Application of Modeling Drugs in Animal Models of Chemical Phlebitis: Review

Objective: This review aims to determine the impact of different drugs and methods on the successful establishment of an animal model for chemical phlebitis (CP). Design: Search the Cochrane Library, ProQuest Academic Journal Library, PubMed, Web of Science, Ovid, Embase, CINAHL complete (EESCO) and other related databases to determine the literature. Screen out articles consistent with this review and summarize them. Results: Since the establishment of the database, a total of 1463 articles have been retrieved. After reading the title, abstract and full text, and excluding non-related and duplicate articles, 22 reports were finally included. Among them, there are 8 articles using different medication methods to compare the effects of establishing a CP model. The included articles explored the effects of different animal models, drug types, and their dose, concentration, speed, and time on the CP model. Conclusion: The factors of dose, concentration and time were positively correlated with the incidence of CP. The effect of speed factors on CP and the results of different animal models are inconsistent. It requires further research in the future.

Application of Ji Desheng Snake Pills Combined with Hypertonic Glucose External Application in Treating Drug-Induced Superficial Phlebitis Caused by Parenteral Nutrition

Objective: The efficacy of Ji Desheng snake pills combined with hypertonic glucose external application in treating drug-induced superficial phlebitis caused by parenteral nutrition (PN) is observed. Methods: Fifty-two cases of drug-induced superficial phlebitis after peripheral parenteral nutrition (PPN) were selected, which were randomly divided into experimental group and control group in accordance with the phlebitis grading. In the experimental group, Ji Desheng snake pills were crushed to make a paste with 50% glucose solution, which was then applied to the affected area of phlebitis, the surface was covered with clean gauze, and properly fixed with tape or bandage. The drug was replaced once a day. In the control group, the gauze soaked with 50% magnesium sulfate solution was used, which was applied to the affected part three times a day in wet, and the efficacy was observed respectively on the 1st, 3rd, 5th and 7th days after applying the drug. Results: On the 1st and 3rd days after treatment, the observed effective rate of the experimental group was higher than that of the control group (42.31% vs. 15.38% and 76.92% vs. 46.15%, respectively). The difference was statistically significant (p th and 7th days after treatment, there was no statistical significance with respect to the efficacy between the experimental group and the control group (p > 0.05). Conclusion: The significant efficacy could be found in early stage after drug-induced superficial phlebitis was treated by Ji Desheng snake pills combined with hypertonic glucose external application, which was superior to that of the traditional treatment of wet application by using gauze soaked in 50% magnesium sulfate solution.

Effectiveness of Magnesium Sulphate with Glycerin Dressing versus Heparinoid Ointment Application on Management of Phlebitis among Patients Admitted in Selected Wards of BPKIHS

Background: Phlebitis is the inflammation of the tunica intima of the vein. If left untreated may lead to infection or thrombus formation. Early detection and appropriate interventions reduce the occurrence and severity of cannula related phlebitis. Objective: To evaluate the effectiveness of magnesium sulphate with glycerin dressing as compared to heparinoid ointment application on management of peripheral cannula induced phlebitis. Materials and Methods: A Quasi-experimental design was carried among admitted patients in Medical-Surgical Units of BPKIHS. Out among 50 admitted patients with cannula induced phlebitis. Simple random sampling technique was used to allocate the wards to each interventional group and purposive sampling technique to select samples where instruments baseline Performa and observation scale was used to collect data. Results: The study findings revealed significantly reduction of phlebitis score after 48 hours of treatment with both interventions. Thus it was concluded that both the applications were effective in reducing level of phlebitis. Regarding effectiveness, there was a statistically significant difference in phlebitis score in both experimental groups after comparison baseline within 8, 16, 32, 40, 48 hours of administration of intervention (P = 0.05). The mean visual infusion scale score was more in MSG group as compared with that of HPA group. It shows that there is more reduction of VIP score in Magnesium sulphate with glycerin (MSG) group. Conclusion: In the research, study findings revealed that Magnesium sulphate with glycerin dressing is more effective than heparinoid ointment on management of peripheral cannula induced phlebitis.

Biomechanical aspects of catheter-related thrombophlebitis

Short peripheral catheters (SPCs) are the most common intravenous devices used in medical practice. Short peripheral catheter thrombophlebitis (SPCT) is the most frequent complication associated with SPCs, causing discomfort and usually leading to removal of the catheter and insertion of a new one at a different site. The aim of this research was to explore whether biomechanical factors, in addition to biochemical factors, also play a role in the formation of thrombophlebitis. Hence, two of the biomechanical aspects of SPCT were investigated: the physical pressure load exerted by the SPC on the endothelial monolayer, and disturbances in the flow patterns due to the SPC. Endothelial activation was studied by subjecting human umbilical vein endothelial cells (HUVEC) to a weight load of SPC pieces and measuring the release profile of von-Willebrand Factor (vWF) over time, using ELISA. vWF release was chosen as the measure for endothelial activation since it was the major component of the Weibel-Palade Bodies (WPBs), which underwent exocytosis by endothelial cells during activation. Flow patterns were analyzed on a 3D computational fluid dynamics (CFD) model of a brachiocephalic vein with SPC. vWF release profiles were significantly higher in the HUVECs subjected to the load, indicating HUVEC activation. CFD simulations demonstrated a decrease in flow velocities along the catheter body, between the catheter and the vein, due to an enlarged boundary layer. Results indicate that the contact region between the SPC body and the vein wall can be partially responsible for SPCT development, and inflammatory and coagulatory processes initiated by stimulated endothelial cells may be amplified due to disturbed blood flow.

A Prospective Study to Compare Routine versus Need Based Change of IV Cannula on Development of Infusion Phlebitis in Adult Surgical Patients

（IV） Intravenous therapy is one of the most commonly performed procedures in hospitalized patients yet phlebitis affects 27% to 70% of all patients receiving IV therapy. The incidence of phlebitis has proved to be a menace in effective care of surgical patients, delaying their recovery and increasing duration of hospital stay and cost. The recommendations for reducing its incidence and severity have been varied and of questionable efficacy. The current study was undertaken to evaluate whether elective change of IV cannula at fixed intervals can have any impact on incidence or severity of phlebitis in surgical patients. All patients admitted to the Department of Surgery, SMIMS undergoing IV cannula insertion, fulfilling the selection criteria and willing to participate in the study, were segregated into two random groups prospectively： Group A wherein cannula was changed electively after 24 hours into a fresh vein preferably on the other upper limb and Group B wherein IV caunula was changed only on development of phlebitis or leak i.e. need-based change. The material/brand and protocol for insertion of IV cannula were standardised for all patients, including skin preparation, insertion, fixation and removal. After carmulation, assessment was made after 6 hours, 12 hours and every 24 hours thereafter at all venepuncture sites. VIP and VAS scales were used to record phlebitis and pain respectively. Upon analysis, though there was a lower VIP score in group A compared to group B （0.89 vs. 1.32）, this difference was not statistically significant （p-value = 0.277）. Furthermore, the differences in pain, as assessed by VAS, at the site of puncture and along the vein were statistically insignificant （p-value 〉 0.05）. Our results are in contradiction to few other studies which recommend a policy of routine change of carmula. Further we advocate a close and thorough monitoring of the venepuncture site and the length of vein immediately distal to the puncture site, as well as a meticulous standardized protocol for IV access.

Clinical observation and experimental study on Kangfuxin fluid in treating indwelling needle-related phlebitis

Objective To investigate the therapeutic effect of Kangfuxin Fluid on indwelling needle-related phlebitis by observation of clinical samples and pharmacological study.Methods Eighty-five patients with indwelling needle-related phlebitis in the neurosurgery department of a Grade A hospital in Shanxi Province from June 2019 to November 2021 were randomly divided into the study group(43 cases)and the vehicle group(42 cases).Patients in the study group were treated with KFX,and patients in the control group were treated with hydrocolloid dressing.The time for symptoms(such as redness and pain)to disappear was recorded.The effect of tissue repair was evaluated by the fin crosscutting model and the anti-inflammatory effect was evaluated by the inflammatory models.Q-PCR assay was used to detect the mRNA expression levels of IL-6 and TNF-αin LPS-stimulated zebrafish.The effect on promoting angiogenesis was evaluated by the inter-segmental blood vascular defect model of zebrafish.Results The curative effect of the study group was better than the control group.The pain resolution time and the swelling resolution time in the study group were(1.67±0.90)d and(2.25±0.92)d,respectively,shorter than those in the control group(P<0.05).KFX can improve the ISV index,increase the regeneration length of the fin,inhibit the migration of neutrophils in three inflammatory models and reduce the mRNA expression levels of IL-6 and TNF-αin LPS-stimulated zebrafish.Conclusion KFX exerts great clinical efficacy in the treatment of indwelling needle-induced phlebitis which may be associated with inflammation inhibition,angiogenesis promotion,and tissue repair.

A clinical study on the prevention of phlebitis caused by Cinobufagin using hand exercise combined with Jinhuang ointment

Objective:The aim of this study is to observe the clinical effect of hand exercise combined with jinhuang ointment on the prevention of phlebitis due to cinobufagin.Methods:A total of 90 cancer patients who have been receiving intravenous(Ⅳ)infusion of cinobufagin from May 2018 to June 2019 in the oncology department of our hospital were selected.They were then divided into three groups in a random manner,which include 30 cases in the control group,30 cases in the jinhuang ointment group,and 30 cases in the group of hand exercise combined with jinhuang ointment.The control group had a routine care before cinobufagin was infused from the first day of hospitalization.During the routine care mentioned previously,the jinhuang ointment group was given locally jinhuang ointment inunction,qd,and kept for 6 hours.Hand exercises were then done on the combined group excluding jinhuang ointment application,qd,at 10min.After treatment for 1 week,the phlebitis and pain incidences on the venipuncture site were then compared between the three groups.Results:After the 1-week treatment,the incidences of grade Ⅰ/Ⅱ phlebitis in the control group,the jinhuang ointment group,and the group of hand exercise combined with jinhuang ointment were 53.5%,23.3%,and 10%,respectively.The results have shown a significant decrease in the jinhuang ointment group and the combined group as in comparison with the control group(P=0.0169,P=0.0003).Even with the incidence of the combined group being lower than that of the jinhuang ointment group,no statistically significant difference(P=0.1659)was found.The incidences of grade Ⅲ/Ⅳ phlebitis in the control group,the jinhuang ointment group,and the group of hand exercise combined with jinhuang ointment were 23.3%,3.3%,and 3.3%,respectively.Both the jinhuang ointment group and the combined group had significantly lower results than that of the control group(P=0.0003,P=0.0227).There was no difference in the results of the combined group and the jinhuang ointment group.The incidences of pain in the control group,the jinhuang ointment group,and the group of hand exercise combined with jinhuang ointment were 56.7%,36.7%,and 20%,respectively.There was no significant difference in the results of the jinhuang ointment group and the control group(P=0.1205);the combined group has shown a significant decrease in the incidence compared with the control group(P=0.0035);the incidence of pain in the combined group was lower than that of the jinhuang ointment group,but without a statistical difference(P=0.1520).Conclusion:Hand exercise together with jinhuang ointment inunction can significantly reduce the incidence of phlebitis produced by cinobufagin.

多磺酸粘多糖乳膏联合光子治疗仪治疗化学性静脉炎的临床疗效

目的研究化学性静脉炎患者采用多磺酸粘多糖乳膏联合光子治疗的效果。方法选取2022年1月—2023年6月重庆市中医院收治的108例化学性静脉炎患者为研究对象,按随机数字表法将其分为对照组和观察组,每组54例。对照组采用多磺酸粘多糖乳膏治疗,观察组在对照组基础上采用光子治疗。比较两组患者的治疗效果。结果观察组的静脉弹性恢复及红肿消退时间均短于对照组,组间差异有统计学意义(P<0.05)。治疗后,观察组的疼痛数字评价量表评分低于对照组,差异有统计学意义(P<0.05)。观察组的治疗总有效率、治疗总满意率分别为98.15%、100.00%,均高于对照组的85.19%、83.33%,组间差异有统计学意义(P<0.05)。观察组的不良反应发生率为1.85%,低于对照组的18.52%,差异有统计学意义(P<0.05)。结论化学性静脉炎患者采用多磺酸粘多糖乳膏联合光子治疗的效果显著,可快速缓解患者症状,减轻其疼痛,且不良反应发生率较低,值得临床推广使用。

复方桐叶烧伤油联合氦氖激光照射治疗可达龙微量泵注射所致静脉炎的疗效研究

目的:探讨复方桐叶烧伤油联合氦氖激光照射治疗可达龙微量泵注射所致静脉炎的疗效。方法:采用随机数字表法将2021年6月—2023年6月医院收治的72例可达龙微量泵注射所致静脉炎病人分为两组。两组均应用氦氖激光照射干预,对照组采用常规50%硫酸镁溶液湿敷,观察组采用复方桐叶烧伤油湿敷,5 d为1个疗程,两组病人均连续治疗2个疗程。比较两组病人干预效果、静脉炎严重程度、输液部位疼痛程度、中医证候积分、症状改善情况、舒适度及护理满意度。结果:观察组治疗总有效率高于对照组(P<0.05);两组病人干预前静脉炎严重程度、输液部位视觉模拟评分(VAS)、中医证候积分、Kolcaba舒适状况量表(GCQ)评分比较差异无统计学意义(P>0.05);观察组干预后静脉炎严重程度轻于对照组,输液部位VAS评分、中医证候积分低于对照组,GCQ评分高于对照组(P<0.05);相比于对照组,观察组疼痛缓解、红肿消退时间较短,护理满意度较高(P<0.05)。结论:可达龙微量泵注射所致静脉炎病人应用复方桐叶烧伤油联合氦氖激光照射治疗具有较好的效果,可以缓解疼痛,缩短红肿消退时间,改善临床症状,提高病人舒适度和护理满意度,具有较高的临床应用价值。

两种迷你中线导管置管方法的效果比较

目的 探讨提高一次穿刺成功率、减少并发症的迷你中线导管置管方法。方法 将130例拟行迷你中线导管穿刺的患者随机分为对照组和观察组各65例。对照组采用盲穿置管法,导管留置于前臂浅静脉。观察组在超声引导下进行迷你中线导管置管,导管留置于上臂静脉。观察并比较两组患者一次穿刺成功率、置管操作时间、并发症发生率及导管留置时间。结果 对照组64例、观察组63例完成研究。观察组患者一次穿刺成功率(96.83%)显著高于对照组(85.94%);静脉炎发生率显著低于对照组,置管操作时间、导管留置时间显著长于对照组(均P<0.05)。结论 采用超声引导下迷你中线导管置管可以提高一次穿刺成功率,降低静脉炎发生率,延长导管留置时间。

中药膏剂外敷预防缺血性脑卒中肢体障碍患者留置针发生静脉炎的临床研究

目的使用成人外周静脉留置针相关静脉炎风险评价(IINPR)量表工具,筛选使用静脉留置针的高风险缺血性脑卒中肢体障碍患者,使用外用中药疗法,进行静脉炎预防性干预对照研究。方法建立研究入组标准,选择2021年3月至2022年6月潍坊医学院附属高密市人民医院患者138例,采用随机数表法分为观察组和对照组,每组各69例。所有患者进行IINPR量表评分。两组患者均给予留置针常规维护方案,对IINPR量表评分≥4分患者涂敷中药膏剂预防外周静脉导管(PIVC)静脉炎。结果观察终点观察组IINPR量表评分为(3.13±1.01)分,低于对照组的(4.91±1.34)分,差异有统计学意义(P<0.05)。观察组静脉炎发生率为5.80%,低于对照组的18.84%,差异有统计学意义(P<0.05)。观察组静脉留置针留置时间为(97.74±6.88)h,长于对照组的(66.38±10.81)h,差异有统计学意义(P<0.05)。结论本研究中西医结合,采用IINPR量表评分,静脉炎高危患者及时采取中药外敷预防干预措施,可以降低缺血性脑卒中患者外周静脉导管静脉炎发生率、延长静脉留置针留置时间。

外周静脉炎预防措施的最佳证据总结

目的总结预防外周静脉炎的最佳证据,为临床开展循证实践提供参考和依据。方法在WHO、GIN等6个指南网站检索相关指南和证据综合,在UpToDate和万方等7个中英文数据库补充检索系统评价和临床决策,并对纳入文献进行质量评价和证据提取。结果最终纳入11篇文献,包括9篇系统评价和2篇临床决策,总结出药物、敷料、固定方式3个方面的13条证据。结论外周静脉炎预防措施的最佳证据可指导临床实践,为减少外周静脉炎的发生,缓解患者痛苦,保障治疗的有效进行提供依据。

药物性静脉炎的中医药治疗和护理干预研究进展

药物性静脉炎不仅增加患者痛苦和经济负担,同时也不利于疾病的治疗。中医药在临床应用广泛,其在治疗药物性静脉炎方面有着独特的优势。本文就药物性静脉炎发生原因、中医药治疗方法和护理干预进行综述,旨在为临床治疗药物性静脉炎提供新思路和帮助护理人员提高护理安全和用药意识。

静脉注射丁二磺酸腺苷蛋氨酸对外周浅静脉影响的回顾性研究

目的了解静脉注射注射用丁二磺酸腺苷蛋氨酸(思美泰)对外周浅表静脉的影响,为合理治疗因静脉注射思美泰而产生的静脉炎而提供科学依据。结合静脉炎的产生机制及原因提出相应的处理方法及护理措施,预防及减轻静脉炎的相关症状。方法采用回顾性研究方法,抽取2023年1月1日—2023年12月31日就诊于宜昌市中心人民医院介入放射科的163名患者作为研究对象,其中61名患者采用留置针依照药品说明书静脉输注思美泰作为试验组,102名患者采用留置针静脉输注等渗性液体作为对照组。利用思美泰的药理特性、产生静脉炎的原因及机制、静脉炎的分型和分级等专业知识进行调查研究,主要观察疼痛、皮肤红肿范围、静脉呈条索状无弹性的长度及静脉炎级别等指标。结果在严格按照说明书的配置方法及输液速度进行操作采用留置针静脉输注思美泰时外周浅表静脉可发生静脉炎。发生的静脉炎主要见于红肿型和硬结型(χ^(2)=8.69,P<0.05),其中静脉炎可见于1级、2级、3级其中以3级多见(χ^(2)=116.22,P<0.01),其产生的疼痛以2分和3分为主(χ^(2)=85.12,P<0.01)。结论静脉注射思美泰可导致外周浅表静脉发生静脉炎。

四黄紫金散水胶体治疗肠外营养致输液性静脉炎的效果观察

目的探讨四黄紫金散水胶体治疗肠外营养致输液性静脉炎(IP)的临床效果。方法回顾性选取2023年6至11月在浙江省肿瘤医院肠外营养致IP患者100例为研究对象。其中50例患者采用四黄紫金散水胶体外敷治疗IP(观察组),50例患者采用50%硫酸镁湿敷治疗IP(对照组)。比较两组患者治疗前与治疗72 h后IP临床分级、IP彩超分级、疼痛评分及疼痛缓解时间、红肿消退时间。结果观察组患者的IP临床分级治愈率、IP彩超分级治愈率均明显高于对照组(74.00%比44.00%、70.00%比36.00%,均P<0.05)。治疗72 h后观察组疼痛评分明显低于对照组[0(0,1.00)分比1.50(0,3.00)分],疼痛缓解时间优于对照组[(16.84±1.18)h比(23.84±1.50)h],红肿消退时间短于对照组[(12.50±1.15)h比(15.52±1.75)h](均P<0.05)。结论四黄紫金散水胶体治疗肠外营养致IP效果良好,能显著提高IP治愈率,减轻患处疼痛,且起效时间短,适合临床使用。

新生儿沐浴用留置针防水装置的设计及应用

目的探讨自行设计的留置针防水装置在新生儿沐浴中的应用效果。方法选取2021年1—12月福建医科大学附属第二医院接受静脉留置针治疗且病情允许沐浴的新生儿252例为研究对象,将2021年1—6月采用常规保护套进行新生儿沐浴的静脉留置针患儿124例作为对照组,将2021年7—12月采用留置针防水装置进行新生儿沐浴的静脉留置针患儿128例作为观察组。对比2组沐浴后留置针的使用情况及静脉炎等并发症的发生情况。结果观察组留置针留置时间为(92.56±3.31)h,长于对照组的(65.44±4.13)h,非计划拔管率(2.34%)低于对照组(13.71%),差异均有统计学意义(P<0.05)。观察组静脉炎发生率(4.68%)低于对照组(22.58%),差异有统计学意义(P<0.05)。结论该留置针防水装置操作简便、安全,将其用于新生儿沐浴期间,可有效延长留置针的使用时间,减少非计划拔管,同时安全性良好,可降低静脉炎的发生概率。

虎杖四黄汤湿热敷对预防七叶皂苷钠所致静脉炎临床研究

目的:观察虎杖四黄汤湿热敷对预防七叶皂苷钠所致静脉炎的效果。方法:选取180例静脉滴注七叶皂苷钠患者为研究对象,按入院先后顺序分为对照组、硫酸镁组、虎杖四黄汤组各60例。对照组采用常规护理方案,治疗前常规宣教并加强巡视,查看局部皮肤情况及时给予处理;硫酸镁组采用50%硫酸镁湿敷膜外敷;虎杖四黄汤组采用虎杖四黄汤药液湿热敷。硫酸镁组及虎杖四黄汤组患者均在药物输注5 min后进行外敷保持到七叶皂苷钠输完30 min后撤除。疗程4 d,每天1次。比较3组静脉炎发生率、护理满意度,比较3组治疗前后疼痛评分的变化。结果:治疗4 d后,虎杖四黄汤组静脉炎发生率为11.67%,硫酸镁组静脉炎发生率为23.33%,对照组静脉炎发生率为33.33%,虎杖四黄汤组静脉炎发生率低于硫酸镁组及对照组,差异有统计学意义(P<0.05)。治疗4 d后,3组疼痛评分均较治疗前下降(P<0.05),采用单因素方差分析进行组间比较,差异有统计学意义(P<0.05);虎杖四黄汤组疼痛改善情况优于硫酸镁组和对照组,差异有统计学意义(P<0.05)。虎杖四黄汤组护理满意度为96.67%,硫酸镁组护理满意度为90.00%,对照组护理满意度为80.00%,差异有统计学意义(P<0.05)。结论:虎杖四黄汤湿热敷可有效预防输注七叶皂苷钠所致的静脉炎,有效减轻穿刺侧肢体疼痛,提高护理满意度及用药依从性。

基于Logistic回归模型的头孢类药物引起静脉炎危险因素分析

目的:探讨基于Logistic回归模型的头孢类药物引起静脉炎危险因素。方法:选取345例输注头孢类药物的住院患者为研究对象,根据是否发生静脉炎分为研究组(n=27)和对照组(n=318)。比较两组患者一般资料、头孢类药物用药情况,分析头孢类药物引起静脉炎的相关因素。结果:研究组中,患者静脉炎1级4例,2级16例,3级7例,经对症治疗后所有患者均转归有效,无严重后遗症发生。单因素分析结果显示,两组患者年龄、药物过敏史、用药时间、滴注速度均有统计学差异(P<0.05);多因素Logistic回归结果显示,合并药物过敏史、用药时间≥7 d是头孢类药物引起静脉炎的独立危险因素(P<0.05)。结论:合并药物过敏史、头孢类药物用药时间≥7 d可能会增加患者静脉炎发生风险;因此,临床应用头孢类药物时,应重点关注既往存在药物过敏史及用药时间过长的患者,规范使用,减少静脉炎的发生。

活血祛瘀方在PICC相关血栓性浅静脉炎患者中的应用

目的 评价发生经外周中心静脉置管(PICC)相关的血栓性浅静脉炎患者应用活血祛瘀方湿敷治疗的临床效果。方法 选取2019年1月1日至2022年12月31日在河南省人民医院因乳腺癌入院采用PICC进行化疗后发生血栓性浅静脉炎的86例患者作为研究对象,随机分为对照组42例、试验组44例,对照组接受常规干预,试验组在对照组的基础上接受活血祛瘀方湿敷治疗。比较治疗前后视觉模拟评分(VAS)、上臂臂围变化情况、临床症状消失时间(包括血栓性浅静脉炎痊愈时间、红肿消退时间、疼痛好转时间)、静脉炎治疗情况、生化指标(白细胞计数、血清C反应蛋白)变化情况,同时记录治疗期间不良反应情况。结果 通过干预治疗,两组患者VAS评分均逐渐下降,且对照组低于试验组(P<0.05);两组患者上臂的臂围变化情况差异无统计学意义(P>0.05);试验组患者血栓性浅静脉炎痊愈用时、皮肤红肿消退时间、疼痛好转时间均比对照组短(P<0.05);试验组患者治疗7 d后总有效率之间比较差异无统计学意义(P>0.05);治疗后,白细胞计数和血清C反应蛋白均有所降低,且试验组更低(P<0.05)。两组不良反应发生情况差异无统计学意义(P>0.05)。结论 乳腺癌切除术后采用PICC输液时发生浅静脉炎的患者在基础治疗的同时应用活血祛瘀方湿敷治疗的临床效果明确,可以减轻炎症反应,促进患者恢复,且安全性高。

行气活血止痛膏对输液性静脉炎疗效及相关炎性因子影响的实验研究

目的探讨行气活血止痛膏中药外治法在静脉炎治疗中的应用效果。方法以甘露醇为致炎物,通过家兔耳缘静脉进行输注,建立静脉炎模型,将建模成功的家兔随机分为4个亚组进行干预,空白对照组常规饲养,不做任何干预处理。干预后通过观察静脉炎表征、血清白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、血管内皮生长因子A(VEGF-A)的含量,探讨行气活血止痛膏对甘露醇致家兔输液性静脉炎的改善作用。结果造模成功率为90.0%。治疗第1天,生理盐水组无效8例、有效1例;喜疗妥组无效6例、有效3例;硫酸镁组无效7例、有效2例;行气活血止痛膏组无效7例、有效2例;4组疗效比较,差异无统计学意义(P=0.431)。治疗第4天,生理盐水组无效5例、有效2例、显效2例;喜疗妥组有效1例、显效5例、治愈3例;硫酸镁组有效2例、显效5例、治愈2例;行气活血止痛膏组有效2例、显效4例、治愈3例。治疗第4天,与生理盐水组比较,喜辽妥组(P=0.001)、硫酸镁组(P=0.020)、行气活血止痛膏组(P=0.003)疗效差异均有统计学意义;硫酸镁组、行气活血止痛膏组疗效与喜疗妥组比较,差异均无统计学意义(P>0.05);与硫酸镁组比较,喜疗妥组、行气活血止痛膏组疗效差异均无统计学意义(P>0.05);与行气活血止痛膏组比较,喜疗妥组、硫酸镁组疗效差异均无统计学意义(P>0.05);生理盐水组治疗有效率为11.1%,治愈率为0%,喜辽妥组有效率为100.0%,治愈率为33.3%,硫酸镁组有效率为77.7%,治愈率为44.4%,行气活血止痛膏组有效率为66.7%,治愈率为22.2%。行气活血止痛膏组、喜疗妥组、硫酸镁组药物有效率高于生理盐水组,差异有统计学意义(P<0.05)。干预后,4个模型亚组血清炎性因子IL-6、TNF-α、VEGF-A水平与空白对照组比较,差异均有统计学意义(P<0.05);生理盐水组与喜辽妥组、硫酸镁组、行气活血止痛膏组血清炎性因子IL-6、TNF-α、VEGF-A含量差异均有统计学意义(P<0.05);与喜辽妥组比较,硫酸镁组和行气活血止痛膏组血清炎性因子IL-6、TNF-α、VEGF-A含量比较,差异均有统计学意义(P<0.05)。空白对照组炎性因子水平最低,生理盐水组炎性因子水平最高。结论行气活血止痛膏对于甘露醇致家兔输液性静脉炎具有改善作用,但相较于常用的喜疗妥软膏疗效较差,因此可对药物配方进行适当调整和改进,以提高疗效。