OBJECTIVE： To evaluate the effectiveness and safety of filiform needle acupuncture for poststroke depression, and to compare acupuncture with the therapeutic efficacy of antidepressant drugs. DATA RETRIEVAL： We retr...OBJECTIVE： To evaluate the effectiveness and safety of filiform needle acupuncture for poststroke depression, and to compare acupuncture with the therapeutic efficacy of antidepressant drugs. DATA RETRIEVAL： We retrieved data from the Chinese National Knowledge Infrastructure （1979-2012）, Wanfang （1980-2012）, VIP （1989-2012）, Chinese Biomedical Literature （1975- 2012）, PubMed （1966-2012）, Ovid Lww （-2012）, and Cochrane Library （-2012） Database using the internet. SELECTION CRITERIA： Randomized controlled trials on filiform needle acupuncture versus antidepressant drugs for treatment of poststroke depression were included. Moreover, the in- cluded articles scored at least 4 points on the Jadad scale. Exclusion criteria： other acupuncture therapies as treatment group, not stroke-induced depression patients, score 〈 4 points, non-ran- domized controlled trials, or animal trials. MAIN OUTCOME MEASURES： These were the Hamilton Depression Scale scores, clinical ef- fective rate, Self-Rating Depression Scale scores, Side Effect Rating Scale scores, and incidence of adverse reaction and events. RESULTS： A total of 17 randomized controlled clinical trials were included. Meta-analysis results displayed that after 4 weeks of treatment, clinical effective rate was better in patients treated with fill- form needle acupuncture than those treated with simple antidepressant drugs [relative risk = 1.11, 95% confidence interval （C/）： 1.03-1.21, P = 0.01]. At 6 weeks, clinical effective rate was similar between filiform needle acupuncture and antidepressant drug groups. At 2 weeks after filiform needle acupuncture, Hamilton Depression Scale （17 items） scores were lower than in the antide- pressant drug group （mean difference = -2.34, 95%CI： -3.46 to -1.22, P 〈 0.000,1）. At 4 weeks, Hamilton Depression Scale （24 items） scores were similar between filiform needle acupuncture and antidepressant drug groups. Self-Rating Depression Scale scores were lower in filiform needle acupuncture group than in the antidepressant drug group. Side Effect Rating Scale was used in only two articles, and no meta-analysis was conducted. Safety evaluation of the 17 arti- cles showed that gastrointestinal tract reactions such as nausea and vomiting were very common in the antidepressant drug group. Incidence of adverse reaction and events was very low in the filiform needle acupuncture group. CONCLUSION： Early filiform needle acupuncture for poststroke depression can perfectly con- trol depression. Filiform needle acupuncture is safe and reliable. Therapeutic effects of filiform needle acupuncture were better than those of antidepressant drugs.展开更多
[Objectives]To observe the clinical effect of Huatanjieyu granule on patients with post-stroke depression.[Methods]Total 76 patients with confirmed post-stroke depression were randomly divided into two groups(treatmen...[Objectives]To observe the clinical effect of Huatanjieyu granule on patients with post-stroke depression.[Methods]Total 76 patients with confirmed post-stroke depression were randomly divided into two groups(treatment group and control group)according to the double-blind principle.The treatment group(38 cases)was treated with Huatanjieyu granule combined with escitalopram,and the control group(38 cases)was treated with escitalopram alone.The course of treatment was 6 weeks.Through clinical efficacy,Hamilton Depression Scale(HAMD)and Treatment Emergent Symptom Scale(TESS)scores were compared,and blood,liver function,renal function and electrocardiogram were examined.[Results]The scores of HAMD and TESS in patients with post-stroke depression were significantly decreased by Huatanjieyu granule,and there were no obvious side effects.The total effective rate was 92.1%in the treatment group and 76.3%in the control group.There was significant difference between the two groups(P<0.01).[Conclusions]Huatanjieyu granule was effective in the treatment of post-stroke depression with little side effects and was easy to be accepted by patients.展开更多
Objective:In cardiovascular disease,a patient’s anxiety and depression can increase cardiac rehabilitation duration and recovery.Lavender aromatherapy as a non-pharmacological intervention effective in other contexts...Objective:In cardiovascular disease,a patient’s anxiety and depression can increase cardiac rehabilitation duration and recovery.Lavender aromatherapy as a non-pharmacological intervention effective in other contexts may be an efficient intervention to alleviating anxiety and depression in patients with Acute Coronary Syndrome(ACS).Methods:In this study,110 ACS patients were randomly assigned to two intervention and control groups.Inhalation of the lavender fragrance was prescribed for the intervention group and the drop of aromatic almond for the control group for 3 days.Results:The first-day anxiety and depression were significantly different in the two groups at 1 h and 9 h after the intervention.The’morning’s difference before the intervention was not significant,but it was substantial 1 h after the intervention.On the third morning of the intervention,this difference was confirmed.Conclusions:This study confirmed the effectiveness of lavender aromatherapy in reducing anxiety and depression in ACS patients.This’study’s results enable intensive care nurses to use aromatherapy with lavender oil as a non-pharmacological and cost-effective intervention to reduce their psychological tensions and increase patient satisfaction during hospitalization in the cardiac care units(CCU).展开更多
The patients with post-stroke depression often form a negative evaluation of themselves,and even have the idea of suicide in serious cases.Therefore,post-stroke depression has become one of the most common complicatio...The patients with post-stroke depression often form a negative evaluation of themselves,and even have the idea of suicide in serious cases.Therefore,post-stroke depression has become one of the most common complications of mental illness after stroke,which seriously hinders the normal rehabilitation of the central nervous system,thus increasing the disability rate,early recurrence rate and mortality rate of patients.Therefore,the active treatment of post-stroke depression is very necessary.Western medicine uses antidepressant drugs for this kind of patients,but because the side effects of antidepressants are relatively large,the compliance of patients is not good,it is not easy to see the effect,while traditional Chinese medicine(TCM)has many ways to deal with post-stroke depression with obvious advantages,the side effects are relatively small,and there is more compliance in patients.This paper focuses on several TCM treatment methods,hoping to provide a reference for the treatment of post-stroke depression.展开更多
Subthreshold depression is a highly prevalent condition in adolescents who are at high risk for developing major depressive disorder.In preclinical models of neurological and psychiatric diseases,Lycium barbarum polys...Subthreshold depression is a highly prevalent condition in adolescents who are at high risk for developing major depressive disorder.In preclinical models of neurological and psychiatric diseases,Lycium barbarum polysaccharide(LBP)extracted from Goji berries had antidepressant effects including but not limited to anti-oxidative and anti-inflammatory properties.However,the effect of LBP on subthreshold depression is unclear.To investigate the clinical efficacy and safety of LBP for treating subthreshold depression in adolescents,we conducted a randomized,double-blind,placebo-controlled trial(RCT)with 29 adolescents with subthreshold depression recruited at The Fifth Affiliated Hospital of Guangzhou Medical University.The participants were randomly assigned to groups where they received either 300 mg LBP(LBP group,n=15,3 boys and 12 girls aged 15.13±2.17 years)or a placebo(placebo group,n=14,2 boys and 12 girls aged 15±1.71 years)for 6 successive weeks.Interim analyses revealed that the LBP group exhibited a greater change in Hamilton Depression Scale(HAMD-24)scores relative to the baseline and a higher remission rate(HAMD-24 total score≤7)at 6 weeks compared with the placebo group.Scores on the Beck Depression Inventory-II(BDI-II),Pittsburgh Sleep Quality Index(PSQI),Kessler Psychological Distress Scale(Kessler),and Screen for Child Anxiety-Related Emotional Disorders(SCARED)were similar between the LBP and placebo groups.No side effects related to the intervention were reported in either group.These results indicate that LBP administration reduced depressive symptoms in adolescents with subthreshold depression.Furthermore,LBP was well tolerated with no treatment-limiting adverse events.Clinical trials involving a larger sample size are needed to further confirm the anti-depressive effects of LBP in adolescents with subthreshold depression.This study was approved by the Medical Ethics Committee of the Fifth Affiliated Hospital of Guangzhou Medical University(Guangzhou,China;approval No.L2019-08)on April 4,2019 and was registered on ClinicalTrials.gov(identifier:NCT04032795)on July 25,2019.展开更多
The management of post-stroke complications plays an important role in the quality of life.Di-Tan Decoction(DTD;涤痰汤)is a widely used traditional Chinese medicine.This study incorporated systematic review and meta-a...The management of post-stroke complications plays an important role in the quality of life.Di-Tan Decoction(DTD;涤痰汤)is a widely used traditional Chinese medicine.This study incorporated systematic review and meta-analysis to evaluate the efficacy of DTD in post-stroke neurological disorders.Randomized clinical trials(RCTs)were searched from English,Chinese and Korean electronic medical databases,by including the keywords"Di-Tan Tang","Di-Tan Decoction","Scour Phlegm Decoction","stroke",and"RCT.Each RCT included control(placebo,conventional therapy,or Western medicine)and experimental(DTD treatment)groups.For patients inflicted with stroke for 1-6 weeks,the outcomes of post-stroke neurological disorders were measured by scales for post-stroke symptoms and were classified as"completely healed","markedly effective","effective"and"ineffective".Totally,11 RCTs(n=490 controls and n=502 DTD subjects)were selected from 210 articles identified in the initial search.A metaanalysis of evaluation criteria in post-stroke symptoms revealed that the overall odds ratio(ORs)for alleviating post-stroke neurological disorders were 0.30-fold lower(95%CI=0.21-0.43)in the DTD group than the control(Western medicine)group(P<0.00001).Moreover,regardless of the type of stroke diagnostic scale applied(including NFA,HDS,and NIHSS),the overall post-stroke symptoms determined were less severe in the DTD group(n=219)than the control group(n=217).No adverse effects of DTD were observed in the 11 RCTs reviewed.All 11 studies used an appropriate method for randomization of subjects to evaluate the risk of bias(ROB),and 7 studies included allocation concealment as well as blinding of patients and practitioners.High-risk ROB was included in6 RCTs.No significant publication bias was derived from the funnel plot.Our results indicate that the administration of DTD alone,and DTD in combination with Western medicine,exert greater efficacy for post-stroke complication therapy,than Western medicine administered alone.More rigorous and regulated studies are required to confirm the therapeutic efficacy of DTD for post-stroke neurological disorders.disorders.展开更多
OBJECTIVE:To observe the effect of Tiaoshen Kaiqiao acupuncture in the treatment of ischemic post-stroke depression.METHODS:This research was a single-blind, positive-controlled trial done in a single entity.Totally58...OBJECTIVE:To observe the effect of Tiaoshen Kaiqiao acupuncture in the treatment of ischemic post-stroke depression.METHODS:This research was a single-blind, positive-controlled trial done in a single entity.Totally58 patients with ischemic post-stroke depression were randomly divided into two groups.The acupuncture group was given Tiaoshen Kaiqiao acupuncture therapy and placebo starch tablets treatment,while the control group was treated with fluoxetine tablets and body acupuncture treatment.Evaluated the clinical efficacy of the two groups with Hamilton Depression Scale(HAMD),Anti Depression Drug Side Effects Rating Scale(SERS), Clinical Global Impression Scale(CGI) respectively before treatment, the fourth weekend of treatment, the eighth weekend of treatment,the twelfth weekend of treatment.The adverse reactions in two groups were observed and documented.RESULTS:The HAMD scale scores of the two groups in different treatment period were significantly decreased compared with that before treatment(P < 0.05); the score reduction of HAMD scale between the two groups had no significant differences(P > 0.05).There was significant difference between the SERS scores of two groups(P < 0.05); the control group had more adverse reactions, and the score would be increased with the extension of treatment time.Effect index(EI) of CGI in the acupuncture group is better than that of control group(P < 0.05).CONCLUSION:The effects of Tiaoshen Kaiqiao acupuncture and fluoxetine in the treatment of ischemic post-stroke depression were similar, but the former had no obvious adverse reaction and side effects.展开更多
Objective To assess the clinical efficacy of acupuncture and moxibustion on depression based on the outcome indexes of the patient subjective reports. Methods One hundred and sixty-three cases of depression conformed ...Objective To assess the clinical efficacy of acupuncture and moxibustion on depression based on the outcome indexes of the patient subjective reports. Methods One hundred and sixty-three cases of depression conformed to the inclusive standards were randomized into a soothing liver and regulating mind group （group A）, an acupoint shallow puncturing group （group B） and a non- acupoint shallow puncturing group （group C）. In group A, the conventional acupuncture was applied to the four gate points [Hegu （合谷 LI 4） and Taichong （太冲 LR 3）], Baihui （百会 GV 20） and Yintang （印堂 GV 29）, direct moxibustion with moxa cone was applied to the four flower points [Geshu （膈俞 BL 17）, Danshu （胆俞 BL 19）]. Finally, intradermal needling was used at Xinshu （心俞 BL 15） and Ganshu （肝俞 BL 18）. In group 13, the acupoints selected were same as those in the soothing liver and regulating mind group, with a shallower needling depth and a shorter duration of moxibustion. In group C, the spots selected were located at 10 mm lateral to the acupoints selected in group A, with same manipulation method as that in group 13. In all the three groups, the treatment was given twice a week, for 12 weeks. Before treatment, 1 month and 3 months after treatment, the scores of symptoms were respectively assessed with the symptom checklist 90 （SCL 90）, and the corresponding short- term, mid-term and long-term efficacies of the acupuncture and moxibustion program for soothing the liver and regulating mind were investigated. Results At each time point after treatment, the scores of somatization, compulsion, depression, anxiety, hostility, extremeness, psychotic behavior and other 8 dimensionalit-ies were significantly different between group A and group C （all P〈0.05）. In the scores of depression, anxiety and hostility there were significant differences between the group A and the group C （all P〈0.05）. Conclusion Acupuncture and moxibustion can improve the scores of SCL 90 for the patients with depression, and the outcome indexes of the patient subjective reports can accurately assess the clinical efficacy.展开更多
目的:评价帕罗西汀合用喹硫平治疗双重抑郁症的疗效和安全性。方法:将符合中国精神障碍分类与诊断标准第三版(Chinese classification and diagnostic criteria of mental disorders,CCMD-3)双重抑郁症诊断标准的66例门诊及住院患者随...目的:评价帕罗西汀合用喹硫平治疗双重抑郁症的疗效和安全性。方法:将符合中国精神障碍分类与诊断标准第三版(Chinese classification and diagnostic criteria of mental disorders,CCMD-3)双重抑郁症诊断标准的66例门诊及住院患者随机分为两组,研究组(n=34)给予帕罗西汀合用喹硫平治疗,对照组(n=32)给予帕罗西汀治疗,疗程12周。于治疗前和治疗后2、4、6、8、12周分别使用汉密顿抑郁量表(Hanmilton Depression Scale,HAMD)、汉密顿焦虑量表(Hanmilton Anxiety Scale,HAMA)、临床总体印象疗效总评量表的病情严重程度(Clinical Global Impression,CGI)、不良反应量表(Treatment E-mergent Symptom Scale,TESS)评定疗效和不良反应。HAMD总分≤7分为痊愈;HAMD总分>7分,减分率≥50%为好转,痊愈和好转合称有效。结果:治疗前研究组和对照组HAMD、HAMA评分差异无统计学意义(P>0.05)。治疗12周后,研究组和对照组的HAMD、HAMA评分均低于治疗前(Ps<0.05);研究组6、8、12周HAMD、HAMA评分均低于对照组(Ps<0.05);研究组有效率高于对照组(P<0.05);两组间不良反应发生率差异无统计学意义(P>0.05)。结论:帕罗西汀合用喹硫平治疗双重抑郁症疗效较好,安全性高。展开更多
目的:总结历年来发表的中药治疗中风后抑郁症(PSD)临床研究文献中的常用方药,以期为PSD的中药治疗与研究提供可信的参考依据。方法:计算机检索中国生物医学文献数据库(CBMd isc 1979 to 4/2008)、中国知网中国期刊全文数据库(CNK I 1994...目的:总结历年来发表的中药治疗中风后抑郁症(PSD)临床研究文献中的常用方药,以期为PSD的中药治疗与研究提供可信的参考依据。方法:计算机检索中国生物医学文献数据库(CBMd isc 1979 to 4/2008)、中国知网中国期刊全文数据库(CNK I 1994 to 4/2008)、重庆维普中文科技期刊数据库(VIP 1989 to 4/2008)中文数据库和Pubm ed、EMbase英文数据库,并手工检索相关杂志,收集发表的关于中药治疗PSD的随机对照试验(RCT)和临床对照试验(CCT)的临床文献。应用频次和构成比统计有效中药的种类和药物,分析其用药规律。结果:75篇文献纳入研究,有70篇提供了基本方,应用频次居前10位的药物种类依次为补益药、活血化瘀药、理气药、安神药、解表药、化痰止咳平喘药、清热药、开窍药、利水渗湿药和平肝熄风药;应用频次居前10位的单味中药依次为柴胡、郁金、菖蒲、当归、甘草、白芍、川芎、远志、香附、茯苓。结论:中医药治疗中风后抑郁症,多以活血化瘀、疏肝理气和补益正气、养心安神为最基本方法,同时配合应用化痰、祛湿、调理脾胃、滋养肝肾等多种治法和药物,标本兼治,方能收到良好的治疗效果。展开更多
基金supported by the Guangdong Provincial"211 Engineering"Stage-III Key Disciplines Construction Project in China,No.Yue 2009431
文摘OBJECTIVE： To evaluate the effectiveness and safety of filiform needle acupuncture for poststroke depression, and to compare acupuncture with the therapeutic efficacy of antidepressant drugs. DATA RETRIEVAL： We retrieved data from the Chinese National Knowledge Infrastructure （1979-2012）, Wanfang （1980-2012）, VIP （1989-2012）, Chinese Biomedical Literature （1975- 2012）, PubMed （1966-2012）, Ovid Lww （-2012）, and Cochrane Library （-2012） Database using the internet. SELECTION CRITERIA： Randomized controlled trials on filiform needle acupuncture versus antidepressant drugs for treatment of poststroke depression were included. Moreover, the in- cluded articles scored at least 4 points on the Jadad scale. Exclusion criteria： other acupuncture therapies as treatment group, not stroke-induced depression patients, score 〈 4 points, non-ran- domized controlled trials, or animal trials. MAIN OUTCOME MEASURES： These were the Hamilton Depression Scale scores, clinical ef- fective rate, Self-Rating Depression Scale scores, Side Effect Rating Scale scores, and incidence of adverse reaction and events. RESULTS： A total of 17 randomized controlled clinical trials were included. Meta-analysis results displayed that after 4 weeks of treatment, clinical effective rate was better in patients treated with fill- form needle acupuncture than those treated with simple antidepressant drugs [relative risk = 1.11, 95% confidence interval （C/）： 1.03-1.21, P = 0.01]. At 6 weeks, clinical effective rate was similar between filiform needle acupuncture and antidepressant drug groups. At 2 weeks after filiform needle acupuncture, Hamilton Depression Scale （17 items） scores were lower than in the antide- pressant drug group （mean difference = -2.34, 95%CI： -3.46 to -1.22, P 〈 0.000,1）. At 4 weeks, Hamilton Depression Scale （24 items） scores were similar between filiform needle acupuncture and antidepressant drug groups. Self-Rating Depression Scale scores were lower in filiform needle acupuncture group than in the antidepressant drug group. Side Effect Rating Scale was used in only two articles, and no meta-analysis was conducted. Safety evaluation of the 17 arti- cles showed that gastrointestinal tract reactions such as nausea and vomiting were very common in the antidepressant drug group. Incidence of adverse reaction and events was very low in the filiform needle acupuncture group. CONCLUSION： Early filiform needle acupuncture for poststroke depression can perfectly con- trol depression. Filiform needle acupuncture is safe and reliable. Therapeutic effects of filiform needle acupuncture were better than those of antidepressant drugs.
基金the Hospital-level Project of Shiyan Taihe Hospital in 2018(2018JJXM092)Shiyan Science and Technology Research and Development Project in 2018(18Y17).
文摘[Objectives]To observe the clinical effect of Huatanjieyu granule on patients with post-stroke depression.[Methods]Total 76 patients with confirmed post-stroke depression were randomly divided into two groups(treatment group and control group)according to the double-blind principle.The treatment group(38 cases)was treated with Huatanjieyu granule combined with escitalopram,and the control group(38 cases)was treated with escitalopram alone.The course of treatment was 6 weeks.Through clinical efficacy,Hamilton Depression Scale(HAMD)and Treatment Emergent Symptom Scale(TESS)scores were compared,and blood,liver function,renal function and electrocardiogram were examined.[Results]The scores of HAMD and TESS in patients with post-stroke depression were significantly decreased by Huatanjieyu granule,and there were no obvious side effects.The total effective rate was 92.1%in the treatment group and 76.3%in the control group.There was significant difference between the two groups(P<0.01).[Conclusions]Huatanjieyu granule was effective in the treatment of post-stroke depression with little side effects and was easy to be accepted by patients.
文摘Objective:In cardiovascular disease,a patient’s anxiety and depression can increase cardiac rehabilitation duration and recovery.Lavender aromatherapy as a non-pharmacological intervention effective in other contexts may be an efficient intervention to alleviating anxiety and depression in patients with Acute Coronary Syndrome(ACS).Methods:In this study,110 ACS patients were randomly assigned to two intervention and control groups.Inhalation of the lavender fragrance was prescribed for the intervention group and the drop of aromatic almond for the control group for 3 days.Results:The first-day anxiety and depression were significantly different in the two groups at 1 h and 9 h after the intervention.The’morning’s difference before the intervention was not significant,but it was substantial 1 h after the intervention.On the third morning of the intervention,this difference was confirmed.Conclusions:This study confirmed the effectiveness of lavender aromatherapy in reducing anxiety and depression in ACS patients.This’study’s results enable intensive care nurses to use aromatherapy with lavender oil as a non-pharmacological and cost-effective intervention to reduce their psychological tensions and increase patient satisfaction during hospitalization in the cardiac care units(CCU).
文摘The patients with post-stroke depression often form a negative evaluation of themselves,and even have the idea of suicide in serious cases.Therefore,post-stroke depression has become one of the most common complications of mental illness after stroke,which seriously hinders the normal rehabilitation of the central nervous system,thus increasing the disability rate,early recurrence rate and mortality rate of patients.Therefore,the active treatment of post-stroke depression is very necessary.Western medicine uses antidepressant drugs for this kind of patients,but because the side effects of antidepressants are relatively large,the compliance of patients is not good,it is not easy to see the effect,while traditional Chinese medicine(TCM)has many ways to deal with post-stroke depression with obvious advantages,the side effects are relatively small,and there is more compliance in patients.This paper focuses on several TCM treatment methods,hoping to provide a reference for the treatment of post-stroke depression.
基金financially supported by the National Natural Science Foundation of China,No.81671347(to KL)The Science and Technology Program of Guangzhou,China,No.202007030012(to KFS and KL)。
文摘Subthreshold depression is a highly prevalent condition in adolescents who are at high risk for developing major depressive disorder.In preclinical models of neurological and psychiatric diseases,Lycium barbarum polysaccharide(LBP)extracted from Goji berries had antidepressant effects including but not limited to anti-oxidative and anti-inflammatory properties.However,the effect of LBP on subthreshold depression is unclear.To investigate the clinical efficacy and safety of LBP for treating subthreshold depression in adolescents,we conducted a randomized,double-blind,placebo-controlled trial(RCT)with 29 adolescents with subthreshold depression recruited at The Fifth Affiliated Hospital of Guangzhou Medical University.The participants were randomly assigned to groups where they received either 300 mg LBP(LBP group,n=15,3 boys and 12 girls aged 15.13±2.17 years)or a placebo(placebo group,n=14,2 boys and 12 girls aged 15±1.71 years)for 6 successive weeks.Interim analyses revealed that the LBP group exhibited a greater change in Hamilton Depression Scale(HAMD-24)scores relative to the baseline and a higher remission rate(HAMD-24 total score≤7)at 6 weeks compared with the placebo group.Scores on the Beck Depression Inventory-II(BDI-II),Pittsburgh Sleep Quality Index(PSQI),Kessler Psychological Distress Scale(Kessler),and Screen for Child Anxiety-Related Emotional Disorders(SCARED)were similar between the LBP and placebo groups.No side effects related to the intervention were reported in either group.These results indicate that LBP administration reduced depressive symptoms in adolescents with subthreshold depression.Furthermore,LBP was well tolerated with no treatment-limiting adverse events.Clinical trials involving a larger sample size are needed to further confirm the anti-depressive effects of LBP in adolescents with subthreshold depression.This study was approved by the Medical Ethics Committee of the Fifth Affiliated Hospital of Guangzhou Medical University(Guangzhou,China;approval No.L2019-08)on April 4,2019 and was registered on ClinicalTrials.gov(identifier:NCT04032795)on July 25,2019.
基金the National Research Foundation of Korea(NRF)funded by the Ministry of Science and ICT(NRF-2019R1A2C1007203)。
文摘The management of post-stroke complications plays an important role in the quality of life.Di-Tan Decoction(DTD;涤痰汤)is a widely used traditional Chinese medicine.This study incorporated systematic review and meta-analysis to evaluate the efficacy of DTD in post-stroke neurological disorders.Randomized clinical trials(RCTs)were searched from English,Chinese and Korean electronic medical databases,by including the keywords"Di-Tan Tang","Di-Tan Decoction","Scour Phlegm Decoction","stroke",and"RCT.Each RCT included control(placebo,conventional therapy,or Western medicine)and experimental(DTD treatment)groups.For patients inflicted with stroke for 1-6 weeks,the outcomes of post-stroke neurological disorders were measured by scales for post-stroke symptoms and were classified as"completely healed","markedly effective","effective"and"ineffective".Totally,11 RCTs(n=490 controls and n=502 DTD subjects)were selected from 210 articles identified in the initial search.A metaanalysis of evaluation criteria in post-stroke symptoms revealed that the overall odds ratio(ORs)for alleviating post-stroke neurological disorders were 0.30-fold lower(95%CI=0.21-0.43)in the DTD group than the control(Western medicine)group(P<0.00001).Moreover,regardless of the type of stroke diagnostic scale applied(including NFA,HDS,and NIHSS),the overall post-stroke symptoms determined were less severe in the DTD group(n=219)than the control group(n=217).No adverse effects of DTD were observed in the 11 RCTs reviewed.All 11 studies used an appropriate method for randomization of subjects to evaluate the risk of bias(ROB),and 7 studies included allocation concealment as well as blinding of patients and practitioners.High-risk ROB was included in6 RCTs.No significant publication bias was derived from the funnel plot.Our results indicate that the administration of DTD alone,and DTD in combination with Western medicine,exert greater efficacy for post-stroke complication therapy,than Western medicine administered alone.More rigorous and regulated studies are required to confirm the therapeutic efficacy of DTD for post-stroke neurological disorders.disorders.
基金Supported by the State Administration of Traditional Chinese Medicine of the People's Republic of China(201407001-6B)
文摘OBJECTIVE:To observe the effect of Tiaoshen Kaiqiao acupuncture in the treatment of ischemic post-stroke depression.METHODS:This research was a single-blind, positive-controlled trial done in a single entity.Totally58 patients with ischemic post-stroke depression were randomly divided into two groups.The acupuncture group was given Tiaoshen Kaiqiao acupuncture therapy and placebo starch tablets treatment,while the control group was treated with fluoxetine tablets and body acupuncture treatment.Evaluated the clinical efficacy of the two groups with Hamilton Depression Scale(HAMD),Anti Depression Drug Side Effects Rating Scale(SERS), Clinical Global Impression Scale(CGI) respectively before treatment, the fourth weekend of treatment, the eighth weekend of treatment,the twelfth weekend of treatment.The adverse reactions in two groups were observed and documented.RESULTS:The HAMD scale scores of the two groups in different treatment period were significantly decreased compared with that before treatment(P < 0.05); the score reduction of HAMD scale between the two groups had no significant differences(P > 0.05).There was significant difference between the SERS scores of two groups(P < 0.05); the control group had more adverse reactions, and the score would be increased with the extension of treatment time.Effect index(EI) of CGI in the acupuncture group is better than that of control group(P < 0.05).CONCLUSION:The effects of Tiaoshen Kaiqiao acupuncture and fluoxetine in the treatment of ischemic post-stroke depression were similar, but the former had no obvious adverse reaction and side effects.
基金Supported by National natural science fund (No: 81173348)Class general financial grant of the China postdoctoral science foundation (No: 2012M511784)+2 种基金Science foundation of the outstanding young innova ve personnel of department of education Guangdong Province (No.2012LYM_0043)Special research foundation of the new teacher category for the doctoral program of higher school by National ministry of education (No.20124425120005)Science founda on of the postdoctoral researchers in Guangzhou University of Chinese Medicine from Guangdong Provincial Department of human resources and social security fund(No.BBK429122K19)
文摘Objective To assess the clinical efficacy of acupuncture and moxibustion on depression based on the outcome indexes of the patient subjective reports. Methods One hundred and sixty-three cases of depression conformed to the inclusive standards were randomized into a soothing liver and regulating mind group （group A）, an acupoint shallow puncturing group （group B） and a non- acupoint shallow puncturing group （group C）. In group A, the conventional acupuncture was applied to the four gate points [Hegu （合谷 LI 4） and Taichong （太冲 LR 3）], Baihui （百会 GV 20） and Yintang （印堂 GV 29）, direct moxibustion with moxa cone was applied to the four flower points [Geshu （膈俞 BL 17）, Danshu （胆俞 BL 19）]. Finally, intradermal needling was used at Xinshu （心俞 BL 15） and Ganshu （肝俞 BL 18）. In group 13, the acupoints selected were same as those in the soothing liver and regulating mind group, with a shallower needling depth and a shorter duration of moxibustion. In group C, the spots selected were located at 10 mm lateral to the acupoints selected in group A, with same manipulation method as that in group 13. In all the three groups, the treatment was given twice a week, for 12 weeks. Before treatment, 1 month and 3 months after treatment, the scores of symptoms were respectively assessed with the symptom checklist 90 （SCL 90）, and the corresponding short- term, mid-term and long-term efficacies of the acupuncture and moxibustion program for soothing the liver and regulating mind were investigated. Results At each time point after treatment, the scores of somatization, compulsion, depression, anxiety, hostility, extremeness, psychotic behavior and other 8 dimensionalit-ies were significantly different between group A and group C （all P〈0.05）. In the scores of depression, anxiety and hostility there were significant differences between the group A and the group C （all P〈0.05）. Conclusion Acupuncture and moxibustion can improve the scores of SCL 90 for the patients with depression, and the outcome indexes of the patient subjective reports can accurately assess the clinical efficacy.
文摘目的:总结历年来发表的中药治疗中风后抑郁症(PSD)临床研究文献中的常用方药,以期为PSD的中药治疗与研究提供可信的参考依据。方法:计算机检索中国生物医学文献数据库(CBMd isc 1979 to 4/2008)、中国知网中国期刊全文数据库(CNK I 1994 to 4/2008)、重庆维普中文科技期刊数据库(VIP 1989 to 4/2008)中文数据库和Pubm ed、EMbase英文数据库,并手工检索相关杂志,收集发表的关于中药治疗PSD的随机对照试验(RCT)和临床对照试验(CCT)的临床文献。应用频次和构成比统计有效中药的种类和药物,分析其用药规律。结果:75篇文献纳入研究,有70篇提供了基本方,应用频次居前10位的药物种类依次为补益药、活血化瘀药、理气药、安神药、解表药、化痰止咳平喘药、清热药、开窍药、利水渗湿药和平肝熄风药;应用频次居前10位的单味中药依次为柴胡、郁金、菖蒲、当归、甘草、白芍、川芎、远志、香附、茯苓。结论:中医药治疗中风后抑郁症,多以活血化瘀、疏肝理气和补益正气、养心安神为最基本方法,同时配合应用化痰、祛湿、调理脾胃、滋养肝肾等多种治法和药物,标本兼治,方能收到良好的治疗效果。
