Hollow fiber-based liquid phase microextraction followed by analytical instrumental techniques for quantitative analysis of heavy metal ions and pharmaceuticals

Hollow-fiber liquid-phase microextraction(HF-LPME)and electromembrane extraction(EME)are miniaturized extraction techniques,and have been coupled with various analytical instruments for trace analysis of heavy metals,drugs and other organic compounds,in recent years.HF-LPME and EME provide high selectivity,efficient sample cleanup and enrichment,and reduce the consumption of organic sol-vents to a few micro-liters per sample.HF-LPME and EME are compatible with different analytical in-struments for chromatography,electrophoresis,atomic spectroscopy,mass spectrometry,and electrochemical detection.HF-LPME and EME have gained significant popularity during the recent years.This review focuses on hollow fiber based techniques(especially HF-LPME and EME)of heavy metals and pharmaceuticals(published 2017 to May 2019),and their combinations with atomic spectroscopy,UV-VIS spectrophotometry,high performance liquid chromatography,gas chromatography,capillary elec-trophoresis,and voltammetry.

Probing the degradation of pharmaceuticals in urine using MFC and studying their removal efficiency by UPLC-MS/MS

Nutrient recovery from source-separated human urine has attracted interest as it is rich in nitrogen and phosphorus that can be utilized as fertilizer.However,urine also contains pharmaceuticals,steroid hormones,etc.and their removal is crucial as they have detrimental effects on the environment and human health.The current study focuses on investigating the degradation of pharmaceuticals using a double-chamber microbial fuel cell(MFC).Urine was spiked with four pharmaceuticals(trimethoprim,lamivudine,levofloxacin,and estrone)at a concentration of 2 mg/mL.The MFC was operated for 7 months in batch mode with this spiked urine as feed.The degradation efficiency of the MFC was studied,for which a selective liquid chromatography-tandem mass-spectrometric method was developed for the quantitation of compounds used in the spiking experiments and was validated with a lower limit of quantification of 0.39 ng/mL.The maximum removal rate achieved was 96%±2%.The degradation mechanism involved processes like sorption and anoxic biodegradation.The voltage curve obtained showed that the presence of pharmaceuticals had an initial negative impact on power generation along with increased organic content;however,after the reactor acclimatization,increased power output was achieved with maximum organics removal at 30 h of retention time.This work opens a new perspective for the anoxic biodegradation of pharmaceuticals and can be useful in future bioremediation studies.

Guarapiranga Reservoir—Pharmaceuticals and Historical Urban Occupation in a Water Source

The pharmaceutical compounds were analyzed in 14 sampling sites and pointed out the pollution sources related to raw sewage input and urban drainage discharge. Five medicine compounds, one illicit drug, and its metabolite were the higher measured content using analytical improvements tailored to identify and quantify organic compounds in low water content. The use of SPE cartridges followed by liquid chromatography with tandem mass spectrometry (LC-ESI-MS/MS) points out the Guavirutuba tributary as the primary water pollution source with higher concentrations in 2011 for pharmaceuticals, cocaine, and benzoylecgonine (metabolite) in the range of 6.7 ± 0.9 ng L-1 to 27.386 ± 142 ng L-1. The Jaceguay stream also located in Guarapiranga was the most preserved area and provided analytical values correspondent which lowered contamination content. Such concentrations mean a possible and feasible water restoration target. The most common compounds (above 90% samples) were: caffeine, atenolol, carbamazepine, cocaine, and benzoylecgonine. The integrated risk index for aquatic chemical pollution (IRICAP) confirms the higher contamination near Guavirutuba stream and the lower near the Jaceguay stream. Published results of cocaine and benzoylecgonine content in Guarapiranga basin corroborated with the analytical results.

Halal pharmaceuticals and cosmeceuticals from the perspective of higher education

The world demands for halal products,covering foods,cosmetics,pharmaceuticals,services and other products,will continue to grow with the increase in global population,especially the Muslims.It is forecasted that in 2030,Muslim population will cover 27%of the global population.The halal industry is a new growth sector in the Malaysian manufacturing sector and is the fastest growing global business across the world.Increase in value of global halal commodity,with a huge market of USD 2.3 trillion(excluding banking)and is expected to grow each year.

Detection of Human Pharmaceuticals in the Surface Water of East Fork Stones River

Pharmaceuticals have been detected nationwide in different environmental matrices including wastewater effluents and surface water. In recent studies, pharmaceuticals have also been found in aquatic plants, fish tissues and plasma of shark bulls. Pharmaceuticals that were detected as indicated in published literature, included steroids, prescription drugs such as antibiotics, anti-depressants, anti-inflammatory drugs, hormones and over the counter (OTC) drugs. We conducted a monitoring study to detect the presence of pharmaceuticals in East fork of the Stones River located in Rutherford County in Middle Tennessee. East Fork Stones River is a six (6) order river that drains a large portion of Rutherford County including Murfreesboro, Tennessee. Grab water samples were collected from Stones River for three seasons: (summer and fall of 2014 and 2015 and winter of 2015 and 2016) each year. Water quality parameters were also determined in situ using Eureka Water ProbesTM multi-parameter sondes. Water samples were analyzed for the presence of pharmaceutical compounds using GC-MS. Chemical Abstract Service Registry Numbers (CASRN or CAS) for detected pharmaceuticals were identified. Pharmaceuticals detected included those used for treatment of chronic alcoholism (Disulfiram: CAS # 97-77-8), a compound (Thiazolidine: CAS # 504-78-9) in the drug Thiazolidinedione which is used for the treatment of type II diabetes, a compound associated with the prevention of anti-inflammatory conditions (Methyl palmitate: CAS # 112-39-0), and emollient in skincare (Undecane: CAS # 1120-21-4). While the quantitative concentrations of these drugs were not determined in this study, their qualitative presence in surface water is noteworthy.

Cogentus Pharmaceuticals公司启动CGT-2168临床试验

2008年1月17日，Cogentus Pharmaceuticals公司宣布开始临床试验，以便确认其研制的新型复合制剂——CGT-2168的抗血小板活性。（GT-2168为一天一次的口服胶囊（施贵宝公司生产的波立维加奥美拉唑），用以改善抗血小板治疗的胃黏膜儇护。之前在JACC刊登的一项研究显示，奥美拉唑与波立维联合服用，会显著降低波立维抗血小板的活性。

Tianjin Pharmaceuticals Corporation

The Tianjin Pharmaceuticals Corporation (TJPC) is a national designated large first-grade enterprise, a scientific research, production and export base for corticosteroids drug, one of the biggest corticosteroids manufacturers in Asia, and also the biggest comprehensive pharmaceutical producer in Tianjin, enjoying the self-operational rights in import and export business. TJPC possesses a state-grade drug quality control centre, a drug research institute with complete categories, a skilled workers school for training technical workers and a specialized technical contingent with tremendous strength.

Anhui Tianyang Pharmaceuticals Co.Ltd

Tianyang Pharmaceuticals Co. Ltd is amedium-sized enterprise with threesubsidiaries, the Wandong VeterinaryPharmaceutical Factory, Wandong FeedAdditive Factory and Kangfa BiologicalProducts Factory, which produce over 120products, such as veterinary medicines, feedadditives, medicines for human use, biologicalproducts and medical packaging products.Its suppository products fill the gaps in theprovince. The company covers an area of70,600 sqm with a workshop floorage of14,300 sqm. It has fixed assets of RMB19.03 million and circulating funds of RMB9.93 million. At present, the company has405 staff and workers including 50

Industry Dynamics in Pharmaceuticals

Pharmaceuticals is a relatively large and mature industry, and of growing significance. The industry has stimulated extensive research on determinants of its growth and development. Specifically, the distribution of firm size has attracted significant attention, due to tis relevance as an indicator of degree of industrial concentration. A large part of this literature has focused, since the early contributions, on the explanation of the shape of firm size distribution in the industry at a given point in time by reference to steady state arguments. The dynamics in question have been relatively neglected however. The main objective of this paper is to help fill this gap. It is shown that interesting issues arise when one considers how firm structure evolves over time, rather than simply attending to equilibrium implications of processes. Information on the shape and time-evolution of the size distribution of firms over an extended period of time can be used to make inferences about an underlying process;specifically, on which characteristics lead to which kinds of dynamics. To that end, we propose a diffusion model to examine the spatial dynamics of firm size. Instead of assuming a steady state as is standard practice, we consider that firm size fluctuates around its long run stationary equilibrium, according to a double process of temporal drift and random disturbance. An empirical application to real data from the Pharmaceutical industry helps fill a second gap in the literature, as only a few diffusion studies have employed real statistical data when analyzing firm size dynamics. Our empirical application confirms results presented elsewhere and offers some new insights.

Developments in the Pharmaceuticals Industry

China’s pharmaceuticals industry is one of the industries making use of foreign funds and running three kinds of foreign-funded enterprises from an early date. In 1980, it signed a contract with the Japanese Pharmaceu-tical Enterprise to establish the China Otsuka Pharmaceuticals Co. Ltd.---the first joint venture in China’s pharma-ceuticals industry. According to incom-

Orgasmic Bodies: Do-It-Yourself Sexualities, Pharmaceuticals, and Creative Economy

Based on bibliographic research, the article examines how pharmaceuticals address people‟s sexual needs and desires,stimulated by creative economy. The main argument indicates that pharmaceuticals create conditions for do-it-yourself sexualities,based on bodily stereotypes disseminated by creative industries, which reflect dominant heteronormative discourses. People shapetheir bodies, enhance sexual experiences, and foster sexual hygiene and prevention of sexually transmitted infections.

Barr Pharmaceuticals公司的异维A酸胶囊获得FDA审批

Barr Pharmaceuticals公司于5月12日宣布其子公司Barr Laboratories的异维A酸胶囊（USP，30mg）获得FDA审批。公司将马上以Claravis为商品名生产该药。公司将生产一系列异维A酸产品，包括Claravis 10mg、20mg、30mg以及40mg装胶囊。

Optimization of Analytical Conditions to Determine Steroids and Pharmaceuticals Drugs in Water Samples Using Solid Phase-Extraction and HPLC

Two reliable methods were optimized to determine two steroids (17?-Estradiol and 17?-Ethinylestradiol) and two pharmaceutical drugs (ibuprofen and naproxen) using Solid-Phase Extraction (SPE) for sample preparation and High Performance Liquid Chromatography (HPLC) for analysis. SPE (C18) conditions were evaluated varying elution solvent volume, pH conditions and sample mass in the cartridge and reduction techniques of the extract. The efficiency of the analytical methods was evaluated by spiking ultrapure water samples with compounds at three and four levels of concentration for steroids and pharmaceutical drugs, re- spectively. The recoveries were independent (P > 0.05) of added mass of target analytes with a repeatability lower than 6.5% for steroids and 12.1% for pharmaceutical compounds. The recovery factor (coefficient of variation, CV) was higher than 83% for steroids (CV 93% for pharmaceuticals (CV < 5.2%). The optimized analytical method was applied for the evaluation of a steroid degradation test using ozone, finding that the estimated limit of detection is sufficient to determine the residual mass (μg?L–1) of 17β-Estradiol after the experiment.

CAS Members Offer Advice on New Pharmaceuticals

A group of CAS members andexperts noted for their pharmaceu-tical knowledge and expertuse tookpart in an exhaustive consultingand lecture program in Hong KongSAR, Shenzhen and Guangzhoufrom Apri 5 to 13, focusing on newresearch approachs to drug com-pounds involved in Chihese tradu-tional medicine.

Recent advances in electrogenerated chemiluminescence biosensing methods for pharmaceuticals

Electrogenerated chemiluminescence(electrochemiluminescence, ECL) generates species at electrode surfaces, which undergoes electron-transfer reactions and forms excited states to emit light. It has become a very powerful analytical technique and has been widely used in such as clinical testing, biowarfare agent detection, and pharmaceutical analysis. This review focuses on the current trends of molecular recognition-based biosensing methods for pharmaceutical analysis since 2010. It introduces a background of ECL and presents the recent ECL developments in ECL immunoassay(ECLIA), immunosensors, enzyme-based biosensors, aptamer-based biosensors, and molecularly imprinted polymers(MIP)-based sensors. At last, the future perspective for these analytical methods is briefly discussed.

Perceptions on the risk and management of unused pharmaceuticals toward the creation of guidelines on handling and disposal

The increased usage of pharmaceuticals, its introduction to and accumulation in the environment are growing environmental and health concerns and have been a topic of interests for several years now. Active Pharmaceutical Ingredients (API) were developed and used because of their biological activity. It is this very nature of medicines that they may also have an untoward effect on animals and microorganisms and to the environment and an indirect effect on public health.

Rapid and Sensitive CZE Method for Quality Control Analysis of Pharmaceuticals Containing Pseudoephedrine, Triprolidine and Paracetamol

A rapid and sensitive CZE (Capillary Zone Electrophoresis) method for pharmaceutical analysis was developed and fully validated. The active compounds: Pseudoephedrine hydrochloride (PSE), Triprolidine hydrochloride (TRI) and Paracetamol (PAR) were separated and quantitatively determined using the tris-borate 30 mM buffer at pH = 9.0 as a Background Electrolyte (BGE). The electrophoretic separation was carried out at 25 kV in an unmodified fused silica capillary of I.D. = 50 μm with a “bubble-cell” for UV detection at 210 nm and 25&deg;C. The separation was reached in about 3 min. After calibration the method was applied for analysis of three commercially available pharmaceutical preparations. The repeatability (RSD%) of migration time (tm) was ranging between 0.47% and 0.90% and of peak areas (A) between 0.63% and 3.64%. The Limit of Detection (LOD) values was of 0.19 μg/mL, 0.31 μg/mL and 0.08 μg/mL for respectively PSE, TRI and PAR. The results obtained in this study showed that the proposed method was useful in routinely analysis of pharmaceuticals.