To achieve a dopamine （DA） response with high sensitivity and high signal-to-noise ratio （S/N） with a patch-clamp system, polypyrrole/graphene （PPy/GR） nanocomposites were steadily electrodeposited by an electro...To achieve a dopamine （DA） response with high sensitivity and high signal-to-noise ratio （S/N） with a patch-clamp system, polypyrrole/graphene （PPy/GR） nanocomposites were steadily electrodeposited by an electrochemical method on a planar mi- croelectrode array （pMEA） fabricated by a standard micromachining process. The electrodeposition process was carried out by chronopotentimetry measurement scanning from 0.1 to 0.8 C/cm2 at the current of 2 mA; 0.5 C/cm2 was found to be optimal. The pMEA modified by PPy/GR at the 0.5 C/cm2 exhibits remarkable properties; for instance, the standard deviation （SD） de- creases from 8.4614×10-al to 5.62×10 11 A, reduced by 33.52%, and the sensitivity increases from 2566.88 to 76114.65 gAmMcm2 , 29.65 times higher than the bare Pt （platinum）. A good linear relationship between the current and DA concentra- tion in the range of 0.30 to 61.71 grn was obtained, with a correlation coefficient of 0.997. The sensor is meaningful for neuro- science research and the treatment of neurological diseases.展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos.61125105,61101048,61271147,and 61002037)National Basic Research Program of China("973" Program)(Grant Nos.2011CB933202,2014CB744605)
文摘To achieve a dopamine （DA） response with high sensitivity and high signal-to-noise ratio （S/N） with a patch-clamp system, polypyrrole/graphene （PPy/GR） nanocomposites were steadily electrodeposited by an electrochemical method on a planar mi- croelectrode array （pMEA） fabricated by a standard micromachining process. The electrodeposition process was carried out by chronopotentimetry measurement scanning from 0.1 to 0.8 C/cm2 at the current of 2 mA; 0.5 C/cm2 was found to be optimal. The pMEA modified by PPy/GR at the 0.5 C/cm2 exhibits remarkable properties; for instance, the standard deviation （SD） de- creases from 8.4614×10-al to 5.62×10 11 A, reduced by 33.52%, and the sensitivity increases from 2566.88 to 76114.65 gAmMcm2 , 29.65 times higher than the bare Pt （platinum）. A good linear relationship between the current and DA concentra- tion in the range of 0.30 to 61.71 grn was obtained, with a correlation coefficient of 0.997. The sensor is meaningful for neuro- science research and the treatment of neurological diseases.
