Transforming Molecules into Medicines: Role of CDMOS in Phase-Appropriate Technology Transfers in Advancing Pharmaceutical Innovation

CDMOs are emerging as critical drivers of innovation within the pharmaceutical and biotech industries. As the pharmaceutical industry continues to evolve, we can expect to see CDMOs play an increasingly important role in drug development and manufacturing. Many companies within these sectors are now leveraging the expertise of CDMOs through technology transfers to foster innovation and enhance the development of new drug products. In the extensive field of drug development, technology transfer plays a crucial role at multiple stages, ranging from preclinical phases to commercialization. By working closely with drug developers, CDMOs can ensure that technologies are transferred seamlessly between phases of drug development, allowing for a more efficient and cost-effective development process. CDMOs also bring a wealth of experience in various areas of drug development, including process development, analytical testing, quality control, and manufacturing. This expertise, combined with a focus on innovation, can help drug developers to overcome technical challenges and optimize their drug development programs. CDMOs can provide drug developers with various manufacturing capabilities, from small-scale clinical trials to large-scale commercial production. This flexibility allows drug developers to focus on their core competencies while relying on CDMOs to provide the necessary infrastructure and support for drug manufacturing. The critical role of CDMOs in advancing pharmaceutical innovation in phase-appropriate technology transfer where there will be a lot of effort and patience with strong technical expertise is required. This article explores the various types of Technology transfer from preclinical to commercial stages and successful strategies to foster innovation.

Development trend and prospect of solid phase extraction technology

Solid phase extraction is widely used in sample pretreatment,concentration and analysis processes due to high selectivity and suitability for low concentration sample system.In this review,we systematically summarized and discussed the development trends of solid phase extraction by bibliometrics method.By analyzing papers output scale,the research and development direction of solid phase extraction technology is prospected.We also give an overview on current strategies of novel solid phase extraction from the separation medium and separation technology.The paper aims to describe the global research profile and the development trends of solid phase extraction,to help researchers to accurately grasp the research trend and to provide support for scientific research institutions to formulate scientific policies and strategic plans.Furthermore,the prospect of the development and application of solid phase extraction is also discussed.

Coupling effect on the thermal hazard assessment of hazardous chemical materials via calorimetric technologies and simulation approaches

The coupling effect of heat absorption and release exists in the thermal decomposition of a few chemical materials.However,the impact of the above coupling on thermal hazard assessment is not considered in the literature studies.In this work,nitroguanidine(NQ)and 1,3,5-trinitro-1,3,5-triazine(RDX)are selected as representative materials to explore the influence of the coupling effect on the thermal hazard assessment of chemical materials.The linear heating experiments of NQ and RDX are carried out by a microcalorimeter and synchronous thermal analyser.The thermal decomposition curves are decoupled by advanced thermokinetics software.The thermal decomposition and kinetic parameters before and after decoupling are calculated.The results of TG experiment show that both NQ and RDX began to lose mass during the endothermic stage.The endothermic melting and exothermic decomposition of NQ and RDX are coupled within this stage.The coupling effect has different degrees of influence on its initial decomposition temperature and safety parameters.Compared with the parameters in the coupling state,the initial decomposition temperature and adiabatic induction period after decoupling decrease.The self-accelerating decomposition temperature increases,and internal thermal runaway time decreases.In the thermal hazard assessment of chemical materials with coupling effects,the calculated parameters after decoupling should be taken as an important safety index。

Studies on the structure and catalytic performance of Cu-Zn-Al catalyst prepared by liquid-phase preparation technology under different heat treatment atmosphere

Cu-Zn-Al slurry catalysts were prepared using a complete liquid-phase preparation technology under different heat treatment atmospheres.The catalysts were characterized using X-ray diffraction,X-ray photoelectron spectroscope,and N2 adsorption-desorption.Their application in the single-step synthesis of dimethyl ether from syngas was also investigated.The results indicate that the type of heat treatment atmosphere has an influence on the Cu species and the Cu0/Cu＋ ratio on the catalyst surface.Moreover,the final Cu/Zn ratio on the catalyst surface is mainly dependent on the composition and reaction environment of the catalyst and less on the type of heat treatment atmosphere.The prepared catalysts can suppress sintering of active sites at high temperatures,and the type of heat treatment atmosphere mainly affects the capability of the catalyst for methanol synthesis.The catalysts perform best using N2 as the heat treatment atmosphere.

Preparation of A New Fiber by Sol-gel Technology in Solid-phase Microextraction (SPME)

The sol-gel technology is applied for the preparation of solid-phase microextraction (SPME) fiber. The fiber demonstrates high thermal stability, efficient extraction rate and the selectivity for non-polar or low-polar analytes. Efficient SPME-GC-FID analyses of benzene- toluene-ethylbenzene-xylenes (BTEXs) and low-polar halocarbon were achieved by the sol-gel coated DSDA-DDBT-TiO2 fiber. Some parameters of the SPME fiber for the determination of halocarbon in aqueous sample were investigated.

Controlling the light wavefront through a scattering medium based on direct digital frequency synthesis technology

Phase modulation is a crucial step when the frequency-based wavefront optimization technique is exploited to measure the optical transmission matrix(TM) of a scattering medium. We report a simple but powerful method, direct digital frequency synthesis(DDS) technology to modulate the phase front of the laser and measure the TM. By judiciously modulating the phase front of a He–Ne laser beam, we experimentally generate a high quality focus at any targeted location through a 2 mm thick 120 grit ground glass diffuser, which is commercially used in laser display and laser holographic display for improving brightness uniformity and reducing speckle. The signal to noise ratio(SNR) of the clear round focus is 50 and the size is about 44 μm. Our study will open up new avenues for enhancing light energy delivery to the optical engine in laser TV to lower the power consumption, phase compensation to reduce the speckle noise, and controlling the lasing threshold in random lasers.

Chinese Telemetry Technology under Fast Development

The history of the development of Chinese telemetry is introduced in the paper. The new telemetry ground station and the new onboard space telemetry system, with the idea of systematic design and the specification, are described.

Hotel Guest Service Technology

For any hotel guest reception technology is an important factor in the quality service process,financial-economic efficiency,and management of the hotel industry.The service process in the same type hotel is standard,meanwhile the service process technology undergoes certain alterations according to the hotel’s size,structure,category,and market segment orientation.Hotel customer service technology is characterized by cycling phases—consistent repeat of the service process before the departure of the guest from the hotel.The article discusses the four-phase cycle of guest reception,related to the hotel services and transactions.Each phase of the cycle consists of standard transactions/phases,which are carried out between hotel clients and the hotel itself.

Ka-Band CTDRSS Terminal Technology for Meeting the Needs of Launch Vehicle TT&C

To meet the application requirements for a Ka-band space-based TT&C terminal for a launch vehicle,this paper proposes the implementation scheme of a space-based TT&C terminal,analyzes and solves the miniaturized design of equipment and the key technology for high-efficiency heat dissipation.The phased array antenna test shows that without external heat dissipation measures,the phased array antenna can work for a long time to meet the working requirements of launch vehicle,which has been verified in the LM-8 mission,and has wide engineering application prospects.

Application of Combined Production Logging Technology in Horizontal Wells

随着海上油气田开发的不断深化,水平井技术已在增储上产中起到了巨大作用,但也面临着出水及含水不断升高的问题。进行水平段储层生产测井,确定井下层内生产情况及储层动用情况,是后期控水稳产、措施挖潜的关键。水平井因井眼轨迹与储层平行、流体重力分异明显、上/下坡流共存等因素,常规居中测量中心流速的测井技术已不适用;同时,水平井为单层开采,剩余油饱和度分布无标准水层刻度,为生产层剩余油分布监测提出了挑战。提出了阵列式多相流测井仪组合(MAPS)和剩余油饱和度测井技术(RPM)的组合测井方式,通过水平段截面速度剖面、流体性质分布以及剩余油饱和度分布三者间的相互验证、综合解释的解决方案,取得了良好效果。

数字经济、绿色技术创新与能源效率提升——基于城市面板数据的实证分析

提高能源效率是我国经济绿色转型和实现双碳目标的必然要求,当下数字经济已成为能源效率提升的新动能。本文基于数字经济的“四化”框架,在理论分析的基础上,运用2011~2020年我国284个地级市的面板数据,实证检验了数字经济影响能源效率提升的机制、特征和路径。结果表明:(1)数字经济及各维度对能源效率提升的总体效应为正,其中产业数字化促进作用最强,且数字经济对能源效率的提升具有区域异质性;(2)数字经济对能源效率的提升存在双门槛,呈现中间波动但总体促进的“N”型特征;(3)数字经济可通过促进绿色技术创新进而提升能源效率,且绿色技术创新水平的提高有助于城市跨越数字经济的第二个门槛,实现数字经济发展与能源效率提升的共赢。

辽宁省科技成果转化存在的问题及对策研究

在国家创新驱动的发展国策下,科技成果转化日益成为促进区域经济发展的重要引擎,党和国家的政策也明确指出了科技创新和经济相结合的发展方向,因此,科技成果转化作为两者的结合点被提上了日程,成为制约区域经济发展的重要环节。然而,辽宁在科技资源分配及产学研协调沟通机制上存在不足,导致辽宁科技创新成果的本地转化率并不高,这在一定程度上限制了辽宁经济的增长。基于此,本文通过梳理科技创新价值链和科技成果转化过程研究,剖析辽宁省科技成果转化存在的问题,并根据辽宁的实际情况和区域特色,构建具有辽宁地方特色的科技成果转化模式,期望能够引领地区产业发展,提高区域科技创新能力,有效促进科技成果本地转化。

电磁超表面全息成像技术研究进展

超表面全息术的出现极大地促进了全息成像技术的发展,同时也拓展了电磁超表面的应用范围。为进一步梳理超表面全息成像的发展脉络,以技术发展的时间轴为主线,系统地回顾了超表面技术的发展历程,以及受益于超表面技术的全息成像模式的进步。随着技术的进步,超表面全息术逐渐从可见光频段向微波频段发展,从静态重现向动态全息演变,因此,着重介绍了超表面全息术的未来方向——可重构超表面及其动态全息技术,并且从超表面单元高性能创新技术、超表面阵列全息模式以及超表面全息系统研究3个方面对可重构超表面全息术的发展做了展望。

微波光子信号同步及其在分布式相参雷达中的应用

分布式相参雷达技术通过多节点高性能信号同步实现跨平台的信号级相参融合,可大幅提升雷达探测、跟踪和抗干扰等能力,是雷达领域的重要发展方向之一。随着雷达频率范围的拓展、瞬时带宽的增大和搭载平台的多样化,分布式相参雷达技术对节点间信号的时间、空间、频率、相位同步性能提出了越来越高的要求,这使得传统电学信号同步技术面临巨大挑战。文中介绍了分布式相参雷达对信号时、空、频、相同步的性能要求和国内外相关技术的研究进展,重点总结了微波光子同步技术的基本原理和代表性成果;构建了微波光子分布式相参探测原理验证系统,验证了微波光子分布式相参的可行性,为推动分布式相参雷达的前沿发展与工程化应用提供了关键技术支撑。

IRS辅助上行NOMA和速率最大化方案

针对非正交多址接入(non-orthogonal multiple access,NOMA)系统在无线环境下传输速率较低的问题,利用智能反射面(intelligent reflecting surface,IRS)可以改变入射信号相移的特性,提出一种基于IRS辅助上行NOMA和速率最大化算法.首先,在满足每个用户功率、每个用户最小速率、IRS相位偏移的约束条件下,构建一个联合用户功率、IRS相移多变量优化模型;然后,通过问题公式的等效简化将原非凸问题转换为2个容易处理的子问题;最后,通过交替方向乘子法(alternating direction method of multipliers,ADMM)、引入松弛变量等方法对子问题进行求解.仿真结果表明,相较于逐次凸逼近法(successiveconvexapproximation,SCA)所提出的算法平均提升了系统0.4 bit/(s·Hz)的和速率,证明了基于ADMM的算法有效提高系统的和速率.

电动汽车用多相电驱重构型车载充电系统关键技术综述

电驱重构型车载充电系统为电动汽车电气部分提供了一种全新轻量化设计思路,旨在利用电驱单元分时执行电驱与充电2种变流功能。相较于三相电驱系统,多相电驱系统具有输出转矩平滑、容错性能强等诸多优势特性。鉴于此,该文首先归纳现有并网式多相电驱重构型车载充电系统的拓扑结构与控制策略,并介绍其容错运行方案;然后,着重分析太阳能电动汽车用多能量端口电驱重构型车载充电系统的工作原理与控制策略;最后,总结全文并对多相电驱重构型车载充电系统的发展方向进行展望。

储热技术研究展望

近年来,储热技术被广泛认为是实现碳中和、碳达峰的一项关键技术备受关注。通过从CNKI、Web of Science等数据库中筛选储热技术相关文献,运用CiteSpace软件进行知识映射,展开系统分析、统计及可视化,绘制出储热技术研究力量合作网络图谱,展示该技术研究力量的分布与科研合作情况。同时针对关键词进行分析,总结储热技术的研究热点、研究前沿及发展趋势,指出相变储热和混合储热模式是未来研究的重点。针对储热材料稳定性差、使用寿命短,有机相变材料成本高、安全性低,系统设备初始造价高、成本回收期长等储热技术现存问题,从政策干预和市场需求角度提出了改进建议。

低碳脂肪胺的治理技术研究进展

低碳脂肪胺(LCFAs)的末端处理技术主要分为物理法、化学法和生物法等3类,物理方法主要包括液相吸收法、吸附法、空气吹脱法、膜分离法;化学法主要包括低温等离子体法、高温催化氧化、光催化氧化、微波辐射法和液相高级氧化法。重点介绍各种方法的原理、处理效率和优缺点等。研究表明,LCFAs的去除方法虽然多样,但每种方法在不同程度上都存在一定局限性。鉴于LCFAs出色的水溶性,提出将液相吸收法与高级氧化法/生物法联合使用将是一种十分具有前景的LCFAs治理技术。最后对LCFAs未来的治理方向提出了展望。

高压作用下水泥基粉末材料的接触硬化研究综述

在高压作用下,一些具有无定型相的水泥基粉末材料会发生接触硬化现象,粉末颗粒在压力作用下发生缩聚运动,并在粉末颗粒间形成结构键,进而快速形成具有一定强度及耐水性的人造石材。本文综述了压力作用下水泥基粉末材料接触硬化的成键机理以及粉末水分含量、干燥条件、钙硅比、压制过程对其接触硬化性能影响的研究进展。相关研究结果表明,压力作用下粉末颗粒间会形成氢键、范德华力、固体桥键等结构键;粉末水分含量是影响接触硬化性能的重要因素,在压力作用下,水分可以改变粉末颗粒的表面性质并影响颗粒之间的结合,进而改变压制成品的力学性能;钙硅比对接触硬化性能的影响显著,不同粉末材料在压制时的最佳钙硅比亦是不同;摩擦力的存在降低了压制效率,造成压制成品密度、强度分布不均匀,润滑剂的加入可以有效降低摩擦力的影响;此外,降低压制模具高径比并使用双面压制可有效提升压制成品的质量。

火炮摇架焊缝缺陷智能分类

针对火炮摇架结构复杂,焊缝内部缺陷检测效果不理想,选择对非平面物体和复杂结构体均适用的超声相控阵检测技术对摇架焊缝缺陷进行检测。将得到的超声相控阵图谱与ResNeXt网络模型相结合,实现焊缝缺陷的智能分类。将SK卷积单元引入ResNeXt网络模型,对摇架焊缝缺陷进行定性分析。改进后的网络模型比原ResNeXt网络的分类准确率提升5.5%,最终达到98.2%。