With the quick emergence of antibiotic resistance and multi-drug resistant microbes,more and more attention has been paid to the development of new antimicrobial agents that have potential to take the challenge.Polysa...With the quick emergence of antibiotic resistance and multi-drug resistant microbes,more and more attention has been paid to the development of new antimicrobial agents that have potential to take the challenge.Polysaccharides,as one of the major classes of biopolymers,were explored for their antimicrobial properties and applications,owing to their easy accessibility,biocompatibility and easy modification.Polysaccharides and their derivatives have variable demonstrations and applications as antimicrobial agents and antimicrobial biomaterials.A variety of polysaccharides,such as chitosan,dextran,hyaluronic acid,cellulose,other plant/animal-derived polysaccharides and their derivatives have been explored for antimicrobial applications.We expect that this review can summarize the important progress of this field and inspire new concepts,which will contribute to the development of novel antimicrobial agents in combating antibiotic resistance and drug-resistant antimicrobial infections.展开更多
New graft copolymers were synthesized by graft-ing N-vinylcaprolactam onto dextran.Their composition and structure were investigated by elemental analyses,infrared spectra and thermogravimetric analyses.By optical tra...New graft copolymers were synthesized by graft-ing N-vinylcaprolactam onto dextran.Their composition and structure were investigated by elemental analyses,infrared spectra and thermogravimetric analyses.By optical transmit-tance measurements,it was found that the aqueous solutions of these graft copolymers showed a temperature-dependent transmittance change due to the introduction of thermosensi-tive poly(N-vinylcaprolactam)graft chains.Moreover,the lower critical solution temperature(LCST)of the graft copolymer in aqueous solution was dependent on its grafting extent and concentration.The LCST value was found to increase with the increase of the grafting extent and decrease with the increase of the copolymer concentration.With these stimuli-response properties,such polysaccharide derivative may hold potential applications in biomedicine and biotechnology.展开更多
基金financially supported by the Natural Science Foundation of Shanghai(No.18ZR1410300)the National Natural Science Foundation of China(Nos.21861162010,21774031,and 31800801)+1 种基金the National Key Research and Development Program of China(No.2016YFC1100401)Research program of State Key Laboratory of Bioreactor Engineering,the Fundamental Research Funds for the Central Universities(Nos.22221818014 and 50321041917001)。
文摘With the quick emergence of antibiotic resistance and multi-drug resistant microbes,more and more attention has been paid to the development of new antimicrobial agents that have potential to take the challenge.Polysaccharides,as one of the major classes of biopolymers,were explored for their antimicrobial properties and applications,owing to their easy accessibility,biocompatibility and easy modification.Polysaccharides and their derivatives have variable demonstrations and applications as antimicrobial agents and antimicrobial biomaterials.A variety of polysaccharides,such as chitosan,dextran,hyaluronic acid,cellulose,other plant/animal-derived polysaccharides and their derivatives have been explored for antimicrobial applications.We expect that this review can summarize the important progress of this field and inspire new concepts,which will contribute to the development of novel antimicrobial agents in combating antibiotic resistance and drug-resistant antimicrobial infections.
基金supported by the National Natural Science Foundation of China(Grants No.20676155,No.30470476,No.20273086)Natural Science Foundation of Guangdong Province(Grants No.039184,No.06023103)+1 种基金Department of Science and Technology of Guangdong Province(Grant No.2004B33101003)Program for New Century Excellent Talents in Universities of China(NCET-04-0810).
文摘New graft copolymers were synthesized by graft-ing N-vinylcaprolactam onto dextran.Their composition and structure were investigated by elemental analyses,infrared spectra and thermogravimetric analyses.By optical transmit-tance measurements,it was found that the aqueous solutions of these graft copolymers showed a temperature-dependent transmittance change due to the introduction of thermosensi-tive poly(N-vinylcaprolactam)graft chains.Moreover,the lower critical solution temperature(LCST)of the graft copolymer in aqueous solution was dependent on its grafting extent and concentration.The LCST value was found to increase with the increase of the grafting extent and decrease with the increase of the copolymer concentration.With these stimuli-response properties,such polysaccharide derivative may hold potential applications in biomedicine and biotechnology.
