Natural products have attracted the interest of the scientific community due to their importance and application.Alexine is a naturally polyhydroxylated pyrrolizidine alkaloid that is broadly found in plant sources an...Natural products have attracted the interest of the scientific community due to their importance and application.Alexine is a naturally polyhydroxylated pyrrolizidine alkaloid that is broadly found in plant sources and isolated from Alexa leiopetala.The biological properties such as glycosidase inhibitors,anti-virus,and anti-HIV activities,makes it interesting target for synthetical studies.This review reports different approaches and methodologies to the synthesis of alexine,and its stereoisomers as the target compounds in numerous studies.展开更多
1-epi-Castanospermine（5） was synthesized from readily available 2,3,4,6-tetra-O-benzyl-1-deoxynojirimycin（11） in 9 steps and 21% overall yield, with selective debenzylation, Barbier reaction and reductive aminatio...1-epi-Castanospermine（5） was synthesized from readily available 2,3,4,6-tetra-O-benzyl-1-deoxynojirimycin（11） in 9 steps and 21% overall yield, with selective debenzylation, Barbier reaction and reductive amination as the main reaction steps.展开更多
文摘Natural products have attracted the interest of the scientific community due to their importance and application.Alexine is a naturally polyhydroxylated pyrrolizidine alkaloid that is broadly found in plant sources and isolated from Alexa leiopetala.The biological properties such as glycosidase inhibitors,anti-virus,and anti-HIV activities,makes it interesting target for synthetical studies.This review reports different approaches and methodologies to the synthesis of alexine,and its stereoisomers as the target compounds in numerous studies.
基金Financial support from the National Natural Science Foundation of China(No.21272240)National Science and Technology Major Projects for“Major New Drugs Innovation and Development”(No.2013ZX09508104)National Engineering Research Center for Carbohydrate Synthesis of Jiangxi Normal University
文摘1-epi-Castanospermine（5） was synthesized from readily available 2,3,4,6-tetra-O-benzyl-1-deoxynojirimycin（11） in 9 steps and 21% overall yield, with selective debenzylation, Barbier reaction and reductive amination as the main reaction steps.
