A series of （1E）-phenyl-2-（3＇,4＇-dihydroxyphenyl）ethenesulfonate derivatives were designed and synthesized as anti-amyotrophic lateral sclerosis （ALS） agents, based on the lead compound caffeic acid phenethyl ...A series of （1E）-phenyl-2-（3＇,4＇-dihydroxyphenyl）ethenesulfonate derivatives were designed and synthesized as anti-amyotrophic lateral sclerosis （ALS） agents, based on the lead compound caffeic acid phenethyl ester （CAPE）. And their neuroprotective activities were evaluated. The results indicated that replacement of the carboxylic ester by sulfonic ester did not produce better neuroprotective activity in the model of LPS induced inflammation in BV2 cells. However, the results in the model of H2O2 induced damage in PC12 cells showed that the neuroprotective activities of all the target compounds and CAPE were about the same.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.20972011,21042009,21172014)
文摘A series of （1E）-phenyl-2-（3＇,4＇-dihydroxyphenyl）ethenesulfonate derivatives were designed and synthesized as anti-amyotrophic lateral sclerosis （ALS） agents, based on the lead compound caffeic acid phenethyl ester （CAPE）. And their neuroprotective activities were evaluated. The results indicated that replacement of the carboxylic ester by sulfonic ester did not produce better neuroprotective activity in the model of LPS induced inflammation in BV2 cells. However, the results in the model of H2O2 induced damage in PC12 cells showed that the neuroprotective activities of all the target compounds and CAPE were about the same.
