With the projected global surge in hydrogen demand, driven by increasing applications and the imperative for low-emission hydrogen, the integration of machine learning(ML) across the hydrogen energy value chain is a c...With the projected global surge in hydrogen demand, driven by increasing applications and the imperative for low-emission hydrogen, the integration of machine learning(ML) across the hydrogen energy value chain is a compelling avenue. This review uniquely focuses on harnessing the synergy between ML and computational modeling(CM) or optimization tools, as well as integrating multiple ML techniques with CM, for the synthesis of diverse hydrogen evolution reaction(HER) catalysts and various hydrogen production processes(HPPs). Furthermore, this review addresses a notable gap in the literature by offering insights, analyzing challenges, and identifying research prospects and opportunities for sustainable hydrogen production. While the literature reflects a promising landscape for ML applications in hydrogen energy domains, transitioning AI-based algorithms from controlled environments to real-world applications poses significant challenges. Hence, this comprehensive review delves into the technical,practical, and ethical considerations associated with the application of ML in HER catalyst development and HPP optimization. Overall, this review provides guidance for unlocking the transformative potential of ML in enhancing prediction efficiency and sustainability in the hydrogen production sector.展开更多
Offshore carbon dioxide(CO_(2)) geological storage(OCGS) represents a significant strategy for addressing climate change by curtailing greenhouse gas emissions. Nonetheless, the risk of CO_(2) leakage poses a substant...Offshore carbon dioxide(CO_(2)) geological storage(OCGS) represents a significant strategy for addressing climate change by curtailing greenhouse gas emissions. Nonetheless, the risk of CO_(2) leakage poses a substantial concern associated with this technology. This study introduces an innovative approach for establishing OCGS leakage scenarios, involving four pivotal stages, namely, interactive matrix establishment, risk matrix evaluation, cause–effect analysis, and scenario development, which has been implemented in the Pearl River Estuary Basin in China. The initial phase encompassed the establishment of an interaction matrix for OCGS systems based on features, events, and processes. Subsequent risk matrix evaluation and cause–effect analysis identified key system components, specifically CO_(2) injection and faults/features. Building upon this analysis, two leakage risk scenarios were successfully developed, accompanied by the corresponding mitigation measures. In addition, this study introduces the application of scenario development to risk assessment, including scenario numerical simulation and quantitative assessment. Overall, this research positively contributes to the sustainable development and safe operation of OCGS projects and holds potential for further refinement and broader application to diverse geographical environments and project requirements. This comprehensive study provides valuable insights into the establishment of OCGS leakage scenarios and demonstrates their practical application to risk assessment, laying the foundation for promoting the sustainable development and safe operation of ocean CO_(2) geological storage projects while proposing possibilities for future improvements and broader applications to different contexts.展开更多
Software Development Life Cycle (SDLC) is one of the major ingredients for the development of efficient software systems within a time frame and low-cost involvement. From the literature, it is evident that there are ...Software Development Life Cycle (SDLC) is one of the major ingredients for the development of efficient software systems within a time frame and low-cost involvement. From the literature, it is evident that there are various kinds of process models that are used by the software industries for the development of small, medium and long-term software projects, but many of them do not cover risk management. It is quite obvious that the improper selection of the software development process model leads to failure of the software products as it is time bound activity. In the present work, a new software development process model is proposed which covers the risks at any stage of the development of the software product. The model is named a Hemant-Vipin (HV) process model and may be helpful for the software industries for development of the efficient software products and timely delivery at the end of the client. The efficiency of the HV process model is observed by considering various kinds of factors like requirement clarity, user feedback, change agility, predictability, risk identification, practical implementation, customer satisfaction, incremental development, use of ready-made components, quick design, resource organization and many more and found through a case study that the presented approach covers many of parameters in comparison of the existing process models. .展开更多
Based on the analysis of the development process system status of domestic and foreign civil aircraft airborne system suppliers,this paper proposes the overall construction idea of"a set of civil aircraft process...Based on the analysis of the development process system status of domestic and foreign civil aircraft airborne system suppliers,this paper proposes the overall construction idea of"a set of civil aircraft process system"based on IPD(Integrated product development)in the organization.The development stage,process,activity and task are the logical framework elements of the system construction."Based on process decomposition,vertical stratification,horizontal segmentation,combination of special and common,process customized to tools,role and process integration,giving full consideration to the interface between supplier management and process modules"etc.are the concrete ideas.Moreover,formulate top⁃level system construction standards,implemented by process system management tool platform,so that the process system and development work can be effectively integrated to effectively guide the development work of airborne system suppliers,and meet the quality and airworthiness requirements of civil aircraft development.Through the development application of a certain type of flight control system,the process system and tool platform were verified and optimized in practice.展开更多
Objective To identify the critical risks in the process of innovative drug research and development,and to provide reference for improving the efficiency of innovative drug development and risk control in China.Method...Objective To identify the critical risks in the process of innovative drug research and development,and to provide reference for improving the efficiency of innovative drug development and risk control in China.Methods Expert investigation and analytic hierarchy process were used to determine the weights of different risks.Results and Conclusion The research and analysis results showed that the risks at different stages of development had different effects on the success rate of drug development,among which the risk at the drug discovery stage influenced the most.In the drug discovery stage,inappropriate target selection had the greatest impact on the success rate of drug development.The lack of appropriate cell tissue or animal models had the greatest impact on the success rate of drug development from the discovery of a compound to the application for clinical trials.The difference in changes between nonclinical and clinical studies had the greatest impact on the success rate of drug development from early clinical studies to pivotal clinical studies.Incorrect dose selection had the greatest impact on the success rate of drug development from pivotal clinical studies to marketing authorization applications.The biggest impact from the marketing authorization application to the approval stage was inadequate communication with regulators.After investigating the weight of risk factors in the process of innovative drug development based on scientific methods,a new perspective for the risk control of new drug development and improving the research and development efficiency is provided.展开更多
Machine Translation are increasingly welcomed and used during recent years with the commonly application of Internet and the acceleration of the integration of world economy. To know about the history and development ...Machine Translation are increasingly welcomed and used during recent years with the commonly application of Internet and the acceleration of the integration of world economy. To know about the history and development process of Machine Translation during 1930s-1970 s could help researchers gain new insights through restudying old material.展开更多
This paper reviewed the trend and development of semi-solid metal technique. The processes and mechanisms for producing slurry of SSM and its industrial applications have been summarized and discussed. Discussions on ...This paper reviewed the trend and development of semi-solid metal technique. The processes and mechanisms for producing slurry of SSM and its industrial applications have been summarized and discussed. Discussions on the basic rheological theory are presented for more applications. Further consideration of the development and application of SSM technique is also proposed.展开更多
he design verification steps that take place in today’s automotive industry, which constitute the values of each successive or simultaneous phase in the new product development process, create a complex structure wit...he design verification steps that take place in today’s automotive industry, which constitute the values of each successive or simultaneous phase in the new product development process, create a complex structure with the inclusion of each new technology and discipline. Therefore, step by step, each design verification phase definition in the flow contains important phase transition measurements or approval tolerances that ensure the simplicity and continuity of vehicle development processes. In addition, classification of design verification stages within the framework of this study or evaluation in two classes (static and dynamic) is a new approach, but it is a synthesis with the analysis of the new product development process. The vehicle’s basic structure, which constitutes the ergonomic and functional requirements of the vehicle in a static environment, takes into account the dynamic environment variables with crash or accident tests. Increasing new technology adaptations in the automotive industry have changed the new product development process that performs this function structurally and created the concept of design verification under consecutive or simultaneous process simplicity. From the autonomous driving to the use of alternative energy, possible accident scenarios and design verification phase transitions in the integration of parts and systems of the newly developed vehicle create a new structure that models and directs the lean product development process especially in the automotive industry in the coming days. In the lean product development process that takes place in the automotive industry, the design verification transition steps or the approval-control analysis of the development stages, which form a new and effective approach, are re-modeling the entire flow. Therefore, successful execution of design verification steps used in the control of new interdisciplinary product development phase transitions provides value creation.?Within the scope of this study, the effectiveness of the static and dynamic design verification steps, which are carried out in 5 global automotive companies included in the research, which constitute the stage transitions of the new product development process, has been measured. Apart from the design verification transition stages, the process variables that differ among the automotive companies involved in the research are excluded from the scope of this study. In other words, in field researches in the automotive industry, new vehicle design steps or basic engineering steps in the new product development process steps, while creating independent fixed variables, interdisciplinary collaborations, static and dynamic design verification transition stages they perform, or their sequence in the basic flow, is accepted as a dependent variable. Therefore, in the study, the positive effect of the automotive companies that included the static and dynamic design verification phase transition approvals in the lean product development process was investigated. Under the comparative analysis structure of the research, the effect of automotive companies, which accept international vehicle specifications as static design verification input, on market performance has been examined in depth. The detailed depth in the comparison analysis conducted under the second field studies of the study is due to the prediction of dynamic design verification stages to provide a high impact on the market performance, according to the static verification analysis. The new product development stages of the dependent variables were fixed and the flow-oriented?“effect”?of the independent variables in the basic process influenced by the design verification activities was analyzed under the new automotive industry company comparisons. In addition, the impact of the automotive design activities that make up the comparison analysis of the research on the scope of the lean product development stage and its effect on the basic process flow has been demonstrated competition-oriented. Therefore, sub-variables, options, criteria, results, which form a defined comparison problem, create basic test values that affect the problem.展开更多
The next generation of advanced light sources requires photons with large average flux and high brightness,which needs advanced electron gun matched with excellent photocathode materials. K_2CsSb photocathode has the ...The next generation of advanced light sources requires photons with large average flux and high brightness,which needs advanced electron gun matched with excellent photocathode materials. K_2CsSb photocathode has the advantages of high quantum efficiency, long lifetime and instantaneous response. This study introduces the design of a set of K_2CsSb photocathode preparation systems and detailed preparation process of K_2CsSb photocathodes, including sequential deposition process and co-deposition process, and finally develops a K_2CsSb photocathode. The influence of laser power on the quantum efficiency is also investigated.展开更多
Hainan's betel nut processing industry continues to develop,and the yield has reached 231000 t. There are some problems in betel nut industry such as unreasonable initial processing layout,processing capacity surp...Hainan's betel nut processing industry continues to develop,and the yield has reached 231000 t. There are some problems in betel nut industry such as unreasonable initial processing layout,processing capacity surplus,and deep processing industry lag. It is suggested that we should guide the initial processing layout of betel nut according to local conditions,and carry out overall deep processing planning of betel nut; support betel nut deep processing plant in the main producing areas,establish betel nut initial processing and deep processing serial production line,and develop new betel nut product; build betel nut production,processing,transport and marketing information database and market information early warning mechanism,and improve betel nut processing information service platform to timely provide information services and continuously develop betel nut industry.展开更多
The development and delivery of high quality therapeutic products necessitates the need for highthrough-put (HTP) process development tools. Traditionally, these works requires a combination of shake flask and small-s...The development and delivery of high quality therapeutic products necessitates the need for highthrough-put (HTP) process development tools. Traditionally, these works requires a combination of shake flask and small-scale stirred tank bioreactor (STR) which are labor and resource intensive and time-consuming. Here we demonstrate a strategy for rapid and robust cell culture process development by evaluating and implementing the use of a new HTP disposable micro bioreactor (MBR) called AMBRTM system (Advanced Microscale Bioreactor) that has the capabilities for automated sampling, feed addition, pH, dissolved oxygen (DO), gassing and agitation controls. In these studies the performance of two monoclonal antibody (MAb) producing cell lines (MAb1 and MAb2) was evaluated both in the AMBR system and 3-L STR. We demonstrated that cell culture performance (growth and viability, production titer and product quality) were similar in both vessel systems. Furthermore, process control and feed optimization were demonstrated in an additional cell line (MAb3) in the disposable MBR and its performance confirmed at STR scale. The results indicate that the AMBR system can be used to streamline the process development effort and facilitate a rapid and robust cell culture process development effort for MAb programs in a HTP manner.展开更多
This article presents a multiscale simulation approach starting at the molecular level for the adsorption process development. A grand canonical Monte Carlo method is used for the prediction of adsorption isotherms of...This article presents a multiscale simulation approach starting at the molecular level for the adsorption process development. A grand canonical Monte Carlo method is used for the prediction of adsorption isotherms of methanol on an activated carbon at the molecular level. The adsorption isotherms obtained in the linear region (or adsorption constant) are exploited as a model parameter required for the adsorption process simulation. The adsorption process model described by a set of partial differential equations (PDEs) is solved by using the conservation element and solution element method, which produces a fast and an accurate numerical solution to PDEs. The simulation results obtained from the adsorption constant estimated at the molecular level are in good agreement with the experimental results of the pulse response. The systematical multiscale simulation approach addressed in this study may be useful to accelerate the adsorption process development by reducing the number of experiments.展开更多
Mechatronic product development is a complex and multidisciplinary field that encompasses various domains, including, among others, mechanical engineering, electrical engineering, control theory and software engineeri...Mechatronic product development is a complex and multidisciplinary field that encompasses various domains, including, among others, mechanical engineering, electrical engineering, control theory and software engineering. The integration of artificial intelligence technologies is revolutionizing this domain, offering opportunities to enhance design processes, optimize performance, and leverage vast amounts of knowledge. However, human expertise remains essential in contextualizing information, considering trade-offs, and ensuring ethical and societal implications are taken into account. This paper therefore explores the existing literature regarding the application of artificial intelligence as a comprehensive database, decision support system, and modeling tool in mechatronic product development. It analyzes the benefits of artificial intelligence in enabling domain linking, replacing human expert knowledge, improving prediction quality, and enhancing intelligent control systems. For this purpose, a consideration of the V-cycle takes place, a standard in mechatronic product development. Along this, an initial assessment of the AI potential is shown and important categories of AI support are formed. This is followed by an examination of the literature with regard to these aspects. As a result, the integration of artificial intelligence in mechatronic product development opens new possibilities and transforms the way innovative mechatronic systems are conceived, designed, and deployed. However, the approaches are only taking place selectively, and a holistic view of the development processes and the potential for robust and context-sensitive artificial intelligence along them is still needed.展开更多
The IEC 61131-3 standard defines a model and a set of programming languages for the development of industrial automation software. It is widely accepted by industry and most of the commercial tool vendors advertise co...The IEC 61131-3 standard defines a model and a set of programming languages for the development of industrial automation software. It is widely accepted by industry and most of the commercial tool vendors advertise compliance with it. On the other side, Model Driven Development (MDD) has been proved as a quite successful paradigm in general-purpose computing. This was the motivation for exploiting the benefits of MDD in the industrial automation domain. With the emerging IEC 61131 specification that defines an object-oriented (OO) extension to the function block model, there will be a push to the industry to better exploit the benefits of MDD in automation systems development. This work discusses possible alternatives to integrate the current but also the emerging specification of IEC 61131 in the model driven development process of automation systems. IEC 61499, UML and SysML are considered as possible alternatives to allow the developer to work in higher layers of abstraction than the one supported by IEC 61131 and to more effectively move from requirement specifications into the implementation model of the system.展开更多
In Kiruna,nearly all the residents support the migration plan in order to make LKAB able to continue the mining process.Based on current condition,a larger part of this town will be demolished by the sinking land caus...In Kiruna,nearly all the residents support the migration plan in order to make LKAB able to continue the mining process.Based on current condition,a larger part of this town will be demolished by the sinking land caused by iron ore mining processing operated by LKAB.Since then,most of the buildings in the sinking district will be relocated in another district.However,the situation in Kiruna is not quite the same as when this kind of migration happens in another place.In other place,while migration happens,even if not most,a large part of the local residents will resist and fight for their house and properties.Concentrated on the ownership of different buildings and tried find the relationship between the public and private buildings to discover some issue that will help to work on the computational urban design.展开更多
The development of women’s higher education in China can be divided into four stages:emergence(1908-1948);foundation(1949-1976);accelerating development(1977-2008);and the qualitative leap(2009-2020).This work consid...The development of women’s higher education in China can be divided into four stages:emergence(1908-1948);foundation(1949-1976);accelerating development(1977-2008);and the qualitative leap(2009-2020).This work considers the principal institutional mechanisms that contributed to this development.First,flexibly planned parenthood gradually promoted gender equality and openness in society facilitated by systematic“awards,grants,and loans”initiatives to support women’s higher education economically.Second,compulsory education ensured that left-out and migrant children had access to higher education.Third,effective connectivity across different education types bridged education gaps between those with different levels of education.Fourth,China made great efforts to invite and integrate international experiences that promoted the development of women’s higher education.Looking beyond these achievements,we also discuss the future trends of women’s higher education in China.展开更多
Product development process management plays an important role in concurrent engineering (CE). The integration platform is a useful tool for effectively supporting the software development and integration. Based on th...Product development process management plays an important role in concurrent engineering (CE). The integration platform is a useful tool for effectively supporting the software development and integration. Based on the analysis of practical requirements for product development process management for CE, a CORBA-based integration platform of product development process management (IP-PDPM) is designed and developed. The design principles for IP-PDPM are described. The system architecture and functions of the platform are given, the key technologies for the implementation of IP-PDPM are presented, the application integration mechanism and its implementation techniques are also detailed.展开更多
In this paper,the development process of the construction of soil environmental quality standards in China is reviewed,and the construction situation of soil environmental quality standards in typical developed countr...In this paper,the development process of the construction of soil environmental quality standards in China is reviewed,and the construction situation of soil environmental quality standards in typical developed countries is introduced.According to characteristics of soil environment and practice of soil environment management in China,the relevant suggestions are discussed,thereby further perfecting construction work of soil environmental quality standards in China.展开更多
Longtan pearl plum, as a new dominant fruit industry in Guangxi, has developed rapidly in recent years and become one of the major economic sources of fruit growers in Guangxi. It has a positive effect on promoting ec...Longtan pearl plum, as a new dominant fruit industry in Guangxi, has developed rapidly in recent years and become one of the major economic sources of fruit growers in Guangxi. It has a positive effect on promoting economic development and helping farmers to get out of poverty in Guangxi. But there is almost nothing to do with the processing and utilization. Taking the route of processing and utilization is an inevitable trend of development of Longtan pearl plum industry with the increase of the planting area and yield year by year. In this paper, based on the analysis of edible value of Longtan pearl plum, the development direction of processing and utilization of Longtan pearl plum was expounded, and some suggestions on the problems existing in the processing and utilization were put forward to provide reference for the processing and utilization of Longtan pearl plum.展开更多
Today the cycle time of the product develop is requ ir ed to be shortened. At the same time the requirement of the customers becomes mo re and more diverse and complex. The capability of the develop unit is limited b ...Today the cycle time of the product develop is requ ir ed to be shortened. At the same time the requirement of the customers becomes mo re and more diverse and complex. The capability of the develop unit is limited b ecause of the existence of heterogeneous systems and distributed environments. I n this paper, we bring forward a new approach to solve the problem in product de velopment process. We also settle part key technologies in it. A great deal of information from all kinds of sources in the distributed develop ment process is interweaved. The solution to organize the workflow and manage th e information in the process is called for anxiously. We use a new approach that is asynchronous and synchronous coupling product development approach based on the network. The approach extends the develop process from the time axis. Then t he activities in the process are organized from the asynchronous and synchronous aspects. The state of every activity projects at the ASN (active semantic netwo rk). The ASN includes decision system, intelligent agent, user interface and net work. The ASN decides the types and states of the activities and deals with the couple relationship among them. The knowledge stored in ASN is open to all users through the relative interfaces. Every specialist keeps contact with their user s relying on collaborative platform implements CSCW (computer support collaborat ive work) that integrated product/process design and development. The lack of gl obal communication in product development process can be prevented in the most d egree. The key technologies that exist in the asynchronous and synchronous coupling pro duct develop approach include: integrated development structure, orderly organiz ation of information, transparent management of process, agile transfer of infor mation and rapid prototype. The development process can be completed quickly by these technologies. The technologies involve wide content. In this paper, we dis cuss some key technologies. We validate the approach by the projectrapid response manufacturing a pplication in the distributed environment. The expensive device, high technology and low using lead to RE (Rapid engineering) and RP (Rapid prototype) service a pplication by the network. RE and RP develop rapidly due to the accelerated prod uct development process. RE and RP application service platform is built in the project.展开更多
基金express their gratitude to the Higher Institution Centre of Excellence (HICoE) fund under the project code (JPT.S(BPKI)2000/016/018/015JId.4(21)/2022002HICOE)Universiti Tenaga Nasional (UNITEN) for funding the research through the (J510050002–IC–6 BOLDREFRESH2025)Akaun Amanah Industri Bekalan Elektrik (AAIBE) Chair of Renewable Energy grant,and NEC Energy Transition Grant (202203003ETG)。
文摘With the projected global surge in hydrogen demand, driven by increasing applications and the imperative for low-emission hydrogen, the integration of machine learning(ML) across the hydrogen energy value chain is a compelling avenue. This review uniquely focuses on harnessing the synergy between ML and computational modeling(CM) or optimization tools, as well as integrating multiple ML techniques with CM, for the synthesis of diverse hydrogen evolution reaction(HER) catalysts and various hydrogen production processes(HPPs). Furthermore, this review addresses a notable gap in the literature by offering insights, analyzing challenges, and identifying research prospects and opportunities for sustainable hydrogen production. While the literature reflects a promising landscape for ML applications in hydrogen energy domains, transitioning AI-based algorithms from controlled environments to real-world applications poses significant challenges. Hence, this comprehensive review delves into the technical,practical, and ethical considerations associated with the application of ML in HER catalyst development and HPP optimization. Overall, this review provides guidance for unlocking the transformative potential of ML in enhancing prediction efficiency and sustainability in the hydrogen production sector.
文摘Offshore carbon dioxide(CO_(2)) geological storage(OCGS) represents a significant strategy for addressing climate change by curtailing greenhouse gas emissions. Nonetheless, the risk of CO_(2) leakage poses a substantial concern associated with this technology. This study introduces an innovative approach for establishing OCGS leakage scenarios, involving four pivotal stages, namely, interactive matrix establishment, risk matrix evaluation, cause–effect analysis, and scenario development, which has been implemented in the Pearl River Estuary Basin in China. The initial phase encompassed the establishment of an interaction matrix for OCGS systems based on features, events, and processes. Subsequent risk matrix evaluation and cause–effect analysis identified key system components, specifically CO_(2) injection and faults/features. Building upon this analysis, two leakage risk scenarios were successfully developed, accompanied by the corresponding mitigation measures. In addition, this study introduces the application of scenario development to risk assessment, including scenario numerical simulation and quantitative assessment. Overall, this research positively contributes to the sustainable development and safe operation of OCGS projects and holds potential for further refinement and broader application to diverse geographical environments and project requirements. This comprehensive study provides valuable insights into the establishment of OCGS leakage scenarios and demonstrates their practical application to risk assessment, laying the foundation for promoting the sustainable development and safe operation of ocean CO_(2) geological storage projects while proposing possibilities for future improvements and broader applications to different contexts.
文摘Software Development Life Cycle (SDLC) is one of the major ingredients for the development of efficient software systems within a time frame and low-cost involvement. From the literature, it is evident that there are various kinds of process models that are used by the software industries for the development of small, medium and long-term software projects, but many of them do not cover risk management. It is quite obvious that the improper selection of the software development process model leads to failure of the software products as it is time bound activity. In the present work, a new software development process model is proposed which covers the risks at any stage of the development of the software product. The model is named a Hemant-Vipin (HV) process model and may be helpful for the software industries for development of the efficient software products and timely delivery at the end of the client. The efficiency of the HV process model is observed by considering various kinds of factors like requirement clarity, user feedback, change agility, predictability, risk identification, practical implementation, customer satisfaction, incremental development, use of ready-made components, quick design, resource organization and many more and found through a case study that the presented approach covers many of parameters in comparison of the existing process models. .
文摘Based on the analysis of the development process system status of domestic and foreign civil aircraft airborne system suppliers,this paper proposes the overall construction idea of"a set of civil aircraft process system"based on IPD(Integrated product development)in the organization.The development stage,process,activity and task are the logical framework elements of the system construction."Based on process decomposition,vertical stratification,horizontal segmentation,combination of special and common,process customized to tools,role and process integration,giving full consideration to the interface between supplier management and process modules"etc.are the concrete ideas.Moreover,formulate top⁃level system construction standards,implemented by process system management tool platform,so that the process system and development work can be effectively integrated to effectively guide the development work of airborne system suppliers,and meet the quality and airworthiness requirements of civil aircraft development.Through the development application of a certain type of flight control system,the process system and tool platform were verified and optimized in practice.
文摘Objective To identify the critical risks in the process of innovative drug research and development,and to provide reference for improving the efficiency of innovative drug development and risk control in China.Methods Expert investigation and analytic hierarchy process were used to determine the weights of different risks.Results and Conclusion The research and analysis results showed that the risks at different stages of development had different effects on the success rate of drug development,among which the risk at the drug discovery stage influenced the most.In the drug discovery stage,inappropriate target selection had the greatest impact on the success rate of drug development.The lack of appropriate cell tissue or animal models had the greatest impact on the success rate of drug development from the discovery of a compound to the application for clinical trials.The difference in changes between nonclinical and clinical studies had the greatest impact on the success rate of drug development from early clinical studies to pivotal clinical studies.Incorrect dose selection had the greatest impact on the success rate of drug development from pivotal clinical studies to marketing authorization applications.The biggest impact from the marketing authorization application to the approval stage was inadequate communication with regulators.After investigating the weight of risk factors in the process of innovative drug development based on scientific methods,a new perspective for the risk control of new drug development and improving the research and development efficiency is provided.
文摘Machine Translation are increasingly welcomed and used during recent years with the commonly application of Internet and the acceleration of the integration of world economy. To know about the history and development process of Machine Translation during 1930s-1970 s could help researchers gain new insights through restudying old material.
基金the National Natural Science foundation of China! (59995440)
文摘This paper reviewed the trend and development of semi-solid metal technique. The processes and mechanisms for producing slurry of SSM and its industrial applications have been summarized and discussed. Discussions on the basic rheological theory are presented for more applications. Further consideration of the development and application of SSM technique is also proposed.
文摘he design verification steps that take place in today’s automotive industry, which constitute the values of each successive or simultaneous phase in the new product development process, create a complex structure with the inclusion of each new technology and discipline. Therefore, step by step, each design verification phase definition in the flow contains important phase transition measurements or approval tolerances that ensure the simplicity and continuity of vehicle development processes. In addition, classification of design verification stages within the framework of this study or evaluation in two classes (static and dynamic) is a new approach, but it is a synthesis with the analysis of the new product development process. The vehicle’s basic structure, which constitutes the ergonomic and functional requirements of the vehicle in a static environment, takes into account the dynamic environment variables with crash or accident tests. Increasing new technology adaptations in the automotive industry have changed the new product development process that performs this function structurally and created the concept of design verification under consecutive or simultaneous process simplicity. From the autonomous driving to the use of alternative energy, possible accident scenarios and design verification phase transitions in the integration of parts and systems of the newly developed vehicle create a new structure that models and directs the lean product development process especially in the automotive industry in the coming days. In the lean product development process that takes place in the automotive industry, the design verification transition steps or the approval-control analysis of the development stages, which form a new and effective approach, are re-modeling the entire flow. Therefore, successful execution of design verification steps used in the control of new interdisciplinary product development phase transitions provides value creation.?Within the scope of this study, the effectiveness of the static and dynamic design verification steps, which are carried out in 5 global automotive companies included in the research, which constitute the stage transitions of the new product development process, has been measured. Apart from the design verification transition stages, the process variables that differ among the automotive companies involved in the research are excluded from the scope of this study. In other words, in field researches in the automotive industry, new vehicle design steps or basic engineering steps in the new product development process steps, while creating independent fixed variables, interdisciplinary collaborations, static and dynamic design verification transition stages they perform, or their sequence in the basic flow, is accepted as a dependent variable. Therefore, in the study, the positive effect of the automotive companies that included the static and dynamic design verification phase transition approvals in the lean product development process was investigated. Under the comparative analysis structure of the research, the effect of automotive companies, which accept international vehicle specifications as static design verification input, on market performance has been examined in depth. The detailed depth in the comparison analysis conducted under the second field studies of the study is due to the prediction of dynamic design verification stages to provide a high impact on the market performance, according to the static verification analysis. The new product development stages of the dependent variables were fixed and the flow-oriented?“effect”?of the independent variables in the basic process influenced by the design verification activities was analyzed under the new automotive industry company comparisons. In addition, the impact of the automotive design activities that make up the comparison analysis of the research on the scope of the lean product development stage and its effect on the basic process flow has been demonstrated competition-oriented. Therefore, sub-variables, options, criteria, results, which form a defined comparison problem, create basic test values that affect the problem.
文摘The next generation of advanced light sources requires photons with large average flux and high brightness,which needs advanced electron gun matched with excellent photocathode materials. K_2CsSb photocathode has the advantages of high quantum efficiency, long lifetime and instantaneous response. This study introduces the design of a set of K_2CsSb photocathode preparation systems and detailed preparation process of K_2CsSb photocathodes, including sequential deposition process and co-deposition process, and finally develops a K_2CsSb photocathode. The influence of laser power on the quantum efficiency is also investigated.
基金Supported by Special Project for Research,Development,Demonstration and Extension of Applied Technology in Hainan Province(ZDXM2014101)
文摘Hainan's betel nut processing industry continues to develop,and the yield has reached 231000 t. There are some problems in betel nut industry such as unreasonable initial processing layout,processing capacity surplus,and deep processing industry lag. It is suggested that we should guide the initial processing layout of betel nut according to local conditions,and carry out overall deep processing planning of betel nut; support betel nut deep processing plant in the main producing areas,establish betel nut initial processing and deep processing serial production line,and develop new betel nut product; build betel nut production,processing,transport and marketing information database and market information early warning mechanism,and improve betel nut processing information service platform to timely provide information services and continuously develop betel nut industry.
文摘The development and delivery of high quality therapeutic products necessitates the need for highthrough-put (HTP) process development tools. Traditionally, these works requires a combination of shake flask and small-scale stirred tank bioreactor (STR) which are labor and resource intensive and time-consuming. Here we demonstrate a strategy for rapid and robust cell culture process development by evaluating and implementing the use of a new HTP disposable micro bioreactor (MBR) called AMBRTM system (Advanced Microscale Bioreactor) that has the capabilities for automated sampling, feed addition, pH, dissolved oxygen (DO), gassing and agitation controls. In these studies the performance of two monoclonal antibody (MAb) producing cell lines (MAb1 and MAb2) was evaluated both in the AMBR system and 3-L STR. We demonstrated that cell culture performance (growth and viability, production titer and product quality) were similar in both vessel systems. Furthermore, process control and feed optimization were demonstrated in an additional cell line (MAb3) in the disposable MBR and its performance confirmed at STR scale. The results indicate that the AMBR system can be used to streamline the process development effort and facilitate a rapid and robust cell culture process development effort for MAb programs in a HTP manner.
基金the Basic Research Program of the Korea Science & Engineering Foundation (KoSEF, No. R01-2006-000-10786-0).
文摘This article presents a multiscale simulation approach starting at the molecular level for the adsorption process development. A grand canonical Monte Carlo method is used for the prediction of adsorption isotherms of methanol on an activated carbon at the molecular level. The adsorption isotherms obtained in the linear region (or adsorption constant) are exploited as a model parameter required for the adsorption process simulation. The adsorption process model described by a set of partial differential equations (PDEs) is solved by using the conservation element and solution element method, which produces a fast and an accurate numerical solution to PDEs. The simulation results obtained from the adsorption constant estimated at the molecular level are in good agreement with the experimental results of the pulse response. The systematical multiscale simulation approach addressed in this study may be useful to accelerate the adsorption process development by reducing the number of experiments.
文摘Mechatronic product development is a complex and multidisciplinary field that encompasses various domains, including, among others, mechanical engineering, electrical engineering, control theory and software engineering. The integration of artificial intelligence technologies is revolutionizing this domain, offering opportunities to enhance design processes, optimize performance, and leverage vast amounts of knowledge. However, human expertise remains essential in contextualizing information, considering trade-offs, and ensuring ethical and societal implications are taken into account. This paper therefore explores the existing literature regarding the application of artificial intelligence as a comprehensive database, decision support system, and modeling tool in mechatronic product development. It analyzes the benefits of artificial intelligence in enabling domain linking, replacing human expert knowledge, improving prediction quality, and enhancing intelligent control systems. For this purpose, a consideration of the V-cycle takes place, a standard in mechatronic product development. Along this, an initial assessment of the AI potential is shown and important categories of AI support are formed. This is followed by an examination of the literature with regard to these aspects. As a result, the integration of artificial intelligence in mechatronic product development opens new possibilities and transforms the way innovative mechatronic systems are conceived, designed, and deployed. However, the approaches are only taking place selectively, and a holistic view of the development processes and the potential for robust and context-sensitive artificial intelligence along them is still needed.
文摘The IEC 61131-3 standard defines a model and a set of programming languages for the development of industrial automation software. It is widely accepted by industry and most of the commercial tool vendors advertise compliance with it. On the other side, Model Driven Development (MDD) has been proved as a quite successful paradigm in general-purpose computing. This was the motivation for exploiting the benefits of MDD in the industrial automation domain. With the emerging IEC 61131 specification that defines an object-oriented (OO) extension to the function block model, there will be a push to the industry to better exploit the benefits of MDD in automation systems development. This work discusses possible alternatives to integrate the current but also the emerging specification of IEC 61131 in the model driven development process of automation systems. IEC 61499, UML and SysML are considered as possible alternatives to allow the developer to work in higher layers of abstraction than the one supported by IEC 61131 and to more effectively move from requirement specifications into the implementation model of the system.
文摘In Kiruna,nearly all the residents support the migration plan in order to make LKAB able to continue the mining process.Based on current condition,a larger part of this town will be demolished by the sinking land caused by iron ore mining processing operated by LKAB.Since then,most of the buildings in the sinking district will be relocated in another district.However,the situation in Kiruna is not quite the same as when this kind of migration happens in another place.In other place,while migration happens,even if not most,a large part of the local residents will resist and fight for their house and properties.Concentrated on the ownership of different buildings and tried find the relationship between the public and private buildings to discover some issue that will help to work on the computational urban design.
基金“Promoting research by writing”:Exploring the code of writing,supported by the Special Fund for basic scientific research of the Central University,Northwestern Polytechnical University(project no.KCJS23WT25).“Research on the construction of the linking-up curriculum system:Taking the industry characteristic research university as an example”was established by the Ministry of Education’s Youth Fund for Humanities and Social Sciences,the Department of Social Sciences of the Ministry of Education(project no.23YJC880099).
文摘The development of women’s higher education in China can be divided into four stages:emergence(1908-1948);foundation(1949-1976);accelerating development(1977-2008);and the qualitative leap(2009-2020).This work considers the principal institutional mechanisms that contributed to this development.First,flexibly planned parenthood gradually promoted gender equality and openness in society facilitated by systematic“awards,grants,and loans”initiatives to support women’s higher education economically.Second,compulsory education ensured that left-out and migrant children had access to higher education.Third,effective connectivity across different education types bridged education gaps between those with different levels of education.Fourth,China made great efforts to invite and integrate international experiences that promoted the development of women’s higher education.Looking beyond these achievements,we also discuss the future trends of women’s higher education in China.
文摘Product development process management plays an important role in concurrent engineering (CE). The integration platform is a useful tool for effectively supporting the software development and integration. Based on the analysis of practical requirements for product development process management for CE, a CORBA-based integration platform of product development process management (IP-PDPM) is designed and developed. The design principles for IP-PDPM are described. The system architecture and functions of the platform are given, the key technologies for the implementation of IP-PDPM are presented, the application integration mechanism and its implementation techniques are also detailed.
基金Supported by Preparation Project of Science Popularization Materials for Publicity and Education of Soil Environmental Protection,Ministry of Environmental Protection(H201606)
文摘In this paper,the development process of the construction of soil environmental quality standards in China is reviewed,and the construction situation of soil environmental quality standards in typical developed countries is introduced.According to characteristics of soil environment and practice of soil environment management in China,the relevant suggestions are discussed,thereby further perfecting construction work of soil environmental quality standards in China.
基金Supported by Special Project for Guangxi Science and Technology Bases and Talent(GK AD16380088,GK AD17195040)Key Research and Development Plan of Guangxi(GK AB18221070)+1 种基金Major Science and Technology Project of Guangxi(GK AA17202029,G AA17204058-19,G AA17204058-20)Project of Guangxi Academy of Agricultural Sciences(2015YT87,2018YT29,2018YM05)
文摘Longtan pearl plum, as a new dominant fruit industry in Guangxi, has developed rapidly in recent years and become one of the major economic sources of fruit growers in Guangxi. It has a positive effect on promoting economic development and helping farmers to get out of poverty in Guangxi. But there is almost nothing to do with the processing and utilization. Taking the route of processing and utilization is an inevitable trend of development of Longtan pearl plum industry with the increase of the planting area and yield year by year. In this paper, based on the analysis of edible value of Longtan pearl plum, the development direction of processing and utilization of Longtan pearl plum was expounded, and some suggestions on the problems existing in the processing and utilization were put forward to provide reference for the processing and utilization of Longtan pearl plum.
文摘Today the cycle time of the product develop is requ ir ed to be shortened. At the same time the requirement of the customers becomes mo re and more diverse and complex. The capability of the develop unit is limited b ecause of the existence of heterogeneous systems and distributed environments. I n this paper, we bring forward a new approach to solve the problem in product de velopment process. We also settle part key technologies in it. A great deal of information from all kinds of sources in the distributed develop ment process is interweaved. The solution to organize the workflow and manage th e information in the process is called for anxiously. We use a new approach that is asynchronous and synchronous coupling product development approach based on the network. The approach extends the develop process from the time axis. Then t he activities in the process are organized from the asynchronous and synchronous aspects. The state of every activity projects at the ASN (active semantic netwo rk). The ASN includes decision system, intelligent agent, user interface and net work. The ASN decides the types and states of the activities and deals with the couple relationship among them. The knowledge stored in ASN is open to all users through the relative interfaces. Every specialist keeps contact with their user s relying on collaborative platform implements CSCW (computer support collaborat ive work) that integrated product/process design and development. The lack of gl obal communication in product development process can be prevented in the most d egree. The key technologies that exist in the asynchronous and synchronous coupling pro duct develop approach include: integrated development structure, orderly organiz ation of information, transparent management of process, agile transfer of infor mation and rapid prototype. The development process can be completed quickly by these technologies. The technologies involve wide content. In this paper, we dis cuss some key technologies. We validate the approach by the projectrapid response manufacturing a pplication in the distributed environment. The expensive device, high technology and low using lead to RE (Rapid engineering) and RP (Rapid prototype) service a pplication by the network. RE and RP develop rapidly due to the accelerated prod uct development process. RE and RP application service platform is built in the project.