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POST-BUCKLING ANALYSIS AND STRUCTURE OPTIMIZATION OF INTEGRAL FUSELAGE PANEL SUBJECTED TO AXIAL COMPRESSION LOAD 被引量:3
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作者 孙为民 郭亮 +1 位作者 童明波 董登科 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI 2010年第4期281-287,共7页
Build-up panels for the commercial aircraft fuselage subjected to the axial compression load are studied by both experimental and theoretical methods.An integral panel is designed with the same overall size and weight... Build-up panels for the commercial aircraft fuselage subjected to the axial compression load are studied by both experimental and theoretical methods.An integral panel is designed with the same overall size and weight as the build-up structure,and finite element models(FEMs)of these two panels are established.Experimental results of build-up panels agree well with the FEM results with the nonliearity and the large deformation,so FEMs are validated.FEM calculation results of these two panels indicate that the failure mode of the integral panel is different from that of the build-up panel,and the failure load increases by 18.4% up to post-buckling.Furthermore,the integral structure is optimized by using the multi-island genetic algorithm and the sequential quadratic programming.Compared with the initial design,the optimal mass is reduced by 8.7% and the strength is unchanged. 展开更多
关键词 aircraft PANELS axial loads post-buckling structure optimization
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VARIATIONAL PRINCIPLES OF PERFORATED THIN PLATES AND FINITE ELEMENT METHOD FOR BUCKLING AND POST-BUCKLING ANALYSIS
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作者 Yang Xiao Cheng Changjun (Department of Mechanics,Lanzhou University,Lanzhou,730000) 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 1991年第2期147-156,共10页
On the basis of the general theory of perforated thin plates under large deflections, variational principles with deflection w and stress function F as variables are stated in detail.Based on these princi- ples,finite... On the basis of the general theory of perforated thin plates under large deflections, variational principles with deflection w and stress function F as variables are stated in detail.Based on these princi- ples,finite element method is established for analysing the buckling and post-buckling of perforated thin plates. It is found that the property of element is very complicated,owing to the multiple connexity of the region. 展开更多
关键词 variational principle finite element method perforated thin plate buckling and post-buckling analysis
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ON THE POST-BUCKLING ANALYSIS OF PLASTIC STRUCTURES UNDER IMPULSIVE LOADING 被引量:1
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作者 Ru Chongqing Wang Ren, Department of Mechanics, Peking University, Beijing, China 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 1990年第1期45-49,共5页
An analytical method is suggested to analyze the plastic post-buckling behavior under impulsive loading. The fundamental equation of motion of a cylindrical shell is taken as an example to explain the main concept and... An analytical method is suggested to analyze the plastic post-buckling behavior under impulsive loading. The fundamental equation of motion of a cylindrical shell is taken as an example to explain the main concept and procedure. The axial and the radial displacements are decoupled by an approximate scheme, so that only one non-linear equation for the radial buckling displacement is to be solved. By expanding it in terms of an amplitude measure as a time variable, we may get the post-buckling behavior in the form of a series solution. The post-buckling behavior of a rectangular plate used as a special case of cylindrical shell is discussed. 展开更多
关键词 plastic buckling dynamic post-buckling cylindrical shell
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A Simplified Model for Buckling and Post-Buckling Analysis of Cu Nanobeam Under Compression
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作者 Jiachen Guo Yunfei Xu +2 位作者 Zhenyu Jiang Xiaoyi Liu Yang Cai 《Computer Modeling in Engineering & Sciences》 SCIE EI 2020年第11期611-623,共13页
Both of Buckling and post-buckling are fundamental problems of geometric nonlinearity in solid mechanics.With the rapid development of nanotechnology in recent years,buckling behaviors in nanobeams receive more attent... Both of Buckling and post-buckling are fundamental problems of geometric nonlinearity in solid mechanics.With the rapid development of nanotechnology in recent years,buckling behaviors in nanobeams receive more attention due to its applications in sensors,actuators,transistors,probes,and resonators in nanoelectromechanical systems(NEMS)and biotechnology.In this work,buckling and post-buckling of copper nanobeam under uniaxial compression are investigated with theoretical analysis and atomistic simulations.Different cross sections are explored for the consideration of surface effects.To avoid complicated high order buckling modes,a stressbased simplified model is proposed to analyze the critical strain for buckling,maximum deflection,and nominal failure strain for post-buckling.Surface effects should be considered regarding critical buckling strain and the maximum post-buckling deflection.The critical strain increases with increasing nanobeam cross section,while themaximumdeflection increases with increasing loading strain but stays nearly the same for different cross sections,and the underlying mechanisms are revealed by our model.The maximum deflection is also influenced by surface effects.The nominal failure strains are captured by our simulations,and they are in good agreement with the simplified model.Our results can be used for helping design strain gauge sensors and nanodevices with self-detecting ability. 展开更多
关键词 Nanobeam BUCKLING post-buckling simplified model atomistic simulation
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AN IMPROVED ARC-LENGTH METHOD AND APPLICATION IN THE POST-BUCKLING ANALYSIS FOR COMPOSITE STRUCTURES
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作者 ZHU Ju-fen(朱菊芬) +1 位作者 CHU Xiao-ting(初晓婷) 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI 2002年第9期1081-1088,共8页
Based on the conventional arc-length method, an improved arc-length method with high-efficiency is proposed. The weighted modifications with respect to the variation of structural stiffness and extra-interpolation mod... Based on the conventional arc-length method, an improved arc-length method with high-efficiency is proposed. The weighted modifications with respect to the variation of structural stiffness and extra-interpolation modification by using the information of known equilibrium points are introduced to improve the incremental arc-length. An approximate expansion method for the accumulated and expected arc-length is used to ensure the convergence at given load levels in large range of applications. Numerical results show that the improved arc-length method has well adaptability and higher efficiency in the post-buckling analysis of plates and shells structures for tracing whole load-deflection path and obtaining the convergence values at any specified load levels. 展开更多
关键词 NONLINEAR finite element analysis arc-length method
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Nonlinear Bifurcation and Post-buckling Analysis of Cylindrical Composite Stiffened Laminates Based on Weak Form Quadrature Element Method
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作者 Xiang Ou Xiaohu Yao Run Zhang 《Acta Mechanica Solida Sinica》 SCIE EI CSCD 2023年第6期817-836,共20页
This paper presents a weak form quadrature element formulation in the analysis of nonlinear bifurcation and post-buckling of cylindrical composite stiffened laminates subjected to transverse loads.A total Lagrangian u... This paper presents a weak form quadrature element formulation in the analysis of nonlinear bifurcation and post-buckling of cylindrical composite stiffened laminates subjected to transverse loads.A total Lagrangian updating scheme is used in combination with arc-length method,and the branch-switching method is adopted to identify the whole post-buckling procedure of the laminates.The formulation of the shell model and beam model are based on the basic concept of Ahmad.The coincidence of discrete nodes and integration points in quadrature element endows it with compactness and conciseness in the nonlinear buckling analysis of the cylindrical stiffened laminates.Several numerical examples are firstly presented to verify the effectiveness and accuracy of present formulation.Parametric studies on the effects of the height-to-breadth ratio,lamination schemes,positions,distribution,number of the stiffeners on the bifurcation and post-buckling behavior are performed. 展开更多
关键词 Cylindrical composite stiffened laminates Weak form quadrature element formulation Nonlinear bifurcation bucking post-buckling analysis
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Research status and prospects of the fractal analysis of metal material surfaces and interfaces
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作者 Qinjin Dai Xuefeng Liu +2 位作者 Xin Ma Shaojie Tian Qinghe Cui 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS 2025年第1期20-38,共19页
As a mathematical analysis method,fractal analysis can be used to quantitatively describe irregular shapes with self-similar or self-affine properties.Fractal analysis has been used to characterize the shapes of metal... As a mathematical analysis method,fractal analysis can be used to quantitatively describe irregular shapes with self-similar or self-affine properties.Fractal analysis has been used to characterize the shapes of metal materials at various scales and dimensions.Conventional methods make it difficult to quantitatively describe the relationship between the regular characteristics and properties of metal material surfaces and interfaces.However,fractal analysis can be used to quantitatively describe the shape characteristics of metal materials and to establish the quantitative relationships between the shape characteristics and various properties of metal materials.From the perspective of two-dimensional planes and three-dimensional curved surfaces,this paper reviews the current research status of the fractal analysis of metal precipitate interfaces,metal grain boundary interfaces,metal-deposited film surfaces,metal fracture surfaces,metal machined surfaces,and metal wear surfaces.The relationship between the fractal dimensions and properties of metal material surfaces and interfaces is summarized.Starting from three perspectives of fractal analysis,namely,research scope,image acquisition methods,and calculation methods,this paper identifies the direction of research on fractal analysis of metal material surfaces and interfaces that need to be developed.It is believed that revealing the deep influence mechanism between the fractal dimensions and properties of metal material surfaces and interfaces will be the key research direction of the fractal analysis of metal materials in the future. 展开更多
关键词 metal material surfaces and interfaces fractal analysis fractal dimension HOMOGENEITY
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Multilevel analysis of the central-peripheral-target organ pathway:contributing to recovery after peripheral nerve injury
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作者 Xizi Song Ruixin Li +6 位作者 Xiaolei Chu Qi Li Ruihua Li Qingwen Li Kai-Yu Tong Xiaosong Gu Dong Ming 《Neural Regeneration Research》 SCIE CAS 2025年第10期2807-2822,共16页
Peripheral nerve injury is a common neurological condition that often leads to severe functional limitations and disabilities.Research on the pathogenesis of peripheral nerve injury has focused on pathological changes... Peripheral nerve injury is a common neurological condition that often leads to severe functional limitations and disabilities.Research on the pathogenesis of peripheral nerve injury has focused on pathological changes at individual injury sites,neglecting multilevel pathological analysis of the overall nervous system and target organs.This has led to restrictions on current therapeutic approaches.In this paper,we first summarize the potential mechanisms of peripheral nerve injury from a holistic perspective,covering the central nervous system,peripheral nervous system,and target organs.After peripheral nerve injury,the cortical plasticity of the brain is altered due to damage to and regeneration of peripheral nerves;changes such as neuronal apoptosis and axonal demyelination occur in the spinal cord.The nerve will undergo axonal regeneration,activation of Schwann cells,inflammatory response,and vascular system regeneration at the injury site.Corresponding damage to target organs can occur,including skeletal muscle atrophy and sensory receptor disruption.We then provide a brief review of the research advances in therapeutic approaches to peripheral nerve injury.The main current treatments are conducted passively and include physical factor rehabilitation,pharmacological treatments,cell-based therapies,and physical exercise.However,most treatments only partially address the problem and cannot complete the systematic recovery of the entire central nervous system-peripheral nervous system-target organ pathway.Therefore,we should further explore multilevel treatment options that produce effective,long-lasting results,perhaps requiring a combination of passive(traditional)and active(novel)treatment methods to stimulate rehabilitation at the central-peripheral-target organ levels to achieve better functional recovery. 展开更多
关键词 central nervous system central peripheral target organ multilevel pathological analysis nerve regeneration peripheral nerve injury peripheral nervous system target organs therapeutic approach
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Closed Solution for Initial Post-Buckling Behavior Analysis of a Composite Beam with Shear Deformation Effect
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作者 Yongping Yu Lihui Chen +2 位作者 Shaopeng Zheng Baihui Zeng Weipeng Sun 《Computer Modeling in Engineering & Sciences》 SCIE EI 2020年第4期185-200,共16页
This paper is focused on the post-buckling behavior of the fixed laminated composite beams with effects of axial compression force and the shear deformation.The analytical solutions are established for the original co... This paper is focused on the post-buckling behavior of the fixed laminated composite beams with effects of axial compression force and the shear deformation.The analytical solutions are established for the original control equations(that is not simplified)by applying the Maclaurin series expansion,Chebyshev polynomials,the harmonic balance method and the Newton’s method.The validity of the present method is verified via comparing the analytical approximate solutions with the numerical ones which are obtained by the shooting method.The present third analytical approximate solutions can give excellent agreement with the numerical solutions for a wide range of the deformation amplitudes.What’s more,the effect of shear deformation on the post-bucking configuration of the sandwich beam is also proposed.It can be found that the shear angle has a great influence on the post-buckling load of composite beams.Therefore,the model simplifying the shear formation term as small quantity is not accurate for the case of sandwich beam with soft core. 展开更多
关键词 Analytical solution post-buckling sandwich beam harmonic method
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An Analysis of the Post-buckling of Laminated Plates of Symmetric Cross-Ply
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作者 翁宗诒 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI 1995年第12期1221-1230,共10页
In this paper, general equations relating to the stability of laminated plates ofsymmetric cross-ply with initial imperfection factors are derived by using thevariational principle. Taking the deflection as the pertu... In this paper, general equations relating to the stability of laminated plates ofsymmetric cross-ply with initial imperfection factors are derived by using thevariational principle. Taking the deflection as the perturbation parameter, theequilibrium path of the post-buckling path of a simply supported rectangular plate isinvestigated with the perturbation method. An approximation expression and a typicalnumerical example are presented to manifest the post-buekling behavior of therectangular plate. 展开更多
关键词 post-buckling behavior perturbation method laminated plates.initial imperfection
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Analysis of nonlinear stability and post-buckling for Euler-type beam-column structure
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作者 朱媛媛 胡育佳 程昌钧 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI 2011年第6期719-728,共10页
Based on the assumption of finite deformation, the Hamilton variational principle is extended to a nonlinear elastic Euler-type beam-column structure located on a nonlinear elastic foundation. The corresponding three-... Based on the assumption of finite deformation, the Hamilton variational principle is extended to a nonlinear elastic Euler-type beam-column structure located on a nonlinear elastic foundation. The corresponding three-dimensional (3D) mathematical model for analyzing the nonlinear mechanical behaviors of structures is established, in which the effects of the rotation inertia and the nonlinearity of material and geometry are considered. As an application, the nonlinear stability and the post-buckling for a linear elastic beam with the equal cross-section located on an elastic foundation are analyzed. One end of the beam is fully fixed, and the other end is partially fixed and subjected to an axial force. A new numerical technique is proposed to calculate the trivial solution, bifurcation points, and bifurcation solutions by the shooting method and the Newton- Raphson iterative method. The first and second bifurcation points and the corresponding bifurcation solutions are calculated successfully. The effects of the foundation resistances and the inertia moments on the bifurcation points are considered. 展开更多
关键词 beam-column structure Hamilton variational principle nonlinear stability shooting method Newton-Raphson iterative method post-buckling
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LOCALIZED ANALYSIS OF THIN-WALLED STRUCTURE’S BUCKLING/INITIAL POST-BUCKLING AND ITS ACCURACY
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作者 Huang Baozong Yang Wencheng Shen Xiangfu (Northeast University of Technology) 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 1991年第2期162-168,共7页
A method of localization is proposed to lower the high order of equations in FEM calcula- tion for the stability of a complex thin-walled structure.The localized analysis enables us to obtain both the upper and lower ... A method of localization is proposed to lower the high order of equations in FEM calcula- tion for the stability of a complex thin-walled structure.The localized analysis enables us to obtain both the upper and lower limits for the bifurcating point in a whole linear elastic structural system,as well as an ap- proximate solution to asymptotic post-buckling problem.Some numerical examples are included. 展开更多
关键词 buckling of a thin-walled structure localized analysis upper and lower limits
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A Comparative Study on the Post-Buckling Behavior of Reinforced Thermoplastic Pipes(RTPs)Under External Pressure Considering Progressive Failure 被引量:1
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作者 DING Xin-dong WANG Shu-qing +1 位作者 LIU Wen-cheng YE Xiao-han 《China Ocean Engineering》 SCIE EI CSCD 2024年第2期233-246,共14页
The collapse pressure is a key parameter when RTPs are applied in harsh deep-water environments.To investigate the collapse of RTPs,numerical simulations and hydrostatic pressure tests are conducted.For the numerical ... The collapse pressure is a key parameter when RTPs are applied in harsh deep-water environments.To investigate the collapse of RTPs,numerical simulations and hydrostatic pressure tests are conducted.For the numerical simulations,the eigenvalue analysis and Riks analysis are combined,in which the Hashin failure criterion and fracture energy stiffness degradation model are used to simulate the progressive failure of composites,and the“infinite”boundary conditions are applied to eliminate the boundary effects.As for the hydrostatic pressure tests,RTP specimens were placed in a hydrostatic chamber after filled with water.It has been observed that the cross-section of the middle part collapses when it reaches the maximum pressure.The collapse pressure obtained from the numerical simulations agrees well with that in the experiment.Meanwhile,the applicability of NASA SP-8007 formula on the collapse pressure prediction was also discussed.It has a relatively greater difference because of the ignorance of the progressive failure of composites.For the parametric study,it is found that RTPs have much higher first-ply-failure pressure when the winding angles are between 50°and 70°.Besides,the effect of debonding and initial ovality,and the contribution of the liner and coating are also discussed. 展开更多
关键词 reinforced thermoplastic pipes post-buckling behavior progressive failure of composites DEBONDING initial ovality
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Screening biomarkers for spinal cord injury using weighted gene co-expression network analysis and machine learning 被引量:5
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作者 Xiaolu Li Ye Yang +3 位作者 Senming Xu Yuchang Gui Jianmin Chen Jianwen Xu 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第12期2723-2734,共12页
Immune changes and inflammatory responses have been identified as central events in the pathological process of spinal co rd injury.They can greatly affect nerve regeneration and functional recovery.However,there is s... Immune changes and inflammatory responses have been identified as central events in the pathological process of spinal co rd injury.They can greatly affect nerve regeneration and functional recovery.However,there is still limited understanding of the peripheral immune inflammato ry response in spinal cord inju ry.In this study.we obtained microRNA expression profiles from the peripheral blood of patients with spinal co rd injury using high-throughput sequencing.We also obtained the mRNA expression profile of spinal cord injury patients from the Gene Expression Omnibus(GEO)database(GSE151371).We identified 54 differentially expressed microRNAs and 1656 diffe rentially expressed genes using bioinformatics approaches.Functional enrichment analysis revealed that various common immune and inflammation-related signaling pathways,such as neutrophil extracellular trap formation pathway,T cell receptor signaling pathway,and nuclear factor-κB signal pathway,we re abnormally activated or inhibited in spinal cord inju ry patient samples.We applied an integrated strategy that combines weighted gene co-expression network analysis,LASSO logistic regression,and SVM-RFE algorithm and identified three biomarke rs associated with spinal cord injury:ANO10,BST1,and ZFP36L2.We verified the expression levels and diagnostic perfo rmance of these three genes in the original training dataset and clinical samples through the receiver operating characteristic curve.Quantitative polymerase chain reaction results showed that ANO20 and BST1 mRNA levels were increased and ZFP36L2 mRNA was decreased in the peripheral blood of spinal cord injury patients.We also constructed a small RNA-mRNA interaction network using Cytoscape.Additionally,we evaluated the proportion of 22 types of immune cells in the peripheral blood of spinal co rd injury patients using the CIBERSORT tool.The proportions of naive B cells,plasma cells,monocytes,and neutrophils were increased while the proportions of memory B cells,CD8^(+)T cells,resting natural killer cells,resting dendritic cells,and eosinophils were markedly decreased in spinal cord injury patients increased compared with healthy subjects,and ANO10,BST1 and ZFP26L2we re closely related to the proportion of certain immune cell types.The findings from this study provide new directions for the development of treatment strategies related to immune inflammation in spinal co rd inju ry and suggest that ANO10,BST2,and ZFP36L2 are potential biomarkers for spinal cord injury.The study was registe red in the Chinese Clinical Trial Registry(registration No.ChiCTR2200066985,December 12,2022). 展开更多
关键词 bioinformatics analysis BIOMARKER CIBERSORT GEO dataset LASSO miRNA-mRNA network RNA sequencing spinal cord injury SVM-RFE weighted gene co-expression network analysis
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Social-ecological perspective on the suicidal behaviour factors of early adolescents in China:a network analysis 被引量:4
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作者 Yuan Li Peiying Li +5 位作者 Mengyuan Yuan Yonghan Li Xueying Zhang Juan Chen Gengfu Wang Puyu Su 《General Psychiatry》 CSCD 2024年第1期143-150,共8页
Background In early adolescence,youth are highly prone to suicidal behaviours.Identifying modifiable risk factors during this critical phase is a priority to inform effective suicide prevention strategies.Aims To expl... Background In early adolescence,youth are highly prone to suicidal behaviours.Identifying modifiable risk factors during this critical phase is a priority to inform effective suicide prevention strategies.Aims To explore the risk and protective factors of suicidal behaviours(ie,suicidal ideation,plans and attempts)in early adolescence in China using a social-ecological perspective.Methods Using data from the cross-sectional project‘Healthy and Risky Behaviours Among Middle School Students in Anhui Province,China',stratified random cluster sampling was used to select 5724 middle school students who had completed self-report questionnaires in November 2020.Network analysis was employed to examine the correlates of suicidal ideation,plans and attempts at four levels,namely individual(sex,academic performance,serious physical llness/disability,history of self-harm,depression,impulsivity,sleep problems,resilience),family(family economic status,relationship with mother,relationship with father,family violence,childhood abuse,parental mental illness),school(relationship with teachers,relationship with classmates,school-bullying victimisation and perpetration)and social(social support,satisfaction with society).Results In total,37.9%,19.0%and 5.5%of the students reported suicidal ideation,plans and attempts in the past 6 months,respectively.The estimated network revealed that suicidal ideation,plans and attempts were collectively associated with a history of self-harm,sleep problems,childhood abuse,school bullying and victimisation.Centrality analysis indicated that the most influential nodes in the network were history of self-harm and childhood abuse.Notably,the network also showed unique correlates of suicidal ideation(sex,weight=0.60;impulsivity,weight=0.24;family violence,weight=0.17;relationship with teachers,weight=-0.03;school-bullying perpetration,weight=0.22),suicidal plans(social support,weight=-0.15)and suicidal attempts(relationship with mother,weight=-0.10;parental mental llness,weight=0.61).Conclusions This study identified the correlates of suicidal ideation,plans and attempts,and provided practical implications for suicide prevention for young adolescents in China.Firstly,this study highlighted the importance of joint interventions across multiple departments.Secondly,the common risk factors of suicidal ideation,plans and attempts were elucidated.Thirdly,this study proposed target interventions to address the unique influencing factors of suicidal ideation,plans and attempts. 展开更多
关键词 NETWORK analysis PREVENTION
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Advances in microfluidic-based DNA methylation analysis 被引量:1
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作者 Jiwen Li Tiechuan Li Xuexin Duan 《Nanotechnology and Precision Engineering》 EI CAS CSCD 2024年第1期116-134,共19页
DNA methylation has been extensively investigated in recent years,not least because of its known relationship with various diseases.Progress in analytical methods can greatly increase the relevance of DNA methylation ... DNA methylation has been extensively investigated in recent years,not least because of its known relationship with various diseases.Progress in analytical methods can greatly increase the relevance of DNA methylation studies to both clinical medicine and scientific research.Microflu-idic chips are excellent carriers for molecular analysis,and their use can provide improvements from multiple aspects.On-chip molecular analysis has received extensive attention owing to its advantages of portability,high throughput,low cost,and high efficiency.In recent years,the use of novel microfluidic chips for DNA methylation analysis has been widely reported and has shown obvious superiority to conventional methods.In this review,wefirst focus on DNA methylation and its applications.Then,we discuss advanced microfluidic-based methods for DNA methylation analysis and describe the great progress that has been made in recent years.Finally,we summarize the advantages that microfluidic technology brings to DNA methylation analysis and describe several challenges and perspectives for on-chip DNA methylation analysis.This review should help researchers improve their understanding and make progress in developing microfluidic-based methods for DNA methylation analysis. 展开更多
关键词 Microfluidic chip DNA methylation analysis Molecular analysis High throughput Low cost
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A Review on Sources,Extractions and Analysis Methods of a Sustainable Biomaterial:Tannins 被引量:2
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作者 Antonio Pizzi Marie-Pierre Laborie Zeki Candan 《Journal of Renewable Materials》 EI CAS 2024年第3期397-425,共29页
Condensed and hydrolysable tannins are non-toxic natural polyphenols that are a commercial commodity industrialized for tanning hides to obtain leather and for a growing number of other industrial applications mainly ... Condensed and hydrolysable tannins are non-toxic natural polyphenols that are a commercial commodity industrialized for tanning hides to obtain leather and for a growing number of other industrial applications mainly to substitute petroleum-based products.They are a definite class of sustainable materials of the forestry industry.They have been in operation for hundreds of years to manufacture leather and now for a growing number of applications in a variety of other industries,such as wood adhesives,metal coating,pharmaceutical/medical applications and several others.This review presents the main sources,either already or potentially commercial of this forestry by-materials,their industrial and laboratory extraction systems,their systems of analysis with their advantages and drawbacks,be these methods so simple to even appear primitive but nonetheless of proven effectiveness,or very modern and instrumental.It constitutes a basic but essential summary of what is necessary to know of these sustainable materials.In doing so,the review highlights some of the main challenges that remain to be addressed to deliver the quality and economics of tannin supply necessary to fulfill the industrial production requirements for some materials-based uses. 展开更多
关键词 TANNINS FLAVONOIDS SOURCES extraction methods analysis methods
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Telomerase-related advances in hepatocellular carcinoma:A bibliometric and visual analysis 被引量:2
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作者 Hai-Yang Li Lin-Lin Zheng +9 位作者 Nan Hu Zhi-Hao Wang Chang-Cheng Tao Ya-Ru Wang Yue Liu Zulihumaer Aizimuaji Hong-Wei Wang Rui-Qi Zheng Ting Xiao Wei-Qi Rong 《World Journal of Gastroenterology》 SCIE CAS 2024年第9期1224-1236,共13页
BACKGROUND As a critical early event in hepatocellular carcinogenesis,telomerase activation might be a promising and critical biomarker for hepatocellular carcinoma(HCC)patients,and its function in the genesis and tre... BACKGROUND As a critical early event in hepatocellular carcinogenesis,telomerase activation might be a promising and critical biomarker for hepatocellular carcinoma(HCC)patients,and its function in the genesis and treatment of HCC has gained much attention over the past two decades.AIM To perform a bibliometric analysis to systematically assess the current state of research on HCC-related telomerase.METHODS The Web of Science Core Collection and PubMed were systematically searched to retrieve publications pertaining to HCC/telomerase limited to“articles”and“reviews”published in English.A total of 873 relevant publications related to HCC and telomerase were identified.We employed the Bibliometrix package in R to extract and analyze the fundamental information of the publications,such as the trends in the publications,citation counts,most prolific or influential writers,and most popular journals;to screen for keywords occurring at high frequency;and to draw collaboration and cluster analysis charts on the basis of coauthorship and co-occurrences.VOSviewer was utilized to compile and visualize the bibliometric data.RESULTS A surge of 51 publications on HCC/telomerase research occurred in 2016,the most productive year from 1996 to 2023,accompanied by the peak citation count recorded in 2016.Up to December 2023,35226 citations were made to all publications,an average of 46.6 citations to each paper.The United States received the most citations(n=13531),followed by China(n=7427)and Japan(n=5754).In terms of national cooperation,China presented the highest centrality,its strongest bonds being to the United States and Japan.Among the 20 academic institutions with the most publications,ten came from China and the rest of Asia,though the University of Paris Cité,Public Assistance-Hospitals of Paris,and the National Institute of Health and Medical Research(INSERM)were the most prolific.As for individual contributions,Hisatomi H,Kaneko S,and Ide T were the three most prolific authors.Kaneko S ranked first by H-index,G-index,and overall publication count,while Zucman-Rossi J ranked first in citation count.The five most popular journals were the World Journal of Gastroenterology,Hepatology,Journal of Hepatology,Oncotarget,and Oncogene,while Nature Genetics,Hepatology,and Nature Reviews Disease Primers had the most citations.We extracted 2293 keywords from the publications,120 of which appeared more than ten times.The most frequent were HCC,telomerase and human telomerase reverse transcriptase(hTERT).Keywords such as mutational landscape,TERT promoter mutations,landscape,risk,and prognosis were among the most common issues in this field in the last three years and may be topics for research in the coming years.CONCLUSION Our bibliometric analysis provides a comprehensive overview of HCC/telomerase research and insights into promising upcoming research. 展开更多
关键词 TELOMERASE Bibliometric analysis Telomerase reverse transcriptase PROGNOSIS Treatment Hepatocellular carcinoma
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Micro segment analysis of supercritical methane thermal-hydraulic performance and pseudo-boiling in a PCHE straight channel 被引量:2
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作者 Qian Li Zi-Jie Lin +3 位作者 Liu Yang Yue Wang Yue Li Wei-Hua Cai 《Petroleum Science》 SCIE EI CAS CSCD 2024年第2期1275-1289,共15页
The printed circuit heat exchanger(PCHE) is receiving wide attention as a new kind of compact heat exchanger and is considered as a promising vaporizer in the LNG process. In this paper, a PCHE straight channel in the... The printed circuit heat exchanger(PCHE) is receiving wide attention as a new kind of compact heat exchanger and is considered as a promising vaporizer in the LNG process. In this paper, a PCHE straight channel in the length of 500 mm is established, with a semicircular cross section in a diameter of 1.2 mm.Numerical simulation is employed to investigate the flow and heat transfer performance of supercritical methane in the channel. The pseudo-boiling theory is adopted and the liquid-like, two-phase-like, and vapor-like regimes are divided for supercritical methane to analyze the heat transfer and flow features.The results are presented in micro segment to show the local convective heat transfer coefficient and pressure drop. It shows that the convective heat transfer coefficient in segments along the channel has a significant peak feature near the pseudo-critical point and a heat transfer deterioration when the average fluid temperature in the segment is higher than the pseudo-critical point. The reason is explained with the generation of vapor-like film near the channel wall that the peak feature related to a nucleateboiling-like state and heat transfer deterioration related to a film-boiling-like state. The effects of parameters, including mass flow rate, pressure, and wall heat flux on flow and heat transfer were analyzed.In calculating of the averaged heat transfer coefficient of the whole channel, the traditional method shows significant deviation and the micro segment weighted average method is adopted. The pressure drop can mainly be affected by the mass flux and pressure and little affected by the wall heat flux. The peak of the convective heat transfer coefficient can only form at high mass flux, low wall heat flux, and near critical pressure, in which condition the nucleate-boiling-like state is easier to appear. Moreover,heat transfer deterioration will always appear, since the supercritical flow will finally develop into a filmboiling-like state. So heat transfer deterioration should be taken seriously in the design and safe operation of vaporizer PCHE. The study of this work clarified the local heat transfer and flow feature of supercritical methane in microchannel and contributed to the deep understanding of supercritical methane flow of the vaporization process in PCHE. 展开更多
关键词 Printed circuit heat exchanger Vaporization Supercritical methane Pseudo-boiling Micro segment analysis
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The value of toxicological analysis in acute poisoning patients with uncertain exposure histories:a retrospective and descriptive study from an institute of poisoning 被引量:1
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作者 Qifang Shi Gen Ba +3 位作者 Zhenyu Xia Zhengsheng Mao Hao Sun Jinsong Zhang 《World Journal of Emergency Medicine》 SCIE CAS CSCD 2024年第2期98-104,共7页
BACKGROUND:In clinical practice,some patients might not be able or unwilling to provide a thorough history of medication and poison exposure.The aim of this study was to use toxicological analysis to examine the clini... BACKGROUND:In clinical practice,some patients might not be able or unwilling to provide a thorough history of medication and poison exposure.The aim of this study was to use toxicological analysis to examine the clinical characteristics of patients with acute poisoning whose exposure history was uncertain from a toxicological analysis perspective.METHODS:This was a retrospective and descriptive study from an institute of poisoning.Patient registration information and test reports spanning the period from April 1,2020 to March 31,2022,were obtained.Patients with uncertain exposure histories and who underwent toxicological analysis were included.Clinical manifestations and categories of toxics were analyzed.RESULTS:Among the 195 patients with positive toxicological analysis results,the main causes of uncertain exposure history was disturbance of consciousness(62.6%),unawareness(23.6%)and unwillingness or lack of cooperation(13.8%).The predominant clinical manifestations were disturbed consciousness(62.6%),followed by vomiting and nausea(14.4%)and liver function abnormalities(8.7%).A comparison of clinical manifestations between patients with positive and negative(n=99)toxicological analyses results revealed significantly different proportions of disturbances in consciousness(63%vs.21%),dizziness(1.5%vs.5.1%),multi-organ failure(1.5%vs.7.1%),and local pain(0 vs 4%).The main categories of substances involved were psychiatric medications(23.1%),sedatives(20.5%),insecticides(13.8%),and herbicides(12.8%).CONCLUSION:The clinical manifestations of acute poisoning in patients with an uncertain exposure history are diverse and nonspecific,and toxicological analysis plays a pivotal role in the diagnosis and differential diagnosis of such patients. 展开更多
关键词 Acute poisoning Toxic exposure Toxicological analysis Clinical manifestation
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