Objective This study aimed to evaluate whether the onset of the plateau phase of slow hepatitis B surface antigen decline in patients with chronic hepatitis B treated with intermittent interferon therapy is related to...Objective This study aimed to evaluate whether the onset of the plateau phase of slow hepatitis B surface antigen decline in patients with chronic hepatitis B treated with intermittent interferon therapy is related to the frequency of dendritic cell subsets and expression of the costimulatory molecules CD40,CD80,CD83,and CD86.Method This was a cross-sectional study in which patients were divided into a natural history group(namely NH group),a long-term oral nucleoside analogs treatment group(namely NA group),and a plateau-arriving group(namely P group).The percentage of plasmacytoid dendritic cell and myeloid dendritic cell subsets in peripheral blood lymphocytes and monocytes and the mean fluorescence intensity of their surface costimulatory molecules were detected using a flow cytometer.Results In total,143 patients were enrolled(NH group,n=49;NA group,n=47;P group,n=47).The results demonstrated that CD141/CD1c double negative myeloid dendritic cell(DNmDC)/lymphocytes and monocytes(%)in P group(0.041[0.024,0.069])was significantly lower than that in NH group(0.270[0.135,0.407])and NA group(0.273[0.150,0.443]),and CD86 mean fluorescence intensity of DNmDCs in P group(1832.0[1484.0,2793.0])was significantly lower than that in NH group(4316.0[2958.0,5169.0])and NA group(3299.0[2534.0,4371.0]),Adjusted P all<0.001.Conclusion Reduced DNmDCs and impaired maturation may be associated with the onset of the plateau phase during intermittent interferon therapy in patients with chronic hepatitis B.展开更多
We perform ^(23)Na nuclear magnetic resonance(NMR) and magnetization measurements on an S=1,quasi-2D honeycomb lattice antiferromagnet Na_(3)Ni_(2)BiO_(6).A large positive Curie-Weiss constant of 22.9 K is observed.Th...We perform ^(23)Na nuclear magnetic resonance(NMR) and magnetization measurements on an S=1,quasi-2D honeycomb lattice antiferromagnet Na_(3)Ni_(2)BiO_(6).A large positive Curie-Weiss constant of 22.9 K is observed.The NMR spectra at low fields are consistent with a zigzag magnetic order,indicating a large easy-axis anisotropy.With the field applied along the c*axis,the NMR spectra confirm the existence of a 1/3-magnetization plateau phase between 5.1 T and 7.1 T.The transition from the zigzag order to the 1/3-magnetization plateau phase is also found to be a first-order type.A monotonic decrease of the spin gap is revealed in the 1/3-magnetization plateau phase,which reaches zero at a quantum critical field H_(C)≈8.35 T before entering the fully polarized phase.These data suggest the existence of exchange frustration in the system along with strong ferromagnetic interactions,hosting the possibility for Kitaev physics.Besides,well below the ordered phase,the 1/T_(1) at high fields shows either a level off or an enhancement upon cooling below 3 K,which suggests the existence of low-energy fluctuations.展开更多
The effect of doping additional Bi on the magnetoresistance （MR） of La2/3Ca1/3BxMn1-x O3 was investigated. It is found that traditional colossal magnetoresistance （CMR） peak can only be observed in the x〈0.05 sam...The effect of doping additional Bi on the magnetoresistance （MR） of La2/3Ca1/3BxMn1-x O3 was investigated. It is found that traditional colossal magnetoresistance （CMR） peak can only be observed in the x〈0.05 samples and the peak value decreases with the increase of x, but the x≥0.05 samples show a magnetoresistance plateau above 200 K because of the presence of additional （La,Ca,Bi）-O layers. Moreover, this MR plateau is enhanced for the segregation of the La, Ca, and Bi elements.展开更多
A total of 11 earthquakes with 15 Rayleigh wave paths, recorded at 11 broadband digital PASSCAL seismometers installed in the Tibet Plateau by the Sino-U. S. joint research group, were used to determine the phase vel...A total of 11 earthquakes with 15 Rayleigh wave paths, recorded at 11 broadband digital PASSCAL seismometers installed in the Tibet Plateau by the Sino-U. S. joint research group, were used to determine the phase velocity and attenuation coefficient of surface waves in periods of 10-130 s. The average shear wave velocity andquality factor Qβ structures in the crust and upper mantle were obtained in this region. The result shows the average oP is low and there exists a high attenuation (Qβ= 93- 141 ) layer in the crust. The depth range of the lowoP value layer (16-42 km) is consistent with the range of low velocity layer (21-51 km) in the crust. Below63 km in the lower crust, oP decreases with depth from 114 to 34 at depth of 180 km. The low shear wave velocity and low value of Qβ at the same depth range in the crust indicate that the rocks in the range is probablymelted or Partially melted. According to the shear wave velocity structure, the average thickness of the crust is about 71 km and a clear velocity discontiniuty appears at the depth of 51 km. The low-velocity zone (4. 26 km/s) at depth of 96-180 km may be corresponding to the asthenosphere.展开更多
基金supported by the National Key Research and Development Program[2022YFC2603500,2022YFC2603505]Capital Clinical Diagnostic Techniques and Translational Application Projects(Z211100002921059)+2 种基金Capital’s Funds for Health Improvement and Research[2022-1-2172]Beijing Hospitals Authority Clinical Medicine Development of Special Funding Support[XMLX 202127]National Science and Technology Major Project of China[2017ZX10203202-003]。
文摘Objective This study aimed to evaluate whether the onset of the plateau phase of slow hepatitis B surface antigen decline in patients with chronic hepatitis B treated with intermittent interferon therapy is related to the frequency of dendritic cell subsets and expression of the costimulatory molecules CD40,CD80,CD83,and CD86.Method This was a cross-sectional study in which patients were divided into a natural history group(namely NH group),a long-term oral nucleoside analogs treatment group(namely NA group),and a plateau-arriving group(namely P group).The percentage of plasmacytoid dendritic cell and myeloid dendritic cell subsets in peripheral blood lymphocytes and monocytes and the mean fluorescence intensity of their surface costimulatory molecules were detected using a flow cytometer.Results In total,143 patients were enrolled(NH group,n=49;NA group,n=47;P group,n=47).The results demonstrated that CD141/CD1c double negative myeloid dendritic cell(DNmDC)/lymphocytes and monocytes(%)in P group(0.041[0.024,0.069])was significantly lower than that in NH group(0.270[0.135,0.407])and NA group(0.273[0.150,0.443]),and CD86 mean fluorescence intensity of DNmDCs in P group(1832.0[1484.0,2793.0])was significantly lower than that in NH group(4316.0[2958.0,5169.0])and NA group(3299.0[2534.0,4371.0]),Adjusted P all<0.001.Conclusion Reduced DNmDCs and impaired maturation may be associated with the onset of the plateau phase during intermittent interferon therapy in patients with chronic hepatitis B.
基金Project supported by the National Key R&D Program of China (Grant Nos. 2023YFA1406500, 2022YFA1402700, and 2021YFA1400400)the National Natural Science Foundation of China (Grant Nos. 12134020, 12374156, 12104503,12061131004, 12225407, and 12074174)。
文摘We perform ^(23)Na nuclear magnetic resonance(NMR) and magnetization measurements on an S=1,quasi-2D honeycomb lattice antiferromagnet Na_(3)Ni_(2)BiO_(6).A large positive Curie-Weiss constant of 22.9 K is observed.The NMR spectra at low fields are consistent with a zigzag magnetic order,indicating a large easy-axis anisotropy.With the field applied along the c*axis,the NMR spectra confirm the existence of a 1/3-magnetization plateau phase between 5.1 T and 7.1 T.The transition from the zigzag order to the 1/3-magnetization plateau phase is also found to be a first-order type.A monotonic decrease of the spin gap is revealed in the 1/3-magnetization plateau phase,which reaches zero at a quantum critical field H_(C)≈8.35 T before entering the fully polarized phase.These data suggest the existence of exchange frustration in the system along with strong ferromagnetic interactions,hosting the possibility for Kitaev physics.Besides,well below the ordered phase,the 1/T_(1) at high fields shows either a level off or an enhancement upon cooling below 3 K,which suggests the existence of low-energy fluctuations.
基金Funded by the Foundation for the Author of National Excellent Doctoral Dissertation of China (FANEDD) (No. 200233)
文摘The effect of doping additional Bi on the magnetoresistance （MR） of La2/3Ca1/3BxMn1-x O3 was investigated. It is found that traditional colossal magnetoresistance （CMR） peak can only be observed in the x〈0.05 samples and the peak value decreases with the increase of x, but the x≥0.05 samples show a magnetoresistance plateau above 200 K because of the presence of additional （La,Ca,Bi）-O layers. Moreover, this MR plateau is enhanced for the segregation of the La, Ca, and Bi elements.
文摘A total of 11 earthquakes with 15 Rayleigh wave paths, recorded at 11 broadband digital PASSCAL seismometers installed in the Tibet Plateau by the Sino-U. S. joint research group, were used to determine the phase velocity and attenuation coefficient of surface waves in periods of 10-130 s. The average shear wave velocity andquality factor Qβ structures in the crust and upper mantle were obtained in this region. The result shows the average oP is low and there exists a high attenuation (Qβ= 93- 141 ) layer in the crust. The depth range of the lowoP value layer (16-42 km) is consistent with the range of low velocity layer (21-51 km) in the crust. Below63 km in the lower crust, oP decreases with depth from 114 to 34 at depth of 180 km. The low shear wave velocity and low value of Qβ at the same depth range in the crust indicate that the rocks in the range is probablymelted or Partially melted. According to the shear wave velocity structure, the average thickness of the crust is about 71 km and a clear velocity discontiniuty appears at the depth of 51 km. The low-velocity zone (4. 26 km/s) at depth of 96-180 km may be corresponding to the asthenosphere.
