Aggregation-induced Emission Probe for Fluorescence/Photoacoustic Dual-modality Imaging and Photodynamic/Photothermal Treatment

The combination of near-infrared(NIR)fluorescence imaging(FLI)and photoacoustic imaging(PAI)can effectively compensate for each other’s inherent limitations,which can provide reliable and rich information on tumor biology.Therefore,the development of FL/PA dual-modality imaging probes is beneficial for achieving precision cancer diagnosis and treatment.Herein,we designed an efficient phototherapy agent methoxy bithiophene indene(OTIC),which was based on aggregation-induced emission(AIE)active fluorophores.To improve the water dispersion and enrichment of OTIC at the tumor site,OTIC nanoparticles(OTIC NPs)were prepared by a nanoprecipitation method.The balance between radiation and non-radiation energy dissipation was regulated by the strong donor-acceptor interaction and intramolecular motion.So OTIC NPs exhibited bright NIR fluorescence,photoacoustic signals,efficient generation of reactive oxygen species,and high photothermal conversion efficiency under NIR irradiation.Accurate imaging of the tumor and mice sentinel lymph nodes(SLNs)with OTIC NPs was visualized by NIR FL/PA dual-modal imaging.With the comprehensive imaging information provided by OTIC NPs in vivo,tumors were ablated under laser irradiation,which greatly improved the therapeutic efficacy.OTIC NPs would be possible to realize the precise guidance of FL/PA imaging for tumor treatment in the future clinical application.

Chemically exfoliated WS2 nanosheets efficiently inhibit amyloid β-peptide aggregation and can be used for photothermal treatment of Alzheimer＇s disease

Polymerization of amyloid-β peptide （Aβ） into amyloid fibrils is a critical step in the pathogenesis of Alzheimer＇s disease （AD）. Inhibition of Aβ aggregation and destabilization of preformed Aβ fibrils have promising effects against AD and have been used in clinic trials. Herein, we demonstrate, for the first time, the application of WS2 nanosheets, to not only effectively inhibit Aβ aggregation, but also dissociate preformed Aβ aggregates upon near infrared （NIR） irradiation. Additionally, the biocompatible WS2 nanosheets possess the ability to cross the blood-brain barrier （BBB） to overcome the limitations of most previously reported Aβ inhibitors. Through van der Waals and electrostatic interactions between Aβ40 and WS2, Aβ40 monomers can be selectively adsorbed on the surface of the nanosheet to inhibit the Aβ40 aggregation process. Intriguingly, the unique high NIR absorption property of WS2 enables amyloid aggregates to be dissolved upon NIR irradiation. These results will promote biological applications of WS2 and provide new insight into the design of multifunctional nanomaterials for AD treatment.

OPTICAL COHER ENCE TOMOGRAPHY OF ADIPOSE TISSUE AT PHOTODYNAMIC/PHOTOTHERMAL TRE ATMENT IN VITRO

Temporal changes in structure and refractive index distribution of adipose tissue at photo-dynamic/photothermal treatment were studied with OCT in vitro.Ethanol-water solutions of indocyanine green(ICG)and brilliant green(BG)were used for fat tissue staining.CW laser diode(808 nm)and LED light source(442 and 597 nm)were used for ir adiation of stained tissue slices.The data received supporting the hypothesis that photodynamic/photothermal treatment,induces fat cell lipolysis during a certain period of time after light exposure.

Gold Nanorods-mediated Photothermal Therapy Guided by Vascular Interventional Radiation to Inhibit Cancer Metastasis

The purpose of this study was to investigate the inhibitory effect of gold nanorods-mediated photothermal therapy on liver metastasis of colorectal cancer under the guidance of vascular interventional radiology.A total of 80 patients admitted to our hospital from February 2018 to February 2020 were selected and randomly divided into study group and control group with 40 cases each,among which the control group received 125I seed implantation combined with chemotherapy.On this basis,the study group were added the gold nanorods(AuNRs)to the photothermal therapy additionally.The clinical efficacy,postoperative complications and postoperative survival rates of the two groups were compared.The results showed that the total clinical effective rate was 82.5%in the study group,which was significantly better than 67.5%in the control group,and the difference was statistically significant(P<0.05).In addition,the incidence of leukocytosis,nausea,vomiting and delayed diarrhea in the study group was significantly lower than that in the control group,with statistically significant differences(P<0.05).There were no statistically significant differences in the proportion of elevated body temperature,liver dysfunction,or moderate liver pain between the two groups(P>0.05).Therefore,under the guidance of vascular interventional radiology,Au NRs are safe and effective materials for the treatment of liver metastasis of colorectal cancer,which can reduce complications and improve postoperative survival rates.

Polydopamine nanoparticle-dotted food gum hydrogel with excellent antibacterial activity and rapid shape adaptability for accelerated bacteria-infected wound healing

Most commonly used wound dressings have severe problems,such as an inability to adapt to wound shape or a lack of antibacterial capacity,affecting their ability to meet the requirements of clinical applications.Here,a nanocomposite hydrogel(XKP)is developed by introducing polydopamine nanoparticles(PDA NPs)into a food gum matrix(XK,consisting of xanthan gum and konjac glucomannan,both FDA-approved food thickening agents)for skin wound healing.In this system,the embedded PDA NPs not only interact with the food gum matrix to form a hydrogel with excellent mechanical strength,but also act as photothermal transduction agents to convert near-infrared laser radiation to heat,thereby triggering bacterial death.Moreover,the XKP hydrogel has high elasticity and tunable water content,enabling it to adapt to the shape of the wound and insulate it,providing a moist environment suitable for healing.In-vivo skin wound healing results clearly demonstrate that XKP can significantly accelerate the healing of wounds by reducing the inflammatory response and promoting vascular reconstruction.In summary,this strategy provides a simple and practical method to overcome the drawbacks of traditional wound dressings,and provides further options when choosing suitable wound healing materials for clinical applications.