In this paper, the design and verification process of an automobile-engine-fan control system on chip （SoC） are introduced. The SoC system, SHU-MV08, reuses four new intellectual property （IP） cores and the design...In this paper, the design and verification process of an automobile-engine-fan control system on chip （SoC） are introduced. The SoC system, SHU-MV08, reuses four new intellectual property （IP） cores and the design flow is accomplished with 0.35 btm chartered CMOS technology. Some special functions of IP cores, the detailed integration scheme of four IP cores, and the verification method of the entire SoC are presented. To settle the verification problems brought by analog IP cores, NanoSim based chip-level mixed-signal verification method is introduced. The verification time is greatly reduced and the first tape-out achieves success which proves the validity of our design.展开更多
In this study, an Alzheimer＇s disease model was established in rats through stereotactic injection of condensed amyloid beta 1-40 into the bilateral hippocampus, and the changes of gene expression profile in the hipp...In this study, an Alzheimer＇s disease model was established in rats through stereotactic injection of condensed amyloid beta 1-40 into the bilateral hippocampus, and the changes of gene expression profile in the hippocampus of rat models and sham-operated rats were compared by genome expression profiling analysis. Results showed that the expression of 50 genes was significantly up-regulated （fold change 〉 2）, while 21 genes were significantly down-regulated in the hippocampus of Alzheimer＇s disease model rats （fold change 〈 0.5） compared with the sham-operation group. The differentially expressed genes are involved in many functions, such as brain nerve system development, neuronal differentiation and functional regulation, cellular growth, differentiation and apoptosis, synaptogenesis and plasticity, inflammatory and immune responses, ion channels/transporters, signal transduction, cell material/energy metabolism. Our findings indicate that several genes were abnormally expressed in the metabolic and signal transduction pathways in the hippocampus of amyloid beta 1 40-induced rat model of Alzheimer＇s disease, thereby affecting the hippocampal and brain functions.展开更多
In this paper, the effect of four sequential cuts in side milling of Ti6Al4V on chip formation and residual stresses （RS） are investigated using finite element method （FEM）. While the open literature is limited ma...In this paper, the effect of four sequential cuts in side milling of Ti6Al4V on chip formation and residual stresses （RS） are investigated using finite element method （FEM）. While the open literature is limited mainly to the studies of orthogonal sequential cutting with the constant uncut chip thickness greater than 0.01 mm, it is suggested herein to investigate not only the variable uncut chip thickness which characterises the down milling process, but also the uncut chip thickness in the sub-micron range using a finite cutting edge radius. For the resulting ductile machining regime, the characteristics of the chip mor- phology, the force profiles, the plastic deformation and temperature distributions have been analyzed. Furthermore, this study revealed that the RS should be extracted toward the area where the insert exits the workpiece in the FE simulation of the down-milling process. The simulation of a number of sequential cuts due to the consecutive engagements of the insert is required in order to capture the gradual accumulation of the RS before reaching an asymptotic convergence of the RS profile. The predicted RS are in reasonable agreement with the experimental results.展开更多
Titanium alloys are one of the most important design materials for the aircraft industry. The high strength-to-density-ratio and the compatibility with carbon fibre reinforced plastic are the reasons for a raising app...Titanium alloys are one of the most important design materials for the aircraft industry. The high strength-to-density-ratio and the compatibility with carbon fibre reinforced plastic are the reasons for a raising application in this field. The outstanding properties lead to challenging machining processes. High strength and low heat conductivity affect high mechanical and thermal loads for the cutting edge. Thus, the machining process is characterized by a rapid development of tool wear even at low cutting parameter. To reach a sufficient productivity it is necessary to dissipate the resulting heat from the cutting edge by a coolant. Therefore the cryogenic machining of two different titanium alloys is investigated in this work. The results point out the different behavior of the machining processes under cryogenic conditions because of the reduced thermal load for the cutting tool. According to this investigation, the cryogenic cooling with COa enables an increase of the tool life in comparison to emulsion based cooling principles when machining the α＋β-titanium alloy Ti-6Al-4V. The machining process of the high strength titanium alloy Ti-6Al-2Sn-4Zr-6Mo requires an additional lubrication realized by a minimum quantity lubrication （MQL） with oil. This combined cool- ing leads to a smoother chip underside and to slender shear bands between the different chip segments.展开更多
The purpose of this study was to develop a protein chip technique based on receptor binding assays to measure bioavailable serum sex hormone levels (BSSHL). 224 aging healthy Chinese were investigated to get the refer...The purpose of this study was to develop a protein chip technique based on receptor binding assays to measure bioavailable serum sex hormone levels (BSSHL). 224 aging healthy Chinese were investigated to get the referenced values of BSSHL for the first time. In the assays recombined sex hormone receptor proteins were jointed to polysaccharide coated slides to make protein chip,; the dose-dependence curves of sex hormone on chip were prepared. The data showed that this method had good precision (CV>16%); accuracy (Bias>10%),; the sensitivity could reach 1 pmol/L. From the results, BSSHL of men; women declined with aging, but no significant differences were observed. The BSSHL of aging men were higher than those of women. The bioavailable serum;rogen level of men was 52–112 pmol/L, women’s was 3–70 pmol/L; the whole group was 41.9–81.4 pmol/L. The bioavailable serum estrogen level of men was 0.8–3.0 pmol/L, women’s was 1.2–2.5 pmol/L; the whole group was 0.6–2.64 pmol/L. Based on the assays, BSSHL measurement by protein chip can meet the needs of epidemiological studies in terms of speed, accuracy; sample volume required,; was helpful in quantitative assessment of aging people’s health.展开更多
基金Project supported by the IC Special Foundation of Shanghai Municipal Commission of Science and Technology (Grant No.09706201300)the Shanghai Municipal Commission of Economic and Information (Grant No.090344)the Shanghai High-Tech Industrialization of New Energy Vehicles (Grant No.09625029),and the Graduate Innovation Foundation of Shanghai University
文摘In this paper, the design and verification process of an automobile-engine-fan control system on chip （SoC） are introduced. The SoC system, SHU-MV08, reuses four new intellectual property （IP） cores and the design flow is accomplished with 0.35 btm chartered CMOS technology. Some special functions of IP cores, the detailed integration scheme of four IP cores, and the verification method of the entire SoC are presented. To settle the verification problems brought by analog IP cores, NanoSim based chip-level mixed-signal verification method is introduced. The verification time is greatly reduced and the first tape-out achieves success which proves the validity of our design.
基金sponsored by the National Natural Science Foundation of China,No. 30973779
文摘In this study, an Alzheimer＇s disease model was established in rats through stereotactic injection of condensed amyloid beta 1-40 into the bilateral hippocampus, and the changes of gene expression profile in the hippocampus of rat models and sham-operated rats were compared by genome expression profiling analysis. Results showed that the expression of 50 genes was significantly up-regulated （fold change 〉 2）, while 21 genes were significantly down-regulated in the hippocampus of Alzheimer＇s disease model rats （fold change 〈 0.5） compared with the sham-operation group. The differentially expressed genes are involved in many functions, such as brain nerve system development, neuronal differentiation and functional regulation, cellular growth, differentiation and apoptosis, synaptogenesis and plasticity, inflammatory and immune responses, ion channels/transporters, signal transduction, cell material/energy metabolism. Our findings indicate that several genes were abnormally expressed in the metabolic and signal transduction pathways in the hippocampus of amyloid beta 1 40-induced rat model of Alzheimer＇s disease, thereby affecting the hippocampal and brain functions.
文摘In this paper, the effect of four sequential cuts in side milling of Ti6Al4V on chip formation and residual stresses （RS） are investigated using finite element method （FEM）. While the open literature is limited mainly to the studies of orthogonal sequential cutting with the constant uncut chip thickness greater than 0.01 mm, it is suggested herein to investigate not only the variable uncut chip thickness which characterises the down milling process, but also the uncut chip thickness in the sub-micron range using a finite cutting edge radius. For the resulting ductile machining regime, the characteristics of the chip mor- phology, the force profiles, the plastic deformation and temperature distributions have been analyzed. Furthermore, this study revealed that the RS should be extracted toward the area where the insert exits the workpiece in the FE simulation of the down-milling process. The simulation of a number of sequential cuts due to the consecutive engagements of the insert is required in order to capture the gradual accumulation of the RS before reaching an asymptotic convergence of the RS profile. The predicted RS are in reasonable agreement with the experimental results.
文摘Titanium alloys are one of the most important design materials for the aircraft industry. The high strength-to-density-ratio and the compatibility with carbon fibre reinforced plastic are the reasons for a raising application in this field. The outstanding properties lead to challenging machining processes. High strength and low heat conductivity affect high mechanical and thermal loads for the cutting edge. Thus, the machining process is characterized by a rapid development of tool wear even at low cutting parameter. To reach a sufficient productivity it is necessary to dissipate the resulting heat from the cutting edge by a coolant. Therefore the cryogenic machining of two different titanium alloys is investigated in this work. The results point out the different behavior of the machining processes under cryogenic conditions because of the reduced thermal load for the cutting tool. According to this investigation, the cryogenic cooling with COa enables an increase of the tool life in comparison to emulsion based cooling principles when machining the α＋β-titanium alloy Ti-6Al-4V. The machining process of the high strength titanium alloy Ti-6Al-2Sn-4Zr-6Mo requires an additional lubrication realized by a minimum quantity lubrication （MQL） with oil. This combined cool- ing leads to a smoother chip underside and to slender shear bands between the different chip segments.
文摘The purpose of this study was to develop a protein chip technique based on receptor binding assays to measure bioavailable serum sex hormone levels (BSSHL). 224 aging healthy Chinese were investigated to get the referenced values of BSSHL for the first time. In the assays recombined sex hormone receptor proteins were jointed to polysaccharide coated slides to make protein chip,; the dose-dependence curves of sex hormone on chip were prepared. The data showed that this method had good precision (CV>16%); accuracy (Bias>10%),; the sensitivity could reach 1 pmol/L. From the results, BSSHL of men; women declined with aging, but no significant differences were observed. The BSSHL of aging men were higher than those of women. The bioavailable serum;rogen level of men was 52–112 pmol/L, women’s was 3–70 pmol/L; the whole group was 41.9–81.4 pmol/L. The bioavailable serum estrogen level of men was 0.8–3.0 pmol/L, women’s was 1.2–2.5 pmol/L; the whole group was 0.6–2.64 pmol/L. Based on the assays, BSSHL measurement by protein chip can meet the needs of epidemiological studies in terms of speed, accuracy; sample volume required,; was helpful in quantitative assessment of aging people’s health.
