To compare the effects of polysaccharide nucleic acid fraction of bacillus calmette guerin (BCG PSN) and thymopeptides on T lymphocytes of normal and immunosuppressed mice, CD4 + and CD8 + T lymphocyte subsets of...To compare the effects of polysaccharide nucleic acid fraction of bacillus calmette guerin (BCG PSN) and thymopeptides on T lymphocytes of normal and immunosuppressed mice, CD4 + and CD8 + T lymphocyte subsets of single nucleic cell in thymus, spleen and peripheral blood were detected successively by flow cytometry after application of BCG PSN and thymopeptides. Meanwhile, CD4 +/CD8 + ratio was also calculated. The results showed that both BCG PSN and thymopeptides could decrease the proportion of CD4 + CD8 + T lymphocyte subsets in the thymus, at the same time increase CD4 + T lymphocyte, CD8 +T lymphocyte proportion in the three tissues. The fluctuation in amplitude was greater in thymopeptides group than that in BCG PSN group. It is concluded that acting location of thymopeptides is in thymus, its stimulating action is stronger than that of BCG PSN, while BCG PSN not only accelerates the differentiation in thymus, but also has some direct stimulation to peripheral CD4 +T lymphocytes, and can maintain CD4 +/CD8 + ratio within normal range. So, BCG PSN is safer.展开更多
目的探讨卡介菌多糖核酸联合玉屏风颗粒治疗慢性荨麻疹的疗效及对血清中白细胞介素-2(IL-2)和白细胞介素-6(IL-6)的影响。方法将慢性荨麻疹患者90例采用随机数字表法随机分为治疗组和对照组,各45例。对照组口服地氯雷他定片,1片/次,1次/...目的探讨卡介菌多糖核酸联合玉屏风颗粒治疗慢性荨麻疹的疗效及对血清中白细胞介素-2(IL-2)和白细胞介素-6(IL-6)的影响。方法将慢性荨麻疹患者90例采用随机数字表法随机分为治疗组和对照组,各45例。对照组口服地氯雷他定片,1片/次,1次/天;卡介菌多糖核酸注射液,肌内注射,每次1 m L,2~3次/周。治疗组采取卡介菌多糖核酸注射液,肌内注射,每次1 m L,2~3次/周;玉屏风颗粒,开水冲服,每次5 g,3次/天。两组患者连续治疗8周。比较两组患者的症状评分、临床疗效及复发率。检测两组血清IL-2及IL-6水平。结果治疗组治疗后患者的瘙痒程度、风团数目、风团持续时间、每日风团发作次数及风团最大直径评分显著低于对照组同期(P<0.01)。治疗组患者的愈显率为91.11%,显著高于对照组为71.11%(P<0.05)。治疗组复发率13.33%,明显低于对照组复发率33.33%(P<0.05)。治疗组治疗后患者血清中IL-2及IL-6水平明显高于对照组同期,差异有统计学意义(P<0.01)。结论卡介菌多糖核酸联合玉屏风颗粒治疗慢性荨麻疹的疗效明显,上调患者血清中IL-2及IL-6水平可能是其作用机制之一。展开更多
文摘To compare the effects of polysaccharide nucleic acid fraction of bacillus calmette guerin (BCG PSN) and thymopeptides on T lymphocytes of normal and immunosuppressed mice, CD4 + and CD8 + T lymphocyte subsets of single nucleic cell in thymus, spleen and peripheral blood were detected successively by flow cytometry after application of BCG PSN and thymopeptides. Meanwhile, CD4 +/CD8 + ratio was also calculated. The results showed that both BCG PSN and thymopeptides could decrease the proportion of CD4 + CD8 + T lymphocyte subsets in the thymus, at the same time increase CD4 + T lymphocyte, CD8 +T lymphocyte proportion in the three tissues. The fluctuation in amplitude was greater in thymopeptides group than that in BCG PSN group. It is concluded that acting location of thymopeptides is in thymus, its stimulating action is stronger than that of BCG PSN, while BCG PSN not only accelerates the differentiation in thymus, but also has some direct stimulation to peripheral CD4 +T lymphocytes, and can maintain CD4 +/CD8 + ratio within normal range. So, BCG PSN is safer.
文摘目的探讨卡介菌多糖核酸联合玉屏风颗粒治疗慢性荨麻疹的疗效及对血清中白细胞介素-2(IL-2)和白细胞介素-6(IL-6)的影响。方法将慢性荨麻疹患者90例采用随机数字表法随机分为治疗组和对照组,各45例。对照组口服地氯雷他定片,1片/次,1次/天;卡介菌多糖核酸注射液,肌内注射,每次1 m L,2~3次/周。治疗组采取卡介菌多糖核酸注射液,肌内注射,每次1 m L,2~3次/周;玉屏风颗粒,开水冲服,每次5 g,3次/天。两组患者连续治疗8周。比较两组患者的症状评分、临床疗效及复发率。检测两组血清IL-2及IL-6水平。结果治疗组治疗后患者的瘙痒程度、风团数目、风团持续时间、每日风团发作次数及风团最大直径评分显著低于对照组同期(P<0.01)。治疗组患者的愈显率为91.11%,显著高于对照组为71.11%(P<0.05)。治疗组复发率13.33%,明显低于对照组复发率33.33%(P<0.05)。治疗组治疗后患者血清中IL-2及IL-6水平明显高于对照组同期,差异有统计学意义(P<0.01)。结论卡介菌多糖核酸联合玉屏风颗粒治疗慢性荨麻疹的疗效明显,上调患者血清中IL-2及IL-6水平可能是其作用机制之一。
