Phase Relation of Harmonics in Nonlinear Focused Ultrasound

The phase relation of harmonics in high-intensity focused ultrasound is investigated numerically and experimen- tally. The nonlinear Westervelt equation is solved to model nonlinear focused sound field by using the finite difference time domain method. Experimental waveforms are measured by a robust needle hydrophone. Then the relative phase quantity is introduced and obtained by using the zero-phase filter. The results show that the nth harmonic relative phase quantity is approximately （n - 1） π/3 at geometric center and increases along the axial direction. Moreover, the relative phase quantity decreases with the increase of source amplitude. This phase relation gives an explanation of some nonlinear phenomena such as the discrepancy of positive and negative pressure.

Magnetic metal organic framework for pre-concentration of ampicillin from cow milk samples

The aim of this study is a present of a simple solvothermal synthesis approach to preparation of Cu-based magnetic metal organic framework(MMOF)and subsequently its application as sorbent for ultrasound assisted magnetic solid phase extraction(UAMSPE)of ampicillin(AMP)from cow milk samples prior to high performance liquid chromatography-Ultraviolet(HPLC-UV)determination.Characteristics of prepared MMOF were fully investigated by different techniques which showed the exclusive properties of proposed sorbent in terms of proper functionality,desirable magnetic property and also high specific surface area.Different influential factors on extraction recovery including sorbent dosage,ultrasonic time,washing solvent volume and eluent solvent volume were assessed using central composite design(CCD)based response surface methodology(RSM)as an operative and powerful optimization tool.This is the first report for determination of AMP using MMOF.The proposed method addressed some drawbacks of other methods and sorbents for determination of AMP.The presented method decreases the extraction time(4 min)and also enhances adsorption capacity(250 mg/g).Moreover,the magnetic property of presented sorbent(15 emu/g)accelerates the extraction process which does not need filtration,centrifuge and precipitation procedures.Under the optimized conditions,the proposed method is applicable for linear range of 1.0-5000.0 μg/L with detection limit of 0.29 μg/L,satisfactory recoveries(≥95.0%)and acceptable repeatability(RSD less than 4.0%).The present study indicates highly promising perspectives of MMOF for highly effective analysis of AMP in complicated matrices.

A coherence-based phase aberration correction method in medical ultrasound

A coherence-based correction method was proposed in order to improve the lateral resolution and enhance the contrast of medical ultrasound imaging in the presence of phase aberration. The averaged coherence factor was proposed at first and used as a metric to evaluate phase aberration correction. By maximizing the averaged coherence factor, the time delay parameter of each channel was adjusted. A new set of coherence factors was calculated and the corrected data was optimized to form the final B-mode image. The simulations on point targets and a cyst phantom showed that the proposed method outperformed the nearest neighboring cross correlation method and conventional coherence-weighting method, and the lateral resolution and contrast ratio was improved by approximately 0.24mm and 18dB respectively. The proposed method combined the advantages of phase error correction and coherence-weighting, which could improve imaging qualities effectively in medical ultrasound.