Improved Pittsburgh Sleep Quality Index scores on first postoperative night achieved by propofol anesthesia in patients undergoing ambulatory gynecologic surgery

BACKGROUND Sleep disturbance on the first postoperative night commonly develops for patients after day surgeries. The choice of either total intravenous anesthesia by propofol or total inhalation anesthesia with sevoflurane has become an issue for preventing sleep disturbance.AIM To compare sleep quality on the first postoperative night for female patients after total intravenous anesthesia by propofol and total inhalation anesthesia with sevoflurane.METHODS We enrolled 61 American Society of Anesthesia(ASA) class Ⅰ-Ⅱ outpatients who underwent minor gynecologic surgeries by either propofol or sevoflurane anesthesia. Sleep quality of the very night was assessed by the Pittsburgh Sleep Quality Index(PSQI) on the next day, and PSQI scores were compared by the Wilcoxon signed-rank test and paired t-test pre-operatively and postoperatively.RESULTS For the propofol group, the mean postoperative global PSQI score(3.3 ± 1.3) was lower than the mean preoperative global PSQI score(4.9 ± 2.3)(P < 0.001);for the sevoflurane group, the mean postoperative global PSQI score(6.5 ± 2.8) was higher than the mean preoperative global PSQI score(5.5 ± 3.2)(P = 0.02). Eighty percent of patients receiving propofol anesthesia subjectively reported improved sleep quality, but only 17% of patients receiving sevoflurane anesthesia reported improved sleep quality.CONCLUSION Sleep quality assessed by the PSQI is better improved in ASA class Ⅰ-Ⅱ female patients receiving propofol anesthesia other than sevoflurane anesthesia for undergoing minor gynecologic surgeries.

Sleep quality in middle-aged and elderly hemodialysis patients:Impact of a structured nursing intervention program

BACKGROUND Poor sleep quality is common among hemodialysis patients and can significantly impact their well-being.This study aimed to evaluate the effectiveness of a structured nursing intervention program in improving sleep quality in middleaged and elderly hemodialysis patients.AIM To evaluate the impact of nursing intervention on sleep quality in hemodialysis patients.METHODS This cross-sectional study was conducted in a tertiary hospital,the First Affiliated Hospital of Nanchang University,in 2023.This study included 105 middle-aged and elderly hemodialysis patients aged≥45 years who underwent maintenance hemodialysis for at least 3 mo,utilizing the Pittsburgh Sleep Quality Index(PSQI)to identify poor sleepers.Those identified underwent a 12-wk nursing intervention program focusing on education,relaxation techniques,and counseling.Post-intervention,sleep quality was reassessed using the PSQI.RESULTS The study found that 68.6%of hemodialysis patients were poor sleepers.Following the 12-wk nursing intervention program,there was a significant decrease in the mean global PSQI score from 8.9±3.2 to 5.1±2.7(P<0.001),indicating improved sleep quality.This demonstrated the effectiveness of the structured nursing intervention in enhancing sleep quality for middle-aged and elderly hemodialysis patients.CONCLUSION The structured nursing intervention program focusing on sleep hygiene education,relaxation techniques,and counseling effectively improved sleep quality among middle-aged and elderly hemodialysis patients.The significant decrease in the mean global PSQI score post-intervention indicates the positive impact of tailored nursing interventions in addressing poor sleep quality in this patient population.These findings emphasize the importance of implementing targeted nursing interventions to enhance the quality of life for hemodialysis patients by addressing the prevalent issue of poor sleep quality.

Relationship between sleep quality and blood pressure level in nurses performing shift work

Objective:The aim of the study was to evaluate the quality of sleep in nurses performing shift work in therapeutic and surgical depar tments and to establish possible relationships between level of blood pressure(BP)and quality of sleep.Methods:A total of 20 nurses of the therapeutic depar tments and 20 nurses of the surgical depar tments were enrolled in the study.Sleep quality was assessed using the Pittsburgh Sleep Quality Index(PSQI).BP was measured according to the standard protocol using the Korotkoff method;a sphygmomanometer was used for this twice with an interval of 2 min between 10:00 a.m.and 10:30 a.m.The average value for the 2 indicators was calculated.The diagnosis of essential ar terial hyper tension(AH)was established according to the recommendations of the European Association of Cardiology and the European Association of Hypertension(2018).Results:The overall assessment of the sleep quality of the nurses involved in shift work indicates poor sleep quality;this was true in respondents of both the surgical and therapeutic profiles.However,it was observed that the quality of sleep was significantly lower in nurses of the therapeutic departments.Moreover,poor sleep quality was associated with AH,which was diagnosed in 65%of the nurses of the therapeutic departments and 45%of the nurses of the surgical departments,that is,in almost all of the subjects.Herewith,in the nurses of the therapeutic departments,the level of systolic BP exceeded that of the nurses of the surgical departments.Conclusions:Poor sleep quality is a significant risk factor for AH development and is relevant to nurses performing shift work.Additional clinical studies should be conducted to better understand the mechanisms underlying such adverse cardiometabolic outcomes associated with sleep disorders in the health-sector shift workers.

Persistent alterations in gray matter in COVID-19 patients experiencing sleep disturbances:a 3-month longitudinal study

Sleep disturbances are among the most prevalent neuropsychiatric symptoms in individuals who have recovered from severe acute respiratory syndrome coronavirus 2 infections.Previous studies have demonstrated abnormal brain structures in patients with sleep disturbances who have recovered from coronavirus disease 2019(COVID-19).However,neuroimaging studies on sleep disturbances caused by COVID-19 are scarce,and existing studies have primarily focused on the long-term effects of the virus,with minimal acute phase data.As a result,little is known about the pathophysiology of sleep disturbances in the acute phase of COVID-19.To address this issue,we designed a longitudinal study to investigate whether alterations in brain structure occur during the acute phase of infection,and verified the results using 3-month follow-up data.A total of 26 COVID-19 patients with sleep disturbances(aged 51.5±13.57 years,8 women and 18 men),27 COVID-19 patients without sleep disturbances(aged 47.33±15.98 years,9 women and 18 men),and 31 age-and gender-matched healthy controls(aged 49.19±17.51 years,9 women and 22 men)were included in this study.Eleven COVID-19 patients with sleep disturbances were included in a longitudinal analysis.We found that COVID-19 patients with sleep disturbances exhibited brain structural changes in almost all brain lobes.The cortical thicknesses of the left pars opercularis and left precuneus were significantly negatively correlated with Pittsburgh Sleep Quality Index scores.Additionally,we observed changes in the volume of the hippocampus and its subfield regions in COVID-19 patients compared with the healthy controls.The 3-month follow-up data revealed indices of altered cerebral structure(cortical thickness,cortical grey matter volume,and cortical surface area)in the frontal-parietal cortex compared with the baseline in COVID-19 patients with sleep disturbances.Our findings indicate that the sleep disturbances patients had altered morphology in the cortical and hippocampal structures during the acute phase of infection and persistent changes in cortical regions at 3 months post-infection.These data improve our understanding of the pathophysiology of sleep disturbances caused by COVID-19.

Relationship of depression and sleep quality,diseases and general characteristics

BACKGROUND Depression is the most common type of depressive disorder.The most common sleep disorder associated with depression is insomnia.Insomnia and depression are closely related.AIM To investigate the relationship of designed questionnaire items and depression,and analyze the related factors with depression.METHODS Questionnaire included Patient Health Questionnaire-9(PHQ-9)and Pittsburgh sleep quality index(PSQI),12 kinds of diseases,8 general characteristics,and 20 insomnia characteristics,totally 56 items were filled out by 411 patients enrolled.RESULTS All the 9 items of PHQ-9,6 components of PSQI(except sleep duration),education,living situation,exercise,years of insomnia,western medicine treatment,Chinese medicine treatment,psychotherapy,kinds of insomnia,treatment expected to treat insomnia,psychological counseling,habit of 1 h before bed,habit of lunch break,diagnosed depression,coronary heart disease,mental illness showed significant difference between without and with depression group.By univariate analysis and multivariate analysis.The odds ratio of education,exercise,kinds of insomnia,habit of 1 h before bed,diagnosed depression,coronary heart disease(P=0.01)showed significant difference.Their odds ratios were 0.71(0.55,0.93),2.09(1.32,3.31),0.76(0.63,0.91),0.89(0.81,0.98),0.32(0.17,0.60),0.43(0.23,0.79).CONCLUSION We demonstrated that education,exercise,kinds of insomnia,habit of 1 h before bed,diagnosed depression and coronary heart disease affect the depression.

Sleep quality in elderly patients with obstructive sleep apnea syndrome

AIM:To investigate the sleep quality in elderly patients with obstructive sleep apnea syndrome (OSAS). METHODS:54 cases of elderly patients with OSAS were evaluated by the pittsburgh sleep quality index (PSQI) questionnaire. RESULTS:Among 54 OSAS patients, 35 cases (65%) reported poor quality of sleep, only 7(13%) cases reported good. A significant negative correlation was found between apnea/hypopnea index (AHI) and PSQI, and part of its components. CONCLUSION:Elderly patients with OSAS often complain of poor quality of sleep. Daytime dysfunction, poor subjective sleep quality, low habitual sleep efficiency and long sleep latency constitutes the principal parts of the symptoms about sleep.

Can subjective sleep quality, evaluated at the age of 73, have an influence on successful aging? The PROOF study

Objective: Sleep complaints are recurrent in Geriatrics and are often attributed to physiological aging. The aim of this work is to describe subjective sleep quality and its impact on successful aging. Methods: Subjective sleep quality was evaluated by using the Pittsburgh subjective sleep quality questionnaire. Two visual analogical scales (graduate from 0 to 10) were used to quantify perceived state of health and life satisfaction. Objective respiratory sleep parameters were also collected. Results: 370 data were analysed (46.2% of males). The average age was 73.2 +/- 1. The level of perceived state of health was 6.9 +/- 2, and life satisfaction level was 7.7 +/-2. Subjective sleep quality was significantly related to perceived health status (p = 0.034) and life satisfaction (p = 0.005). There was no significant association between sleep quality and objective respiratory sleep parameters. Conclusion: The assessment of sleep quality plays an important role in the management of elderly persons and can help them to age more successfully.

Relationship of Lifestyle Habits with Sleep Quality among Japanese in Their 20s

The purpose of this study was to analyze the effects of lifestyle on sleep quality in young Japanese adults. A cross-sectional study was conducted on the web. We analyzed 637 eligible subjects (316 men and 321 women) aged 20 - 29 years. Information on diet and individual lifestyle characteristics, including sleep quality, which was assessed using the Pittsburgh Sleep Quality Index Japanese version (PSQI-J). Results were obtained by participants completing an online questionnaire. The participants were divided into two groups based on whether they were students (“student group”) or not (“not student group”). The participants with a PSQI-J global score of 6 or higher were evaluated as low-sleep-quality. Logistic regression analyses were performed to evaluate associations of lifestyle habits with low-sleep-quality. Logistic regression analyses were applied for “student group” and “not student group”. The results showed that days of eating out at dinner (OR: 1.11, CI: 1.00 - 1.22) and skipping dinner (OR: 1.21, CI: 1.05 - 1.42) were significant and independent predictors for low-sleep-quality among the “not student group”. There were no significant and independent predictors for low-sleep-quality among “student group”. Our results suggested that excessive intake by eating out and deficient intake by skipping dinner might lead to a high PSQI-J score. It is necessary for young people to receive education on the importance of cooking their own meals for traditional and daytime eating. The implication of this study lies in the fact that we have analyzed the effects of lifestyle habits on quality of sleep.

Effect of Eating out on Quality and Quantity of Sleep among Japanese in Their 20s

The purpose of this study was to analyze the effects of eating out or skipping meals on the quality or quantity of sleep in young Japanese adults. We analyzed 584 eligible subjects (283 men and 301 women) aged 20 - 29 years. Information on diet and individual lifestyle characteristics, including sleep quality, which was assessed by the Pittsburgh Sleep Quality Index Japanese version (PSQI-J), were obtained by participants completing an online questionnaire. Kendall’s tau coefficient was used to measure the ordinal association between diet and sleep quality. The Mann-Whitney U test was performed to evaluate differences in sleep quality by frequency of eating out and frequency of skipping meals. The results revealed a significant difference in sleep duration and PSQI-J score between people who eat out >2 times a week (“high restaurants group”) and those who do not (“low restaurants group”). Furthermore, whereas the mean sleep duration in the “high restaurants group” was 6.59 hours, the mean sleep duration in the “low restaurants group” was 6.90 hours (p = 0.007). The PSQI-J score was significantly higher in the “high restaurants group” than in the “low restaurants group” (4.91 versus 4.37, p = 0.006). Significant differences were also evident in the test’s component scores: C2, C3, and C7. No significant difference was found in sleep duration and PSQI-J score between the groups in terms of frequency of skipping meals (breakfast, lunch, and dinner). Our results suggested that excessive intake by eating out more than twice a week may lead to short sleep duration and high PSQI-J score.

Sleep Quality in Non Dialysis Chronic Kidney Disease: Associated Factors and Influence on Prognosis

Deficient sleep quality (SQ) has been linked with a higher hospitalization rate and mortality in dialysis patients, however the prevalence of sleep disorders and their influence on prognosis in non-dialysis chronic kidney disease (CKD) has been poorly investigated. The aim of this study was to assess factors related with SQ in CKD patients (stages I-IV) followed in a nephrology outpatient clinic as well as the long-term impact of SQ on patient’s outcome. Between January and May 2008, Pittsburgh Sleep Quality Index (PSQI) was self-administered by 122 patients (68 males and 54 females) with a mean age of 65 years. Patients were classified as “good” (global PSQI < 6) and “poor” sleepers (global PSQI ≥ 6). We identified 66 (54%) poor sleepers (PS), characterized by an older age (66 ± 14.2 vs 57 ± 17.0, p < 0.01), female predominance (59% vs 26%, p < 0.01) and worse renal function (49 ± 19.1 vs 57 ± 23.2 ml/min, p < 0.05). There was a significant correlation between phosphate and PSQI score (r = 0.234, p = 0.01), however no correlation with calcium or PTH. Vitamin D was also lower in PS (17 ± 7.2 vs 23 ± 15.1 ng/ml, p < 0.05). Until June 2015, hospitalization rate was higher among PS (64% vs 44%, p < 0.05). In this period, there was also a trend towards higher mortality for PS (18% vs 16%). In summary, over 50% of CKD patients have poor SQ, which was associated with older age, female gender, worse renal function, lower vitamin D and higher phosphate levels. Deficient sleep was associated with a greater probability of hospitalization and might be a prognostic marker in CKD.

Survey of the Sleep Quality of Medical Staff in a Grade A Tertiary Hospital during the Novel Coronavirus Pneumonia Outbreak

This study aimed to investigate the sleep quality of medical staff in China who are combatting novel coronavirus pneumonia(COVID-19).To perform this,a survey of 127 medical staff from three separate wards(the general ward,isolation ward,and fever clinic)of a Grade A tertiary hospital in China was conducted.The survey questionnaire measured general characteristics and included the Pittsburgh Sleep Quality Index(PSQI).We consequently found that global PSQI scores differed significantly between the different wards(χ2=44.561,P<0.001).Whilst the medical staff in the general ward did not report any sleep disturbances,those in the isolation ward and the fever clinic both exhibited various degrees of sleep disturbance(global PSQI score>7).Medical staff in the isolation ward had the worst sleep quality(mean rank=91.74),followed by those in the fever clinic(mean rank=70.52)and the general ward(mean rank=39.10),respectively.The primary sleep disturbances reported by the medical staff from the isolation ward included difficulty falling asleep(24 cases,71.42%),waking early or at night(28 cases,80%),and nightmares(18 cases,51.42%).In addition,31.42%(11 cases)of the medical staff from the isolation ward had less than six hours of sleep a night,and 65.71%(23 cases)felt that their sleep quality was poor;meanwhile,for the staff from the fever clinic these ratios were 16.67%(seven cases)and 33.33%(14 cases),respectively.In contrast,among medical staff in the general ward,98%(49 cases)reported sleeping for more than six hours a night,and 96%felt that their sleep quality was good.In conclusion,of the medical staff providing treatment for COVID-19,those in isolation wards and fever clinics are more likely to experience sleep disturbances.

Effect of Mindfulness-based Cognitive Training on Sleep Quality and Mindfulness Cognitive Level of College Students

Objective:To study the effect of mindfulness-based cognitive training on sleep quality and mindfulness cognitive level of college students who score below the critical value of sleep disorders.Methods:The subjects were freshmen of a university in Shanghai who had scored below the critical value of sleep disorders.They were divided into the control group and experimental group by a random number table method,with 35 students in each group.No intervention was provided in the control group,and the mindfulness-based cognitive training(1 hour per day,5 days per week for 8 consecutive weeks)was performed in the intervention group.Eight weeks later,the Pittsburgh Sleep Quality Index(PSQI)and Five Facet Mindfulness Questionnaire(FFMQ)scores were compared between the two groups before and after the intervention for changes in the sleep quality and mindfulness cognitive level.Results:The sleep quality and daytime dysfunction were significantly improved,the sleep latency was shortened,the sleep duration was prolonged(P<0.05),and the mindfulness level of the subjects was significantly improved(P<0.05)in the intervention group compared with the control group.Conclusion:Mindfulness-based cognitive training can significantly improve the sleep quality of college students who scored below the critical value of sleep disorders.Furthermore,its psychological mechanism may be associated with the improvement of the mindfulness level of college students.

龙胆泻肝汤加减联合劳拉西泮对肝郁化火型失眠症患者PSQI各因子评分、单胺类神经递质和血清TNF-α影响

目的:观察龙胆泻肝汤加减联合劳拉西泮对肝郁化火型失眠症患者PSQI各因子评分、单胺类神经递质和血清TNF-α的影响。方法:选取我院收治的肝郁化火型失眠症140例患者作为研究对象,按随机数字表法分为观察组和对照组各70例,对照组给予劳拉西泮治疗,观察组在对照组基础上联合龙胆泻肝汤治疗。观察两组临床疗效、匹兹堡睡眠质量指数(PSQI)各因子评分,检测单胺类神经递质、血清肿瘤坏死因子-α(TNF-α),比较不良反应发生情况。结果:观察组总有效率95.71%显著高于对照组77.14%(P<0.05);治疗后两组PSQI除睡眠障碍外各因子评分较治疗前显著下降(P<0.05),且观察组显著低于对照组(P<0.05);治疗后两组5-HT、5-HIAA、GABA水平显著高于治疗前(P<0.05),治疗后两组NE、DA水平与治疗前比较显著下降(P<0.05),且观察组各指标变化情况显著优于对照组(P<0.05);治疗后两组血清TNF-α水平显著高于治疗前(P<0.05),且观察组血清TNF-α水平显著高于对照组(P<0.05);对照组与观察组不良反应发生率比较差异无统计学意义(P>0.05)。结论:龙胆泻肝汤加减联合劳拉西泮可有效改善肝郁化火型失眠症患者睡眠质量,有效调节单胺类神经递质和血清TNF-α水平。

耳穴压豆法治疗艾滋病失眠患者的PSQI量表分析

目的:探讨耳穴压豆疗法治疗艾滋病失眠患者的临床效果。方法:根据诊断标准选取艾滋病失眠患者272例,耳穴压豆疗法治疗4个疗程,每个疗程7 d,采用匹兹堡睡眠质量指数量表(PSQI)作为疗效评定标准。结果:272例患者治疗7 d后,其中有69例患者睡眠质量改善,有效率达25. 37%。随着治疗时间延长,治疗有效率逐渐增加,至28 d有效率达94. 12%。PSQI各因子及总分逐渐减少,第1个疗程(治疗7 d)后PSQI各因子及总得分较治疗前降低,差异有统计学意义,其中睡眠质量、睡眠时间、睡眠障碍、催眠药应用及总分在治疗14 d后差异有统计学意义,入睡时间、睡眠效率及日间功能障碍治疗21 d后差异有统计学意义。治疗28 d后除催眠药应用外,PSQI各因子及总分与常模比较差异有统计学意义,但睡眠效率较正常人高。结论:耳穴压豆疗法治疗艾滋病患者失眠有一定的临床疗效,值得进一步观察探讨。

曲唑酮片联合唑吡坦治疗失眠对SDRS PSQI评分及PSG指标的影响

目的分析曲唑酮片联合唑吡坦治疗失眠对睡眠障碍评定量表(SDRS)、匹兹堡睡眠质量指数(PSQI)及多导睡眠图(PSG)的影响。方法纳入120例于2018-05—2021-10于郑州大学第二附属医院接受治疗的失眠患者,A组40例施予曲唑酮片治疗,B组40例施予唑吡坦治疗,C组40例施予曲唑酮片联合唑吡坦治疗,对比3组SDRS、PSQI评分及PSG各指标。结果治疗后7 d、14 d、28 d,C组SDRS评分分别为(14.04±5.57)分、(10.15±4.32)分、(7.82±3.62)分,均较A组(18.73±6.41、12.15±5.53、11.37±4.55)、B组(18.32±5.92、12.42±4.37、11.23±4.65)低,差异均有统计学意义(P<0.05);C组PSQI评分分别为(12.29±1.29)分、(12.35±1.04)分、(7.14±0.63)分,均较A组(15.83±1.34、14.32±1.27、12.29±1.29)、B组(15.84±1.43、14.45±1.15、12.35±1.04)低,差异均有统计学意义(P<0.05);C组中PSG睡眠效率、睡眠总时间、醒觉时间、入睡时间(82.53±6.74、389.24±33.34、80.27±32.63、29.24±4.77)各项指标优于A组(74.18±6.83、333.61±34.69、120.53±33.48、36.08±4.17)、B组(73.84±7.03、334.63±35.75、120.63±34.15、35.93±3.84),差异均有统计学意义(P<0.05)。结论失眠患者给予曲唑酮片联合唑吡坦治疗效果显著,有助于改善患者的SDRS、PSQI评分及PSG指标。

黄连阿胶汤联合劳拉西泮片治疗阴虚火旺证不寐的疗效及对PSG和PSQI的影响

目的:观察黄连阿胶汤联合劳拉西泮片治疗阴虚火旺证不寐的疗效及对多导睡眠图(PSG)和匹兹堡睡眠质量指数(PSQI)的影响。方法:将138例阴虚火旺证不寐患者随机分为两组,对照组69例应用劳拉西泮片治疗,治疗组69例应用黄连阿胶汤联合劳拉西泮片治疗,两组均连续治疗30d。记录两组治疗后临床疗效,统计两组患者治疗前后中医证候积分、PSG和PSQI变化情况。结果:治疗组总有效率为94.20%,对照组总有效率为81.16%,治疗组优于对照组(P<0.05);两组患者治疗后中医证候积分均较治疗前显著下降(P<0.05),且治疗组患者治疗后中医证候积分低于对照组(P<0.05);两组患者治疗后睡眠潜伏期、觉醒次数均较治疗前显著下降(P<0.05),且睡眠效率和实际睡眠时间均较治疗前显著上升(P<0.05);治疗后两组比较,治疗组患者治疗后睡眠潜伏期、觉醒次数均低于对照组(P<0.05),睡眠效率和实际睡眠时间均高于对照组(P<0.05);两组患者治疗后PSQI中睡眠时间、入睡时间、睡眠障碍、日间功能、睡眠效率、睡眠质量各项评分和PSQI总分均较治疗前显著下降(P<0.05),且治疗组患者上述指标均低于对照组(P<0.05)。结论:黄连阿胶汤联合劳拉西泮片治疗阴虚火旺证不寐,临床疗效显著,能明显改善PSG和PSQI。

呼吸湿化治疗仪对老年轻中度OSAHS患者作用效果、SF-36、PSQI评分的影响

目的:研究呼吸湿化治疗仪对老年轻中度阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者作用效果、健康调查简表(SF-36)、匹兹堡睡眠质量指数(PSQI)评分的影响。方法:将2018年1月10日-2020年10月30日沈阳医学院附属第二医院收治的91例老年轻中度OSAHS患者纳入研究。将其按照电脑随机数字表法分为研究组(n=45)和常规组(n=46)。常规组予以常规鼻导管氧疗干预,研究组则予以呼吸湿化治疗仪干预。分析两组临床疗效、治疗前后SF-36、PSQI评分及血清白细胞介素-6(IL-6)、正五聚蛋白-3(PTX-3)水平的差异。结果:研究组治疗总有效率高于常规组,治疗后SF-36评分均高于常规组,PSQI评分与血清IL-6、PTX-3水平均低于常规组,差异均有统计学意义(P<0.05)。结论:呼吸湿化治疗仪对老年轻中度OSAHS患者的作用效果较为理想,可明显改善患者的生活质量与睡眠质量,同时可降低IL-6、PTX-3表达水平。

深刺少阳经腧穴结合中药对难治性突发性聋患者THI、PSQI评分的影响

目的:观察不同刺法结合中药对难治性突发性聋患者耳鸣、睡眠的改善作用。方法:选取来自三家医院耳鼻喉科的门诊患者84例,将患者随机分为深刺组:深刺结合中药汤剂;普通针刺组:普通针刺结合中药汤剂;中药组:口服中药汤剂。每组28例患者,治疗30次为1个疗程。针刺每天1次,每周针刺5次,周六、周日休息,共治疗30天。中药治疗方法:口服中药汤剂,每次150毫升,每日3次,统一煎中药和配送,周六、周日休息,共服用30天。针刺选穴:听会(患侧)、耳门(患侧)、听宫(患侧)、翳风(患侧)、率谷(患侧)、瘛脉(患侧)、风池(双侧)、头皮针:晕听区;中渚(双侧),外关(双侧),每治疗10天测定纯音听阈值,治疗前后测定耳鸣残疾量表(THI)和匹兹堡睡眠质量指数量表(PSQI)的得分,并进行比较,治疗前后配对t检验,SPSS统计分析。结果:深刺组治疗前耳鸣残疾量表得分显著高于治疗后得分(P<0.05);深刺组治疗10天后听阈均值明显低于治疗前听阈均值(P<0.05),治疗20天后听阈均值明显低于治疗10天后听阈均值(P<0.05),治疗30天后听阈均值明显低于治疗20天后听阈均值(P<0.05);普通针刺组治疗前匹兹堡睡眠质量指数得分显著高于治疗后得分(P<0.05),普通针刺组治疗20天后听阈均值明显低于治疗10天后听阈值(P<0.05),治疗30天后听阈均值明显低于治疗20天后听阈值(P<0.05),治疗30天后听阈均值明显低于治疗前听阈值(P<0.05);中药组治疗前耳鸣残疾量表得分显著高于治疗后得分(P<0.05);治疗30天后听阈均值比治疗20天后听阈均值有明显下降作用(P<0.05)。结论:深刺组和中药组改善耳鸣效果好,普通针刺组改善睡眠效果好。

氟哌噻吨美利曲辛联合劳拉西泮片对失眠症睡眠质量及负性情绪的影响

目的 探讨氟哌噻吨美利曲辛联合劳拉西泮片对失眠症患者睡眠质量及负性情绪的影响。方法 回顾性收集2021年1月至2023年12月接受劳拉西泮片治疗的32例失眠症患者临床资料,作为对照组,同期收集32例接受氟哌噻吨美利曲辛联合劳拉西泮片治疗的失眠症患者的临床资料,作为观察组。比较两组患者睡眠质量、负性情绪、多导睡眠参数以及用药不良反应。结果 治疗后,观察组匹兹堡睡眠质量指数(PSQI)相较对照组更低(P<0.05)。观察组实际睡眠总时间、快速眼动睡眠阶段睡眠时间(RT)相较于对照组更长;睡眠潜伏期、夜间觉醒次数、觉醒时间、非快速眼动睡眠阶段1的占比(S1)相较于对照组更短(P<0.05)。观察组焦虑自评量表(SAS)、抑郁自评量表(SDS)评分相较于对照组更低(P<0.05)。两组患者药物不良反应发生率差异无统计学意义(P>0.05)。结论 氟哌噻吨美利曲辛联合劳拉西泮片对失眠症患者睡眠质量、负性情绪具有改善效果,且安全性较高。