This work deals with a study of the dynamic and buckling analysis of polymer hybrid composite(PHC) beam. The beam has variable thickness and is reinforced by carbon nanotubes(CNTs) and nanoclay(NC) simultaneously. The...This work deals with a study of the dynamic and buckling analysis of polymer hybrid composite(PHC) beam. The beam has variable thickness and is reinforced by carbon nanotubes(CNTs) and nanoclay(NC) simultaneously. The governing equations are derived based on the first shear deformation theory(FSDT). A three-phase HalpinTsai approach is used to predict the mechanical properties of the PHC. We focus our attention on the effect of the simultaneous addition of NC and CNT on the vibration and buckling analysis of the PHC beam with variable thickness. Also a comparison study is done on the sensation of three impressive parameters including CNT, NC weight fractions, and the shape factor of fillers on the mechanical properties of PHC beams,as well as fundamental frequencies of free vibrations and critical buckling load. The results show that the increase of shape factor value, NC, and CNT weight fractions leads to considerable reinforcement in mechanical properties as well as increase of the dimensionless fundamental frequency and buckling load. The variation of CNT weight fraction on elastic modulus is more sensitive rather than shear modulus but the effect of NC weight fraction on elastic and shear moduli is fairly the same. The shape factor values more than the medium level do not affect the mechanical properties.展开更多
Protein-based drugs have received extensive attention in the field of drug research in recent years.However,protein-based drug activity is difficult to maintain during oral delivery,which limits its application.This s...Protein-based drugs have received extensive attention in the field of drug research in recent years.However,protein-based drug activity is difficult to maintain during oral delivery,which limits its application.This study developed bifunctional oral lipid polymer hybrid nanoparticles(R8-PEG-PPNPs)that deliver superoxide dismutase(SOD)for the treatment of ulcerative colitis(UC).R8-PEG-PPNPs was composed of PCADK,PLGA,lecithin,and co-modified with stearic acid-octa-arginine and polyethylene glycol.The nanoparticles(NPs)are uniformly dispersed with a complete spherical structure.In vitro stability and release studies showed that R8-PEG-PPNPs exhibited good stability and protection.In vitro cell culture experiments demonstrated that R8-PEG-PPNPs as carriers have no significant toxic effects on cells at concentration below 1000µg/mL and promote cellular uptake.In experiments with ulcerative colitis mice,R8-PEG-PPNPs were able to enhance drug absorption by intestinal epithelial cells and accumulate effectively at the site of inflammation.Its therapeutic effect further demonstrates that R8-PEG-PPNPs are a promising delivery system for oral delivery of protein-based drugs.展开更多
Arbitrary micro-scale three-dimensional(3D)structures fabrication is a dream to achieve many exciting goals that have been pursued for a long time.Among all these applications,the direct 3D printing to fabricate human...Arbitrary micro-scale three-dimensional(3D)structures fabrication is a dream to achieve many exciting goals that have been pursued for a long time.Among all these applications,the direct 3D printing to fabricate human organs and integrated photonic circuits are extraordinary attractive as they can promote the current technology to a new level.Among all the 3D printing methods available,two-photon polymerization(2PP)is very competitive as it is the unique method to achieve sub-micron resolution to make any desired tiny structures.For the conventional 2PP,the building block is the photoresist.However,the requirement for the building block is different for different purposes.It is very necessary to investigate and improve the photoresist properties according to different requirements.In this paper,we presented one hybrid method to modify the mechanical strength and light trapping efficiency of the photoresist,which transfers the photoresist into the micro-concretes.The micro-concrete structure can achieve±22%strength modification via a silica nano-particles doping.The structures doped with gold nano-particles show tunable plasmonic absorption.Dye doped hybrid structure shows great potential to fabricate 3D micro-chip laser.展开更多
The corrosion condition of flue gas desulfurization (FGD) equipment for the coal-fired power plant was defined as the strong corrosion grade. The lining system of hybrid polymer composite was used in internal cylinder...The corrosion condition of flue gas desulfurization (FGD) equipment for the coal-fired power plant was defined as the strong corrosion grade. The lining system of hybrid polymer composite was used in internal cylinder of steel chimney, and a corrosion-resistant and heat-resistant protective layer was formed on the metal surface. The corrosion-resistant and ageing-resistant properties of hybrid polymer composite prepared at low temperature after four years of practical use were investigated by differential scanning calorimeter (DSC), scanning electron microscopy (SEM) and measurement of gravimetric variation, contact angle, abrasion resistance, bonding strength and tensile strength. The properties of hybrid polymer composites prepared at 25℃ and –15℃ were comparatively analyzed in the paper.展开更多
A novel POSS-containing organic-inorganic hybrid crosslinked polymer was prepared by hydrosilylation reaction of octahydridosilsesquioxane (TsHs) with 4,4'-bis(4-altyloxybenzoyloxy)phenyl (diene A). Its structu...A novel POSS-containing organic-inorganic hybrid crosslinked polymer was prepared by hydrosilylation reaction of octahydridosilsesquioxane (TsHs) with 4,4'-bis(4-altyloxybenzoyloxy)phenyl (diene A). Its structure and property was characterized by FFIR, 29Si NMR, TGA and ellipsometer, respectively. The results show that the hybrid polymer possesses high thermal stability and low dielectric constant of 1.97 at optical frequencies.展开更多
Particulate carriers such as polymeric micelles (PMs) and liposomes have been investigated to increase drug accumulation in tumors and reduce distribution to healthy tissues. In this study, we prepared PM and hybrid n...Particulate carriers such as polymeric micelles (PMs) and liposomes have been investigated to increase drug accumulation in tumors and reduce distribution to healthy tissues. In this study, we prepared PM and hybrid nanoparticles (HNPs) with poly(ethylene oxide)-block-poly(methacrylic acid) (PEO-b-PMAA) for loading cisplatin, and evaluated cisplatin release, cytotoxicity, and biodistribution in mice. PM composed of PEO-b-PMAA and HNPs composed of egg phosphatidylcholine (EPC)/PEO-b-PMAA at molar ratios of 50/2.8 (HNP-P5) and 50/50 (HNP-P50), respectively, were prepared by a nanoprecipitation method. The sizes of PM, HNP-P5, and HNP-P50 after inclusion of cisplatin were approximately 200, 100, and 55 nm, respectively, and their entrapment efficiencies were approximately 44% - 66%. In the drug-release study, HNP-P5 and HNP-P50 showed reduced release of cisplatin compared with PM. Regarding the cytotoxic assay, HNP-P5 exhibited lower cytotoxicity for mouse Lewis lung carcinoma (LLC) and mouse colon carcinoma Colon 26 cells than PM and HNP-P50. In terms of biodistribution, PM could significantly improve blood circulation and tumor accumulation after intravenous injection into Colon 26 tumor-bearing mice compared with free cisplatin, but HNP-P5 and HNP-P50 did not. EPC in HNPs might be destabilized in the circulation, although it could reduce release of cisplatin in in vitro experiments. This study suggested that polymeric micelles composed of PEO-b-PMAA are a better carrier for cisplatin than hybrid nanoparticles composed of PEO-b-PMAA and EPC.展开更多
Atom transfer radical polymerization (ATRP) using cuprous chloride/2,2'-bipyridine (bipy) was applied to graft polymerization of styrene on the surface of silica nanoparticles to synthesize polymer-inorganic hybri...Atom transfer radical polymerization (ATRP) using cuprous chloride/2,2'-bipyridine (bipy) was applied to graft polymerization of styrene on the surface of silica nanoparticles to synthesize polymer-inorganic hybrid nanoparticles, 2-(4Chloromethylphenyl) ethyltriethoxysilane (CTES) was immobilized on the surface of silica nanoparticles through condensation reaction of the silanol groups on silica with triethoxysilane group of CTES. Then ATRP of St was initiated by this surface-modified silica nanoparticles bearing benzyl chloride groups, and formed PSt graft chains on the surface of silica nanoparticles. The thickness of the graft chains increased with reaction time. End group analysis confirmed the occurrence of ATRP. Thermal analysis indicated that thermal stabilization of these resulting hybrid nanoparticles also increases with polymerization conversion. The results above show that this 'grafting from' reaction could be used for the preparation of polymer-inorganic hybrid nanoparticles with controlled structure of the polymer's end groups.展开更多
A poly (St-co-BA) latex was successfully synthesized by using an organic-inorganic hybrid compound (OIHC), an aliphatic carboxylate sodium/nano-silica composite, as the emulsifier, and investigated by particle size an...A poly (St-co-BA) latex was successfully synthesized by using an organic-inorganic hybrid compound (OIHC), an aliphatic carboxylate sodium/nano-silica composite, as the emulsifier, and investigated by particle size analyzer, transmission electron microscope (TEM), optical contact angle measurement (OCA) and dynamic mechanical analyzer (DMA). It was found that the protective agent, sodium polyacrylate (PA),could obviously improve the polymerization stability and the functional monomer, glycidyl methacrylate (GMA), could enhance the store stability of the latex. The particle size of poly(St-co-BA) latex decreased and then leveled off as OIHC content increased. TEM shows that the prepared polymers were a~:tually organic-inorganic nanocomposites, and these films have better waterproof property than those prepared by traditional poly(St-co-BA) latex or organic silicone modified poly(St-co-BA) latex. The nanocomposite polymer has much higher glass transition temperature than organic silicone modified poly(St-co-BA) polymer containing the same organic silicone content.展开更多
Hybrid mesoporous polystyrene-silica materials were successfully prepared through HCl-catalyzed sol-gel reactions of tetraethyl orthosilicate (TEOS) and triethoxysilyl-functionalized polystyrene obtained via atom tran...Hybrid mesoporous polystyrene-silica materials were successfully prepared through HCl-catalyzed sol-gel reactions of tetraethyl orthosilicate (TEOS) and triethoxysilyl-functionalized polystyrene obtained via atom transfer radical polymerization (ATRP) of styrene, in the presence of citric acid (CA) as non-surfactant template or pore-forming agent and followed by ethanol extraction to remove template molecules. The materials were characterized by infrared spectroscopy OR), N-2 adsorption-desorption measurements, powder X-ray diffraction (XRD), thermogravimetric analysis (TGA) and transmission electron microscopy (TEM). The results indicate that the materials prepared with 50 wt%-60 wt% template contents have average pore sizes of 2-3 nm and large surface areas (ca. 886 m(2)/g) as well as high pore volumes (ca. 0.53 cm(3)/g). The mesoporosity arises from interconnected channels and pores with disordered arrangements. The pore diameters and pore volumes increase as the template content is increased. The pore diameters show a little change upon heating at 200degreesC overnight. However, the materials do not have good hydrothermal stability.展开更多
Basalt fiber reinforcement in polymer matrix composites is becoming more and more popular because of its environmental friendliness and mechanical qualities that are comparable to those of synthetic fibers.Basalt fibe...Basalt fiber reinforcement in polymer matrix composites is becoming more and more popular because of its environmental friendliness and mechanical qualities that are comparable to those of synthetic fibers.Basalt fiber strengthened vinyl ester matrix polymeric composite with filler addition of nano-and micro-sized silicon carbide(SiC)element spanning from 2 weight percent to 10 weight percent was studied for its mechanical and wear properties.The application of Artificial Neural Network(ANN)to correlate the filler addition composition for optimum mechanical properties is required due to the non-linear mechanical and tribological features of composites.The stuffing blend and composition of the composite are optimized using the hybrid model and Genetic Algorithm(GA)to maximize the mechanical and wear-resistant properties.The predicted and tested ANN–GA optimal values obtained for the composite combination had a tensile,flexural,impact resilience,hardness and wear properties of 202.93 MPa,501.67 MPa,3.460 J/s,43 HV and 0.196 g,respectively,for its optimum combination of filler and reinforcement.It can be noted that the nano-sized SiC filler particle enhances most of the properties of the composite which diversifies its applications.The predicted mechanical and wear values of the developed ANN–GA model were in closer agreement with the experimental values which validate the model.展开更多
文摘This work deals with a study of the dynamic and buckling analysis of polymer hybrid composite(PHC) beam. The beam has variable thickness and is reinforced by carbon nanotubes(CNTs) and nanoclay(NC) simultaneously. The governing equations are derived based on the first shear deformation theory(FSDT). A three-phase HalpinTsai approach is used to predict the mechanical properties of the PHC. We focus our attention on the effect of the simultaneous addition of NC and CNT on the vibration and buckling analysis of the PHC beam with variable thickness. Also a comparison study is done on the sensation of three impressive parameters including CNT, NC weight fractions, and the shape factor of fillers on the mechanical properties of PHC beams,as well as fundamental frequencies of free vibrations and critical buckling load. The results show that the increase of shape factor value, NC, and CNT weight fractions leads to considerable reinforcement in mechanical properties as well as increase of the dimensionless fundamental frequency and buckling load. The variation of CNT weight fraction on elastic modulus is more sensitive rather than shear modulus but the effect of NC weight fraction on elastic and shear moduli is fairly the same. The shape factor values more than the medium level do not affect the mechanical properties.
基金the financial support received form National Natural Science Foundation of China(No.82073784)Jilin Province Science and Technology Development Program(No.20200801012GH)Industrial Technology Research and Development Projects from the Development and Reform Commission of Jilin Province(No.2019C050-4).
文摘Protein-based drugs have received extensive attention in the field of drug research in recent years.However,protein-based drug activity is difficult to maintain during oral delivery,which limits its application.This study developed bifunctional oral lipid polymer hybrid nanoparticles(R8-PEG-PPNPs)that deliver superoxide dismutase(SOD)for the treatment of ulcerative colitis(UC).R8-PEG-PPNPs was composed of PCADK,PLGA,lecithin,and co-modified with stearic acid-octa-arginine and polyethylene glycol.The nanoparticles(NPs)are uniformly dispersed with a complete spherical structure.In vitro stability and release studies showed that R8-PEG-PPNPs exhibited good stability and protection.In vitro cell culture experiments demonstrated that R8-PEG-PPNPs as carriers have no significant toxic effects on cells at concentration below 1000µg/mL and promote cellular uptake.In experiments with ulcerative colitis mice,R8-PEG-PPNPs were able to enhance drug absorption by intestinal epithelial cells and accumulate effectively at the site of inflammation.Its therapeutic effect further demonstrates that R8-PEG-PPNPs are a promising delivery system for oral delivery of protein-based drugs.
基金financially supported by A*STAR, SERC 2014 Public Sector Research Funding (PSF) (Grant: SERC Project, 1421200080)973 Program of China (2013CBA01700)Chinese Nature Science Grant (61675207, U1609209)
文摘Arbitrary micro-scale three-dimensional(3D)structures fabrication is a dream to achieve many exciting goals that have been pursued for a long time.Among all these applications,the direct 3D printing to fabricate human organs and integrated photonic circuits are extraordinary attractive as they can promote the current technology to a new level.Among all the 3D printing methods available,two-photon polymerization(2PP)is very competitive as it is the unique method to achieve sub-micron resolution to make any desired tiny structures.For the conventional 2PP,the building block is the photoresist.However,the requirement for the building block is different for different purposes.It is very necessary to investigate and improve the photoresist properties according to different requirements.In this paper,we presented one hybrid method to modify the mechanical strength and light trapping efficiency of the photoresist,which transfers the photoresist into the micro-concretes.The micro-concrete structure can achieve±22%strength modification via a silica nano-particles doping.The structures doped with gold nano-particles show tunable plasmonic absorption.Dye doped hybrid structure shows great potential to fabricate 3D micro-chip laser.
文摘The corrosion condition of flue gas desulfurization (FGD) equipment for the coal-fired power plant was defined as the strong corrosion grade. The lining system of hybrid polymer composite was used in internal cylinder of steel chimney, and a corrosion-resistant and heat-resistant protective layer was formed on the metal surface. The corrosion-resistant and ageing-resistant properties of hybrid polymer composite prepared at low temperature after four years of practical use were investigated by differential scanning calorimeter (DSC), scanning electron microscopy (SEM) and measurement of gravimetric variation, contact angle, abrasion resistance, bonding strength and tensile strength. The properties of hybrid polymer composites prepared at 25℃ and –15℃ were comparatively analyzed in the paper.
基金supported by the National Natural Science Fundation of China(Nos.90606011 and50472038)Ph.D.Program Foundation of Ministry of Education of China(No.20070255012)+1 种基金Shanghai LeadingAcademic Discipline Project(No.B603)the Program of Introducing Talents of Discipline to Universities(No.111-2-04)
文摘A novel POSS-containing organic-inorganic hybrid crosslinked polymer was prepared by hydrosilylation reaction of octahydridosilsesquioxane (TsHs) with 4,4'-bis(4-altyloxybenzoyloxy)phenyl (diene A). Its structure and property was characterized by FFIR, 29Si NMR, TGA and ellipsometer, respectively. The results show that the hybrid polymer possesses high thermal stability and low dielectric constant of 1.97 at optical frequencies.
文摘Particulate carriers such as polymeric micelles (PMs) and liposomes have been investigated to increase drug accumulation in tumors and reduce distribution to healthy tissues. In this study, we prepared PM and hybrid nanoparticles (HNPs) with poly(ethylene oxide)-block-poly(methacrylic acid) (PEO-b-PMAA) for loading cisplatin, and evaluated cisplatin release, cytotoxicity, and biodistribution in mice. PM composed of PEO-b-PMAA and HNPs composed of egg phosphatidylcholine (EPC)/PEO-b-PMAA at molar ratios of 50/2.8 (HNP-P5) and 50/50 (HNP-P50), respectively, were prepared by a nanoprecipitation method. The sizes of PM, HNP-P5, and HNP-P50 after inclusion of cisplatin were approximately 200, 100, and 55 nm, respectively, and their entrapment efficiencies were approximately 44% - 66%. In the drug-release study, HNP-P5 and HNP-P50 showed reduced release of cisplatin compared with PM. Regarding the cytotoxic assay, HNP-P5 exhibited lower cytotoxicity for mouse Lewis lung carcinoma (LLC) and mouse colon carcinoma Colon 26 cells than PM and HNP-P50. In terms of biodistribution, PM could significantly improve blood circulation and tumor accumulation after intravenous injection into Colon 26 tumor-bearing mice compared with free cisplatin, but HNP-P5 and HNP-P50 did not. EPC in HNPs might be destabilized in the circulation, although it could reduce release of cisplatin in in vitro experiments. This study suggested that polymeric micelles composed of PEO-b-PMAA are a better carrier for cisplatin than hybrid nanoparticles composed of PEO-b-PMAA and EPC.
基金This project was supported by the National Natural Science Foundation of China to K.Y Qiu (Grant No. 29874002) and Outstanding Young Scientist Award to Y. Wei (Grant No. 29825504)
文摘Atom transfer radical polymerization (ATRP) using cuprous chloride/2,2'-bipyridine (bipy) was applied to graft polymerization of styrene on the surface of silica nanoparticles to synthesize polymer-inorganic hybrid nanoparticles, 2-(4Chloromethylphenyl) ethyltriethoxysilane (CTES) was immobilized on the surface of silica nanoparticles through condensation reaction of the silanol groups on silica with triethoxysilane group of CTES. Then ATRP of St was initiated by this surface-modified silica nanoparticles bearing benzyl chloride groups, and formed PSt graft chains on the surface of silica nanoparticles. The thickness of the graft chains increased with reaction time. End group analysis confirmed the occurrence of ATRP. Thermal analysis indicated that thermal stabilization of these resulting hybrid nanoparticles also increases with polymerization conversion. The results above show that this 'grafting from' reaction could be used for the preparation of polymer-inorganic hybrid nanoparticles with controlled structure of the polymer's end groups.
基金Supported by the National "863" Project (No. 2001 AA 320206)and Shanghai Nano Special Foundation(No. 0120nm034).
文摘A poly (St-co-BA) latex was successfully synthesized by using an organic-inorganic hybrid compound (OIHC), an aliphatic carboxylate sodium/nano-silica composite, as the emulsifier, and investigated by particle size analyzer, transmission electron microscope (TEM), optical contact angle measurement (OCA) and dynamic mechanical analyzer (DMA). It was found that the protective agent, sodium polyacrylate (PA),could obviously improve the polymerization stability and the functional monomer, glycidyl methacrylate (GMA), could enhance the store stability of the latex. The particle size of poly(St-co-BA) latex decreased and then leveled off as OIHC content increased. TEM shows that the prepared polymers were a~:tually organic-inorganic nanocomposites, and these films have better waterproof property than those prepared by traditional poly(St-co-BA) latex or organic silicone modified poly(St-co-BA) latex. The nanocomposite polymer has much higher glass transition temperature than organic silicone modified poly(St-co-BA) polymer containing the same organic silicone content.
基金This project was supported by the National Natural Science Foundation of China to K. Y. Qiu (Grant No. 29874002) and Outstanding Young Scientist Award to Y. Wei (Grant No. 29825504).
文摘Hybrid mesoporous polystyrene-silica materials were successfully prepared through HCl-catalyzed sol-gel reactions of tetraethyl orthosilicate (TEOS) and triethoxysilyl-functionalized polystyrene obtained via atom transfer radical polymerization (ATRP) of styrene, in the presence of citric acid (CA) as non-surfactant template or pore-forming agent and followed by ethanol extraction to remove template molecules. The materials were characterized by infrared spectroscopy OR), N-2 adsorption-desorption measurements, powder X-ray diffraction (XRD), thermogravimetric analysis (TGA) and transmission electron microscopy (TEM). The results indicate that the materials prepared with 50 wt%-60 wt% template contents have average pore sizes of 2-3 nm and large surface areas (ca. 886 m(2)/g) as well as high pore volumes (ca. 0.53 cm(3)/g). The mesoporosity arises from interconnected channels and pores with disordered arrangements. The pore diameters and pore volumes increase as the template content is increased. The pore diameters show a little change upon heating at 200degreesC overnight. However, the materials do not have good hydrothermal stability.
文摘Basalt fiber reinforcement in polymer matrix composites is becoming more and more popular because of its environmental friendliness and mechanical qualities that are comparable to those of synthetic fibers.Basalt fiber strengthened vinyl ester matrix polymeric composite with filler addition of nano-and micro-sized silicon carbide(SiC)element spanning from 2 weight percent to 10 weight percent was studied for its mechanical and wear properties.The application of Artificial Neural Network(ANN)to correlate the filler addition composition for optimum mechanical properties is required due to the non-linear mechanical and tribological features of composites.The stuffing blend and composition of the composite are optimized using the hybrid model and Genetic Algorithm(GA)to maximize the mechanical and wear-resistant properties.The predicted and tested ANN–GA optimal values obtained for the composite combination had a tensile,flexural,impact resilience,hardness and wear properties of 202.93 MPa,501.67 MPa,3.460 J/s,43 HV and 0.196 g,respectively,for its optimum combination of filler and reinforcement.It can be noted that the nano-sized SiC filler particle enhances most of the properties of the composite which diversifies its applications.The predicted mechanical and wear values of the developed ANN–GA model were in closer agreement with the experimental values which validate the model.