term side effects limit its appeal for maintenance.Tacrolimus,a drug belonging to the same family,has been used in patients with refractory diseases with fewer side effects.Sirolimus and everolimus have interesting effects on regulatory T cell populations and may become viable options in the future.Mycophenolate mofetil is not effective for induction but is a valid alternative for patients who are intolerant to azathioprine.B celldepleting drugs,such as rituximab and belimumab,have been successfully used in refractory cases and are useful in both the short and long term.Other promising treatments include anti-tumor necrosis factors,Janus kinases inhibitors,and chimeric antigen receptor T cell therapy.This growing armamentarium allows us to imagine a more tailored approach to the treatment of autoimmune hepatitis in the near future.展开更多
目的:通过收集血流限制训练法联合抗阻训练的相关文献,依照系统评价和Meta分析的范式,分析血流限制训练法联合抗阻训练与抗阻训练对运动者肌肉相关指标和专项能力的不同影响,旨在为运动者在训练实践中运用血流限制训练提供数据支持。方...目的:通过收集血流限制训练法联合抗阻训练的相关文献,依照系统评价和Meta分析的范式,分析血流限制训练法联合抗阻训练与抗阻训练对运动者肌肉相关指标和专项能力的不同影响,旨在为运动者在训练实践中运用血流限制训练提供数据支持。方法:检索中外数据库(中国知网、万方、PubMed、Web of Science和SPORTDiscus),应用血流限制训练法联合抗阻训练对对象为运动者中大学生运动者肢体围度、肌肉质量、肌肉力量和专项运动能力影响的随机对照试验,检索起止时间为2000-01-01/2023-10-12。至少2名研究者采用Cochrane协作网偏倚风险评估工具和标准对纳入文献进行质量评价。使用RevMan 5.4软件进行异质性检验、数据合并、亚组分析、绘制森林图和敏感性分析,绘制漏斗图并进行发表偏倚评价和敏感性分析。评价指标为肢体围度、肌肉厚度、肌肉力量和专项能力等,对不同专项运动能力进行亚组分析。结果:①共纳入18项随机对照试验,共403例受试者,根据Cochrane协作网偏倚风险评估工具,纳入文献中文献质量为A级的有16篇,B级有2篇。②将血流限制训练法联合抗阻训练与抗阻训练之间的效果进行对比,在肢体围度方面,两组间无显著性差异(SMD=0.03,95%CI:-0.16-0.21,P=0.78);在肌肉厚度方面(SMD=0.14,95%CI:0.01-0.27,P=0.03)及肌肉力量方面(SMD=0.37,95%CI:0.14-0.60,P=0.001)两组间有显著性差异。③对专项能力指标进行亚组分析结果显示,距离指标的分析结果存在高异质性(I2=73%),时间指标的分析结果存在高异质性(I2=55%),分析可能原因是各研究的测试方法及评估指标意义的不同导致;功率指标的分析结果显示无异质性(I2=0%);血流限制训练法联合抗阻训练对距离指标具有显著影响(P<0.01)。④合并效应结果显示,血流限制训练法联合抗阻训练比较抗阻训练对于专项能力的影响(P=0.41),提示不同训练方法对于专项能力不存在显著性影响。结论:①两种训练方法均能够促进大学生运动者的肌肉厚度、肌肉力量和专项能力,血流限制训练法联合抗阻训练相较于抗阻训练在促进运动员肌肉厚度、肌肉力量和部分专项能力方面具有显著性效果。因此,可以在专项训练之中科学合理地融合血流限制训练法,以差异性的生理刺激综合作用于肌肉,以取得更好的训练效果。②然而,由于纳入的研究数量较少,以及其他可能存在的局限性,今后需要纳入更多的高质量、多项目类型和性别的随机对照试验来证实。展开更多
Information on the genetic relationship between tropical maize (Zea mays L), germplasm and temperate maize germplasm is of great value to maize breeding. The objective of this study was to determine the combining abil...Information on the genetic relationship between tropical maize (Zea mays L), germplasm and temperate maize germplasm is of great value to maize breeding. The objective of this study was to determine the combining ability and genetic relationship of 25 inbreds extracted from five tropical maize populations and a land race, with four temperate maize inbreds (Huangzaosi, Mol7, B73 and Dan 340). The 25 tropical inbreds were crossed with the four temperate inbreds and evaluated. Lines from Suwanl and POP28 had high general combining ability (GCA) for grain yield. The lines from POP32 (ETO) had the highest special combining ability (SCA) with B73; the average SCA value of the 5 lines was 879 kg/ha. The lines from Suwanl had the second-highest SCA (584 kg/ha) with Huangzaosi. The lines from Suwanl had the greatest relative heterosis (20%) with B73, followed by the lines from POP32 (ETO) with B73 (19%). Five heterotic patterns have been identified from this study: Suwanl × Reid, ETO × Reid, POP28× Reid, POP28× Ludahong-gu, and Suwan1× Lancaster.展开更多
Modern secretaries need to master a lot of oldand new skills including some required skills and some modernabilities.And secretaries in modern offices also have to mastersome special skills to be supportive to their b...Modern secretaries need to master a lot of oldand new skills including some required skills and some modernabilities.And secretaries in modern offices also have to mastersome special skills to be supportive to their bosses.展开更多
[Objectives] The paper was to screen resistant sugarcane varieties against brown stripe disease,and to breed disease-resistant germplasm resource.[Methods]The combining ability for resistance to sugarcane brown stripe...[Objectives] The paper was to screen resistant sugarcane varieties against brown stripe disease,and to breed disease-resistant germplasm resource.[Methods]The combining ability for resistance to sugarcane brown stripe disease was analyzed based on 23 female parents,21 male parents and 29 cross combinations. [Results]The average heritability of resistance to sugarcane brown stripe disease successively were female parents( 95. 3%),cross combinations( 93. 0%)and male parents( 79. 1%). The general combining ability of 12 female parents showed negative effect,including Pma 98-40,Yacheng 93-26,Yunrui 05-283,Yuetang 91-976,Chuanzhe 19,ROC10,Yunzhe 06-80,ROC26,Zhanzhe 74-141,K86-110,Yunzhe 03-194 and ROC25. The general combining ability of 10 male parents showed negative effect,including Q 199,Yunrui 06-649,Yunrui 05-733,CP 84-1198,CP 88-1762,Yacheng 84-125,Yunrui 05-784,Yuetang 00-236,CP72-3591 and CP 94-110. The special combining ability of 16 cross combinations showed negative effect,including Pma 98-40 × Yunrui 05-649,Yacheng 93-26 ×Yunrui 05-733,Yunrui 05-283 × Q199,Yuetang 91-976 × CP 84-1198,Chuanzhe 19 × CP 88-1762 and ROC10 × Yuenong 73-204. [Conclusions] There were significant differences in combining ability among female parents,male parents and cross combinations,which were mainly controlled by additive and non-additive gene.展开更多
Auditing standards require external auditors to provide reasonable assurance that the financial statements are free from material misstatements, either due to fraud or error. Inability of the external auditors to dete...Auditing standards require external auditors to provide reasonable assurance that the financial statements are free from material misstatements, either due to fraud or error. Inability of the external auditors to detect the material misstatements, particularly fraud, may expose them to litigation. The present study aims to examine the effect of personality factors (i.e., neuroticism, extraversion, conscientiousness, openness to experience and agreeableness) on the external auditors' ability to detect the likelihood of fraud. An experimental approach is adopted by sending case materials to audit partners and audit managers attached to auditing firms operating in Malaysia. The result shows that personality does not have a positive effect on the external auditors' ability to detect the likelihood of fraud.展开更多
China's high-speed railway industry achieved dazzling development over the years, but not much research has been devoted to this industry from the perspeetive of competition policy. This paper focuses on the industri...China's high-speed railway industry achieved dazzling development over the years, but not much research has been devoted to this industry from the perspeetive of competition policy. This paper focuses on the industrial organization of China's high-speed railway industry and the applicability of the Anti-Monopoly Law. We intend to answer the following questions: (l) Why is the high-speed railway industry not an industry of natural monopoly? Which segments of the industry have elements of natural monopoly? (2) At the level of corporate organization, what is the legal and economic rationale behind the patterns of China's high-speed railway undertakings evolving from government-affiliated enterprises to special legal person enterprises and then shareholding companies? (3) The applicability of the Anti-Monopoly Law to the high-speed railway industry. Our conclusions from the perspective of competition policy are worth referencing for similar industries such as electric power, telecommunications, and water and gas supply.展开更多
文摘The issue of education for people with disabilities has become of increasing concern. How can we effectively guarantee the basic right to education for persons with disabilities? Will the revised Regulation on Education for Persons with Disabilities meet their needs? This article takes the Regulation on Education for Persons with Disabilities as the core and compares it with the related special educational laws of the United States, Britain and Japan. The following conclusions were drawn from this study: In terms of educational concept, the three countries follow the concept of inclusive education, and pursue equity and educational justice. They not only pay attention to inclusive education but also focus on improving the quality of education for students with disabilities. All three countries focus on accommodating children with special needs, but each implements its programs in a different way. These practices can be used as reference for the development of a special needs education law in China.
文摘Autoimmune hepatitis is an uncommon condition that affects both adults and children and is characterized by chronic and recurrent inflammatory activity in the liver.This inflammation is accompanied by elevated IgG and autoantibody levels.Historically,treatment consists of steroids with the addition of azathioprine,which results in remission in approximately 80%of patients.Despite significant advancements in our understanding of the immune system over the past two decades,few modifications have been made to treatment algorithms,which have remained largely unchanged since they were first proposed more than 40 years ago.This review summarized the various treatment options currently available as well as our experiences using them.Although steroids are the standard treatment for induction therapy,other medications may be considered.Cyclosporin A,a calcineurin inhibitor that decreases T cell activation,has proven effective for induction of remission,but its long-term side effects limit its appeal for maintenance.Tacrolimus,a drug belonging to the same family,has been used in patients with refractory diseases with fewer side effects.Sirolimus and everolimus have interesting effects on regulatory T cell populations and may become viable options in the future.Mycophenolate mofetil is not effective for induction but is a valid alternative for patients who are intolerant to azathioprine.B celldepleting drugs,such as rituximab and belimumab,have been successfully used in refractory cases and are useful in both the short and long term.Other promising treatments include anti-tumor necrosis factors,Janus kinases inhibitors,and chimeric antigen receptor T cell therapy.This growing armamentarium allows us to imagine a more tailored approach to the treatment of autoimmune hepatitis in the near future.
文摘目的:通过收集血流限制训练法联合抗阻训练的相关文献,依照系统评价和Meta分析的范式,分析血流限制训练法联合抗阻训练与抗阻训练对运动者肌肉相关指标和专项能力的不同影响,旨在为运动者在训练实践中运用血流限制训练提供数据支持。方法:检索中外数据库(中国知网、万方、PubMed、Web of Science和SPORTDiscus),应用血流限制训练法联合抗阻训练对对象为运动者中大学生运动者肢体围度、肌肉质量、肌肉力量和专项运动能力影响的随机对照试验,检索起止时间为2000-01-01/2023-10-12。至少2名研究者采用Cochrane协作网偏倚风险评估工具和标准对纳入文献进行质量评价。使用RevMan 5.4软件进行异质性检验、数据合并、亚组分析、绘制森林图和敏感性分析,绘制漏斗图并进行发表偏倚评价和敏感性分析。评价指标为肢体围度、肌肉厚度、肌肉力量和专项能力等,对不同专项运动能力进行亚组分析。结果:①共纳入18项随机对照试验,共403例受试者,根据Cochrane协作网偏倚风险评估工具,纳入文献中文献质量为A级的有16篇,B级有2篇。②将血流限制训练法联合抗阻训练与抗阻训练之间的效果进行对比,在肢体围度方面,两组间无显著性差异(SMD=0.03,95%CI:-0.16-0.21,P=0.78);在肌肉厚度方面(SMD=0.14,95%CI:0.01-0.27,P=0.03)及肌肉力量方面(SMD=0.37,95%CI:0.14-0.60,P=0.001)两组间有显著性差异。③对专项能力指标进行亚组分析结果显示,距离指标的分析结果存在高异质性(I2=73%),时间指标的分析结果存在高异质性(I2=55%),分析可能原因是各研究的测试方法及评估指标意义的不同导致;功率指标的分析结果显示无异质性(I2=0%);血流限制训练法联合抗阻训练对距离指标具有显著影响(P<0.01)。④合并效应结果显示,血流限制训练法联合抗阻训练比较抗阻训练对于专项能力的影响(P=0.41),提示不同训练方法对于专项能力不存在显著性影响。结论:①两种训练方法均能够促进大学生运动者的肌肉厚度、肌肉力量和专项能力,血流限制训练法联合抗阻训练相较于抗阻训练在促进运动员肌肉厚度、肌肉力量和部分专项能力方面具有显著性效果。因此,可以在专项训练之中科学合理地融合血流限制训练法,以差异性的生理刺激综合作用于肌肉,以取得更好的训练效果。②然而,由于纳入的研究数量较少,以及其他可能存在的局限性,今后需要纳入更多的高质量、多项目类型和性别的随机对照试验来证实。
基金funded by the Natural Science Foundation of Yunnan Province(980006Z).
文摘Information on the genetic relationship between tropical maize (Zea mays L), germplasm and temperate maize germplasm is of great value to maize breeding. The objective of this study was to determine the combining ability and genetic relationship of 25 inbreds extracted from five tropical maize populations and a land race, with four temperate maize inbreds (Huangzaosi, Mol7, B73 and Dan 340). The 25 tropical inbreds were crossed with the four temperate inbreds and evaluated. Lines from Suwanl and POP28 had high general combining ability (GCA) for grain yield. The lines from POP32 (ETO) had the highest special combining ability (SCA) with B73; the average SCA value of the 5 lines was 879 kg/ha. The lines from Suwanl had the second-highest SCA (584 kg/ha) with Huangzaosi. The lines from Suwanl had the greatest relative heterosis (20%) with B73, followed by the lines from POP32 (ETO) with B73 (19%). Five heterotic patterns have been identified from this study: Suwanl × Reid, ETO × Reid, POP28× Reid, POP28× Ludahong-gu, and Suwan1× Lancaster.
文摘Modern secretaries need to master a lot of oldand new skills including some required skills and some modernabilities.And secretaries in modern offices also have to mastersome special skills to be supportive to their bosses.
基金Supported by National Industrial Technology System Project(CARS-20-1-1)Project of Innovative Talents of Science and Technology in Yunnan Province(2014HC015)+1 种基金Science and Technology Plan Benefiting People in Yunnan Province(Agriculture,2014RA059)Key New Product Project of Yunnan Province(2012BB014)
文摘[Objectives] The paper was to screen resistant sugarcane varieties against brown stripe disease,and to breed disease-resistant germplasm resource.[Methods]The combining ability for resistance to sugarcane brown stripe disease was analyzed based on 23 female parents,21 male parents and 29 cross combinations. [Results]The average heritability of resistance to sugarcane brown stripe disease successively were female parents( 95. 3%),cross combinations( 93. 0%)and male parents( 79. 1%). The general combining ability of 12 female parents showed negative effect,including Pma 98-40,Yacheng 93-26,Yunrui 05-283,Yuetang 91-976,Chuanzhe 19,ROC10,Yunzhe 06-80,ROC26,Zhanzhe 74-141,K86-110,Yunzhe 03-194 and ROC25. The general combining ability of 10 male parents showed negative effect,including Q 199,Yunrui 06-649,Yunrui 05-733,CP 84-1198,CP 88-1762,Yacheng 84-125,Yunrui 05-784,Yuetang 00-236,CP72-3591 and CP 94-110. The special combining ability of 16 cross combinations showed negative effect,including Pma 98-40 × Yunrui 05-649,Yacheng 93-26 ×Yunrui 05-733,Yunrui 05-283 × Q199,Yuetang 91-976 × CP 84-1198,Chuanzhe 19 × CP 88-1762 and ROC10 × Yuenong 73-204. [Conclusions] There were significant differences in combining ability among female parents,male parents and cross combinations,which were mainly controlled by additive and non-additive gene.
文摘Auditing standards require external auditors to provide reasonable assurance that the financial statements are free from material misstatements, either due to fraud or error. Inability of the external auditors to detect the material misstatements, particularly fraud, may expose them to litigation. The present study aims to examine the effect of personality factors (i.e., neuroticism, extraversion, conscientiousness, openness to experience and agreeableness) on the external auditors' ability to detect the likelihood of fraud. An experimental approach is adopted by sending case materials to audit partners and audit managers attached to auditing firms operating in Malaysia. The result shows that personality does not have a positive effect on the external auditors' ability to detect the likelihood of fraud.
文摘China's high-speed railway industry achieved dazzling development over the years, but not much research has been devoted to this industry from the perspeetive of competition policy. This paper focuses on the industrial organization of China's high-speed railway industry and the applicability of the Anti-Monopoly Law. We intend to answer the following questions: (l) Why is the high-speed railway industry not an industry of natural monopoly? Which segments of the industry have elements of natural monopoly? (2) At the level of corporate organization, what is the legal and economic rationale behind the patterns of China's high-speed railway undertakings evolving from government-affiliated enterprises to special legal person enterprises and then shareholding companies? (3) The applicability of the Anti-Monopoly Law to the high-speed railway industry. Our conclusions from the perspective of competition policy are worth referencing for similar industries such as electric power, telecommunications, and water and gas supply.