Brain-derived neurotrophic factor(BDNF), which regulates neuronal survival, growth differentiation, and synapse formation, is known to be associated with depression and post-traumatic stress disorder(PTSD). However, t...Brain-derived neurotrophic factor(BDNF), which regulates neuronal survival, growth differentiation, and synapse formation, is known to be associated with depression and post-traumatic stress disorder(PTSD). However, the molecular mechanism for those mental disorders remains unknown. Studies have shown that BDNF is associated with PTSD risk and exaggerated startle reaction(a major arousal manifestation of PTSD) in United States military service members who were deployed during the wars in Iraq and Afghanistan. The frequency of the Met/Met in BDNF gene was greater among those with PTSD than those without PTSD. Among individuals who experienced fewer lifetime stressful events, the Met carriers have significantly higher total and startle scores on the PTSD Checklist than the Val/Val carriers. In addition, subjects with PTSD showed higher levels of BDNF in their peripheral blood plasma than the non-probable-PTSD controls. Increased BDNF levels and startle response were observed in both blood plasma and brain hippocampus by inescapable tail shock in rats. In this paper, we reviewed these data to discuss BDNF as a potential biomarker for PTSD risk and its possible roles in the onset of PTSD.展开更多
Post-stroke depression is associated with reduced expression of brain-derived neurotrophic factor （BDNF）. In this study, we evaluated whether BDNF overexpression affects depression-like behavior in a rat model of po...Post-stroke depression is associated with reduced expression of brain-derived neurotrophic factor （BDNF）. In this study, we evaluated whether BDNF overexpression affects depression-like behavior in a rat model of post-stroke depression. The middle cerebral artery was occluded to produce a model of focal cerebral ischemia. These rats were then subjected to isolation-housing combined with chronic unpredictable mild stress to generate a model of post-stroke depression. A BDNF gene lentiviral vector was injected into the hippocampus. At 7 days after injection, western blot assay and real-time quantitative PCR revealed that BDNF expression in the hippo- campus was increased in depressive rats injected with BDNF lentivirus compared with depressive rats injected with control vector. Furthermore, sucrose solution consumption was higher, and horizontal and vertical movement scores were increased in the open field test in these rats as well. These findings suggest that BDNF overexpression in the hippocampus of post-stroke depressive rats alleviates depression-like behaviors.展开更多
In the regulation of human nervous system, cognitive function and other genes, epigenetics changes the expression of genes after being influenced by the external environment. DNA methylation levels are also different ...In the regulation of human nervous system, cognitive function and other genes, epigenetics changes the expression of genes after being influenced by the external environment. DNA methylation levels are also different in different ethnic groups, and a large number of studies have shown that post-traumatic stress disorder (PTSD) has a certain genetic predisposition. Through the national differences of PTSD brain-derived neurotrophic factor genes, it not only provides new research directions for the pathogenesis and treatment of 5-HT-related mental diseases, but also provides information and new genetic indicators for forensic personal identification, paternity testing and assessment of mental status. A review studies on the national differences of brain-derived neurotrophic factor genes in patients with post-traumatic stress disorder.展开更多
<b>Objective:</b> To explore the pathogenesis of PTSD in the brain-derived neurotrophic factor (BDNF) gene methylation of patients with posttraumatic stress disorder (Posttraumatic Stress Disorder, PTSD) i...<b>Objective:</b> To explore the pathogenesis of PTSD in the brain-derived neurotrophic factor (BDNF) gene methylation of patients with posttraumatic stress disorder (Posttraumatic Stress Disorder, PTSD) in Hainan Province, the relationship between the influence of BDNF gene methylation and the influence of PTSD. <b>Methods:</b> A case-control study method was adopted, strictly in accordance with DSM-IV and PTSD diagnosis, and 150 Li PTSD patients matched with gender and age of 300 Han PTSD patients were selected as the research objects. The peripheral venous whole blood of the subjects was drawn, genomic DNA was extracted, modified with bisulfite, and directly sequenced to quantitatively detect the methylation status of the CpG island in the promoter region of brain-derived neurotrophic factor (BDNF). <b>Results:</b> The results showed that the methylation levels of CPGl, CPG2, CPG3, CPG4, CPG5, CPG6, CPG7, CPG9, CPGl2, CPGl3, CPGl4, CPGl5, CPGl6, CPGl7, and CPGl8 in THE BDNF promoter were significantly different between the HAN PTSD group and the Li PTSD group (<i>P</i> < 0.001). <b>Conclusion:</b> It is suggested that CPG methylation in the promoter region of BDNF gene is closely related to patients with PTSD. There is a statistical difference in the level of CpG methylation in the promoter region of BDNF gene in PTSD between Li and Han ethnic groups in Hainan Province. CpG methylation in the promoter region of BDNF gene may be used as a biomarker for the diagnosis of PTSD.展开更多
There are four deposit types related to a Permian mafic complex in northern Xinjiang, i.e., copper-nickel sulfide deposit, vanadic titanomagnetite deposit, magnetite （-cobalt） deposit and Cu-Ni- VTiFe composite depo...There are four deposit types related to a Permian mafic complex in northern Xinjiang, i.e., copper-nickel sulfide deposit, vanadic titanomagnetite deposit, magnetite （-cobalt） deposit and Cu-Ni- VTiFe composite deposit. The deposits are distributed spanning tectonic units with close and consecutive metallogenic ages. A transitional deposit type can occur among the end-member deposits. Trace elements of host rocks show that they can derive from similar source area. Hence, they constitute a particular metallogenic series related to a mafic-ultramafic complex that is also a symbol series of the post-collisional stage of the Central Asia Metallogenic Province （CAMP）. The metallogenic ages of the series are between 260 Ma and 300 Ma throughout the Permian. Unlike mineralization from a mantle plume, the metallogenic period of this series spans at least 40 Ma. Compared with related deposits of the Emeishan mantle plume, the North Xinjiang series has a similar ore-forming element assemblage but has preferably developed Cu-Ni sulfide deposits rather than vanadic titanomagnetite deposits. In concomitance with this series, North Xinjiang area has developed a set of syntectonic Au-Cu-Mo metallogenic series related to a felsic volcanic-intrusive complex, which might indicate that there is no direct relationship with mantle plume activity. From early to late, i.e., the sequence of copper-nickel sulfide to magnetite （-cobalt） to vanadic titanomagnetite deposit, the host rock series evolves from mafic-ultramafic and tholeiite series to mafic and alkalic series, the ~REE content tends to increase with increasing of REE fractionation, and some of the trace elements （particularly LIL） also show an increasing tendency. The above evolutionary regularity possibly reflects a course where the magma source deepens and thermal interface moves down, energy gradually exhausts, and neo-continental crust forming in the postcollision stage tends to stabilize.展开更多
基金Supported by Center for the Study of Traumatic Stress,Department of Psychiatry,Uniformed Services University of the Health Sciences
文摘Brain-derived neurotrophic factor(BDNF), which regulates neuronal survival, growth differentiation, and synapse formation, is known to be associated with depression and post-traumatic stress disorder(PTSD). However, the molecular mechanism for those mental disorders remains unknown. Studies have shown that BDNF is associated with PTSD risk and exaggerated startle reaction(a major arousal manifestation of PTSD) in United States military service members who were deployed during the wars in Iraq and Afghanistan. The frequency of the Met/Met in BDNF gene was greater among those with PTSD than those without PTSD. Among individuals who experienced fewer lifetime stressful events, the Met carriers have significantly higher total and startle scores on the PTSD Checklist than the Val/Val carriers. In addition, subjects with PTSD showed higher levels of BDNF in their peripheral blood plasma than the non-probable-PTSD controls. Increased BDNF levels and startle response were observed in both blood plasma and brain hippocampus by inescapable tail shock in rats. In this paper, we reviewed these data to discuss BDNF as a potential biomarker for PTSD risk and its possible roles in the onset of PTSD.
基金supported by a grant from the Experimental Animal Science and Technology Project of Zhejiang Province in China,No.2012C37083
文摘Post-stroke depression is associated with reduced expression of brain-derived neurotrophic factor （BDNF）. In this study, we evaluated whether BDNF overexpression affects depression-like behavior in a rat model of post-stroke depression. The middle cerebral artery was occluded to produce a model of focal cerebral ischemia. These rats were then subjected to isolation-housing combined with chronic unpredictable mild stress to generate a model of post-stroke depression. A BDNF gene lentiviral vector was injected into the hippocampus. At 7 days after injection, western blot assay and real-time quantitative PCR revealed that BDNF expression in the hippo- campus was increased in depressive rats injected with BDNF lentivirus compared with depressive rats injected with control vector. Furthermore, sucrose solution consumption was higher, and horizontal and vertical movement scores were increased in the open field test in these rats as well. These findings suggest that BDNF overexpression in the hippocampus of post-stroke depressive rats alleviates depression-like behaviors.
文摘In the regulation of human nervous system, cognitive function and other genes, epigenetics changes the expression of genes after being influenced by the external environment. DNA methylation levels are also different in different ethnic groups, and a large number of studies have shown that post-traumatic stress disorder (PTSD) has a certain genetic predisposition. Through the national differences of PTSD brain-derived neurotrophic factor genes, it not only provides new research directions for the pathogenesis and treatment of 5-HT-related mental diseases, but also provides information and new genetic indicators for forensic personal identification, paternity testing and assessment of mental status. A review studies on the national differences of brain-derived neurotrophic factor genes in patients with post-traumatic stress disorder.
文摘<b>Objective:</b> To explore the pathogenesis of PTSD in the brain-derived neurotrophic factor (BDNF) gene methylation of patients with posttraumatic stress disorder (Posttraumatic Stress Disorder, PTSD) in Hainan Province, the relationship between the influence of BDNF gene methylation and the influence of PTSD. <b>Methods:</b> A case-control study method was adopted, strictly in accordance with DSM-IV and PTSD diagnosis, and 150 Li PTSD patients matched with gender and age of 300 Han PTSD patients were selected as the research objects. The peripheral venous whole blood of the subjects was drawn, genomic DNA was extracted, modified with bisulfite, and directly sequenced to quantitatively detect the methylation status of the CpG island in the promoter region of brain-derived neurotrophic factor (BDNF). <b>Results:</b> The results showed that the methylation levels of CPGl, CPG2, CPG3, CPG4, CPG5, CPG6, CPG7, CPG9, CPGl2, CPGl3, CPGl4, CPGl5, CPGl6, CPGl7, and CPGl8 in THE BDNF promoter were significantly different between the HAN PTSD group and the Li PTSD group (<i>P</i> < 0.001). <b>Conclusion:</b> It is suggested that CPG methylation in the promoter region of BDNF gene is closely related to patients with PTSD. There is a statistical difference in the level of CpG methylation in the promoter region of BDNF gene in PTSD between Li and Han ethnic groups in Hainan Province. CpG methylation in the promoter region of BDNF gene may be used as a biomarker for the diagnosis of PTSD.
文摘There are four deposit types related to a Permian mafic complex in northern Xinjiang, i.e., copper-nickel sulfide deposit, vanadic titanomagnetite deposit, magnetite （-cobalt） deposit and Cu-Ni- VTiFe composite deposit. The deposits are distributed spanning tectonic units with close and consecutive metallogenic ages. A transitional deposit type can occur among the end-member deposits. Trace elements of host rocks show that they can derive from similar source area. Hence, they constitute a particular metallogenic series related to a mafic-ultramafic complex that is also a symbol series of the post-collisional stage of the Central Asia Metallogenic Province （CAMP）. The metallogenic ages of the series are between 260 Ma and 300 Ma throughout the Permian. Unlike mineralization from a mantle plume, the metallogenic period of this series spans at least 40 Ma. Compared with related deposits of the Emeishan mantle plume, the North Xinjiang series has a similar ore-forming element assemblage but has preferably developed Cu-Ni sulfide deposits rather than vanadic titanomagnetite deposits. In concomitance with this series, North Xinjiang area has developed a set of syntectonic Au-Cu-Mo metallogenic series related to a felsic volcanic-intrusive complex, which might indicate that there is no direct relationship with mantle plume activity. From early to late, i.e., the sequence of copper-nickel sulfide to magnetite （-cobalt） to vanadic titanomagnetite deposit, the host rock series evolves from mafic-ultramafic and tholeiite series to mafic and alkalic series, the ~REE content tends to increase with increasing of REE fractionation, and some of the trace elements （particularly LIL） also show an increasing tendency. The above evolutionary regularity possibly reflects a course where the magma source deepens and thermal interface moves down, energy gradually exhausts, and neo-continental crust forming in the postcollision stage tends to stabilize.
