In a karst tunnel, fissures or cracks that are filled with weathered materials are a type of potential water outlet as they are easily triggered and converted into groundwater outlets under the influence of high groun...In a karst tunnel, fissures or cracks that are filled with weathered materials are a type of potential water outlet as they are easily triggered and converted into groundwater outlets under the influence of high groundwater pressure. A terrible water inrush caused by potential water outlets can seriously hinder the project construction. Potential water outlets and water sources that surrounding the tunnel must be detected before water inflow can be treated. This paper provides a successful case of the detection and treatment of water inflow in a karst tunnel and proposes a potential water outlet detection(PWOD) method in which heavy rainfall(>50 mm/d) is considered a trigger for a potential water outlet. The Daba tunnel located in Hunan province, China, has been constructed in a karst stratum where the rock mass has been weathered intensely by the influence of two faults. Heavy rain triggered some potential water outlets, causing a serious water inrush. The PWOD method was applied in this project for the treatment of water inflow, and six potential water outlets in total were identified through three heavy rains. Meanwhile, a geophysical prospecting technique was also used to detect water sources. The connections between water outlets and water sources were identified with a 3-D graphic that included all of them. According to the distribution of water outlets and water sources, the detection area was divided into three sections and separately treated by curtain grouting.展开更多
AIM:To make clear whether CD147 (EMMPRIN) expression in pathological tumor samples with a fine-needle aspiration biopsy is useful for pathological diagnosis of early hepatocellular carcinoma (HCC). METHODS:Twenty-two ...AIM:To make clear whether CD147 (EMMPRIN) expression in pathological tumor samples with a fine-needle aspiration biopsy is useful for pathological diagnosis of early hepatocellular carcinoma (HCC). METHODS:Twenty-two patients (15 men and 7 women; median age 68 years,range 56-81 years) underwent a liver tissue biopsy in order to make a diagnosis of HCC. Paraffin-embedded liver biopsy tissue samples from 22 patients were stained with anti-CD147 antibody,murine monoclonal antibody 12C3 (MAb12C3) for immunohistochemical analysis. An immunohistochemical analysis of CD147 was performed and the degree of staining compared between tumor and non-tumor tissue. In addition,the degree of staining within tumor tissue was compared according to a number of clinicopathological variables. RESULTS:The degree of staining of CD147 was significantly higher in tumor tissues than non-tumor tissues,even in tumors less than 15 mm in diameter.The expression of this protein was significantly elevated in HCC tissue specimens from patients with a low value of serum AST and γ-GTP.展开更多
基金supported by the National Key Research and Development Project (Grant No.2016YFC0801604)Natural Science Foundation of Shandong Province (Grant No.ZR2017MEE070)
文摘In a karst tunnel, fissures or cracks that are filled with weathered materials are a type of potential water outlet as they are easily triggered and converted into groundwater outlets under the influence of high groundwater pressure. A terrible water inrush caused by potential water outlets can seriously hinder the project construction. Potential water outlets and water sources that surrounding the tunnel must be detected before water inflow can be treated. This paper provides a successful case of the detection and treatment of water inflow in a karst tunnel and proposes a potential water outlet detection(PWOD) method in which heavy rainfall(>50 mm/d) is considered a trigger for a potential water outlet. The Daba tunnel located in Hunan province, China, has been constructed in a karst stratum where the rock mass has been weathered intensely by the influence of two faults. Heavy rain triggered some potential water outlets, causing a serious water inrush. The PWOD method was applied in this project for the treatment of water inflow, and six potential water outlets in total were identified through three heavy rains. Meanwhile, a geophysical prospecting technique was also used to detect water sources. The connections between water outlets and water sources were identified with a 3-D graphic that included all of them. According to the distribution of water outlets and water sources, the detection area was divided into three sections and separately treated by curtain grouting.
文摘AIM:To make clear whether CD147 (EMMPRIN) expression in pathological tumor samples with a fine-needle aspiration biopsy is useful for pathological diagnosis of early hepatocellular carcinoma (HCC). METHODS:Twenty-two patients (15 men and 7 women; median age 68 years,range 56-81 years) underwent a liver tissue biopsy in order to make a diagnosis of HCC. Paraffin-embedded liver biopsy tissue samples from 22 patients were stained with anti-CD147 antibody,murine monoclonal antibody 12C3 (MAb12C3) for immunohistochemical analysis. An immunohistochemical analysis of CD147 was performed and the degree of staining compared between tumor and non-tumor tissue. In addition,the degree of staining within tumor tissue was compared according to a number of clinicopathological variables. RESULTS:The degree of staining of CD147 was significantly higher in tumor tissues than non-tumor tissues,even in tumors less than 15 mm in diameter.The expression of this protein was significantly elevated in HCC tissue specimens from patients with a low value of serum AST and γ-GTP.
