A cocrystal of diosgenin with piperazine in 2:1 stoichiometry was successfully synthesized.The solid form was prepared by liquid assisted grinding,slurry and crystallization methods.The cocrystal was characterized by ...A cocrystal of diosgenin with piperazine in 2:1 stoichiometry was successfully synthesized.The solid form was prepared by liquid assisted grinding,slurry and crystallization methods.The cocrystal was characterized by powder X-ray diffraction,differential scanning calorimetry,thermogravimetric analysis,Fourier transform infrared spectroscopy,and structure determined by single crystal X-ray diffraction,the hydrogen bonds formed into fish bone structure along the[010]direction and all the molecules packed into 3D layer structure along a axis.After formation of cocrystal,the solubility of diosgenin was improved,and the solubility value in 0.2%SDS solution was approximately 1.5 times as large as that of the parent material.展开更多
A soluble, poly(ethylene glycol)-supported piperazine catalyst was prepared. This soluble catalyst efficiently catalyzes the Knoevenagel condensation of various aromatic aldehydes with diethyl malonate or ethyl acet...A soluble, poly(ethylene glycol)-supported piperazine catalyst was prepared. This soluble catalyst efficiently catalyzes the Knoevenagel condensation of various aromatic aldehydes with diethyl malonate or ethyl acetoacetate in a homogeneous phase to afford the desired alkenes in good purity and yield with a facile work-up process. It was found that the polymer reagent could be repeatedly used at least four times without the too much loss of activity. The catalyst has shown a good activity, stability, and recycling capability.展开更多
A series of piperazine-based Gemini and Bola surfactants were synthesized. Gemini 1 and 5 have well surface activities. Their critical micelle concentrations (cmc) is 6.47×10^-4 mol/L and 1.17×10^-3mol/L, ...A series of piperazine-based Gemini and Bola surfactants were synthesized. Gemini 1 and 5 have well surface activities. Their critical micelle concentrations (cmc) is 6.47×10^-4 mol/L and 1.17×10^-3mol/L, respectively. Bola surfactants 2 and compound 3, possessing better water solubility, have lower surface activities. Calculation, carried out by MM2 energy minimization, showed that compound with more hydrophobic chains in a spacer of limited length is difficult to be synthesized.展开更多
A rapid analysis method of piperazine ferulate tablets by optic-fiber sensing technology with UV-vis absorption spectrum was established. Qualitative and quantitative data were obtained and compared by maximum and min...A rapid analysis method of piperazine ferulate tablets by optic-fiber sensing technology with UV-vis absorption spectrum was established. Qualitative and quantitative data were obtained and compared by maximum and minimum wavelength, absorbance and contrast spectra. Similarity method was used to identify authenticity of drugs. The difference of contents measured by this method and UV determination method in China Pharmacopoeia showed no statistical significance (P40.05), while the similarity can be used as a parameter to identify the authenticity of drugs.展开更多
6/3-(4-Chlorophenyl)-s-triazolo[3, 4-b][1, 3, 4]thiadiazoles (2,a-e) and (Sa-e) were synthesized respectively by intermolecular cyclization of 5-aryl / 4-chlorophenyl-4-amino-3- mercapto-1, 2, 4-triazoles (la-e...6/3-(4-Chlorophenyl)-s-triazolo[3, 4-b][1, 3, 4]thiadiazoles (2,a-e) and (Sa-e) were synthesized respectively by intermolecular cyclization of 5-aryl / 4-chlorophenyl-4-amino-3- mercapto-1, 2, 4-triazoles (la-e) and (4) with 4-chlorobenzoic acid / aryl acids, which were condensed with piperazine under phase transfer catalyst TBAB to yield the corresponding free bases of monopiperazine derivatives and followed to form water-soluble salts (3a-e) and (6a-e) with hydrochloric acid in good yields. The in vitro biological results showed that piperazine group conjugated with the above fused heterocycles played an important role in antibacterial activity. The structures of novel compounds were confirmed by IR, 'H NMR, MS and elemental analysis.展开更多
The surface tension study is very crucial for the design of CO2 gas absorption contacting equipment. The significance of the surface tension has been increasing due to its consideration in various technological fields...The surface tension study is very crucial for the design of CO2 gas absorption contacting equipment. The significance of the surface tension has been increasing due to its consideration in various technological fields. This property influences the mass transfer and hydrodynamics of gas absorption systems, mainly multiphase systems, in which the interface between gas and liquid exists. Therefore, in this study, surface tension of aqueous solutions of sodium L-prolinate(SP) and piperazine(PZ) blends were measured at ten different temperatures from(298.15 to 343.15) K. The SP mass fractions were 0.10, 0.20, and 0.30;while the mass fractions of PZ were 0.02 and 0.05. The experimental results showed that the surface tension increase with increasing the mass fractions of SP and PZ in aqueous blends, and decrease linearly with rising temperature. The experimental data of surface tension were correlated by two empirical correlations as a function of temperature and mass fractions for estimating the predicted data using the optimized correlation coefficients. Moreover, the modeling of surface tension data was carried out using Artificial Neural Network(ANN) approach. The results obtianed from ANN modeling were compared with applied empirical correlation. It was found that the ANN approach outperformed the empirical correlation used in this study. Besides, a quantitative analysis of variation(ANOVA) was performed in order to determine the significance of data. The surface tension of aqueous SP and SP + PZ was also compared with various conventional solvents.展开更多
A novel model for the 1: 2 complex of piperazine with some phenols in solution is established and verified. In CDCl3 solution, one piperazine molecule is tied to two phenol molecules by hydrogen bonds of O-H---N and N...A novel model for the 1: 2 complex of piperazine with some phenols in solution is established and verified. In CDCl3 solution, one piperazine molecule is tied to two phenol molecules by hydrogen bonds of O-H---N and N-H---O. And the protons of >NH and -OH groups exchange quickly and simultaneously between the atoms of phenol oxygen and piperazine nitrogen.展开更多
The present study was designed to investigate the influence of the pretreatment of piperazine ferulate on pharmacokinetic parameters of methotrexate in methotrexate-induced renal injury rats.A simple and efficient hig...The present study was designed to investigate the influence of the pretreatment of piperazine ferulate on pharmacokinetic parameters of methotrexate in methotrexate-induced renal injury rats.A simple and efficient high performance liquid chromatography coupled with mass spectrometry(HPLC-MS)method was developed to determine methotrexate in rat plasma.Methotrexate and syringic acid(internal standard)were extracted from rat plasma samples by protein precipitation with acetonitrile.The analysis was performed on a CAPCELL PAK C18column(150 mm×4.6 mm,5μm)with acetonitrile and 5 mmol/l ammonium acetate aqueous(10:90,v/v).The linear range was 5.0×10-2to 100.0μg/ml for methotrexate.Other parameters were all within the acceptance criteria.The validated method was successfully applied the pharmacokinetic study of methotrexate between two methotrexate treated groups(with and without the pretreatment of piperazine ferulate).Compared with the methotrexate treated alone group,the pharmacokinetic parameters in the methotrexate with the pretreatment of piperazine ferulate group showed significantly lower MRT(0-t),MRT(0-∞) and T1/2.Results suggested that methotrexate can be rapidly eliminated,cleared or metabolized in rat blood,which might be related to the pretreatment of piperazine ferulate.The method provided deeper insights into rational clinical use of methotrexate with the pretreatment of piperazine ferulate on cancer patients with renal dysfunction.展开更多
We have designed and synthesized a series of new phthalimidopiperazines, biological activity test show that the target compounds(Ic, Ie, ii) can inhibit HIV-I RT with IC50 20.0, 43.8, and 63.7 mu M, respectively.
Two new coordination polymers, [Cd(N3)2(Baep)l/2]n (1) and [Cd2(N3)4(CH3OH)(Bapp)I/.2]n (2) (Baep = 1,4-bis(2-aminoethyl)piperazine, Bapp = 1,4-bis(3-aminopropyl)piperazine) were synthesized. The c...Two new coordination polymers, [Cd(N3)2(Baep)l/2]n (1) and [Cd2(N3)4(CH3OH)(Bapp)I/.2]n (2) (Baep = 1,4-bis(2-aminoethyl)piperazine, Bapp = 1,4-bis(3-aminopropyl)piperazine) were synthesized. The crystal of 1 is of monoclinic system, space group P21/c with a = 9.341(7), b = 11.677(9), c = 8.195(6) A, fl = 93.925(13), V= 891.8(11) A3, Z= 4, μ(MoKa) = 2.42 mm-1, Mr = 280.58, Dc = 2.090 g/cm3, the final R = 0.0297 and wR = 0.0720. The crystal of 2 is of triclinic system, space group PI with a = 9.121(5), b = 9.666(5), c = 10.250(6) A, a = 72.91(2), β= 77.10(2), V = 73.95(2)°, V = 820.0(8)°, Z = 2,μ(MoKa) = 2.62 mm-1, Mr= 522.10, Dc = 2.114 g/cm3, the final R = 0.0251 and wR = 0.0632. Single-crystal X-ray diffraction studies reveal that 1 is a 3D structure based on a dinuclear unit {Cd2(N3)a(Baep)}, in which the Baep ligands formed in situ display two different bridging modes. Compound 2 also has a 3D structure based on a tetranuclear cluster {Cda(N3)8(CH3OH)2(Bapp)}, in which the azido anions exhibit four different bridging modes (μ-1,1, μ-1,3, μ-l,l,1 and μ-1,1,3). The thermal stability and fluorescent property of 1 and 2 have also been investigated.展开更多
An improved method for preparation of 4-methyl-2-phenyl piperazine and its derivatives with higher yield and inexpensive reagents was developed, the products were characterized by 1H-NMR and MS.
A new polymer [Zn2(cam)2(bpmp)]n 1 (H2cam = D-(+)-camphoric acid, bpmp = bis(4-pyridylmethyl)piperazine) was synthesized under hydrothermal conditions. The compound crystallizes in the monoclinic system, sp...A new polymer [Zn2(cam)2(bpmp)]n 1 (H2cam = D-(+)-camphoric acid, bpmp = bis(4-pyridylmethyl)piperazine) was synthesized under hydrothermal conditions. The compound crystallizes in the monoclinic system, space group P21/n with a = 12.305(9), b = 12.945(9), c = 13.619(10) A, β = 116.833(8)°, V= 1936(2)A3, Z = 4, Mr = 397.76, Dc= 1.365 Mg/m3,μ = 1.292 mm-1, F(000) = 832, the final R = 0.0578 and wR = 0.1678 for 2838 observed reflections with I 〉 2σ(I). The compound presents a three-dimensional (3D) network extended by homochiral 2D layer and bpmp ligands. From the topology point of view, the structure could be described as a 3D 6-connected mab net with (44.610.8) topology. In addition, infrared spectroscopy, elemental analyses, thermogravimetric analysis and powder X-ray diffraction properties of 1 are also investigated.展开更多
Oxidations of piperazine, 1-methylpiperazine and 1-ethylpiperazine by bromamine-T (BAT) in buffered acidic medium have been kinetically studied at 303 K. The reaction shows a first-order dependence of the rate each on...Oxidations of piperazine, 1-methylpiperazine and 1-ethylpiperazine by bromamine-T (BAT) in buffered acidic medium have been kinetically studied at 303 K. The reaction shows a first-order dependence of the rate each on [BAT]0 and [piperazine]0, and an inverse fractional-order dependence on [H+]. The additions of halide ions and the reduction product of BAT, p-toluenesulfonamide, have no effect on the reaction rate. The variation of ionic strength of the solvent medium has no influence on the rate. Activation parameters have been evaluated from the Arrhenius and Eyring plots. A common mechanism consistent with the kinetic data has been proposed for all piperazines. The protonation constants of substrates have been evaluated. The Hammett linear free-energy relationship has been observed for the reaction with ρ = ?0.5 indicating that the electron-donating groups enhance the reaction rate by stabilizing the transition state. An isokinetic relationship observed shows β = 368 K indicating the dominance of enthalpy factors on the reaction rate.展开更多
The reaction of Pr(Ⅲ) salt with 1,2,4,5-benzenetetracarboxylic acid(H4betc) and piperazine(pip) yielded a lanthanide metal-organic framework {[Pr(betc)(H2O)2](H2pip)0.5}n(1)under hydrothermal conditions...The reaction of Pr(Ⅲ) salt with 1,2,4,5-benzenetetracarboxylic acid(H4betc) and piperazine(pip) yielded a lanthanide metal-organic framework {[Pr(betc)(H2O)2](H2pip)0.5}n(1)under hydrothermal conditions. Compound 1 was characterized by single-crystal X-ray structural analysis, elemental analysis, IR, X-ray powder diffraction, and thermal gravimetric. Compound 1crystallizes in monoclinic, space group P21/n with a = 11.023(5), b = 11.109(5), c = 11.456(5) A, β = 110.065(5)°, V = 1317.7(9) A3, Mr = 471.14, Z = 4, F(000) = 920, Dc = 2.375 g/cm^3, μ(Mo Kα) = 3.761 mm-1, the final R = 0.0286 and w R = 0.0821(I 〉 2σ(I)). Compound 1 exhibits a 2D network with(4, 4) topology, and a 3D supramolecular framework formed by hydrogen-bonding interactions. The proton conductivity of compound 1 has been investigated at ~97% relative humidity and different temperature.展开更多
Derivatives of piperazine,which is one of the most important heterocycles,are often used as linkers to connect active substructures that show promising bioactivities,especially in the field of agrochemicals.From 2000 ...Derivatives of piperazine,which is one of the most important heterocycles,are often used as linkers to connect active substructures that show promising bioactivities,especially in the field of agrochemicals.From 2000 to 2022,many piperazine-containing compounds were found to exhibit excellent activities against fungi,bacteria,insects,plant viruses,and weeds and have also been used as plant growth regulators.Currently,the development of novel pesticides to prevent the invasion of crop pathogens and ensure the quality and yields of crops is still needed.We herein investigated and summarized the role that piperazine plays in the discovery of pesticides to provide a comprehensive summary of the broad activities of piperazine derivatives in agricultural applications and offer a potential reference for novel pesticide design using piperazine-containing compounds.Moreover,structure–activity relationships(SARs)analyses of bioactive piperazine-containing compounds are also discussed for a deeper understanding.展开更多
In accordance with the research specifications and guidelines in China,we developed a novel experimental method to detect new piperazine‑type drugs,such as 1‑(3‑trifluoromethylphenyl)piperazine and 1‑(3‑chlorophenyl)p...In accordance with the research specifications and guidelines in China,we developed a novel experimental method to detect new piperazine‑type drugs,such as 1‑(3‑trifluoromethylphenyl)piperazine and 1‑(3‑chlorophenyl)piperazine.In this study,a new pretreatment method and gas chromatography(GC)/nitrogen–phosphorus detector detection technique were used to characterize these two kinds of drugs in urine and blood samples.For the purpose of isolation of these trace drugs from the samples,liquid‑liquid extraction/solid‑phase extraction was modified and validated for this specific study.The pretreatment method presented in this paper has many advantages,such as high recovery rate,high extraction efficiency,high detection sensitivity,low limit of detection,and simple operation.The GC/NPD instrument is popular in most laboratories because it can meet the routine requirements of forensic science.All these aspects make this combination of sample pretreatment and GC/NPD technique the most suitable choice for drug detection in biological samples.展开更多
A series of fluorine- and piperazine-containing 1,2,4-triazole thione derivatives were synthesized by the Mannich reaction of triazole intermediates with various substituted piperazines and formaldehyde in high yields...A series of fluorine- and piperazine-containing 1,2,4-triazole thione derivatives were synthesized by the Mannich reaction of triazole intermediates with various substituted piperazines and formaldehyde in high yields. Structures of title compounds were confirmed by melting points, IR,~1H NMR,^(13)C NMR and elemental analysis. The preliminary bioassays for 17 novel title compounds showed that several compounds have significant fungicidal activity against Cercospora arachidicola, Physalospora piricola and Rhizoctonia cerealis at 50 mg/m L.展开更多
The goal of this study is to design and synthesize a linear segmented shape memory poly(urethane-urea) (SMPUU) that possesses near-body-temperature shape memory temperature (Ttran) and enhanced mechanical proper...The goal of this study is to design and synthesize a linear segmented shape memory poly(urethane-urea) (SMPUU) that possesses near-body-temperature shape memory temperature (Ttran) and enhanced mechanical properties by incorporating flexible poly(ethylene glycol) 400 (PEG400) to form poly(D,L-lactic acid)-based macro- diols (PDLLA-PEG400-PDLLA) and then rigid piperazine (PPZ) as a chain extender to form the desired SMPUUs (PEG400-PUU-PPZ). PEG400 increased Mn while maintaining a lower Tg of PDLLA-PEG400-PDLLA, which together with PPZ improved the mechanical properties of PEG400-PUU-PPZ. The obtained optimum SMPUU with enhanced mechanical properties (O'y = 24.28 MPa; zf = 698%; Uf = 181.5 MJIm3) and a Tg of 40.62~C exhibited sound shape memory properties as well, suggesting a promising SMPUU for in vivo biomedical applications.展开更多
基金support by National Key research and development Program of China(Grant No.2016YFC1000900)CAMS Innovation Found for Medical Sciences(Grant No.2017-I2M-1-010)+1 种基金Construction and application of technology integration system for efficient identification of natural/effective active small molecules(Grant No.2018ZX09711001-001)National Science and Technology Major Project of China(Grant No.2018ZX09711001-010).
文摘A cocrystal of diosgenin with piperazine in 2:1 stoichiometry was successfully synthesized.The solid form was prepared by liquid assisted grinding,slurry and crystallization methods.The cocrystal was characterized by powder X-ray diffraction,differential scanning calorimetry,thermogravimetric analysis,Fourier transform infrared spectroscopy,and structure determined by single crystal X-ray diffraction,the hydrogen bonds formed into fish bone structure along the[010]direction and all the molecules packed into 3D layer structure along a axis.After formation of cocrystal,the solubility of diosgenin was improved,and the solubility value in 0.2%SDS solution was approximately 1.5 times as large as that of the parent material.
基金Supported by the National Natural Science Foundation of China(No.20872001)the Natural Science Foundation of Education Administration of Anhui Province,China(No.KJ2008A064)
文摘A soluble, poly(ethylene glycol)-supported piperazine catalyst was prepared. This soluble catalyst efficiently catalyzes the Knoevenagel condensation of various aromatic aldehydes with diethyl malonate or ethyl acetoacetate in a homogeneous phase to afford the desired alkenes in good purity and yield with a facile work-up process. It was found that the polymer reagent could be repeatedly used at least four times without the too much loss of activity. The catalyst has shown a good activity, stability, and recycling capability.
文摘A series of piperazine-based Gemini and Bola surfactants were synthesized. Gemini 1 and 5 have well surface activities. Their critical micelle concentrations (cmc) is 6.47×10^-4 mol/L and 1.17×10^-3mol/L, respectively. Bola surfactants 2 and compound 3, possessing better water solubility, have lower surface activities. Calculation, carried out by MM2 energy minimization, showed that compound with more hydrophobic chains in a spacer of limited length is difficult to be synthesized.
文摘A rapid analysis method of piperazine ferulate tablets by optic-fiber sensing technology with UV-vis absorption spectrum was established. Qualitative and quantitative data were obtained and compared by maximum and minimum wavelength, absorbance and contrast spectra. Similarity method was used to identify authenticity of drugs. The difference of contents measured by this method and UV determination method in China Pharmacopoeia showed no statistical significance (P40.05), while the similarity can be used as a parameter to identify the authenticity of drugs.
基金This project was supported by the State Basic Research and Development Project(No.G1998051112).
文摘6/3-(4-Chlorophenyl)-s-triazolo[3, 4-b][1, 3, 4]thiadiazoles (2,a-e) and (Sa-e) were synthesized respectively by intermolecular cyclization of 5-aryl / 4-chlorophenyl-4-amino-3- mercapto-1, 2, 4-triazoles (la-e) and (4) with 4-chlorobenzoic acid / aryl acids, which were condensed with piperazine under phase transfer catalyst TBAB to yield the corresponding free bases of monopiperazine derivatives and followed to form water-soluble salts (3a-e) and (6a-e) with hydrochloric acid in good yields. The in vitro biological results showed that piperazine group conjugated with the above fused heterocycles played an important role in antibacterial activity. The structures of novel compounds were confirmed by IR, 'H NMR, MS and elemental analysis.
基金CO2 Research Centre (CO2RES), Universiti Teknologi PETRONAS for financial and technical support to complete the present research work
文摘The surface tension study is very crucial for the design of CO2 gas absorption contacting equipment. The significance of the surface tension has been increasing due to its consideration in various technological fields. This property influences the mass transfer and hydrodynamics of gas absorption systems, mainly multiphase systems, in which the interface between gas and liquid exists. Therefore, in this study, surface tension of aqueous solutions of sodium L-prolinate(SP) and piperazine(PZ) blends were measured at ten different temperatures from(298.15 to 343.15) K. The SP mass fractions were 0.10, 0.20, and 0.30;while the mass fractions of PZ were 0.02 and 0.05. The experimental results showed that the surface tension increase with increasing the mass fractions of SP and PZ in aqueous blends, and decrease linearly with rising temperature. The experimental data of surface tension were correlated by two empirical correlations as a function of temperature and mass fractions for estimating the predicted data using the optimized correlation coefficients. Moreover, the modeling of surface tension data was carried out using Artificial Neural Network(ANN) approach. The results obtianed from ANN modeling were compared with applied empirical correlation. It was found that the ANN approach outperformed the empirical correlation used in this study. Besides, a quantitative analysis of variation(ANOVA) was performed in order to determine the significance of data. The surface tension of aqueous SP and SP + PZ was also compared with various conventional solvents.
文摘A novel model for the 1: 2 complex of piperazine with some phenols in solution is established and verified. In CDCl3 solution, one piperazine molecule is tied to two phenol molecules by hydrogen bonds of O-H---N and N-H---O. And the protons of >NH and -OH groups exchange quickly and simultaneously between the atoms of phenol oxygen and piperazine nitrogen.
文摘The present study was designed to investigate the influence of the pretreatment of piperazine ferulate on pharmacokinetic parameters of methotrexate in methotrexate-induced renal injury rats.A simple and efficient high performance liquid chromatography coupled with mass spectrometry(HPLC-MS)method was developed to determine methotrexate in rat plasma.Methotrexate and syringic acid(internal standard)were extracted from rat plasma samples by protein precipitation with acetonitrile.The analysis was performed on a CAPCELL PAK C18column(150 mm×4.6 mm,5μm)with acetonitrile and 5 mmol/l ammonium acetate aqueous(10:90,v/v).The linear range was 5.0×10-2to 100.0μg/ml for methotrexate.Other parameters were all within the acceptance criteria.The validated method was successfully applied the pharmacokinetic study of methotrexate between two methotrexate treated groups(with and without the pretreatment of piperazine ferulate).Compared with the methotrexate treated alone group,the pharmacokinetic parameters in the methotrexate with the pretreatment of piperazine ferulate group showed significantly lower MRT(0-t),MRT(0-∞) and T1/2.Results suggested that methotrexate can be rapidly eliminated,cleared or metabolized in rat blood,which might be related to the pretreatment of piperazine ferulate.The method provided deeper insights into rational clinical use of methotrexate with the pretreatment of piperazine ferulate on cancer patients with renal dysfunction.
文摘We have designed and synthesized a series of new phthalimidopiperazines, biological activity test show that the target compounds(Ic, Ie, ii) can inhibit HIV-I RT with IC50 20.0, 43.8, and 63.7 mu M, respectively.
基金supported by the National Basic Research Program of China(973Program,2012CB821702)the National Natural Science Foundation of China(21173221and20903096)+1 种基金the State Key Laboratory of Structural ChemistryFujian Institute of Research onthe Structure of Matter,Chinese Academy of Sciences,Fuzhou,Fujian350002,China
文摘Two new coordination polymers, [Cd(N3)2(Baep)l/2]n (1) and [Cd2(N3)4(CH3OH)(Bapp)I/.2]n (2) (Baep = 1,4-bis(2-aminoethyl)piperazine, Bapp = 1,4-bis(3-aminopropyl)piperazine) were synthesized. The crystal of 1 is of monoclinic system, space group P21/c with a = 9.341(7), b = 11.677(9), c = 8.195(6) A, fl = 93.925(13), V= 891.8(11) A3, Z= 4, μ(MoKa) = 2.42 mm-1, Mr = 280.58, Dc = 2.090 g/cm3, the final R = 0.0297 and wR = 0.0720. The crystal of 2 is of triclinic system, space group PI with a = 9.121(5), b = 9.666(5), c = 10.250(6) A, a = 72.91(2), β= 77.10(2), V = 73.95(2)°, V = 820.0(8)°, Z = 2,μ(MoKa) = 2.62 mm-1, Mr= 522.10, Dc = 2.114 g/cm3, the final R = 0.0251 and wR = 0.0632. Single-crystal X-ray diffraction studies reveal that 1 is a 3D structure based on a dinuclear unit {Cd2(N3)a(Baep)}, in which the Baep ligands formed in situ display two different bridging modes. Compound 2 also has a 3D structure based on a tetranuclear cluster {Cda(N3)8(CH3OH)2(Bapp)}, in which the azido anions exhibit four different bridging modes (μ-1,1, μ-1,3, μ-l,l,1 and μ-1,1,3). The thermal stability and fluorescent property of 1 and 2 have also been investigated.
文摘An improved method for preparation of 4-methyl-2-phenyl piperazine and its derivatives with higher yield and inexpensive reagents was developed, the products were characterized by 1H-NMR and MS.
基金Supported by the National Natural Science Foundation of China(No.21076063)Foundation of Henan Educational Committee(No.13A150244)
文摘A new polymer [Zn2(cam)2(bpmp)]n 1 (H2cam = D-(+)-camphoric acid, bpmp = bis(4-pyridylmethyl)piperazine) was synthesized under hydrothermal conditions. The compound crystallizes in the monoclinic system, space group P21/n with a = 12.305(9), b = 12.945(9), c = 13.619(10) A, β = 116.833(8)°, V= 1936(2)A3, Z = 4, Mr = 397.76, Dc= 1.365 Mg/m3,μ = 1.292 mm-1, F(000) = 832, the final R = 0.0578 and wR = 0.1678 for 2838 observed reflections with I 〉 2σ(I). The compound presents a three-dimensional (3D) network extended by homochiral 2D layer and bpmp ligands. From the topology point of view, the structure could be described as a 3D 6-connected mab net with (44.610.8) topology. In addition, infrared spectroscopy, elemental analyses, thermogravimetric analysis and powder X-ray diffraction properties of 1 are also investigated.
文摘Oxidations of piperazine, 1-methylpiperazine and 1-ethylpiperazine by bromamine-T (BAT) in buffered acidic medium have been kinetically studied at 303 K. The reaction shows a first-order dependence of the rate each on [BAT]0 and [piperazine]0, and an inverse fractional-order dependence on [H+]. The additions of halide ions and the reduction product of BAT, p-toluenesulfonamide, have no effect on the reaction rate. The variation of ionic strength of the solvent medium has no influence on the rate. Activation parameters have been evaluated from the Arrhenius and Eyring plots. A common mechanism consistent with the kinetic data has been proposed for all piperazines. The protonation constants of substrates have been evaluated. The Hammett linear free-energy relationship has been observed for the reaction with ρ = ?0.5 indicating that the electron-donating groups enhance the reaction rate by stabilizing the transition state. An isokinetic relationship observed shows β = 368 K indicating the dominance of enthalpy factors on the reaction rate.
基金supported by National Natural Science Foundation of China(21401147)Basic Research Program of Natural Science from Shaanxi Provincial Government(2015JQ2032)+2 种基金Scientific Research Program from Education Department of Shaanxi Provincial Government(2013JK0654)Opening Foundation from State Key Laboratory of Coordination Chemistry in Nanjing University(201219)the Program for Distinguished Young Scholars of Xi’an Polytechnic University(201403)
文摘The reaction of Pr(Ⅲ) salt with 1,2,4,5-benzenetetracarboxylic acid(H4betc) and piperazine(pip) yielded a lanthanide metal-organic framework {[Pr(betc)(H2O)2](H2pip)0.5}n(1)under hydrothermal conditions. Compound 1 was characterized by single-crystal X-ray structural analysis, elemental analysis, IR, X-ray powder diffraction, and thermal gravimetric. Compound 1crystallizes in monoclinic, space group P21/n with a = 11.023(5), b = 11.109(5), c = 11.456(5) A, β = 110.065(5)°, V = 1317.7(9) A3, Mr = 471.14, Z = 4, F(000) = 920, Dc = 2.375 g/cm^3, μ(Mo Kα) = 3.761 mm-1, the final R = 0.0286 and w R = 0.0821(I 〉 2σ(I)). Compound 1 exhibits a 2D network with(4, 4) topology, and a 3D supramolecular framework formed by hydrogen-bonding interactions. The proton conductivity of compound 1 has been investigated at ~97% relative humidity and different temperature.
基金The financial supports from National Natural Science Foundation of China(NSFC,Nos.32072445,21762012)the Program of Introducing Talents to Chinese Universities(No.D20023)+1 种基金the S&T Planning Project of Guizhou Province(No.[2017]5788)Graduate Research Fund in Guizhou Province(No.YJSKYJJ[2021]038).
文摘Derivatives of piperazine,which is one of the most important heterocycles,are often used as linkers to connect active substructures that show promising bioactivities,especially in the field of agrochemicals.From 2000 to 2022,many piperazine-containing compounds were found to exhibit excellent activities against fungi,bacteria,insects,plant viruses,and weeds and have also been used as plant growth regulators.Currently,the development of novel pesticides to prevent the invasion of crop pathogens and ensure the quality and yields of crops is still needed.We herein investigated and summarized the role that piperazine plays in the discovery of pesticides to provide a comprehensive summary of the broad activities of piperazine derivatives in agricultural applications and offer a potential reference for novel pesticide design using piperazine-containing compounds.Moreover,structure–activity relationships(SARs)analyses of bioactive piperazine-containing compounds are also discussed for a deeper understanding.
基金supported by Fundamental research fund of Institute of Forensic Science,Ministry of Public Security(The detection of new drugs analysis in biological samples.No.2012JB005)Academician Foundation of the Ministry of Public Security of the People’s Republic of China(No.2011-23214203,23215243,23317015)+2 种基金Beijing Municipal Education Commission University Science and Technology Park Construction Project(2011-08111603)Program for Young Innovative Research Team in China University of Political Science and Law(2014CXTD04,16CXTD05)the opening project fund of Shanghai Key Laboratory of Criminal Scene Evidence(2011-23417049).
文摘In accordance with the research specifications and guidelines in China,we developed a novel experimental method to detect new piperazine‑type drugs,such as 1‑(3‑trifluoromethylphenyl)piperazine and 1‑(3‑chlorophenyl)piperazine.In this study,a new pretreatment method and gas chromatography(GC)/nitrogen–phosphorus detector detection technique were used to characterize these two kinds of drugs in urine and blood samples.For the purpose of isolation of these trace drugs from the samples,liquid‑liquid extraction/solid‑phase extraction was modified and validated for this specific study.The pretreatment method presented in this paper has many advantages,such as high recovery rate,high extraction efficiency,high detection sensitivity,low limit of detection,and simple operation.The GC/NPD instrument is popular in most laboratories because it can meet the routine requirements of forensic science.All these aspects make this combination of sample pretreatment and GC/NPD technique the most suitable choice for drug detection in biological samples.
基金supported by the National Natural Science Foundation of China (No. 21372133)‘‘111’’ Project of Ministry of Education of China (No. B06005)
文摘A series of fluorine- and piperazine-containing 1,2,4-triazole thione derivatives were synthesized by the Mannich reaction of triazole intermediates with various substituted piperazines and formaldehyde in high yields. Structures of title compounds were confirmed by melting points, IR,~1H NMR,^(13)C NMR and elemental analysis. The preliminary bioassays for 17 novel title compounds showed that several compounds have significant fungicidal activity against Cercospora arachidicola, Physalospora piricola and Rhizoctonia cerealis at 50 mg/m L.
文摘The goal of this study is to design and synthesize a linear segmented shape memory poly(urethane-urea) (SMPUU) that possesses near-body-temperature shape memory temperature (Ttran) and enhanced mechanical properties by incorporating flexible poly(ethylene glycol) 400 (PEG400) to form poly(D,L-lactic acid)-based macro- diols (PDLLA-PEG400-PDLLA) and then rigid piperazine (PPZ) as a chain extender to form the desired SMPUUs (PEG400-PUU-PPZ). PEG400 increased Mn while maintaining a lower Tg of PDLLA-PEG400-PDLLA, which together with PPZ improved the mechanical properties of PEG400-PUU-PPZ. The obtained optimum SMPUU with enhanced mechanical properties (O'y = 24.28 MPa; zf = 698%; Uf = 181.5 MJIm3) and a Tg of 40.62~C exhibited sound shape memory properties as well, suggesting a promising SMPUU for in vivo biomedical applications.