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Compact TE-pass polarizer based on lithium-niobate-on-insulator assisted by indium tin oxide and silicon nitride
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作者 刘家敏 张德龙 《Chinese Physics B》 SCIE EI CAS CSCD 2023年第6期284-289,共6页
An indium tin oxide(ITO) and silicon nitride(Si_(3)N_(4)) assisted compact TE-pass waveguide polarizer based on lithiumniobate-on-insulator is proposed and numerically analyzed.By properly designing the ITO and Si_(3)... An indium tin oxide(ITO) and silicon nitride(Si_(3)N_(4)) assisted compact TE-pass waveguide polarizer based on lithiumniobate-on-insulator is proposed and numerically analyzed.By properly designing the ITO and Si_(3)N_(4) assisted structure and utilizing the epsilon-near-zero effect of ITO,the TM mode is strongly confined in the ITO layer with extremely high loss,while the TE mode is hardly affected and passes through the waveguide with low loss.The simulation results show that the polarizer has an extinction ratio of 22.5 dB and an insertion loss of 0.8 dB at the wavelength of 1.55 μm,and has an operating bandwidth of about 125 nm(from 1540 nm to 1665 nm) for an extinction ratio of>20 dB and an insertion loss of<0.95 dB.Moreover,the proposed device exhibits large fabrication tolerances.More notably,the device is compact,with a length of only 7.5 μm,and is appropriate for on-chip applications. 展开更多
关键词 polarizer lithium-niobate-on-insulator integrated optics devices optical waveguide
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Precision integration of grating-based polarizers onto focal plane arrays of near-infrared photovoltaic detectors for enhanced contrast polarimetric imaging 被引量:4
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作者 Bo Feng Yifang Chen +4 位作者 Duo Sun Zongyao Yang Bo Yang Xue Li Tao Li 《International Journal of Extreme Manufacturing》 EI 2021年第3期95-102,共8页
Polarimetric imaging enhances the ability to distinguish objects from a bright background by detecting their particular polarization status,which offers another degree of freedom in infrared remote sensing.However,to ... Polarimetric imaging enhances the ability to distinguish objects from a bright background by detecting their particular polarization status,which offers another degree of freedom in infrared remote sensing.However,to scale up by monolithically integrating grating-based polarizers onto a focal plane array(FPA)of infrared detectors,fundamental technical obstacles must be overcome,including reductions of the extinction ratio by the misalignment between the polarizer and the detector,grating line width fluctuations,the line edge roughness,etc.This paper reports the authors’latest achievements in overcoming those problems by solving key technical issues regarding the integration of large-scale polarizers onto the chips of FPAs with individual indium gallium arsenide/indium phosphide(In Ga As/In P)sensors as the basic building blocks.Polarimetric and photovoltaic chips with divisions of the focal plane of 540×4 pixels and 320×256 superpixels have been successfully manufactured.Polarimetric imaging with enhanced contrast has been demonstrated.The progress made in this work has opened up a broad avenue toward industrialization of high quality polarimetric imaging in infrared wavelengths. 展开更多
关键词 polarimetric imaging grating based polarizer INGAAS/INP focal plane array nanofabrication
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A Novel Polarizer Made from Two-Dimensional Photonic Bandgap Materials
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作者 张淳 乔峰 +1 位作者 万钧 资剑 《Chinese Physics Letters》 SCIE CAS CSCD 2001年第8期1082-1084,共3页
We demonstrate theoretically that two-dimensional photonic bandgap materials are indeed perfect polarizers provided that they have a proper photonic band structure along the incident direction of light.This kind of po... We demonstrate theoretically that two-dimensional photonic bandgap materials are indeed perfect polarizers provided that they have a proper photonic band structure along the incident direction of light.This kind of polarizer is fundamentally different from the conventional ones.It can function in a wide frequency range with high performance and its size can be made very compact,which renders it useful as a micropolarizer in micro-optics. 展开更多
关键词 polarizer POLAR RENDER
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Design optimization of broadband extreme ultraviolet polarizer in high-dimensional objective space
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作者 匡尚奇 李博超 +2 位作者 王依 龚学鹏 林景全 《Chinese Physics B》 SCIE EI CAS CSCD 2022年第7期579-585,共7页
With the purpose of designing the extreme ultraviolet polarizer with many objectives,a combined application of multiobjective genetic algorithms is theoretically proposed.Owing to the multi-objective genetic algorithm... With the purpose of designing the extreme ultraviolet polarizer with many objectives,a combined application of multiobjective genetic algorithms is theoretically proposed.Owing to the multi-objective genetic algorithm,the relationships between different designing objectives of extreme ultraviolet polarizer have been obtained by analyzing the distribution of nondominated solutions in the four-dimensional objective space,and the optimized multilayer design can be obtained by guiding the searching in the desired region based on the multi-objective genetic algorithm with reference direction.Compared with the conventional method of multilayer design,our method has a higher probability of achieving the optimal multilayer design.Our work should be the first research in optimizing the optical multilayer designs in the high-dimensional objective space,and our results demonstrate a potential application of our method in the designs of optical thin films. 展开更多
关键词 extreme ultraviolet polarizer multilayer design multi-objective genetic algorithm
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DEPOLARIZERS MADE OF CHALCEDONY
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作者 LI Yi SU Xiyu +1 位作者 Li Chengxiang FU Jixiao 《Chinese Physics Letters》 SCIE CAS CSCD 1990年第12期544-547,共4页
We report depolarizers made of a new kind of scattering depolarization material,named chalcedony,which can make the polarization directions of the photons in the linearly polarized incident light randomly distributed.... We report depolarizers made of a new kind of scattering depolarization material,named chalcedony,which can make the polarization directions of the photons in the linearly polarized incident light randomly distributed.With a piece of the chalcedony to a thickness of 3mmf a total transmission higher than 50%and the linear polarization degree tending to zero can be easily obtained. 展开更多
关键词 DIRECTIONS LINEARLY POLARIZED
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FSS Based Circular Polarizer for High-Speed Wireless Communication at 75 GHz
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作者 Ghaffer Kiani 《Open Journal of Antennas and Propagation》 2019年第3期23-31,共9页
An FSS based circular polarizer for high-speed wireless communication at 75 GHz is presented. It has been designed on a low loss substrate with cross-dipole elements. Both simulation and measured results showed more t... An FSS based circular polarizer for high-speed wireless communication at 75 GHz is presented. It has been designed on a low loss substrate with cross-dipole elements. Both simulation and measured results showed more than 98% circular polarization at 75 GHz. Moreover, 3 dB axial-ratio bandwidth of 6.8 GHz (Simulation) and 7.8 GHz (Measured) has been achieved. The proposed design has many advantages over the recently published research such as simplicity, low-profile, percentage bandwidth, frequency of operation and relative insertion loss. 展开更多
关键词 CIRCULAR POLARIZATION FREQUENCY SELECTIVE Surface High FREQUENCY Communication Linear POLARIZATION
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Inverse-designed Jones matrix metasurfaces for high-performance meta-polarizers
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作者 王志强 李枫竣 +3 位作者 邓倩媚 万舟 李向平 邓子岚 《Chinese Optics Letters》 SCIE EI CAS CSCD 2024年第2期192-199,共8页
Polarizers have always been an important optical component for optical engineering and have played an indispensable part of polarization imaging systems.Metasurface polarizers provide an excellent platform to achieve ... Polarizers have always been an important optical component for optical engineering and have played an indispensable part of polarization imaging systems.Metasurface polarizers provide an excellent platform to achieve miniaturization,high resolution,and low cost of polarization imaging systems.Here,we proposed freeform metasurface polarizers derived by adjoint-based inverse design of a full-Jones matrix with gradient-descent optimization.We designed multiple freeform polarizers with different filtered states of polarization(SOPs),including circular polarizers,elliptical polarizers,and linear polarizers that could cover the full Poincarésphere.Note that near-unitary polarization dichroism and the ultrahigh polarization extinction ratio(ER)reaching 50 d B were achieved for optimized circular polarizers.The multiple freeform polarizers with filtered polarization state locating at four vertices of an inscribed regular tetrahedron of the Poincarésphere are designed to form a full-Stokes parameters micropolarizer array.Our work provides a novel approach,we believe,for the design of meta-polarizers that may have potential applications in polarization imaging,polarization detection,and communication. 展开更多
关键词 metasurface inverse design Jones matrix polarization imaging
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An ultra-wideband coding polarizer for beam control and RCS reduction
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作者 Huanhuan Gao Xiaojun Huang +3 位作者 Xiongwei Ma Xiaoyan Li Linyan Guo Helin Yang 《Frontiers of physics》 SCIE CSCD 2023年第4期291-299,共9页
Pancharatnam–Berry(PB)phase metasurface,as a special class of gradient metasurfaces,has been paid much attention owing to the robust performance for phase control of circularly polarized waves.Herein,we present an el... Pancharatnam–Berry(PB)phase metasurface,as a special class of gradient metasurfaces,has been paid much attention owing to the robust performance for phase control of circularly polarized waves.Herein,we present an element-based polarizer for the first step,which enables the incident electromagnetic waves into the cross-polarized waves with the relative bandwidth of 71%,and the polarization conversion ratio exceeds 90%at 6.9–14.5 GHz.Then an eight-elements coding polarizer based on the PB phase is presented for the applications on beam control and radar cross section reduction.The simulated values indicate that the reduction of radar cross section is more than 10 dB at 6–16 GHz.Our work reveals the availability of manipulating the waves,beamforming in communication systems and electromagnetic stealth,and so on. 展开更多
关键词 polarizer Pancharatnam-Berry phase coding metasurface beam control RCS reduction
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Transmissive angle-multiplexed meta-polarizer based on a multilayer metasurface
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作者 蒲晨曦 王卓 +2 位作者 孙树林 周磊 何琼 《Chinese Optics Letters》 SCIE EI CAS CSCD 2023年第2期126-132,共7页
Metasurfaces have exhibited great capabilities to control electromagnetic waves,and many multifunctional metasurfaces were recently proposed.However,although angle-multiplexed meta-devices were successfully realized i... Metasurfaces have exhibited great capabilities to control electromagnetic waves,and many multifunctional metasurfaces were recently proposed.However,although angle-multiplexed meta-devices were successfully realized in reflection geometries,their transmission-mode counterparts are difficult to achieve due to the additional requirements.Here,we design and fabricate a transmissive angle-multiplexed meta-polarizer in the microwave regime based on a multilayer metasurface.Coupled-mode-theory analyses reveal that the device exhibits distinct angle-dependent transmissive responses under excitations with different polarizations,and such differences are further enhanced by multiple scatterings inside the device.Microwave experimental results are in good agreement with numerical simulations and theoretical analyses. 展开更多
关键词 metasurfaces angular dispersion multifunctional meta-device polarization modulation
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一种基于Polar译码度量选择的第三方高效PDCCH盲检方法
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作者 王霄峻 马晓静 黄钰华 《Journal of Southeast University(English Edition)》 EI CAS 2024年第1期97-104,共8页
为研究和设计面向第三方场景的高效盲检方法,提出了一种基于Polar译码度量选择的第三方高效PDCCH盲检方法,其技术路线包括Polar译码算法与物理的下行控制信道(PDCCH)盲检算法2个板块.基于Polar译码盲检算法,引入一种基于下行控制信息(D... 为研究和设计面向第三方场景的高效盲检方法,提出了一种基于Polar译码度量选择的第三方高效PDCCH盲检方法,其技术路线包括Polar译码算法与物理的下行控制信道(PDCCH)盲检算法2个板块.基于Polar译码盲检算法,引入一种基于下行控制信息(DCI)长度的Polar译码度量,提出了改进的基于Polar译码度量选择的第三方盲检方法.基于PDCCH盲检算法,引入一种重排序盲检算法.将改进的Polar译码算法与重排序盲检算法有机结合,提出面向第三方场景的高效PDCCH盲检方法.基于MATLAB平台搭建5G PDCCH盲检仿真链路,对所提方法进行验证与分析.结果表明,该方法能够同时有效减小PDCCH盲检次数与DCI候选长度数量,在保证目标捕获准确率的前提下提高盲检效率. 展开更多
关键词 Polar译码 物理的下行控制信道 盲检 下行控制信息
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融合路径度量值和行重特性的Polar码SCL译码算法
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作者 周泉 陈海强 +3 位作者 曾俏丽 廖兰娟 孙友明 黎相成 《电讯技术》 北大核心 2024年第2期295-301,共7页
首先提出基于初始对数似然比(Log-Likelihood Ratio,LR)与路径度量值(Path Metric,PM)的PM-LLR-SCL译码算法,在接收端初始LLR和PM值之间建立映射关系,并通过重排PM值完成翻转功能。其次,提出基于极化码生成矩阵的行重特性和PM值的PM-RW-... 首先提出基于初始对数似然比(Log-Likelihood Ratio,LR)与路径度量值(Path Metric,PM)的PM-LLR-SCL译码算法,在接收端初始LLR和PM值之间建立映射关系,并通过重排PM值完成翻转功能。其次,提出基于极化码生成矩阵的行重特性和PM值的PM-RW-SCL译码算法,不仅考虑了Polar码的最小码距和极化子信道可靠度,同时将路径分裂每一层的PM值引入到译码策略中,从而提高了译码性能。仿真结果显示,与串行抵消列表比特翻转(Successive Cancellation List Bit-flip,SCLF)相比,提出的PM-LLR-SCL算法最大可获得约0.23 dB的性能增益,而基于路径数量的复杂度降低了约62%;与基于行权重的串行抵消列表翻转译码算法相比,PM-RW-SCL算法最大可获得约1.5 dB的性能增益,而复杂度降低了约39%。 展开更多
关键词 Polar码 串行抵消列表比特翻转译码 路径度量值 行重特性
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动态扰动辅助的串行抵消双比特翻转Polar译码算法
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作者 曾俏丽 陈海强 +3 位作者 周泉 刘远博 孙友明 黎相成 《电讯技术》 北大核心 2024年第1期126-131,共6页
针对串行抵消翻转译码算法(Successive Cancellation Flip,SCF)受限于单比特翻转而性能提升有限问题,提出了一种双比特翻转译码算法(Successive Cancellation Flip with 2 Bits,SCF2)。针对SCP算法扰动方差初始值固定的问题,设计了一种... 针对串行抵消翻转译码算法(Successive Cancellation Flip,SCF)受限于单比特翻转而性能提升有限问题,提出了一种双比特翻转译码算法(Successive Cancellation Flip with 2 Bits,SCF2)。针对SCP算法扰动方差初始值固定的问题,设计了一种扰动方差可随码长和码率变化的改进SCP算法。在此基础上,结合翻转和扰动机制,提出了一种动态扰动辅助的串行抵消双比特翻转(Dynamic Perturbation-Aided SCF2,DPA-SCF2)译码算法,并对其译码复杂度和性能进行了分析。仿真结果显示,相比于列表长度为4的循环冗余校验辅助串行抵消列表(Cyclic Redundancy Check Aided Successive Cancellation List,CA-SCL)译码算法,所提算法最大可获得约0.5 dB的性能增益。 展开更多
关键词 Polar码 串行抵消翻转(SCF)译码 串行抵消扰动(SCP)译码 动态扰动
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Hybrid-Vlasov simulation of soft X-ray emissions at the Earth’s dayside magnetospheric boundaries 被引量:2
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作者 M.Grandin H.K.Connor +5 位作者 S.Hoilijoki M.Battarbee Y.Pfau-Kempf U.Ganse K.Papadakis M.Palmroth 《Earth and Planetary Physics》 EI CSCD 2024年第1期70-88,共19页
Solar wind charge exchange produces emissions in the soft X-ray energy range which can enable the study of near-Earth space regions such as the magnetopause,the magnetosheath and the polar cusps by remote sensing tech... Solar wind charge exchange produces emissions in the soft X-ray energy range which can enable the study of near-Earth space regions such as the magnetopause,the magnetosheath and the polar cusps by remote sensing techniques.The Solar wind Magnetosphere Ionosphere Link Explorer(SMILE)and Lunar Environment heliospheric X-ray Imager(LEXI)missions aim to obtain soft Xray images of near-Earth space thanks to their Soft X-ray Imager(SXI)instruments.While earlier modeling works have already simulated soft X-ray images as might be obtained by SMILE SXI during its mission,the numerical models used so far are all based on the magnetohydrodynamics description of the space plasma.To investigate the possible signatures of ion-kinetic-scale processes in soft Xray images,we use for the first time a global hybrid-Vlasov simulation of the geospace from the Vlasiator model.The simulation is driven by fast and tenuous solar wind conditions and purely southward interplanetary magnetic field.We first produce global X-ray images of the dayside near-Earth space by placing a virtual imaging satellite at two different locations,providing meridional and equatorial views.We then analyze regional features present in the images and show that they correspond to signatures in soft X-ray emissions of mirrormode wave structures in the magnetosheath and flux transfer events(FTEs)at the magnetopause.Our results suggest that,although the time scales associated with the motion of those transient phenomena will likely be significantly smaller than the integration time of the SMILE and LEXI imagers,mirror-mode structures and FTEs can cumulatively produce detectable signatures in the soft X-ray images.For instance,a local increase by 30%in the proton density at the dayside magnetopause resulting from the transit of multiple FTEs leads to a 12%enhancement in the line-of-sight-and time-integrated soft X-ray emissivity originating from this region.Likewise,a proton density increase by 14%in the magnetosheath associated with mirror-mode structures can result in an enhancement in the soft X-ray signal by 4%.These are likely conservative estimates,given that the solar wind conditions used in the Vlasiator run can be expected to generate weaker soft X-ray emissions than the more common denser solar wind.These results will contribute to the preparatory work for the SMILE and LEXI missions by providing the community with quantitative estimates of the effects of small-scale,transient phenomena occurring on the dayside. 展开更多
关键词 MAGNETOSPHERE MAGNETOSHEATH numerical simulation SMILE LEXI soft X-ray emissions hybrid-Vlasov model polar cusp flux transfer events mirror-mode waves
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Demonstration of an on-chip TE-pass polarizer using a silicon hybrid plasmonic grating 被引量:4
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作者 BOWEN BAI FENGHE YANG ZHIPING ZHOU 《Photonics Research》 SCIE EI CSCD 2019年第3期289-293,共5页
An on-chip, high extinction ratio transverse electric(TE)-pass polarizer using a silicon hybrid plasmonic grating is proposed and experimentally demonstrated. Utilizing plasmonics to manipulate the effective index and... An on-chip, high extinction ratio transverse electric(TE)-pass polarizer using a silicon hybrid plasmonic grating is proposed and experimentally demonstrated. Utilizing plasmonics to manipulate the effective index and mode distribution, the transverse magnetic mode is reflected and absorbed, while the TE mode passes through with relatively low propagation loss. For a 6-μm-long device, the measurement result shows that the extinction ratio in the wavelength range of 1.52 to 1.58 μm varies from 24 to 33.7 dB and the insertion loss is 2.8–4.9 dB. Moreover,the structure exhibits large alignment tolerance and is compatible with silicon-on-insulator fabrication technology. 展开更多
关键词 TE-pass polarizer using SILICON hybrid PLASMONIC GRATING transverse magnetic mode
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Anisotropic metamaterial-assisted all-silicon polarizer with 415-nm bandwidth 被引量:5
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作者 HONGNAN XU DAOXIN DAI YAOCHENG SHI 《Photonics Research》 SCIE EI CSCD 2019年第12期1432-1439,共8页
Polarizers have been widely used in various optical systems to reduce polarization cross talk.The polarizers based on the silicon nanowire waveguide can provide chip-scale device size and a high polarization extinctio... Polarizers have been widely used in various optical systems to reduce polarization cross talk.The polarizers based on the silicon nanowire waveguide can provide chip-scale device size and a high polarization extinction ratio.However,the working bandwidth for the on-chip silicon polarizers is always limited(<~100 nm)by the strong waveguide dispersion.In this paper,an on-chip all-silicon polarizer with an extremely broad working bandwidth is proposed and demonstrated.The device is based on a 180°sharp waveguide bend,assisted with anisotropic subwavelength grating(SWG)metamaterial cladding to enhance the polarization selectivity.For TE polarization,the effective refractive index for SWG is extraordinary,so the incident TE mode can propagate through the sharp waveguide bend.For TM polarization,the effective refractive index for SWG is ordinary,so the incident TM mode will be coupled into the radiation mode regardless of the wavelength.The fabricated polarizer shows low loss(<1 d B)and high polarization extinction ratio(>20 d B)over a>415 nm bandwidth from1.26 to 1.675μm,which is at least fourfold better than what has been demonstrated in all previous works.To the best of our knowledge,such a device is the first all-silicon polarizer that covers O-,E-,S-,C-,L-,and U-bands. 展开更多
关键词 POLARIZATION WAVEGUIDE polarizer
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Fabrication and application of a graphene polarizer with strong saturable absorption 被引量:2
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作者 Weixiong Li Lilin Yi +2 位作者 Ran Zheng Zhenghua Ni Weisheng Hu 《Photonics Research》 SCIE EI 2016年第2期41-44,共4页
By transferring 100 nm gold-coated CVD monolayer graphene onto the well-polished surface of D-shaped fiber, we achieve a graphene in-line polarizer with a high polarization extinction ratio of ~27 d B and low insertio... By transferring 100 nm gold-coated CVD monolayer graphene onto the well-polished surface of D-shaped fiber, we achieve a graphene in-line polarizer with a high polarization extinction ratio of ~27 d B and low insertion loss of 5 d B at 1550 nm, meanwhile achieving a strong saturable absorption effect of 14%. The manufacture of this graphene in-line polarizer also simplifies the graphene transfer process. To explore the potential applications of the new device, we also demonstrate noise-like pulse generation and supercontinuum spectrum generation. By launching the designed graphene device into a fiber ring laser cavity, 51 nm bandwidth noise-like pulse is obtained. Then, launching the high-power noise-like pulse into high nonlinear fiber, a 1000 nm wide supercontinuum spectrum is obtained, which is favorable for sensing and nonlinearities scientific fields. 展开更多
关键词 Fabrication and application of a graphene polarizer with strong saturable absorption MODE PDL
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TM-pass polarizer based on multilayer graphene polymer waveguide 被引量:1
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作者 蔡可苏 李月娥 +4 位作者 魏文静 穆希皎 马阿宁 王忠 宋丹明 《Optoelectronics Letters》 EI 2018年第3期180-184,共5页
A TM-pass polarizer based on multilayer graphene polymer waveguide is proposed and theoretically analyzed.The mode properties,the extinction ratio,the insertion loss and the bandwidth are also discussed.The results sh... A TM-pass polarizer based on multilayer graphene polymer waveguide is proposed and theoretically analyzed.The mode properties,the extinction ratio,the insertion loss and the bandwidth are also discussed.The results show that a TM-pass polarizer,which only guides the TM mode,can be achieved by multilayer graphene polymer waveguide.With length of 150μm,the proposed polarizer can achieve extinction ratio of 33 dB and insertion loss of 0.5 d B at optical wavelength of 1.55μm.This device has an excellent performance,including large extinction ratio and low insertion loss within the spectral range from 1.45μm to 1.6μm. 展开更多
关键词 TM-pass polarizer MULTILAYER GRAPHENE poly-mer waveguide
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Valleytronic topological filters in silicene-like inner-edge systems
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作者 谢航 吕小龙 杨加恩 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第1期66-74,共9页
Inner edge state with spin and valley degrees of freedom is a promising candidate for designing a dissipationless device due to the topological protection. The central challenge for the application of the inner edge s... Inner edge state with spin and valley degrees of freedom is a promising candidate for designing a dissipationless device due to the topological protection. The central challenge for the application of the inner edge state is to generate and modulate the polarized currents. In this work, we discover a new mechanism to generate fully valley-and spin–valley-polarized current caused by the Bloch wavevector mismatch(BWM). Based on this mechanism, we design some serial-typed inner-edge filters. By using once of the BWM, the coincident states could be divided into transmitted and reflected modes, which can serve as a valley or spin–valley filter. In particular, while with twice of the BWM, the incident current is absolutely reflected to support an off state with a specified valley and spin, which is different from the gap effect.These findings give rise to a new platform for designing valleytronics and spin-valleytronics. 展开更多
关键词 topological insulator inner-edge state valley polarization spin polarization quantum transport
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Lupenone improves motor dysfunction in spinal cord injury mice through inhibiting the inflammasome activation and pyroptosis in microglia via the nuclear factor kappa B pathway
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作者 Fudong Li Xiaofei Sun +3 位作者 Kaiqiang Sun Fanqi Kong Xin Jiang Qingjie Kong 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第8期1802-1811,共10页
Spinal cord injury-induced motor dysfunction is associated with neuroinflammation.Studies have shown that the triterpenoid lupenone,a natural product found in various plants,has a remarkable anti-inflammatory effect i... Spinal cord injury-induced motor dysfunction is associated with neuroinflammation.Studies have shown that the triterpenoid lupenone,a natural product found in various plants,has a remarkable anti-inflammatory effect in the context of chronic inflammation.However,the effects of lupenone on acute inflammation induced by spinal cord injury remain unknown.In this study,we established an impact-induced mouse model of spinal cord injury,and then treated the injured mice with lupenone(8 mg/kg,twice a day)by intrape ritoneal injection.We also treated BV2 cells with lipopolysaccharide and adenosine5’-triphosphate to simulate the inflammatory response after spinal cord injury.Our res ults showed that lupenone reduced IKBa activation and p65 nuclear translocation,inhibited NLRP3 inflammasome function by modulating nuclear factor kappa B,and enhanced the conve rsion of proinflammatory M1 mic roglial cells into anti-inflammatory M2 microglial cells.Furthermore,lupenone decreased NLRP3 inflammasome activation,NLRP3-induced mic roglial cell polarization,and microglia pyroptosis by inhibiting the nuclear factor kappa B pathway.These findings suggest that lupenone protects against spinal cord injury by inhibiting inflammasomes. 展开更多
关键词 INFLAMMASOME inflammation lupenone MICROGLIA polarization PYROPTOSIS spinal cord injury
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Polydatin ameliorates hepatic ischemia-reperfusion injury by modulating macrophage polarization
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作者 Hai-Li Bao Chuan-Zhi Chen +4 位作者 Chang-Zhen Ren Ke-Yan Sun Hao Liu Shao-Hua Song Zhi-Ren Fu 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS CSCD 2024年第1期25-34,共10页
Background:Polydatin,a glucoside of resveratrol,has shown protective effects against various diseases.However,little is known about its effect on hepatic ischemia-reperfusion(I/R)injury.This study aimed to elucidate w... Background:Polydatin,a glucoside of resveratrol,has shown protective effects against various diseases.However,little is known about its effect on hepatic ischemia-reperfusion(I/R)injury.This study aimed to elucidate whether polydatin protects liver against I/R-induced injury and to explore the underlying mechanism.Methods:After gavage feeding polydatin once daily for a week,mice underwent a partial hepatic I/R procedure.Serum alanine aminotransferase(ALT)/aspartate aminotransferase(AST),hematoxylin-eosin(H&E)and TdT-mediated dUTP nick-end labeling(TUNEL)staining were used to evaluate liver injury.The severity related to the inflammatory response and reactive oxygen species(ROS)production was also investigated.Furthermore,immunofluorescence and Western blotting were used to detect macrophage polarization and the NF-κB signaling pathway in macrophages.Results:Compared with the I/R group,polydatin pretreatment significantly attenuated I/R-induced liver damage and apoptosis.The oxidative stress marker(dihydroethidium fluorescence,malondialdehyde,superoxide dismutase and glutathione peroxidase)and I/R related inflammatory cytokines(interleukin1β,interleukin-10 and tumor necrosis factor-α)were significantly suppressed after polydatin treatment.In addition,the result of immunofluorescence indicated that polydatin reduced the polarization of macrophages toward M1 macrophages both in vivo and in vitro.Western blotting showed that polydatin inhibited the pro-inflammatory function of RAW264.7 via down-regulating the NF-κB signaling pathway.Conclusions:Polydatin protects the liver from I/R injury by remodeling macrophage polarization via NFκB signaling. 展开更多
关键词 Hepatic ischemia-reperfusion injury POLYDATIN MACROPHAGE POLARIZATION INFLAMMATION
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