SOLID-LIQUID PHASE TRANSFER CATALYTIC SYN THESIS Ⅸ: THE SYNTHESIS OF α-AMINO ACIDS VIA ALICYLATION OF ALDIMINE UNDER MICROWAVE IRRADIATION,

The rapid alkylation of methyl N-benzylidene glycinate with halides under microwave irradiation using solid-liquid phase transfer condition without solvent has been achieved wilhin only one minute. After hydrolysis of alkylated products the corresponding α-amino acids were obtained in overall yield 43.6～62.5%.

Stodies on the Witting Reaction (Ⅹ Ⅹ Ⅻ) Phase Transfer Catalytic Bis-Witting Reaction of 1,2-and 1,3-Bisylide

The phase transfer catalytic (PTC) bis-Wittig reaction between substitutedbenzaldehyde and 1,2- and 1,3-bisylides in the presence of K2Co3 was discussed.

REGIOSELECTIVE O-ALKYLATION OF MYO-INOSITOL DERIV ATIVES WITH ALKYL HALIDES UNDER S-L PHASE TRANSFER CATALYTIC CONDITIONS

A convenient synthetic approach leading to protected inositol was described based on regioselective O-alkylation using alkyl halide under solid-liquid PTC condition

Studies on the synthesis of amino acids XII.Solid-liquid phase transfer catalytic dicondensation of 1,4-diacety1-2,5-piperazinedione with aldehydes

3,6-Diarylidene-2,5-piperazinediones(2)and 3-alkylidene-6-arylidene-2,5-piperazfnediones (6)were synthesized from diacetyl-2,5-piperazinedione(1)under solid-liquid phase transfer catalytic conditions.2 could be easily convered to a-amino acid by reducing with zinc powder and hydrolyzing with concentrated hydrochloric acid.The effect of different phase transfer catalysts and reaction con- ditions were studied.