Branched chain amino acids alter fatty acid profile in colostrum of sows fed a high fat diet

Background:Branched chain amino acids(BCAAs)are important substrates for milk protein synthesis in the mammary gland,and are tightly related to lipid metabolism.No study has been performed examining the role of BCAAs with high fat diets on milk fat synthesis.This study was designed to investigate the effect of dietary BCAAs on growth performance of piglets,progeny body weight,and milk fat composition in sows fed a high fat diet.Four diets(CON=control diet;HF=high fat diet with 8%soybean oil;HF-MB=HF plus 0.39%BCAAs;HF-HB=HF plus 0.78%BCAAs)were fed to sows from late gestation to weaning.Results:Compared to HF,BCAAs(HF-MB and HF-HB)increased the litter weight(P<0.05)and overall litter weight gain(P<0.05)at weaning and increased colostrum fat content by 27.3–35.8%(P<0.01).Fatty acid profiles between the two doses of BCAAs were similar.Compared with HF,HF-MB tended to decrease the percentage of C18:3n3(P=0.063)and increased the percentage of C18:1n9c(P=0.03).In addition,BCAAs in HF-MB increased the concentration of total fatty acid by 22.1%in colostrum(P=0.03)but decreased that in serum at parturition by 53.2%(P=0.027).The fatty acids in colostrum that increased with BCAAs were C15:0,C17:0,C20:3n6,C20:4n6,C20:5n3 and C22:6n3(P=0.00~0.04).Colostrum fatty acids of C20:0,C21:0,C22:0,C16:1,C20:1,C18:1n9c also tended to be increased(0.05<P<0.1)with BCAAs.The change in sow serum fatty acid profile due to BCAAs was different from that in colostrum.Conclusions:BCAAs in high fat diet of sows altered the fatty acid composition in colostrum and enhanced litter growth.Our study indicated that BCAAs supplementation can enhance mammary fatty acid uptake and mammary fat synthesis and that supplemental BCAAs and fat in late gestation and lactation diets for sows can improve reproductive performance.

Protective role of concomitant administration of flax lignan concentrate and omega-3-fatty acid on myocardial damage in doxorubicin-induced cardiotoxicity

The severe cardiotoxicity incurred due to doxorubicin limits the use of their therapeutic potential.The current study aims to investigate the cardioprotective effect of concomitant administration of flax lignan concentrate(FLC)and omega-3-fatty acid(ω-3-FA)on myocardial damage in doxorubicin-induced cardiotoxicity in Wistar rats.Cardiotoxicity was induced by intraperitoneal injection of doxorubicin(4 mg/kg)on day 7th,14th,21st and 28th day in normal saline.Concomitant administration of FLC(500 mg/kg)andω-3-FA(1 mL/kg)lowered TNF-αlevel,normalized ST,QT and mean arterial blood pressure,elevation in endogenous enzymes levels such as glutathione and lowering in malondialdehyde,super oxide dismutase followed by normalized lipid profile and reduced the mortality rate.The treatment had antiapoptotic potential at cellular level also histopathology of heart tissue(light and electron microscopical).Thus concomitant action of FLC andω-3-FA may be antioxidant,antihyperlipidemic,anti-inflammatory and anti-apoptotic actions seem to the probable mechanisms in doxorubicin induced cardiotoxicity.It can be concluded that FLC andω-3-FA both have distinct mechanism for cardioprotection and hence the additive effect was observed in the present study due to concomitant administration of FLC andω-3-FA.©2013 Beijing Academy of Food Sciences.Production and hosting by Elsevier B.V.All rights reserved.

The AD/HD Syndrome as a Group of Biological Disorders

Problem: There is a need to collect the many and varied data on AD/HD (Attention deficit hyper-activity disorder) into a meaningful overview. Method: Based on peer reviewed and published data as well as own research we try to make sense of the physiological mechanisms resulting in the relevant symptoms. Conclusion: AD/HD clearly has a genetic disposition, but as with many other genetic syndromes, the resulting proteomics must be stressed to become manifest as disease/ disorder. A common trait in the different etiologies is lower arousal.