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A Bingham-Plastic Model for Fluid Mud Transport Under Waves and Currents 被引量:2
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作者 刘春嵘 吴博 呼和敖德 《China Ocean Engineering》 SCIE EI CSCD 2014年第2期227-238,共12页
Simplified equations of fluid mud motion, which is described as Bingham-Plastic model under waves and currents, are presented by order analysis. The simplified equations are non-linear ordinary differential equations ... Simplified equations of fluid mud motion, which is described as Bingham-Plastic model under waves and currents, are presented by order analysis. The simplified equations are non-linear ordinary differential equations which are solved by hybrid numerical-analytical technique. As the computational cost is very low, the effects of wave current parameters and fluid mud properties on the transportation velocity of the fluid mud are studied systematically. It is found that the fluid mud can move toward one direction even if the shear stress acting on the fluid mud bed is much smaller than the fluid mud yield stress under the condition of wave and current coexistence. Experiments of the fluid mud motion under current with fluctuation water surface are carried out. The fluid mud transportation velocity predicted by the presented mathematical model can roughly match that measured in experiments. 展开更多
关键词 motion of fluid mud fluid mud transport Bingham-plastic model wave-current interaction
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Parameters Sensitivity Analysis and Correction for Concrete Damage Plastic Model 被引量:1
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作者 Yaqin Jiang Pengfei Xu +1 位作者 Chengzhi Wang Dianshu Liu 《Journal of Beijing Institute of Technology》 EI CAS 2018年第1期103-108,共6页
In order to understand the effect of hardening ductility parameters and softening ductility parameters of the concrete damage plastic model in LS-DYNA,a sensitivity and reliability analysis of these parameters through... In order to understand the effect of hardening ductility parameters and softening ductility parameters of the concrete damage plastic model in LS-DYNA,a sensitivity and reliability analysis of these parameters through a convenient cube unit test was conducted. The results showed that the peak strength strain was independent of the hardening ductility parameter DH,but affected by AH,BH,and CH. The softening ductility was mainly related to the softening ductility parameter AS,but not affected by the damage ductility exponent BS. In case that the model with default parameters failed to match the AS-controlled damage softening phase,an optimized model with an AS correction was developed. The corrected model with the AS value of 2 matched well with the code model,and exhibited good feasibility in predicting the stress-strain curve of different grades of concrete. Moreover,the practicability of the corrected model was further validated by the conventional triaxial test. The simulated curve exhibited favorable consistence with the trial curve. Therefore,the model with parameter correction could provide a prospective reference for predicting the mechanical properties of concrete. 展开更多
关键词 damage-plastic model concrete sensitivity analysis parameter correction
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Elastoplastic model for discontinuous shear deformation of deep rock mass 被引量:3
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作者 王明洋 范鹏贤 +1 位作者 钱七虎 邓宏见 《Journal of Central South University》 SCIE EI CAS 2011年第3期866-873,共8页
Deep rock mass possesses some unusual properties due to high earth stress,which further result in new problems that have not been well understood and explained up to date.In order to investigate the deformation mechan... Deep rock mass possesses some unusual properties due to high earth stress,which further result in new problems that have not been well understood and explained up to date.In order to investigate the deformation mechanism,the complete deformation process of deep rock mass,with a great emphasis on local shear deformation stage,was analyzed in detail.The quasi continuous shear deformation of the deep rock mass is described by a combination of smooth functions:the averaged distribution of the original deformation field,and the local discontinuities along the slip lines.Hence,an elasto-plastic model is established for the shear deformation process,in which the rotational displacement is taken into account as well as the translational component.Numerical analysis method was developed for case study.Deformation process of a tunnel under high earth stress was investigated for verification. 展开更多
关键词 连续剪切变形 弹塑性模型 深部岩体 变形过程 局部剪切变形 数值分析方法 高技术条件 变形机制
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Slope analysis based on local strength reduction method and variable-modulus elasto-plastic model 被引量:4
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作者 杨光华 钟志辉 +3 位作者 傅旭东 张玉成 温勇 张明飞 《Journal of Central South University》 SCIE EI CAS 2014年第5期2041-2050,共10页
Employing an ideal elasto-plastic model,the typically used strength reduction method reduced the strength of all soil elements of a slope.Therefore,this method was called the global strength reduction method(GSRM).How... Employing an ideal elasto-plastic model,the typically used strength reduction method reduced the strength of all soil elements of a slope.Therefore,this method was called the global strength reduction method(GSRM).However,the deformation field obtained by GSRM could not reflect the real deformation of a slope when the slope became unstable.For most slopes,failure occurs once the strength of some regional soil is sufficiently weakened; thus,the local strength reduction method(LSRM)was proposed to analyze slope stability.In contrast with GSRM,LSRM only reduces the strength of local soil,while the strength of other soil remains unchanged.Therefore,deformation by LSRM is more reasonable than that by GSRM.In addition,the accuracy of the slope's deformation depends on the constitutive model to a large degree,and the variable-modulus elasto-plastic model was thus adopted.This constitutive model was an improvement of the Duncan–Chang model,which modified soil's deformation modulus according to stress level,and it thus better reflected the plastic feature of soil.Most importantly,the parameters of the variable-modulus elasto-plastic model could be determined through in-situ tests,and parameters determination by plate loading test and pressuremeter test were introduced.Therefore,it is easy to put this model into practice.Finally,LSRM and the variable-modulus elasto-plastic model were used to analyze Egongdai ancient landslide.Safety factor,deformation field,and optimal reinforcement measures for Egongdai ancient landslide were obtained based on the proposed method. 展开更多
关键词 理想弹塑性模型 强度折减法 变形模量 边坡稳定性 坡度 土壤元素 平板载荷试验 本构模型
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ELASTOPLASTIC MODEL DESCRIBING CYCLIC CREEPING BEHAVIOUR OF SOFT CLAYS
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作者 王建华 贾有权 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 1993年第1期80-85,共6页
The elastoplastic model in the deviatoric stress space is constructed to describe the cyclic undrained creeping behaviour of soft clays under cyclic stress by using Mises yield criterion and the concept of a field of ... The elastoplastic model in the deviatoric stress space is constructed to describe the cyclic undrained creeping behaviour of soft clays under cyclic stress by using Mises yield criterion and the concept of a field of hardening moduli. Furthermore, the effect of model parameters on the deformation is studied, and a method is given to determine quantitatively model parameters from results of cyclic triaxial tests of the saturated soft clay. 展开更多
关键词 constitutive model plasticITY soil dynamics
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Modeling the viscoelasto-plastic behavior of waxy crude 被引量:9
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作者 Teng Houxing Zhang Jinjun 《Petroleum Science》 SCIE CAS CSCD 2013年第3期395-401,共7页
Waxy crude oil exhibits complex rheological behavior below the pour point temperature, such as viscoelasticity, yield stress, and thixotropy, owing to the formation of a three-dimensional spongelike interlock network ... Waxy crude oil exhibits complex rheological behavior below the pour point temperature, such as viscoelasticity, yield stress, and thixotropy, owing to the formation of a three-dimensional spongelike interlock network structure. This viscoelasto-thixotropic behavior is an important rheologieal behavior of waxy crude oils, determining the flow recovery and safe restart of crude oil pipelines. Up to now, the thixotropic models for waxy crude have been all viscoplastic models, without considering the viscoelastic part before the yield point. In this work, based on analyzing the variation of the elastic stress and viscous stress in the Mujumbar model, a new viscoelasto-plastic model is proposed, whose shear stress is separated into an elastic component and a viscous component. The elastic stress is the product of the shear modulus and elastic strain; the shear modulus is proportional to the structural parameter. For the elastic strain, we followed the line of Zhu and his coauthors and assumed that it may be expressed by an algebraic equation. The model is validated by stepwise shear rate tests and hysteresis loop tests on Daqing and Zhongyuan waxy crude. The results show that the model's fitting and predictive capability is satisfactory. 展开更多
关键词 THIXOTROPY VISCOELASTICITY viscoelasto-plastic model thixotropic model waxy crude
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A viscoelastic-plastic constitutive model with Mohr-Coulomb yielding criterion for sea ice dynamics 被引量:10
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作者 JI Shunying SHEN Hung Tao +2 位作者 WANG Zhilian SHEN H Hayley YUE Qianjin 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2005年第4期54-65,共12页
A new viscoelastic-plastic (VEP) constitutive model for sea ice dynamics was developed based on continuum mechanics. This model consists of four components: Kelvin-Vogit viscoelastic model, Mohr-Coulomb yielding cr... A new viscoelastic-plastic (VEP) constitutive model for sea ice dynamics was developed based on continuum mechanics. This model consists of four components: Kelvin-Vogit viscoelastic model, Mohr-Coulomb yielding criterion, associated normality flow rule for plastic rehololgy, and hydrostatic pressure. The numerical simulations for ice motion in an idealized rectangular basin were made using smoothed particle hydrodynamics (SPH) method, and compared with the analytical solution as well as those based on the modified viscous plastic(VP) model and static ice jam theory. These simulations show that the new VEP model can simulate ice dynamics accurately. The new constitutive model was further applied to simulate ice dynamics of the Bohai Sea and compared with the traditional VP, and modified VP models. The results of the VEP model are compared better with the satellite remote images, and the simulated ice conditions in the JZ20-2 oil platform area were more reasonable. 展开更多
关键词 sea ice dynamics constitutive model viscous plasticity viscoelastic-plastic model Molar-Coulomb criterion
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WAVE ATTENUATION OVER MUD BED: A PSEUDO-PLASTIC MODEL 被引量:3
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作者 ZhangQing-he OnyxW.H.Wai JosephH.W.Lee 《Journal of Hydrodynamics》 SCIE EI CSCD 2003年第6期32-38,共7页
A two-layer model, with the upper layer being the perfect fluid and the lowerlayer being the pseudo-plastic fluid describing water wave attenuation over mud bed, wasestablished. A simplified method based on the princi... A two-layer model, with the upper layer being the perfect fluid and the lowerlayer being the pseudo-plastic fluid describing water wave attenuation over mud bed, wasestablished. A simplified method based on the principle of e-quivalcnt work was applied to solve theboundary value problems. The computational results of the model show that the two-layer perfectfluid model and the perfect-viscous fluid model are all special cases of the present model. Thecomplex nonlinear properties of wave attenuation over mud bed, can be explained by the presentmodel, e. g., the wave dissipation rale decreases wilh the wave height in certain cases, while thesmall wave propagates over mud bed with less energy dissipation and large wave attenuates rapidly inother cases. Other factors influencing the wave attenuation were also discussed. 展开更多
关键词 wave attenuation mud bed pseudo-plastic model equivalent work
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Plastic-elastic Model for Water-based Lubrication Considering Surface Force
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作者 Shuowen Zhang Mingbo Zhao Chenhui Zhang 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2022年第5期208-218,共11页
Water-based lubrication is an effective method to achieve superlubricity,which implies a friction coefficient in the order of 10−3 or lower.Recent numerical,analytical,and experimental studies confirm that the surface... Water-based lubrication is an effective method to achieve superlubricity,which implies a friction coefficient in the order of 10−3 or lower.Recent numerical,analytical,and experimental studies confirm that the surface force effect is crucial for realizing water-based superlubricity.To enhance the contribution of the surface force,soft and plastic materials can be utilized as friction pair materials because of their effect in increasing the contact area.A new numerical model of water-based lubrication that considers the surface force between plastic and elastic materials is developed in this study to investigate the effect of plastic flow in water-based lubrication.Considering the complexity of residual stress accumulation in lubrication problems,a simplified plastic model is proposed,which merely calculates the result of the dry contact solution and avoids repeated calculations of the plastic flow.The results of the two models show good agreement.Plastic deformation reduces the local contact pressure and enhances the function of the surface force,thus resulting in a lower friction coefficient. 展开更多
关键词 Numerical model Water-based lubrication Mixed lubrication plastic model SUPERLUBRICITY
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A work-hardening and softening constitutive model for sand:modified plastic strain energy approach
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作者 FanglePeng M.S.A.Siddiquee ShaomingLiao 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 2005年第1期76-86,共11页
The paper describes an energy-based constitutive model for sand, which is modified based on the modified plastic strain energy approach, represented by a unique relationship between the modified plastic strain energy ... The paper describes an energy-based constitutive model for sand, which is modified based on the modified plastic strain energy approach, represented by a unique relationship between the modified plastic strain energy and a stress parameter, independent of stress history. The modified plastic strain energy approach was developed based on results from a series of drained plastic strain compression tests along various stress paths on saturated dense Toyoura sand with accurate stress and strain measurements. The proposed model is coupled with an isotropically work-hardening and softening, non-associtated, elasto-plastic material description. The constitutive model concerns the inherent and stress system-induced cross-anisotropic elastic deformation properties of sand. It is capable of simulating the deformation characteristics of stress history and stress path, the effects of pressure level, anisotropic strength and void ratio, and the strain localization. 展开更多
关键词 SAND Energy-based Hardening and softening Elasto-plastic model Stress-strain relation
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Thermomechanical analysis of triangular zone cracks in vertical continuous casting slabs based on viscoelastic-plastic model
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作者 Juan Cheng Yan-xin Wu +1 位作者 Yang Wang Jian-xun Fu 《Journal of Iron and Steel Research(International)》 SCIE EI CAS CSCD 2018年第8期813-820,共8页
The triangular zone cracks in 2101 duplex stainless steel produced by the vertical continuous caster have troubled company A for a long time. To simulate the temperature and thermal stress distributions in the solidif... The triangular zone cracks in 2101 duplex stainless steel produced by the vertical continuous caster have troubled company A for a long time. To simulate the temperature and thermal stress distributions in the solidification process of 2101 duplex stainless steel produced by the vertical continuous caster, a two-dimensional viscoelastic-plastic thermomechanically coupled finite element model was established by the secondary development of the commercial nonlinear finite element analysis software MSC Marc. The results show that the thermal stress on the surface reaches a maximum at the exit of the mould, and the highest thermal stresses at the centre of the wide face and the narrow face are 75 and 115 MPa, respectively. Meanwhile, the internal temperature of slab is still higher than the solidus temperature, resulting in no thermal stress. The slab shows different high-temperature strengths and suffers from different stresses at different positions; thus, the risk of cracking also varies. At a location of 6-8 m from the meniscus, the temperature of the triangular zone is 1270-1360℃ and the corresponding permissible high-temperature strength is about 10-30 MPa, while the thermal stress at this time is 60 MPa, which is higher than the high-temperature strength. As a result, triangular zone cracks form easily. 展开更多
关键词 Vertical continuous caster Triangular zone crack Thermomechanical coupling Viscoelastic-plastic model -Finite element analysis
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Evaluation of Blast-Resistant Performance Predicted by Damaged Plasticity Model for Concrete 被引量:8
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作者 还毅 方秦 +1 位作者 陈力 张亚栋 《Transactions of Tianjin University》 EI CAS 2008年第6期414-421,共8页
In order to evaluate the capacity of reinforced concrete (RC) structures subjected to blast loadings,the damaged plasticity model for concrete was used in the analysis of the dynamic responses of blast-loaded RC struc... In order to evaluate the capacity of reinforced concrete (RC) structures subjected to blast loadings,the damaged plasticity model for concrete was used in the analysis of the dynamic responses of blast-loaded RC structures,and all three failure modes were numerically simulated by the finite element software ABAQUS.Simulation results agree with the experimental observations.It is demonstrated that the damaged plasticity model for concrete in the finite element software ABAQUS can predict dynamic responses and typical flexure,flexure-shear and direct shear failure modes of the blast-loaded RC structures. 展开更多
关键词 ABAQUS 混泥土 破损度 可塑性 承重力 修复方法
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Elasto-plastic analysis of masonry with anisotropic plastic material model 被引量:1
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作者 闫凯 郑文忠 王英 《Journal of Harbin Institute of Technology(New Series)》 EI CAS 2011年第5期74-80,共7页
This paper establishes an anisotropic plastic material model to analyze the elasto-plastic behavior of masonry in plane stress state.Being an anisotropic material,masonry has different constitutive relation and fractu... This paper establishes an anisotropic plastic material model to analyze the elasto-plastic behavior of masonry in plane stress state.Being an anisotropic material,masonry has different constitutive relation and fracture energies along each orthotropic axes.Considering the unique material properties of masonry,a new yield criterion for masonry is proposed combining the Hill's yield criterion and the Rankine's yield criterion.The new yield criterion not only introduces compression friction coefficient of shear but also considers yield functions for independent stress state along two material axes of tension.To solve the involved nonlinear equations in numerical analysis,several nonlinear methods are implemented,including Newton-Raphson method for nonlinear equations and Implicit Euler backward mapping algorithm to update stresses.To verify the proposed material model of masonry,a series of tests are operated.The simulation results show that the new developed material model implements successfully.Compared with isotropic material model,the proposed model performs better in elasto-plastic analysis of masonry in plane stress state.The proposed anisotropic model is capable of simulating elasto-plastic behavior of masonry and can be used in related applications. 展开更多
关键词 MASONRY anisotropic plastic material model ISOTROPIC yield criterion elasto-plastic analysis
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Elasto-plastic constitutive modeling for granular materials 被引量:1
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作者 彭芳乐 李建中 《Journal of Central South University of Technology》 EI 2004年第4期440-444,共5页
Based on the modified plastic strain energy approach, an elasto-plastic constitutive modeling for sand was proposed. The hardening function between the modified plastic strain energy and a stress parameter was present... Based on the modified plastic strain energy approach, an elasto-plastic constitutive modeling for sand was proposed. The hardening function between the modified plastic strain energy and a stress parameter was presented, which was independent of stress history and stress paths. The proposed model was related to an isotropically work-hardening and softening, non-associated and elasto-plastic material description. It is shown that the constitutive modeling, the inherent and stress system-induced cross-anisotropic elasticity is also considered. The constitutive model is capable of simulating the effects on the deformation characteristics of stress history and stress path, pressure level and anisotropic strength. 展开更多
关键词 弹塑模型 硬化 应力过程
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Fatigue Analysis of Steel Catenary Risers Based on a Plasticity Model 被引量:1
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作者 Yongqiang Dong Liping Sun 《Journal of Marine Science and Application》 CSCD 2015年第1期76-82,共7页
在链状的起床人设计是精确地在触地地区评估疲劳损坏的钢的最关键的问题。在触地地区的起床人土壤抵抗的适当建模能由优化设计导致重要费用减小。这份报纸论述能被使用数字地模仿起床人土壤相互作用并且评估动态回答和钢的疲劳损坏的一... 在链状的起床人设计是精确地在触地地区评估疲劳损坏的钢的最关键的问题。在触地地区的起床人土壤抵抗的适当建模能由优化设计导致重要费用减小。这份报纸论述能被使用数字地模仿起床人土壤相互作用并且评估动态回答和钢的疲劳损坏的一个粘性模型在触地地区的链状的起床人。利用模型,众多的起床人土壤元素被纳入钢链状的起床人有限元素,各个沿着起床人触地地区在模仿本地基础抑制。起床人土壤相互作用粘性模型在许可的联合装载表面以内说明行为。模型将在这份报纸被代表,允许简单数字实现。更重要地,它能在钢的结构的分析以内被合并有有限元素方法的链状的起床人。模型的适用性理论上被解释,结果通过申请被显示出到一近海 8.625 钢链状的起床人例子。班机橡皮起床人土壤模型的疲劳分析结果也被显示出。根据二个模型的比较结果,粘性框架的疲劳生活分析结果是合理的,起床人土壤相互作用的水平效果能被包括。 展开更多
关键词 塑性模型 疲劳分析 基础约束 悬链线 不锈钢 立管 管土相互作用 数值模拟
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Fractional-order visco-plastic constitutive model for uniaxial ratcheting behaviors 被引量:5
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作者 Wenjie ZHAO Shaopu YANG +1 位作者 Guilin WEN Xuehong REN 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI CSCD 2019年第1期49-62,共14页
This paper proposes a novel unified visco-plastic constitutive model for uniaxial ratcheting behaviors. The cyclic deformation of the material presents remarkable time-dependence and history memory phenomena. The frac... This paper proposes a novel unified visco-plastic constitutive model for uniaxial ratcheting behaviors. The cyclic deformation of the material presents remarkable time-dependence and history memory phenomena. The fractional(fractional-order)derivative is an efficient tool for modeling these phenomena. Therefore, we develop a cyclic fractional-order unified visco-plastic(FVP) constitutive model. Specifically, within the framework of the cyclic elasto-plastic theory, the fractional derivative is used to describe the accumulated plastic strain rate and nonlinear kinematic hardening rule based on the Ohno-Abdel-Karim model. Moreover, a new radial return method for the back stress is developed to describe the unclosed hysteresis loops of the stress-strain properly.The capacity of the FVP model used to predict the cyclic deformation of the SS304 stainless steel is verified through a comparison with the corresponding experimental data found in the literature(KANG, G. Z., KAN, Q. H., ZHANG, J., and SUN, Y. F. Timedependent ratcheting experiments of SS304 stainless steel. International Journal of Plasticity, 22(5), 858–894(2006)). The FVP model is shown to be successful in predicting the rate-dependent ratcheting behaviors of the SS304 stainless steel. 展开更多
关键词 cyclic visco-plastic CONSTITUTIVE fractional DERIVATIVE FRACTIONAL-ORDER uni-fied visco-plastic(FVP)model rate-dependent RATCHETING
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Recent developments of generalized plasticity models for saturated and unsaturated soils 被引量:2
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作者 Hong-en LI Yong-jun HE +2 位作者 Guang-ya FAN Tong-chun LI Manuel PASTOR 《Water Science and Engineering》 EI CAS 2011年第3期329-344,共16页
关键词 generalized plasticity constitutive model Pastor-Zienkiewicz model saturated and unsaturated soils
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An elasto-visco-plastic constitutive model of polypropylene incorporating craze damage behavior and its validation 被引量:1
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作者 桂中祥 胡肖 王子健 《Journal of Central South University》 SCIE EI CAS CSCD 2017年第6期1263-1268,共6页
An elasto-visco-plastic constitutive model incorporating the craze damage behavior was developed for the polypropylene(PP), by using the plastic failure model applied for the concrete, to capture the craze yielding an... An elasto-visco-plastic constitutive model incorporating the craze damage behavior was developed for the polypropylene(PP), by using the plastic failure model applied for the concrete, to capture the craze yielding and stress-whitening phenomena. In addition, the developed constitutive model was implemented into finite element codes in Abaqus to simulate the tensile deformation. The standard uniaxial tensile tests were carried out. The stress-strain curves from the uniaxial tensile tests show that the stress keeps decreasing after yielding and the yield stress rises with the increasing of the strain rate. It is worth noting that the craze damage is more visible with higher strain rate. The stress-whitening can be seen clearly around the fracture. The uniaxial tensile tests using specially designed specimen with circular holes weakening were performed for the validation of the developed model. The simulation results of the tensile deformation of the hole-weakened specimen suggest that the stress-whitening could be attributed to the equivalent visco-plastic strain. By comparing between the simulation analysis and the experimental results, the proposed model can describe the stress whitening phenomenon with good accuracy. 展开更多
关键词 elasto-visco-plastic CONSTITUTIVE model CRAZE YIELDING stress-whitening finite element implementation
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INVESTIGATION ON GRADIENT-DEPENDENT NONLOCAL CONSTITUTIVE MODELS FOR ELASTO-PLASTICITY COUPLED WITH DAMAGE 被引量:1
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作者 沈新普 沈国晓 +1 位作者 陈立新 杨璐 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI 2005年第2期218-233,共16页
Firstly, typical) gradient-dependent nonlocal inelastic models were briefly reviewed. Secondly, based on the principle of ‘gradient-dependent energy dissipation', a gradient-dependent constitutive model for plast... Firstly, typical) gradient-dependent nonlocal inelastic models were briefly reviewed. Secondly, based on the principle of ‘gradient-dependent energy dissipation', a gradient-dependent constitutive model for plasticity coupled with isotropic damage was presented in the framework of continuum thermodynamics. Numerical scheme for calculation of Laplacian term of damage field with the numerical results obtained by FEM calculation was proposed. Equations have been presented on the basis of Taylor series for both 2-dimensional and 3-dimensional cases, respectively. Numerical results have indicated the validity of the proposed gradient-dependent model and corresponding numerical scheme. 展开更多
关键词 DAMAGE plasticITY NONLOCAL constitutive model gradient-dependent
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Short-term versus long-term water maze training effects on hippocampal neuronal synaptic plasticity in a rat model of senile dementia 被引量:1
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作者 Guogui Li 《Neural Regeneration Research》 SCIE CAS CSCD 2008年第9期929-932,共4页
BACKGROUND: Changes in synaptic plasticity might underlie senile dementia, and might be the neurobiological basis for learning and memory dysfunctions in patients with Alzheimer's Disease. OBJECTIVE: To investigate... BACKGROUND: Changes in synaptic plasticity might underlie senile dementia, and might be the neurobiological basis for learning and memory dysfunctions in patients with Alzheimer's Disease. OBJECTIVE: To investigate the effects of water maze training on hippocampal neuronal synaptic plasticity in rats with senile dementia, and to compare changes in synaptic plasticity between short- and long-term water maze training sessions. DESIGN, TIME AND SETTING: A randomized, controlled, neuromorphological observation with animal models of senile dementia was performed at the laboratory of College of Pharmacy, Chongqing Medical University between November 2006 and April 2007. MATERIALS: Fifty male, Sprague Dawley rats were randomized into five groups, with 10 rats per group: model, control, sham-operated, short-term water maze training, and long-term water maze training. METHODS: In the model group, senile dementia was induced by fimbria-fornix lesion method. The control rats remained untreated. In the sham-operated group, water maze training was performed without fimbria-fomix lesion induction. Rats from the short-term water maze training group underwent 20-day water maze training from day 26 after fimbria-fornix lesion induction. The long-term water maze training group underwent 40-day water maze training beginning at day 6 following fimbria-fornix lesion induction. Beginning at day 41, each group underwent 5-day spatial learning and memory training. MAIN OUTCOME MEASURES: Following experimentation, the morphological parameters of synapses, including synaptic numerical density, synaptic surface density, and the average synapse size were stereologically measured. Through the use of an electron microscope, synaptic morphological changes in the hippocampal CA3 region were observed. RESULTS: Compared with the control group, synaptic numerical and surface densities were significantly decreased in the model group (P 〈 0.01). Synaptic numerical and surface densities significantly increased in the short- and long-term water maze training groups, compared with the model group (P 〈 0.01 ), and these values were also significantly greater in the long-term water maze training group than in the short-term water maze training group. The model group exhibited larger average sizes of synaptic conjunctions, compared with the control group (P 〈 0.01). Synaptic conjunction size was significantly less in the short- and long-term water maze training groups than in the model group (P 〈 0.01 ), and the long-term water maze training group exhibited smaller synaptic conjunction sizes compared with the short-term water maze training group (P 〈 0.05). Synaptic morphological changes in the hippocampal neurons were in accordance with stereological measurements. CONCLUSION: Water maze training increased synaptic numerical and surface densities in the hippocampal CA3 region, resulting in numerical and functional changes in synaptic plasticity in rats with senile dementia. Long-term water maze training resulted in better therapeutic effects than short-term water mate training. 展开更多
关键词 Alzheimer's disease HIPPOCAMPUS memory model plasticITY rats SYNAPSE
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