Ecological effect of the plantation of Sabina vulgaris in the Mu Us Sandy Land,China

Vegetation restoration through artificial plantation is an effective method to combat desertification,especially in arid and semi-arid areas.This study aimed to explore the ecological effect of the plantation of Sabina vulgaris on soil physical and chemical properties on the southeastern fringe of the Mu Us Sandy Land,China.We collected soil samples from five depth layers(0-20,20-40,40-60,60-80,and 80-100 cm)in the S.vulgaris plantation plots across four plantation ages(4,7,10,and 16 years)in November 2019,and assessed soil physical(soil bulk density,soil porosity,and soil particle size)and chemical(soil organic carbon(SOC),total nitrogen(TN),available nitrogen(AN),available phosphorus(AP),available potassium(AK),cation-exchange capacity(CEC),salinity,p H,and C/N ratio)properties.The results indicated that the soil predominantly consisted of sand particles(94.27%-99.67%),with the remainder being silt and clay.As plantation age increased,silt and very fine sand contents progressively rose.After 16 years of planting,there was a marked reduction in the mean soil particle size.The initial soil fertility was low and declined from 4 to 10 years of planting before witnessing an improvement.Significant positive correlations were observed for the clay,silt,and very fine sand(mean diameter of 0.000-0.100 mm)with SOC,AK,and p H.In contrast,fine sand and medium sand(mean diameter of 0.100-0.500 mm)showed significant negative correlations with these indicators.Our findings ascertain that the plantation of S.vulgaris requires 10 years to effectively act as a windbreak and contribute to sand fixation,and needs 16 years to improve soil physical and chemical properties.Importantly,these improvements were found to be highly beneficial for vegetation restoration in arid and semi-arid areas.This research can offer valuable insights for the protection and restoration of the vegetation ecosystem in the sandy lands in China.

Progress on the melanoidins produced by the Maillard reaction of fermented food and traditional Chinese medicine

FMs(Food-borne melanoidins)are brown high molecular weight polymers formed by the Mailiard reaction between carbohydrates and nitrogen-containing compounds during the processing of food or Traditional Chinese Medicine(TCM),and are widely found in food-borne products such as TCM concoctions,bakery,brewing,soy sauce,ferment and other food-borne products.FMs not only have a variety of biological activities,such as antioxidant,antibacterial,immunomodulation,regulation of intestinal flora,etc.,and can change the color,aroma and taste of food.The diversity of its components has become a research hotspot at home and abroad in recent years,with a wide range of application prospects.Therefore,this paper summarizes the existing information on FMs at home and abroad,mainly describes their preparation process,physicochemical properties,structural characteristics and functional activity research progress.Typical FMs,such as coffee,biscuits,wine and soy sauce in daily food,and Polygonatum,Perilla oil,Black ginseng,and Red jujube in T,were highlighted.Summarising the current status of research between the chemistry and pharmacodynamics of relevant FMs and presenting challenges and future recommendations for melanoidin research.In future research on FMs,one should pay more attention to basic research,especially isolation and purification and generation mechanisms,to further demonstrate the biological activity of FMs in vivo and in clinical trials.Thus,the potential value of its existence is deeply exploited to meet the needs of technology,production and health.

Changing Rules of Physical and Chemical Properties of Eucalyptus uraphylla spp. Forest at Different Ages in Southwest Yunnan Province

[Objective] The aim was to study on changing rules of physical and chemical properties of Eucalyptus uraphylla spp. forest at different ages in Southwest of Yunnan Province. [Method] In the research, field survey and laboratory analysis were adopted to study on physical and chemical properties of soils for the Eucalyptus uraphylla spp. at the first cutting ages in Lancang County. [Result] With the increasing of forest ages, for physical properties of soils, soil bulk density was increasing, and soil structure became poor; water contents in soils and capillary porosity were improving, but total soil porosity and non-capillary porosity were decreasing. For chemical properties, pH of soil dropped, but soil acidity improved; organic matter, total N, hydrolysable nitrogen, available phosphorus, and available potassium all declined; exchangeable Ca and Mg were improving due to fertilization and Ca and Mg lower consumption. The results showed that plays important roles in water absorption of soils and vegetation growth were improved with age increase by Eucalyptus uraphylla spp. forest, but ventilation and fertility declined accordingly. [Conclusion] The research indicated that dry branches and fallen leaves should be preserved and nutrient cycling should be protected during introduction and management of Eucalyptus uraphylla spp. to guarantee the nutrients in dry branches and leaves are back to soils, providing theoretical references for management of forest plantation and environment protection.

Soil Physical and Chemical Properties of Five Subtropical Forests in Lingao of Hainan

With 5 types of typical forests as research object, the physical and chemical properties of different types of forests were analyzed by sample plot investigation method. The results showed that： the soil total porosity was the highest in the Casuarina equisetifolia forest （46.168%）, but the lowest in the Encalyptus robusta forest （39.46%）. The soil capillary porosity was the highest in the Acacia mangium forest （22.57%）, but the lowest in the secondary forest （18.95%）. The soil water content was the highest in the C. equisetifolia forest, with a mean value of 27.85%, but the lowest in the secondary forest, with a mean value of 4.34%. The soil pH values were in the range of 4.81-6.59, the soils in the A. mangium forest, C. equisetifolia forest and E. robusta forest were strongly acidic （pH 4.5-5.5）, and the soils in the secondary forest and C. nucifera forest were weakly acidic. The soils had organic matter contents in the range of 0.34-28.68 g/kg, and showed an order of A. mangium forest〉C. equisetifolia forest〉E. robusta forest〉secondary forest〉C. nucifera forest, with a decreasing trend with the soil depth increasing. The soil total N contents were in the range of 0.10-1.63 g/kg, the A. mangium forest showed the highest soil total N contents, while the C. nucifera forest exhibited the lowest soil total N contents; the soil total P contents were in the range of 0.21-1.74 g/kg, and the E. robusta forest had the highest soil total P contents; and the soil total K contents were in the range of 0.16-2.15 g/kg, and the A. mangium forest exhibited the highest soil total K contents. The soil available P contents were in the range of 0.98-132.46 mg/kg; and the secondary forests had the highest soil available P contents; and the soil rapidly available K contents were in the range of 3.03-27.35 mg/kg, and the C. nucifera forest exhibited the highest soil rapidly available K contents. The soil ammonium N contents were in the range of 1.38-5.15 mg/kg, and the nitrate N contents were in the range were in the range of 0.56 -3.51 mg/kg. The A. mangium forest showed the highest soil nitrate N contents （with a mean value of 2.29 mg/kg） and ammonium N contents （with a mean value of 3.93 mg/kg）. For the same forest type, with the increase of soil depth, the nitrate nitrogen and ammonium nitrogen content also showed a decreasing trend.

Classification and Distribution of Common Aroma Components in Tobacco Leaf Based on Their Physical and Chemical Properties

[Objective] This study was aimed to find a new method for the classification of common aroma components in tobacco leaves. [Method] Sixty-four common aroma components in tobacco leaves were classified by cluster analysis based on their relative molecular weight. The contents and distribution of aroma components in another 71 C3F and 64 B2F tobacco leaf samples were analyzed by using the new method. [Result] The 64 common aroma components were divided into three categories trough the cluster analysis based on their molecular weight. CategoryⅠ consisted of 12 aroma components which had high molecular weight（281.308±21.536on average） and high boiling point（371.311±29.904 ℃ on average）. Category Ⅱ included 27 components which had low molecular weight（103.722 ± 13.115 on average） and low boiling point（176.132±42.342 ℃ on average）. Category Ⅲ included 25components which had middle molecular weight（175.393 ± 24.906 on average） and middle boiling point（250.562±45.431 ℃ on average）. The content of high-molecularweight aroma components in middle leaves（547.344±224.391 μg/g） was much higher than that in upper leaves（477.549±182.066 μg/g）. The content of low-molecularweight aroma component in middle leaves（17.468±3.459 μg/g） was also significantly higher than that in upper leaves（15.936±3.456 μg/g）. The content of middle-molecular-weight aroma component in middle leaves（44.931 ±8.953 μg/g） was extremely significantly higher than that in upper leaves（37.997±6.042 μg/g）. [Conclusion] This study proposed a new way to classify the aroma components in flue-cured tobacco leaves using the relative molecular weight as the index, which will provide theoretical reference for developing special tobacco leaves.

Effects of Green Manure Mixed Cropping Patterns on Physical and Chemical Properties of Soil and Economic Characters of Flue-cured Tobacco

[Objective] The aim was to clear the suitable green manure cropping pat- terns in Xiangxi tobacco-planting areas. [Method] 8 treatments were set to study the effects of the monoculture and mixed cropping of common vetch （Vicia gigantea Bge.）, perennial ryegrass （Lofium） and rapeseed （Brassica campestris L.） on physi- cal and chemical properties of soil and economic characters of flue-cured tobacco. [Result] （1） Green manure turnover can reduce soil bulk density by 1.08%-8.62%, and the effect of green manure mixed cropping pattern was the best. （2） Green manure turnover also can increase the soil nutrient, soil organic matter, total nitro- gen （N）, total phosphorus （P）, total potassium （K）, alkali-hydrolyzale N, rapidly available P and rapidly available K by 1.44%-6.10%, 0.01-0.12 g/kg, 1.89%- 11.32%, 0.12%-3.56%, 1.06%-11.76%, 0.04%-18.93% and 0.98%-23.12%, respec- tively, and the effect of the monoculture of common vetch was the best.（3） The overall change of soil pH was not obvious.（4）Green manure turnover can increase the yield and output of flue-cured tobacco, and the effect of the monoculture of common vetch was the best. [Conclusion] The monoculture of common vetch can be generalized in the dry land of Xiangxi tobacco-planting areas.

Effects of Crude Oil Contamination on Soil Physical and Chemical Properties in Momoge Wetland of China

Large oilfields are often coincidentally located in major river deltas and wetlands,and potentially damage the structure,function and ecosystem service values of wetlands during oil exploration.In the present study,the effects of crude oil contamination during oil exploration on soil physical and chemical properties were investigated in marshes of the Momoge National Nature Reserve in Jilin Province,China.The concentrations of total petroleum hydrocarbons in the marsh soil near the oil wells are significantly higher than those in the adjacent control marsh.Soil water contents in oil-contaminated marshes are negatively correlated with soil temperature and are significantly lower than those in the control area,especially in fall.Crude oil contamination significantly increases the soil pH up to8.0,and reduces available phosphorus concentrations in the soil.The concentrations of total organic carbon are significantly different among sampling sites.Therefore,crude oil contamination could potentially alkalinize marsh soils,adversely affect soil fertility and physical properties,and cause deterioration of the marshes in the Momoge National Nature Reserve.Phyto-remediation by planting Calamagrostis angustifolia has the potential to simultaneously restore and remediate the petroleum hydrocarbon-contaminated wetlands.Crude oil contamination affects the soil physical and chemical properties,so developing an effective restoration program in the Momoge wetland is neccesary.

Effect of fire severity on physical and biochemical soil properties in Zagros oak(Quercus brantii Lindl.)forests in Iran

Fire affects the physical and chemical properties and soil biological activity of natural ecosystems. This study was conducted in the Miyan Tang region, Ilam Province in western Iran. The study site was 110 hectares, where we sampled soils in areas that were classified by fire severity： low （LS）, high （HS） and medium severity （MS）, and unburned （UB）, which served as the control. In each severity class, 25 transect points were randomly selected for measurement. Around each transect plot center, 3 soil samples were selected randomly and soils collected from the 0 to 20 cm depth were combined into a composite sample that was used in laboratory analysis to represent conditions at that point. Plots in the UB and LS fire classes had similar soil conditions and had higher values of factors such as saturated moisture, organic carbon, carbon dioxide, and silt and clay content. In contrast, plots in the HS and MS fire severity classes were clustered in the positive direction along the first axis that represented gradients in soil acidity, electrical conductivity, cation exchange capacity, accessible phosphorus, accessible potassium, bulk density, and sand. Soil attributes were similar in areas of HS and MS fire severity classes, whereas soil conditions in the LS class and UB controls were most similar. Fire in the LS areas either did not significantly alter the physicalchemical soil properties and microbial basal respiration, or soils were able to recover quickly after being burned.

Robinia pseudoacacia leaves improve soil physical and chemical properties

The role of the leaves of Robinia pseudoacacia L., which is widely distributed in the arid lands, on improving soil physical and chemical properties was analyzed at various incubation periods. The incubated soils added with 0, 25, 50 and 75 g Robinia pseudoacacia leaves were tested after consecutive incubation intervals of 6, 8 and 10 months and the different soil parameters were measured. The results showed the increases in organic matter (OM), extractable K, cation exchange capacity (CEC), aggregate stability and water holding capacity, but the decreases in pH value and bulk density after 6 months’ incubation. The gradual decrease in change rates of soil properties indicated less microbial population and organic residual mineralization under acidic conditions, which were resulted from fast decomposition of leaves after the first 6 months incubation. The increases in soil organic matter content, extractable K, CEC, aggregate stability and water holding capacity and the decreases in soil pH and bulk density provide favorable conditions for crop’s growth.

Physi-Chemical Property Research of Polysaccharides from Pomegranate Flowers

Pomegranate flowers as row materials were used for extraction of polysaccharides by water-extraction and alcohol-precipitation method. After purification, the physical and chemical properties, structure, monosaccharide composition and molecular weight were studied. The results showed that the polysaccharides from pomegranate flowers mainly contained two kinds of water soluble acidic polysaccharides, and monosaccharide composition were arabinose and galactose, both contained hydroxyl, carboxyl, amino, hydroxyl radical, sulfate, beta glycosidic bond and alpha glycosidic bond structure. The molecular weight of PP1 and PP2 were 6.16 × 104 (±6.6%) and 9.01 × 104 (±3.2%), respectively. The results of this study laid the foundation for further development and application of polysaccharides from pomegranate flowers.

Selected physical and chemical properties of mechanically extracted neem seed oil sourced as a preservative for ligno-cellulose in south-western Nigeria

Most of the seeds produced by neem （Azadirachta indica A. Juss） trees in Nigeria are currently underutilized. Hence, relevant literature provides only limited information conceming many of the seed oils from this country, especially where it concems the potential applications of these oils as preservatives for ligno-cellulose against bio-deterioration. Using standard procedures therefore, this study was carried out to evaluate and document selected physical and chemical properties of neem seed oil （NSO）, mechanically extracted using a cold press at 31.03 N-mm^-2 pressure and a room temperature of 25 ± 2℃. The results show that oil yield was 38.42% with a specific gravity of 0.91 ± 0.01. The amount of acid was 18.24 ± 1.31 mg KOH.g^-1 and that of iodine 93.12 ± 2.01 g-100 g^- 1, while saponification and peroxide values were 172.88 ± 2.06 and 1.42 ± 0.04 mg·g^-1 respectively. The implication of the values obtained, particularly those for the chemical properties, as they concern the potential application of NSO as a preservative for ligno-eellulose, is likely that it may be useful in this regard since the values may support some of the documented anti-microbial properties of the oil, although other physical and chemical properties that may affect this potential are recommended for investigations. Conclusions and other recommendations follow in line with the results of the study.

Effects of Long-term Site-specific Fertilization on Soil Physical and Chemical Properties and Nutrients in Dry Farmland

In order to investigate the variation in soil physical and chemical properties and nutrients in the mountainous areas in southern Ningxia, and to provide a theoretical basis for fertilization management in local farmland, the soil p H, total salt content,crop root length, root weight, soil organic matter, available nitrogen, total nitrogen, total phosphorous and total potassium in different fertilization treatments were measured from 2010 to 2016. Multiple comparisons of the data were performed using Duncan's new multiple range test. The results indicated that in the 0-20 cm soil layer, soil p H value and total salt content changed in different patterns, and varied greatly from 2010 to 2016(P<0.05). The changes of both root length and root weight of millet over time fitted S-shaped curves. The root length and root weight in the four fertilization treatments(Treatment 2 to Treatment5) increased faster than those in the control(Treatment 1). The soil organic matter content in all the five treatments gradually increased from 2010 to 2016. The content of alkaline hydrolyzable nitrogen in soil rapidly increased in the first two to three years of the experiment, followed by a slow increase or decrease in 2013, and then raised rapidly again from 2014 to 2016.The soil total nitrogen content varied significantly from 2010 to 2016. The total phosphorus content in soil changed in a different pattern from that of total nitrogen content. The seven-year field trails revealed that soil p H, total salt content, root length, root weight and soil nutrient all changed with the increase of fertilizer level, and that long-term fertilization is of significance for maintaining soil fertility, improving soil quality and reducing soil salinization.

Study on the Quality Evaluation of Steamed Bread and the Physical and Chemical Properties of Wheat

In this study,the different physical and chemical properties of wheat were studied,and on this basis,and the quality of steamed bread made was evaluated.We analyzed the correlation between the evaluation indexes of steamed bread and the basic physical and chemical indexes of wheat,and investigated important factors that affect the evaluation indexes of steamed bread,including flour extraction rate,protein content,amylose content,protein,added amount of yeast,fermentation time and other aspects.According to the study results,it was shown that different factors had different effect on steamed bread quality,with both positive correlation and negative correlation.

Effects of Different Farming Methods and Their Effects on Soil Physicochemical Properties of Guilin Maojian Tea Gardens

In order to further optimize the cultivation and agronomic technology of Guilin Maojian tea gardens, the effects, efficiencies and costs of different farming methods and their effects on the physiochemical properties of tea garden soil were studied through the modification of the test sites with the non-farming land as the control. The results showed that human farming, mini-tiller farming and crawler tractor farming could improve the physical and chemical properties of soil. After farming, the soil had good water retention but low moisture content compared to the control group, while the soil bulk density and hardness value were significantly lower than those of the control, and the porosity of soil was significantly higher than that of contrast. With the passage of time, soil bulk density and hardness value gradually increased after farming, while the porosity of soil decreased gradually. There were great differences in the effects, efficiencies and costs of different farming methods. Crawler tractor had the best and most stable farming effect, and the operation efficiency was 10 times that of human farming while the cost was only 0.39 times of human farming. Therefore, it was feasible to adopt mini-tiller or crawler tractor to carry out mechanical farming of Guilin Maojian tea garden, which provided theoretical references for the soil property improvement using mechanical farming and was favorable for promoting the popularization of farming machines and the acceleration of mechanization of tea gardens. But for tea plantations that are intended to be mechanized, apart from the mechanical and technical personnel to be configured in place, the site conditions, planting modes and mechanical way reservation of tea garden should be planned accordingly. It is recommended to select flat or gentle slope for reclamation, and preference is given to non-sexual tea tree varieties with big line spacing over 180 cm long. Moreover, the main road construction should be more than 3.0 m, and trunk road 2.0 m or above. And isolation ditch and drain should be set between the tea garden and the surrounding mountain forests and farmland.

The Effect of Some Soil Physical and Chemical Properties on Soil Aggregate Stability in Different Locations in Sulaimani and Halabja Governorate

Some soil properties were studied in relation soil aggregate along a climatologically region and different crop land use in the Northeast of Sulaimani City/Kurdistan Region of Iraq. Five locations were selected along these regions ranging from semiarid to sub-humid climatologically conditions. The soil physical, chemical properties, aggregate stability and size distribution were analyzed. A mean-weight-diameter (MWD) value was determined on 5 soils, which was the sum of the percentage of soil on each sieve (6, 3, 1.5, 0.75, 0.375 and 0.125 mm). The results of the measurements could evaluated with linear correlation coefficients for the relationships between aggregate stability (MWD) and soil physical and chemical properties of the different crop land use. The correlation coefficient for the relationship between aggregate stability and organic matter was highly significant (P < 0.0l%) which is in agreement with the findings of [1]. Generally large aggregates (large 6, 3, 3 - 1.5 mm) were present in highest proportions in the most semiarid of the studied areas. Aggregates 0.75 - 0.125 mm were positively correlated to fine, very fine sand and silt fractions and to organic matter. Stability of aggregates showed a positive correlation with clay content and organic matter content, while the carbonate content was strongly correlated with aggregate stability. The land use history affecting soil overlaps the pattern of climatological situations and cultivated crop lands and has to be taken into account. Aggregate size distribution and stability can be used as indicator of soil conservation and productivity.

Extended wet sieving method for determination of complete particle size distribution of general soils

The traditional standard wet sieving method uses steel sieves with aperture?0.063 mm and can only determine the particle size distribution(PSD)of gravel and sand in general soil.This paper extends the traditional method and presents an extended wet sieving method.The extended method uses both the steel sieves and the nylon filter cloth sieves.The apertures of the cloth sieves are smaller than 0.063 mm and equal 0.048 mm,0.038 mm,0.014 mm,0.012 mm,0.0063 mm,0.004 mm,0.003 mm,0.002 mm,and 0.001 mm,respectively.The extended method uses five steps to separate the general soil into many material sub-groups of gravel,sand,silt and clay with known particle size ranges.The complete PSD of the general soil is then calculated from the dry masses of the individual material sub-groups.The extended method is demonstrated with a general soil of completely decomposed granite(CDG)in Hong Kong,China.The silt and clay materials with different particle size ranges are further examined,checked and verified using stereomicroscopic observation,physical and chemical property tests.The results further confirm the correctness of the extended wet sieving method.

Study on Influencing Factors of Farmland Soil Heavy Metals in Central Yunnan Province

[Objective] This study aimed to explore the relationship between contents of heavy metals with soil type, altitude distribution as well as physical and chemical properties. [Method] Based on determination of contents of soil heavy metals and soil physical and chemical properties from agricultural land in Central Yunnan Province, the relationship between soil heavy metals with soil type, altitude distribu- tion and soil physical and chemical properties were analyzed. [Result] The average contents of all heavy metals in farmland of Central Yunnan didn＇t extend their limits of Grade II in the National Soil Environmental Quality Standard （GB15618-1995）. and the heavy metals content in red soil was higher than that in other types. Soil Cd content changes slightly with the altitude, while contents of other heavy metals were greatly affected by altitude. There were extremely significant positive correlation between heavy metals and clay particle content, that is, soil with heavier texture has more heavy metals. There was positive correlation between pH and each heavy metal content; there were positive correlation between Mn with Pb, Cd, Hg and Hg; exchangeable Ca and Mg contents in soil show negative correlations with most heavy metals. [Conclusion] This study has provided scientific bases for the heavy metal management in Central Yunnan area.

Recent advances on application of polysaccharides in cosmetics

Natural products have attracted wide attention in the cosmetics market due to their safety and high efficiency.As a highly active substance in nature,natural polysaccharides have been reported in recent years to have various cosmetic activities such as moisturizing,whitening,anti-aging and repairing skin,and are becoming a hot research topic in the cosmetics industry.At present,the mechanism of polysaccharide exerting cosmetic activity has been widely studied,but the relationship between polysaccharide’s chemical structure and cosmetic activity has not been effectively analyzed,which leads to the limitation of polysaccharide development.In this review,the mechanism of polysaccharides exerting cosmetic activities such as moisturizing,whitening,anti-aging and skin repair was introduced.The potential relationship between the structure and activity of polysaccharides was summarized by analyzing the influence of physical and chemical properties of polysaccharides,such as extraction method,molecular weight,monosaccharide composition,functional group and structural modification,etc.,which laid a foundation for the analysis of the structure-activity relationship of polysaccharides and improved its cosmetic value.

Effects of Once Fenlong Cultivation on Soil Properties and Rice Yield and Quality for 7 Consecutive Years

[Objective] The objective of this study was to explore the long-term effect of Fenlong cultivation for one time. [Method] The physical and chemical properties of soil and rice yield and quality were investigated and determined by measuring the soil at the depth of 23 cm in the paddy field with Fenlong cultivation and 16 cm of control （conventional farming） for 7 years. [Result] Compared with the control, the average yield of early rice of the Fenlong cultivation increased by 1 972.5 kg/hm2 of the first year, an increase of 23.87%, and milled rice and protein increased by 15.95% and 14.61%, while the increase rates of organic matter, available nitrogen, available phosphorus and available potassium per hectare were 74.58%, 67.01%, 104.41% and 129.62%, respectively. In the 7th year after Fenlong cultivation, the yield increased by 234 kg/hm2 from the control, an increase of 3.21%, and milled rice and protein increased by 0.5% and 0.14%, while the increase rates of organic matter, available phosphorus and available potassium per hectare were 745.8%, 62.635 and 73.37%, respectively, and the increase rates of total nitrogen, total phosphorus and total potassium were 46.03%, 50.58% and 36.65%, respectively. During the 7 years after Fenlong cultivation, the yield increased by 3.21-23.87%, and its average net income per season increased by 1 843.61 Yuan/hm2 with a gain of 18.03%. [Conclusion] At the 7th year after Fenlong cultivation, the paddy field still had the furrow remain at a depth of 22 cm, which was 46.67% thicker than the traditional one. The yield and quality of paddy rice increased for 7 consecutive vears showed that Fenlon.q cultivation was highly feasible for paddy field.

Size,shape,charge and“stealthy”surface:Carrier properties affect the drug circulation time in vivo

The present review sets out to discuss recent developments of the effects and mechanisms of carrier properties on their circulation time.For most drugs,sufficient in vivo circulation time is the basis of high bioavailability.Drug carrier plays an irreplaceable role in helping drug avoid being quickly recognized and cleared by mononuclear phagocyte system,to give drug enough time to arrive at targeted organ and tissue to play its therapeutic effect.The physical and chemical properties of drug carriers,such as size,shape,surface charge and surface modification,would affect their in vivo circulation time,metabolic behavior and biodistribution.The final circulation time of carriers is determined by the balance between macrophage recognitions,blood vessel penetration and urine excretion.Therefore,when designing the drug delivery system,we should pay much attention to the properties of drug carriers to get enough in vivo circulation time to arrive at target site eventually.This article mainly reviews the effect of carrier size,size,surface charge and surface properties on its circulation time in vivo,and discusses the mechanism of these properties affecting circulation time.This review has reference significance for the research of long-circulation drug delivery system.