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Biomedical application of photo-crosslinked gelatin hydrogels 被引量:1
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作者 Lei Xiang Wenguo Cui 《Journal of Leather Science and Engineering》 2021年第1期18-41,共24页
During the past decades,photo-crosslinked gelatin hydrogel(methacrylated gelatin,GelMA)has gained a lot of attention due to its remarkable application in the biomedical field.It has been widely used in cell transplant... During the past decades,photo-crosslinked gelatin hydrogel(methacrylated gelatin,GelMA)has gained a lot of attention due to its remarkable application in the biomedical field.It has been widely used in cell transplantation,cell culture and drug delivery,based on its crosslinking to form hydrogels with tunable mechanical properties and excellent bio-compatibility when exposed to light irradiation to mimic the micro-environment of native extracellular matrix(ECM).Because of its unique biofunctionality and mechanical tenability,it has also been widely applied in the repair and regeneration of bone,heart,cornea,epidermal tissue,cartilage,vascular,peripheral nerve,oral mucosa,and skeletal muscle et al.The purpose of this review is to summarize the recent application of GelMA in drug delivery and tissue engineering field.Moreover,this review article will briefly introduce both the development of GelMA and the characterization of GelMA.Finally,we discuss the challenges and future development prospects of GelMA as a tissue engineering material and drug or gene delivery carrier,hoping to contribute to accelerating the development of GelMA in the biomedical field. 展开更多
关键词 GELATIN Gelatin methacryloyl Biomedical application HYDROGELS photo crosslink
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